Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2009
• Auteurs : Hélène GilbertSyrina Al AïnJean Pierre BidanelHervé LagantYvon BillonPhilippe GuillouetJean NobletPierre Sellier
• Organismes : Génétique Animale et Biologie Intégrative Génétique Animale et Biologie Intégrative Génétique Animale et Biologie Intégrative Génétique Animale et Biologie Intégrative Génétique Expérimentale en Productions Animales Insémination Caprine et Porcine Systèmes d'élevage, nutrition animale et humaine Génétique Animale et Biologie Intégrative

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Résumé : absent

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• Type de publi. : Article dans une revue
• Date de publi. : 03/02/2009
• Auteurs : Claire VanlemmensVincent Di MartinoChantal MilanMichel MessnerAnne MinelloChristophe DuvouxThierry PoynardJean-Marc PerarnauMarie-Anne Astrid PiquetGeorges-Philippe PageauxSébastien DharancyChristine SilvainSophie HillaireGérard ThiefinJean-Pierre VinelPatrick HillonEstelle CollinGeorges MantionJean-Philippe MiguetNon Renseigné
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Agents pathogènes et inflammation - UFC (EA 4266) Lipides - Nutrition - Cancer (U866) CHU Pitié-Salpêtrière [AP-HP] Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon) WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis
• Publié dans Annals of Internal Medicine le 25/10/2020

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Résumé : BACKGROUND: Liver transplantation improves survival of patients with end-stage (Child-Pugh stage C) alcoholic cirrhosis, but its benefit for patients with stage B disease is uncertain. OBJECTIVE: To compare the outcomes of patients with Child-Pugh stage B alcoholic cirrhosis who are immediately listed for liver transplantation with those of patients assigned to standard treatment with delay of transplantation until progression to stage C disease. DESIGN: Randomized, controlled trial. SETTING: 13 liver transplantation programs in France. PATIENTS: 120 patients with Child-Pugh stage B alcoholic cirrhosis and no viral hepatitis, cancer, or contraindication to transplantation. INTERVENTIONS: Patients were randomly assigned to immediate listing for liver transplantation (60 patients) or standard care (60 patients). MEASUREMENTS: Overall and cancer-free survival over 5 years. RESULTS: Sixty-eight percent of patients assigned to immediate listing for liver transplantation and 25% of those assigned to standard care received a liver transplant. All-cause death and cirrhosis-related death did not statistically differ between the 2 groups: 5-year survival was 58% (95% CI, 43% to 70%) for those assigned to immediate listing versus 69% (CI, 54% to 80%) for those assigned to standard care. In multivariate analysis, independent predictors of long-term survival were absence of ongoing alcohol consumption (hazard ratio, 7.604 [CI, 2.395 to 24.154]), recovery from Child-Pugh stage C (hazard ratio, 7.633 [CI, 2.392 to 24.390]), and baseline Child-Pugh score less than 8 (hazard ratio, 2.664 [CI, 1.052 to 6.746]). Immediate listing for transplantation was associated with an increased risk for extrahepatic cancer: The 5-year cancer-free survival rate was 63% (CI, 43% to 77%) for patients who were immediately listed and 94% (CI, 81% to 98%) for those who received standard care. LIMITATION: Restriction of the study sample to alcoholic patients may limit the generalizability of results to other settings. CONCLUSION: Immediate listing for liver transplantation did not show a survival benefit compared with standard care for Child-Pugh stage B alcoholic cirrhosis. In addition, immediate listing for transplantation increased the risk for extrahepatic cancer. FUNDING: The French National Program for Clinical Research.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Pierre PayouxPhilippe RemyMalika MiloudiJean-Luc HouetoClaudio StadlerBoulos-Paul BejjaniJérome YelnikYves SamsonOlivier J. RascolYves AgidPhilippe Damier
• Organismes : Imagerie cérébrale et handicaps neurologiques Service de neurologie [Mondor] Laboratoire des Maladies Neurodégénératives - UMR 9199 Service de neurologie [CHU de Poitiers] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Imagerie cérébrale et handicaps neurologiques CHU Pitié-Salpêtrière [AP-HP] Clinique neurologique
• Publié dans Journal of Cerebral Blood Flow and Metabolism le 01/11/2020

