Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2010
• Auteurs : Helen M NorthSébastien BaudIsabelle DebeaujonChristian DubosBertrand DubreucqPhilippe GrappinMarc JullienLoïc LepiniecAnnie Marion-PollMartine MiquelLoïc RajjouJean-Marc RoutaboulMichel M. Caboche
• Organismes : Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin AgroParisTech Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin
• Publié dans The Plant Journal le 26/10/2020

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Résumé : Seeds play a fundamental role in colonization of the environment by spermatophytes, and seeds harvested from crops are the main food source for human beings. Knowledge of seed biology is therefore important for both fundamental and applied issues. This review on seed biology illustrates the important progress made in the field of Arabidopsis seed research over the last decade. Access to 'omics' tools, including the inventory of genes deduced from sequencing of the Arabidopsis genome, has speeded up the analysis of biological functions operating in seeds. This review covers the following processes: seed and seed coat development, seed reserve accumulation, seed dormancy and seed germination. We present new insights in these various fields and describe ongoing biotechnology approaches to improve seed characteristics in crops.

have continued to be exploited over the past decade, despite experimental difficulties resulting from gene duplications/redundancies (e.g. identification of the GA receptor), and will obviously continue to be valuable. However, the study of seed biodiversity, an important topic in terms of evolution, cannot be restricted to the analysis of intra-specific natural variation in Arabidopsis. It is time to look at biological diversity in other seedproducing plants in order to understand what makes them unique in terms of biochemical composition, tolerance to adverse environmental conditions, germination features, competition with other plants, and many other processes. Here we review the present status of Arabidopsis seed research and its biotechnological impact. This research will provide a valuable foundation for studies in other species.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2010
• Auteurs : Jean-Philippe ChampeauxPierre CarcabalJulien RabierPierre CafarelliMartine SencePatrick Moretto-Capelle
• Organismes : Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR)
• Publié dans Physical Chemistry Chemical Physics le 02/11/2020

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Résumé : Neutral and cationic halogen loss of singly and doubly ionised 5-X-uracil (X = F, Cl, Br, I) after collisions with 100 keV protons have been studied in the gas phase. The rates of these dissociation channels are strongly dependant on the nature of the halogen substituent. It is very weak in the case of fluorine but is a dominant channel for iodine. Dissociation mechanisms are proposed for a number of significant channels associated to dehalogenation. It is suggested that some final ion products originate from specific processes. For instance, ion products of mass 38, 39 and 40 amu are very sensitive to the nature of the primarily ejected halogen and result from pathways associated to dehydrogenation and transient formation of the dehalogenated uracil cation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2010
• Auteurs : Michaël MonetV’yacheslav Lehen’kyiFlorian GackiereVirginie FirlejMatthieu VandenbergheMorad RoudbarakiDimitra GkikaAlbin PourtierGabriel BidauxChristian SlomiannyPhilippe DelcourtFrançois RassendrenJean-Pierre BergeratJocelyn CéralineFlorence CabonSandrine HumezNatalia Prevarskaya
• Organismes : Université Paris Descartes - Faculté de Médecine Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate Centre de recherche en neurobiologie - neurophysiologie de Marseille Institut Cochin Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate Laboratoire de Physiologie Cellulaire - U 1003 Institut de biologie de Lille - IBL Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate Laboratoire de Physiologie Cellulaire - U 1003 Institut de Génomique Fonctionnelle Altération génétique des cancers, chimioprévention et réponse thérapeutique Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
• Publié dans Cancer Research le 29/10/2020

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Résumé : Abstract Castration resistance in prostate cancer (PCa) constitutes an advanced, aggressive disease with poor prognosis, associated with uncontrolled cell proliferation, resistance to apoptosis, and enhanced invasive potential. The molecular mechanisms involved in the transition of PCa to castration resistance are obscure. Here, we report that the nonselective cationic channel transient receptor potential vanilloid 2 (TRPV2) is a distinctive feature of castration-resistant PCa. TRPV2 transcript levels were higher in patients with metastatic cancer (stage M1) compared with primary solid tumors (stages T2a and T2b). Previous studies of the TRPV2 channel indicated that it is primarily involved in cancer cell migration and not in cell growth. Introducing TRPV2 into androgen-dependent LNCaP cells enhanced cell migration along with expression of invasion markers matrix metalloproteinase (MMP) 9 and cathepsin B. Consistent with the likelihood that TRPV2 may affect cancer cell aggressiveness by influencing basal intracellular calcium levels, small interfering RNA–mediated silencing of TRPV2 reduced the growth and invasive properties of PC3 prostate tumors established in nude mice xenografts, and diminished expression of invasive enzymes MMP2, MMP9, and cathepsin B. Our findings establish a role for TRPV2 in PCa progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced PCa. Cancer Res; 70(3); 1225–35

