Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/04/2009
• Auteurs : Yann H. KerrPhilippe WaldteufelPhilippe RichaumeWigneron J.-P.P. FerrazzoliAli MahmoodiS. Delwart
• Organismes : Centre d'études spatiales de la biosphère ESTER - LATMOS Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] Array Systems Computing European Space Research and Technology Centre

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Fichiers liés : 30780_20090227103349395_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/04/2009
• Auteurs : Philippe Pierre
• Organismes : Institut de l'Ouest : Droit et Europe

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2009
• Auteurs : Daniel AjzenbergHélène YeraPierre MartyLuc ParisFrédéric DalleJean MenottiDominique AubertJacqueline FranckMarie-Hélène BessièresDorothée QuinioHervé PellouxLaurence DelhaesNicole DesboisPhilippe ThulliezFlorence Robert-GangneuxCatherine Kauffmann-LacroixSophie PujolMeja RabodonirinaMarie-Elisabeth BougnouxBernadette CuisenierChantal DuhamelThanh Hai DuongDenis FilisettiPierre FloriFrançoise Gay-AndrieuFrancine PratlongGilles NevezAnne TotetBernard CarmeHenri BonnabauMarie-Laure DardéIsabelle Villena
• Organismes : Université de Limoges Neuroépidémiologie Tropicale et Comparée Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) Protozooses Transmises par l'Alimentation (Cryptosporidiose, Giardose et Toxoplasmose) : Mode de Contamination et Pathogénie (PROTAL) - EA 3800 Laboratoire Universitaire de Biodiversité et Ecologie Microbienne Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Université de Limoges Neuroépidémiologie Tropicale et Comparée Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) Protozooses Transmises par l'Alimentation (Cryptosporidiose, Giardose et Toxoplasmose) : Mode de Contamination et Pathogénie (PROTAL) - EA 3800
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : We report the genotyping analysis of Toxoplasma gondii isolates in samples collected from 88 immunocompromised patients, along with clinical and epidemiological data. Most of these samples were collected in France during the current decade by the Toxoplasma Biological Resource Center. Lack of specific anti-Toxoplasma treatment, pulmonary toxoplasmosis, and involvement of multiple organs were the 3 main risk factors associated with death for this patient group. Genotyping results with 6 microsatellite markers showed that type II isolates were predominant among patients who acquired toxoplasmic infection in Europe. Non-type II isolates included 13 different genotypes and were mainly collected from patients who acquired toxoplasmosis outside Europe. Type III was the second most common genotype recovered from patients, whereas type I was rare in our population. Three nonarchetypal genotypes were repeatedly recovered from different patients who acquired the infection in sub-Saharan Africa (genotypes Africa 1 and Africa 2) and in the French West Indies (genotype Caribbean 1). The distribution of genotypes (type II vs. non-type II) was not significantly different when patients were stratified by underlying cause of immunosuppression, site of infection, or outcome. We conclude that in immunocompromised patients, host factors are much more involved than parasite factors in patients' resistance or susceptibility to toxoplasmosis.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/04/2009
• Auteurs : Christian CarrieJacques GrillDominique Figarella‑brangerValerie BernierLaetitia PadovaniJean Louis HabrandMohamed BenhasselMartine MegeMarc MahéP. QuétinJean Philippe MaireMarie-Hélène BaronPierre ClavereSophie ChapetPhilippe MaingonClaire AlapetiteLine ClaudeAnne LaprieSophie Dussart
• Organismes : Pharmacologie et nouveaux traitements des cancers Service de pathologie et neuropathologie Centre Alexis Vautrin Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Service de radiothérapie Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) Pôle Kaplan de cancérologie
• Publié dans Journal of Clinical Oncology le 01/11/2020

