Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Sylvain RaffaeleEmmanuelle Maria BayerDavid LafargeStéphanie CluzetSylvie German-RetanaTamy BoubekeurNathalie Leborgne-CastelJean-Pierre CardeJeannine LherminierElodie NoirotSatiat-Jeunemaitre BéatriceJeanny Laroche-TraineauPatrick MoreauThomas OttAndrew J MaulePhilippe ReymondFrançoise Simon-PlasEdward E FarmerJean-Jacques BessouleSébastien Mongrand
• Organismes : Processus d'Action des Enseignants : Déterminants et Impacts Laboratoire Traitement et Communication de l'Information Plante - microbe - environnement : biochimie, biologie cellulaire et écologie Plante - microbe - environnement : biochimie, biologie cellulaire et écologie Institut des sciences du végétal Laboratoire de biogenèse membranaire Laboratoire des interactions plantes micro-organismes Laboratoire de biogenèse membranaire Laboratoire de biogenèse membranaire
• Publié dans The Plant cell le 27/10/2020

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Résumé : Remorins (REMs) are proteins of unknown function specific to vascular plants. We have used imaging and biochemical approaches and in situ labeling to demonstrate that REM clusters at plasmodesmata and in approximately 70-nm membrane domains, similar to lipid rafts, in the cytosolic leaflet of the plasma membrane. From a manipulation of REM levels in transgenic tomato (Solanum lycopersicum) plants, we show that Potato virus X (PVX) movement is inversely related to REM accumulation. We show that REM can interact physically with the movement protein TRIPLE GENE BLOCK PROTEIN1 from PVX. Based on the localization of REM and its impact on virus macromolecular trafficking, we discuss the potential for lipid rafts to act as functional components in plasmodesmata and the plasma membrane.

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Fichiers liés : publi09-lipm-001_rafaelle_remorin_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Guilhem ArrachartGaëlle CreffHubert WadepohlChristophe BlancChristian BonhommeFlorence BabonneauBruno AlonsoJean-Louis BantigniesCarole CarcelJoël  j. E. MoreauPhilippe Dieudonné-GeorgeJean-Louis SauvajolDominique MassiotMichel Wong Chi Man
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Australian Nuclear Science and Technology Organisation [Australie] Laboratoire des colloïdes, verres et nanomatériaux Anorganisch-Chemisches Institut der Universität Heidelberg Laboratoire des colloïdes, verres et nanomatériaux Laboratoire de Chimie de la Matière Condensée de Paris Laboratoire de Chimie de la Matière Condensée de Paris Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Laboratoire des colloïdes, verres et nanomatériaux Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Laboratoire des colloïdes, verres et nanomatériaux Laboratoire des colloïdes, verres et nanomatériaux Conditions Extrêmes et Matériaux : Haute Température et Irradiation Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
• Publié dans Chemistry - A European Journal le 29/10/2020

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Résumé : The hydrolysis and condensation of a silylated derivative of ureidopyrimidinone led to nanostructured hybrid silica, such as that depicted, as clearly shown by powder XRD studies. The nanostructuring was directly related to molecular recognition through hydrogen bonding. By combining FTIR, solution and solid-state NMR spectroscopic data, the transcription of the hydrogen-bonding networks from the precursor to the final product was clearly evidenced.

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• Type de publi. : Autre publication
• Date de publi. : 01/05/2009
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Amalia TroussonSophie BernardPatrice X PetitPhilippe LiereAntoine PianosKhadija El HadriJean-Marc A. LobaccaroM. Said GhandourMichel RaymondjeanMichael SchumacherCharbel Massaad
• Organismes : Régulation de la transcription et maladies génétiques Régulation de la transcription et maladies génétiques Service de radiologie pédiatrique Institut de biologie et chimie des protéines [Lyon] Laboratoire Astrophysique de Toulouse-Tarbes Stéroides et système nerveux : physiopathologie moléculaire et clinique Stéroides et système nerveux : physiopathologie moléculaire et clinique Vieillissement Cellulaire Intégré et Inflammation Génétique, Reproduction et Développement Physiologie et physiopathologie Stéroïdes et système nerveux : physiopathologie moléculaire et clinique Faculté de Médecine Paris-Sud Régulation de la transcription et maladies génétiques
• Publié dans Journal of Neurochemistry le 25/10/2020