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• Type de publi. : Article dans une revue
• Date de publi. : 26/02/2010
• Auteurs : Philippe BarbouxJean-Pierre BonnetAlain DurandSébastien LecommandouxJean-François F Le MeinsJ.-M. NedelecThierry PauportéFabienne PelléValérie RavaineChristophe Schatz
• Organismes : Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI) Groupe d'Etudes des Matériaux Hétérogènes Laboratoire de Chimie Physique Macromoléculaire Laboratoire de Chimie des Polymères Organiques Team 3 LCPO : Polymer Self-Assembly & Life Sciences Laboratoire de Chimie des Polymères Organiques Team 3 LCPO : Polymer Self-Assembly & Life Sciences Laboratoire des Matériaux Inorganiques Laboratoire d'Electrochimie, Chimie des Interfaces et Modélisation pour l'Energie (LECIME - UMR 7575) Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI) Institut des Sciences Moléculaires Laboratoire de Chimie des Polymères Organiques Team 3 LCPO : Polymer Self-Assembly & Life Sciences
• Publié dans L'Actualité Chimique le 02/11/2020

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Résumé : Nanosciences and nanotechnologies: health and environment The contribution of the chemist to nanotechnologies is the bottom-up approach, which consists in the assembly of functionalized objects from molecular precursors. The synthesis relies on the supramolecular assembly of elemental bricks, each contributing with a specific functionality. In the case of medical applications, mineral or organic nanoparticles find applications in optical or magnetic imaging as well as in therapy through controlled release and vectorization of drugs. This paper describes both the concept of synthesis and the process methods to elaborate these materials at the industrial scale. Moreover the structured assembly of nano-objects into textured ceramics, hierarchical materials, thin films or active coating favours both surface exchange and reactants diffusion. These systems with open structure find applications in energy conversion, photovoltaic and depollution.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/02/2010
• Auteurs : Tony Le GallDamien LoizeauErwan PicquetNathalie CarmoyJean-Jacques YaouancLaure Burel-DeschampsPascal DelépinePhilippe GiamarchiPaul-Alain JaffrèsPierre LehnTristan Montier
• Organismes : SynNanoVect Génétique moléculaire et génétique épidémiologique Chimie, Electrochimie Moléculaires et Chimie Analytique Chimie, Electrochimie Moléculaires et Chimie Analytique SynNanoVect Génétique moléculaire et génétique épidémiologique Chimie, Electrochimie Moléculaires et Chimie Analytique SynNanoVect Chimie, Electrochimie Moléculaires et Chimie Analytique SynNanoVect Génétique moléculaire et génétique épidémiologique Chimie, Electrochimie Moléculaires et Chimie Analytique Chimie, Electrochimie Moléculaires et Chimie Analytique SynNanoVect SynNanoVect Génétique moléculaire et génétique épidémiologique SynNanoVect Génétique moléculaire et génétique épidémiologique
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

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Résumé : Cationic lipophosphoramidates constitute a class of cationic lipids we have previously reported to be efficient for gene transfection. Here, we synthesized and studied a novel lipophosphoramidate derivative characterized by an arsonium headgroup linked, via a phosphoramidate linker, to an unconventional lipidic moiety consisting of two diunsaturated linoleic chains. Physicochemical studies allowed us to comparatively evaluate the specific fluidity and fusogenicity properties of the liposomes formed. Although corresponding lipoplexes exhibited significant but relatively modest in vitro transfection efficiencies, they showed a remarkably efficient and reproducible ability to transfect mouse lung, with in vivo transfection levels higher than those observed with a monounsaturated analogue previously described. Thus, these results demonstrate that this diunsaturated cationic lipophosphoramidate constitutes an efficient and versatile nonviral vector for gene transfection. They also invite further evaluations of the transfection activity, especially in vivo, of gene delivery systems incorporating the lipid reported herein and/or other lipids bearing polyunsaturated chains.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/02/2010
• Auteurs : Philippe GosseVirginie DauphinotFrédéric RocheVincent PichotSebastien CelleJean‐claude Barthelemy
• Organismes : Centre Hospitalier Universitaire de Bordeaux Centre Mémoire Ressources et Recherche [Lyon] Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne] Université Jean Monnet - Saint-Étienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne] Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne] Université Jean Monnet - Saint-Étienne
• Publié dans Journal of Clinical Hypertension le 01/11/2020

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Résumé : There are few data on the prevalence of hypertension in European populations based on the ambulatory determination of blood pressure. The Prognostic Indicator of Cardiovascular and Cerebrovascular Events (PROOF) study provided an opportunity to examine this prevalence in a cohort of 955 patients (387 men and 588 women, all aged 65 years) selected from an electoral list. All patients benefited from measurement of blood pressure during consultation and by 24-hour ambulatory determinations. In this population, 18% had treated hypertension, but 31% had a daytime systolic pressure >135 mm Hg. This proportion was even higher (46%) in patients whose fasting blood glucose was >1.1 g/L or >6.1 mmol/L. In the untreated population, 21% had unrecognized hypertension with daytime systolic pressure >135 mm Hg, with an even higher percentage (35%) in the hyperglycemic patients. This study shows a significant proportion of hypertensive patients, whether treated or not, with high ambulatory blood pressure, especially in those with hyperglycemia who have a higher risk of complications.