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Résumé : PURPOSE: To determine event free and overall survival, and long-term cognitive sequelae of children with standard-risk medulloblastoma (SRM) treated with hyperfractionated radiotherapy, conformal reduced boost volume without chemotherapy, and online quality assurance. PATIENTS AND METHODS: Forty-eight patients (age 5 to 18 years) were included in the Medulloblastoma-Société Française d'Oncologie Pédiatrique (MSFOP 98) protocol (December 1998 to October 2001). Patients received hyperfractionated radiotherapy (HFRT; 36 Gy, 1 Gy/fraction twice per day) to the craniospinal axis followed by a boost to the tumor bed (1.5-cm margin) to a dose of 68 Gy. Records of craniospinal irradiation were reviewed before treatment started. Neuropsychologic evaluations were done according to the protocol (1, 3, 5, and 7 years after irradiation). Cognitive outcomes were followed longitudinally with full-scale intelligence quotient (FSIQ) obtained with age-adapted Wechsler scales. RESULTS: After a median follow-up of 77.7 months, 6-year overall survival (OS) and event-free survival (EFS) rates for the cohort were 78% (95% CI, 66% to 90%) and 75%, respectively (95% CI, 62% to 87%). Thanks to quality control, 14 major deviations were detected. Annual full scale IQ decline was 2 points over a 6-year period. Predicted change in FSIQ points per year was 2.15 (95% CI, -1.24 to 3.51) with an intercept (ie, predicted FSIQ) of 93.57 at baseline. CONCLUSION: HFRT protocol with conformal reduced boost and online quality control allows excellent long-term OS and EFS in the absence of chemotherapy. In addition, FSIQ drops seem to be less pronounced than previously reported with standard irradiation regimens.

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2009
• Auteurs : Lena Saint MacaryMyrtil L KahnClaude EstournèsPierre FauDavid TrémouillesMarise BafleurPhilippe RenaudBruno Chaudret
• Organismes : Freescale Semiconducteurs Laboratoire de chimie de coordination Centre interuniversitaire de recherche et d'ingénierie des matériaux Laboratoire de chimie de coordination Équipe Intégration de Systèmes de Gestion de l'Énergie Équipe Intégration de Systèmes de Gestion de l'Énergie Freescale Semiconducteurs Laboratoire de chimie de coordination
• Publié dans Advanced Functional Materials le 25/10/2020

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Résumé : Conditions for the elaboration of nanostructured varistors by Spark Plasma Sintering (SPS) are investigated, using 8 nm zinc oxide nanoparticles synthesized following an organometallic approach. A binary system constituted of zinc oxide and bismuth oxides nanoparticles is used for this purpose. It is synthesized at room temperature in an organic solution through the hydrolysis of dicyclohexylzinc and bismuth acetate precursors. Sintering of this material is performed by SPS at various temperatures and dwell times. The determination of the microstructure and the chemical composition of the as prepared ceramics are based on Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) analysis. The non linear electrical characteristics are evidenced by current-voltage (I-V) measurements. The breakdown voltage of these nanostructured varistors strongly depends on grain sizes. The results show for the first time that, nanostructured varistors are obtained by SPS at sintering temperatures ranging from 550 to 600°C.

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Fichiers liés : PDF-_Saint-Macary.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Hélène MarchandinPascal BattistellaBrigitte CalvetHélène DarbasJean-Marc FrapierHélène Jean-PierreSylvie ParerEstelle Jumas-BilakPhilippe van de PerreSylvain Godreuil
• Organismes : Université de Montpellier CHU de Montpellier, Service de Prévention des infections et de la Résistance Equipe Pathogènes et Environnements, UMR 5119-ECOSYM
• Publié dans Journal of Medical Microbiology le 25/10/2020

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Résumé : We describe what we believe to be the first documented case of Mycobacterium goodii infection in Europe. It is also the second documented report of a pacemaker pocket surgical site infection caused by M. goodii . Although rarely involved in such infections, rapidly growing mycobacteria should be recognized during conventional bacteriological investigations and further identified by molecular tools to provide adequate therapy. In the present case, antimicrobial therapy with doxycycline without removal of the pacemaker was successful.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Philippe MadelineJean-Marc Moriceau
• Organismes : Espaces et Sociétés Centre de recherche d'histoire quantitative
• Publié dans L'Histoire le 28/10/2020

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Résumé : Pierre Lebugle, petit paysan de Normandie, a tenu de 1942 à 1971 un carnet où se mêlent comptes domestiques et propos intimes. L'histoire rurale prend grâce à lui un nouveu relief.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : David RudraufJean-Philippe LachauxAntonio DamasioSylvain BailletLaurent HuguevilleJacques MartinerieHanna DamasioBernard Renault
• Organismes : Neurosciences cognitives et imagerie cérébrale Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Brain and Creativity Institute and Dornsife Cognitive Neuroimaging Center Laboratoire de neurosciences cognitives et d'imagerie cérébrale Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans International Journal of Psychophysiology le 31/10/2020