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Résumé : Continuous stimulation of the globus pallidus (GP) has been shown to be an effective treatment for Parkinson's disease (PD). We used the fact that the implanted quadripolar leads contain electrodes within the GPi and GPe to investigate the clinical effects of acute high-frequency stimulation applied in these nuclei and changes in regional cerebral blood flow (rCBF) as an index of synaptic activity. In five patients treated by chronic GP stimulation, we compared the effects on PD symptoms and the changes in rCBF at rest and during paced right-hand movements, with and without left GPe or GPi stimulation. Although improving contralateral rigidity and akinesia, left GPe stimulation decreased rCBF in the left cerebellum and lateral premotor cortex at rest and significantly increased it in the left primary sensorimotor cortex (SM1) during movement. In contrast, left ventral GPi stimulation, which improved rigidity and worsened akinesia, decreased rCBF in the left SM1, premotor area, anterior cingulum, and supplementary motor area but did not modify the movement-related activation. GPe stimulation seems to result in a reduced activity of motor-related areas and the facilitation of motor cortex activation during movement, the latter component being absent during GPi stimulation, and this may explain the observed worsening of akinesia.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Pierre BouzatGilles FranconyPhilippe DecletyJulien BrunAffif KaddourJean-Charles RenversezClaude JacquotJean-François Payen
• Organismes : Neuro-imagerie fonctionnelle et métabolique Neuro-imagerie fonctionnelle et métabolique Pôle anesthésie-réanimation Pôle anesthésie-réanimation Service des urgences chirurgicales Département de biologie intégrée Pôle anesthésie-réanimation Neuro-imagerie fonctionnelle et métabolique
• Publié dans Annales Françaises d'Anesthésie et de Réanimation le 26/10/2020

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Résumé : INTRODUCTION: Patients with moderate traumatic brain injury (TBI) (Glasgow Coma Scale, GCS, 9-13) or minor TBI (GCS 14-15) are at risk for subsequent neurological deterioration. Serum protein S-100 is believed to reflect brain damage following TBI. In patients with normal or minor CT scan abnormalities on admission, we tested whether the determination of serum protein S-100 beta could predict secondary neurological deterioration. METHODS: Sixty-seven patients with moderate or minor TBI were prospectively studied. Serum samples were collected on admission within 12 hours postinjury to measure serum protein S-100 levels. Neurological outcome was assessed up to seven days after trauma. Secondary neurological deterioration was defined as two points or more decrease from the initial GCS, or any treatment for neurological deterioration. RESULTS: Nine patients had a secondary neurological deterioration after trauma. No differences in serum levels of protein S-100 were found between these patients and those without neurological aggravation (n=58 patients): 0.93 microg/l (0.14-4.85) vs 0.39 microg/l (0.04-6.40), respectively. The proportion of patients with abnormal levels of serum protein S-100 at admission according to two admitted cut-off levels (>0.1 and >0.5 microg/l) was comparable between the two groups of patients. Elevated serum levels of protein S-100 were found in patients with Injury Severity Score (ISS) of more than 16 (n=23 patients): 1.26 microg/l (0.14-6.40) vs 0.22 microg/l (0.04-6.20) in patients with ISS less than 16 (n=44 patients). DISCUSSION: The dosage of serum protein S-100 on admission failed to predict patients at risk for neurological deterioration after minor or moderate TBI. Extracranial injuries can increase serum protein S-100 levels, then limiting the usefulness of this dosage in this clinical setting.

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Fichiers liés : 09-PS100-Bouzat.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Sébastien BriolantMeïli BaragattiPhilippe ParolaFabrice SimonAdama TallCheikh SokhnaPhilippe HovetteModeste Mabika MamfoumbiJean-Louis KoeckJean DelmontAndré SpiegelJacky CastelloJean Pierre GardairJean-François TrapeMaryvonne KombilaPhilippe MinodierThierry FusaiChristophe RogierBruno Pradines
• Organismes : Unité de Recherche en Biologie et Epidémiologie Parasitaires Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
• Publié dans Antimicrobial Agents and Chemotherapy le 26/10/2020