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2010
• Auteurs : Alban LepailleurStéphane LemaîtreXiao FengJana Sopkova-de Oliveira SantosPhilippe DelagrangeJean A. BoutinPierre RenardRonan BureauSylvain Rault
• Organismes : Centre d'Etudes et de Recherche sur le Médicament de Normandie Chongqing Jiaotong University Centre d'Etudes et de Recherche sur le Médicament de Normandie Neuroscience et Pharmacologie Institut de Recherches Servier Les Laboratoires SERVIER Centre d'Etudes et de Recherche sur le Médicament de Normandie Centre d'Etudes et de Recherche sur le Médicament de Normandie
• Publié dans Journal of Chemical Information and Modeling le 27/10/2020

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Fichiers liés : Publi_AANAT_jcim_rev.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/02/2010
• Auteurs : Patricia FauqueFrançoise F. MondonFranck LetourneurMarie-Anne RipocheLaurent JournotSandrine S. BarbauxLuisa L. DandoloCatherine PatratJean-Philippe WolfPierre JouannetHélène JammesDaniel Vaiman
• Organismes : AP-HP - Hôpital Cochin Institut Cochin Institut Cochin Institut Cochin Institut Cochin Institut de Génomique Fonctionnelle Institut Cochin Institut Cochin AP-HP - Hôpital Cochin AP-HP - Hôpital Cochin AP-HP - Hôpital Cochin Institut Cochin Institut Cochin
• Publié dans PLoS ONE le 25/10/2020

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Résumé : BACKGROUND: Assisted Reproductive Technologies (ART) are increasingly used in humans; however, their impact is now questioned. At blastocyst stage, the trophectoderm is directly in contact with an artificial medium environment, which can impact placental development. This study was designed to carry out an in-depth analysis of the placental transcriptome after ART in mice. METHODOLOGY/PRINCIPAL FINDINGS: Blastocysts were transferred either (1) after in vivo fertilization and development (control group) or (2) after in vitro fertilization and embryo culture. Placentas were then analyzed at E10.5. Six percent of transcripts were altered at the two-fold threshold in placentas of manipulated embryos, 2/3 of transcripts being down-regulated. Strikingly, the X-chromosome harbors 11% of altered genes, 2/3 being induced. Imprinted genes were modified similarly to the X. Promoter composition analysis indicates that FOXA transcription factors may be involved in the transcriptional deregulations. CONCLUSIONS: For the first time, our study shows that in vitro fertilization associated with embryo culture strongly modify the placental expression profile, long after embryo manipulations, meaning that the stress of artificial environment is memorized after implantation. Expression of X and imprinted genes is also greatly modulated probably to adapt to adverse conditions. Our results highlight the importance of studying human placentas from ART.

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Fichiers liés : 2010_Fauque_Plosone_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2010
• Auteurs : Julien TotemsVéronique JolivetJean-Philippe OvarlezNadine Martin
• Organismes : ONERA - The French Aerospace Lab [Châtillon] ONERA - The French Aerospace Lab [Châtillon] Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) ONERA - The French Aerospace Lab [Toulouse] GIPSA - Signal et Automatique pour la surveillance, le diagnostic et la biomécanique

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Résumé : Vibration sensing by laser radar with a pulsed emission is a promising technique for long range target recognition and identification. However, compared to its continuous-wave counterpart, it is impaired by its greater sensitivity to speckle noise and its lack of robustness to multiple independent vibrations of the target surface. Using poly-pulse waveforms for greater velocity resolution, we developed a new estimator to take into account signal statistics, and time frequency representations that can achieve better performance than classical processing methods. Simulations show a 5dB improvement in Signal-to- Noise Ratio (SNR) when speckle noise is dominant, and 4dB improvement when signal is weak in regard to detection noise.

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Fichiers liés : 1786431totems.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 02/02/2010
• Auteurs : Jean-Pierre LefebvrePhilippe LasayguesSerge Mensah
• Organismes : Ondes et Imagerie Ondes et Imagerie Ondes et Imagerie

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