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Résumé : In several neurodegenerative diseases of the CNS, oligodendrocytes are implicated in an inflammatory process associated with altered levels of oxysterols and inflammatory enzymes such as secreted phospholipase A2 (sPLA2). In view of the scarce literature related to this topic, we investigated oxysterol effects on these myelinating glial cells. Natural oxysterol 25-hydroxycholesterol (25-OH; 1 and 10 muM) altered oligodendrocyte cell line (158N) morphology and triggered apoptosis (75% of apoptosis after 72 h). These effects were mimicked by 22(S)-OH (1 and 10 muM) which does not activate liver X receptor (LXR) but not by a synthetic LXR ligand (T0901317). Therefore, oxysterol-induced apoptosis appears to be independent of LXR. Interestingly, sPLA2 type IIA (sPLA2-IIA) over-expression partially rescued 158N cells from oxysterol-induced apoptosis. In fact, 25-OH, 24(S)-OH, and T0901317 stimulated sPLA2-IIA promoter and sPLA2 activity in oligodendrocyte cell line. Accordingly, administration of T0901317 to mice enhanced sPLA2 activity in brain extracts by twofold. Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 muM) and by LXR beta at basal oxysterol concentration. Finally, GC coupled to mass spectrometry established that oligodendrocytes contain oxysterols and express their biosynthetic enzymes, suggesting that they may act through autocrine/paracrine mechanism. Our results show the diversity of oxysterol signalling in the CNS and highlight the positive effects of the LXR/PXR pathway which may open new perspectives in the treatment of demyelinating and neurodegenerative diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Amélie Carbonnelle-PuscianChristiane Copie-BergmanMaryse BaiaNadine Martin-GarciaYves AlloryCorinne HaiounAnne CrémadesIssam Abd-AlsamadJean-Pierre FarcetPhilippe GaulardFlavia CastellanoValérie Molinier-Frenkel
• Organismes : Département de pathologie [Mondor] Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Service d'hématologie clinique Institut Mondor de Recherche Biomédicale Service d'Anatomo-Pathologie Institut Mondor de Recherche Biomédicale Service d'immunologie biologique Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Service d'immunologie biologique Institut Mondor de Recherche Biomédicale Service d'immunologie biologique
• Publié dans Leukemia le 25/10/2020

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Résumé : We previously reported a strong IL4I1 gene expression in primary mediastinal B-cell lymphoma (PMBL) and recently identified the protein as a secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, which inhibits T-cell proliferation in vitro. Here, we analyzed the pattern of IL4I1 protein expression in 315 human lymphoid and non-lymphoid malignancies. Besides PMBL, IL4I1 expression in tumors was very frequent. IL4I1 was detected in tumor-associated macrophages from most of the tumors and in neoplastic cells from follicular lymphoma, classic and nodular lymphocyte predominant Hodgkin lymphomas and small lymphocytic lymphoma, three of which are germinal center derived. IL4I1-positive tumor cells were also detected in rare cases of solid cancers, mainly mesothelioma. The enzymatic activity paralleled protein expression, suggesting that IL4I1 is functional in vivo. Depending on the tumor type, IL4I1 may impact on different infiltrating lymphocyte populations with consequences on tumor evolution. In the particular case of follicular lymphoma cells, which are susceptible to antitumor cytotoxic T cells killing but depend on interactions with local T helper cells for survival, a high level of IL4I1 expression seems associated with the absence of bone marrow involvement and a better outcome. These findings plead for an evaluation of IL4I1 as a prognosis factor.

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Fichiers liés : inserm-00392067_edited.pdf Equipe09_LeukemiaHAL.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 27/04/2009
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. : Communication dans un congrès
• Date de publi. : 22/04/2009
• Auteurs : Stanislas MondotJulien TapJean-Pierre FuretPatricia LepageJoel DorePhilippe MarteauMarion Leclerc
• Organismes : MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/04/2009
• Auteurs : Philippe JonnardKarine Le GuenMin-Hui HuJean-Michel AndréEvgueni MeltchakovChristophe HecquetFranck DelmotteAnouk Galtayries
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire de Physico-Chimie des Surfaces

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/04/2009
• Auteurs : Kauzar Saleh ContellE. Lopez-BaezaC. AntolinC. MillanAurelio CanoWigneron J.-P.J. BallingS.S. SchmidlN. SkouYann H. KerrPhilippe RichaumeSilvia Enache JugleaS. DelwartC. BouzinacP. Wursteisen
• Organismes : Department of geography Universitat de València = University of Valencia = Universidade de Valencia Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Universitat de València = University of Valencia = Universidade de Valencia Écologie fonctionnelle et physique de l'environnement University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère European Space Research and Technology Centre European Space Research and Technology Centre European Space Research and Technology Centre

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Fichiers liés : 26197_20090227102904978_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/04/2009
• Auteurs : Alexis HannartJean-Philippe BoulangerJean-Louis DufresnePhilippe Naveau
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Extrèmes : Statistiques, Impacts et Régionalisation

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Résumé : Uncertainties in model projections of future climate change are high, and have not decreased substantially over the last 30 years: IPCC AR4 range of climate sensitivity - the increase in globally averaged surface temperature expected for a doubling of CO2 - is [1.5 °C, 4.5 °C]. The causes and nature of this uncertainty, more specifically whether or not it will be possible to reduce it, is subject to debate. Before digging into this problem, we start by focusing on a basic, somewhat epistemological question: what is uncertainty in the context of climate science, and how should it be quantified? While this question may at first appear trivial, we claim that it has occasionally proved to be a source of confusion in the aforementioned debate. We illustrate this point by revisiting one among the most significant contributions to this debate in the recent past (Roe and Baker, 2007) and highlight the fact that its conclusions are dramatically affected by the chosen definition of uncertainty. To resolve this issue, we propose widely used standard deviation as a unique, broadly applicable definition of uncertainty. We then recall a general result on the propagation of uncertainty available from Probability theory under this definition, and analyse its implication on a simple stochastic Climate toy model. This analysis suggests that high uncertainty is not an inevitable and general consequence of the nature of the climate system, and hence is not doomed to remain high. More specifically, it suggests that reducing uncertainty on feedbacks in GCMs, through an improved understanding of involved physical processes, does lead to a reduction of uncertainty on climate sensitivity projected by models. Finally, we elaborate on foreseeable advances in Climate research and modeling that may lead to a decrease of feedback uncertainty, and subsequently to a reduction of uncertainty on climate sensitivity in the near future.

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