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Résumé : In a MEG experiment, we imaged the early dynamics of the human cerebral cortex during the induction of emotion by visual stimuli. We tested the hypothesis that early cortical responses would correlate with the emotional competence of visual stimuli and subsequent subjective ratings of feeling in a set of specific target regions important for somatosensory, attentional, and motivational functions, just after initial visual and appraisal related cortical responses to picture presentation. Relative to the neutral condition, cortical responses, during the 350-500 ms phase of the MEG evoked response, were stronger for both pleasant and unpleasant stimuli in the orbitofrontal cortex, ventromedial prefrontal cortex, anterior cingulate and somatosensory cortices. These responses, which correlated with subjective ratings of arousal, emerged after an initial spreading of cortical activity from early visual cortex (70-200 ms) to the ventral visual stream, temporopolar and orbitofrontal regions (200-350 ms), higher for emotionally competent stimuli than for neutral in the 200-350 ms window, in a manner compatible with an appraisal function. Heart beats occurring during the first 500 ms post stimulus showed longer intervals for unpleasant than for neutral stimuli relative to the preceding beat. The results support the hypothesis of a sequence of processing regarding the emergence of feelings and suggest that, even in the early phase of feeling induction, actual body responses to the inducing stimuli could be represented in the brain.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Elvire BourgeoisLinh Pham VanMichel SamsonSéverine DiemAnne BarraStéphane RogaJean-Marc GombertElke SchneiderMichel DyPierre GourdyJean-Philippe GirardAndré Herbelin
• Organismes : Cytokines, hématopoïèse et réponse immune Cytokines, hématopoïèse et réponse immune Signalisation et Réponses aux Agents Infectieux et Chimiques Détoxication et réparation tissulaire Cytokines, hématopoïèse et réponse immune Laboratoire d'immunologie [CHU de Poitiers] Institut de pharmacologie et de biologie structurale Laboratoire d'immunologie [CHU de Poitiers] Cytokines, hématopoïèse et réponse immune Cytokines, hématopoïèse et réponse immune Institut de médecine moléculaire de Rangueil Institut de pharmacologie et de biologie structurale Cytokines, hématopoïèse et réponse immune Université Paris Descartes - Paris 5
• Publié dans European Journal of Immunology le 22/10/2020

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Résumé : IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, given that purified iNKT cells express the T1/ST2 receptor constitutively and respond to IL-33 by in vitro expansion and functional activation. Conversely to the expected pro-Th2 effect, IL-33 induced a preferential increase in IFN-gamma rather than IL-4 production upon TCR engagement that depended on endogenous IL-12. Moreover, in combination with the pro-inflammatory cytokine IL-12, IL-33 enhanced IFN-gamma production by both iNKT and NK cells. Taken together these data support the conclusion that IL-33 can contribute as a co-stimulatory factor to innate cellular immune responses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Jean-Philippe EmpanaYves DauvilliersJean-François DartiguesKaren RitchieJerome GariepyXavier JouvenChristophe TzourioPhilippe AmouyelAlain BessetPierre Ducimetiere
• Organismes : AVENIR Team 'Epidemiology of sudden cardiac death'
• Publié dans Stroke le 31/10/2020

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Résumé : Background and Purpose— Excessive daytime sleepiness, one of the most frequent sleep complaints in the elderly, may affect survival, but inconsistent results have been observed in that population so far. We therefore estimated the risk of mortality for excessive daytime sleepiness (EDS) in community-dwelling elderly participating in the Three City Study. Methods— The Three City Study is a French population-based multicenter prospective study including 9294 subjects (60% women) aged ≥65 years at recruitment between 1999 to 2001. At baseline, 8269 subjects rated EDS and nocturnal sleep complaints as never, rare, regular, and frequent in response to an administered questionnaire and provided information on medication use for sleep or anxiety. Hazard ratios (HR) of EDS (regular or frequent) for mortality over 6 years were estimated by a Cox proportional hazard model. Results— At baseline, 18.7% of the study participants had regular or frequent EDS. After 6 years of follow-up, 762 subjects had died including 260 from cancer and 196 from cardiovascular disease. EDS was associated with a significant 33% increased risk of mortality (95% CI: 1.13 to 1.61) after adjustment for age, gender, study center, body mass index, previous cardiovascular disease, Mini Mental State Examination score, and cardiovascular risk factors. Further adjustment for current use of medication for sleep and for depressive symptoms slightly diminished the HRs. EDS was equally predictive of mortality in those who snored loudly and in those who did not. EDS was related to cardiovascular mortality but not to mortality attributable to cancer. Conclusion— EDS might be independently associated with total and cardiovascular mortality in community-dwelling elderly.

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