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Résumé : ABSTRACT The distribution and range of 50% inhibitory concentrations (IC 50 s) of doxycycline were determined for 747 isolates obtained between 1997 and 2006 from patients living in Senegal, Republic of the Congo, and Gabon and patients hospitalized in France for imported malaria. The statistical analysis was designed to answer the specific question of whether Plasmodium falciparum has different phenotypes of susceptibility to doxycycline. A triple normal distribution was fitted to the data using a Bayesian mixture modeling approach. The IC 50 geometric mean ranged from 6.2 μM to 11.1 μM according to the geographical origin, with a mean of 9.3 μM for all 747 parasites. The values for all 747 isolates were classified into three components: component A, with an IC 50 mean of 4.9 μM (±2.1 μM [standard deviation]); component B, with an IC 50 mean of 7.7 μM (±1.2 μM); and component C, with an IC 50 mean of 17.9 μM (±1.4 μM). According to the origin of the P. falciparum isolates, the triple normal distribution was found in each subgroup. However, the proportion of isolates predicted to belong to component B was most important in isolates from Gabon and Congo and in isolates imported from Africa (from 46 to 56%). In Senegal, 55% of the P. falciparum isolates were predicted to be classified as component C. The cutoff of reduced susceptibility to doxycycline in vitro was estimated to be 35 μM.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Laurent ZiniUmberto CapitanioPaul PerrotteClaudio JeldresShahrokh F. ShariatPhilippe ArjaneHugues WidmerFrancesco MontorsiJean-Jacques PatardPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Service d'urologie Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Department of urology Institut de Génétique et Développement de Rennes Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans Urology le 26/10/2020

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Résumé : OBJECTIVES: To examine the population-based survival rates of patients with metastatic renal cell carcinoma (RCC) treated with cytoreductive nephrectomy (CNT) and compare them with those of patients treated without surgery. METHODS: Of the 43,143 patients with RCC identified in the 1988-2004 Surveillance, Epidemiology, and End Results database, 5372 had metastatic RCC. Of those, 2447 were treated with CNT (45.5%) and 2925 (54.5%) were not. Univariable and multivariable Cox regression models, as well as matched and unmatched Kaplan-Meier survival analyses, were used. The covariates consisted of age, sex, tumor size, and year of diagnosis. RESULTS: The 1-, 2-, 5-, and 10-year overall survival rate of the patients treated with CNT was 53.6%, 36.3%, 19.4%, and 12.7% compared with 18.5%, 7.4%, 2.3%, and 1.2% for the no-surgery patients, respectively. The corresponding cancer-specific survival rates were 58.1%, 40.8%, 24.3%, and 18.8% and 24.4%, 11.0%, 4.1%, and 2.9% for the same patient groups. On multivariate analysis, independent predictor status was recorded for treatment type, tumor size, and patient age (all P <.001). Also, relative to CNT, the no-surgery group had a 2.5-fold greater rate of overall and cancer-specific mortality (P <.001). In the matched analyses, virtually the same effect was recorded (hazard ratio 2.6, P <.001). CONCLUSION: The results of our study have shown that CNT significantly improves the survival of patients with metastatic RCC.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Pierre-Jean PanteixValérie Baco-CarlesPhilippe TailhadesMathilde RieuPascal LenormandFlorence AnsartMarie-Laure Fontaine
• Organismes : Centre interuniversitaire de recherche et d'ingénierie des matériaux Centre interuniversitaire de recherche et d'ingénierie des matériaux Centre interuniversitaire de recherche et d'ingénierie des matériaux Centre interuniversitaire de recherche et d'ingénierie des matériaux Centre interuniversitaire de recherche et d'ingénierie des matériaux Institut Européen des membranes
• Publié dans Solid State Sciences le 31/10/2020

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Résumé : The development of third generation Solid Oxide Fuel Cells (SOFC) with metallic mechanical supports presents several advantages over that of ceramic stacks by offering a lower cost and longer lifetime of the stacks. As a consequence, it is necessary to prepare metallic porous compacts that remain stable at the operating temperature of the SOFC (700–800 C) under reductive atmosphere. This paper presents an innovative process to elaborate iron, nickel and cobalt porous compacts. The process is based on the thermal decomposition of metal oxalate precursors with controlled morphology into metallic powders with coralline shape. Uniaxial compaction of such powders (without binder addition to the powders) under low uniaxial pressures (rising from 20 to 100 MPa) gave rise to green compacts with high porosity and good mechanical properties. After annealing at 800 C under H2 atmosphere, the compacts still present interconnected porosity high enough to allow sufficient gas flow to feed a SOFC single cell in hydrogen: the porosity rises from 25 to 50% for iron compacts, from 20 to 50% for cobalt compacts, and is higher than 40% for nickel compacts. Results from physicochemical characterization (XRD, SEM, gas permeation, Hg porosimetry) corroborated the process for SOFC application.

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Fichiers liés : Panteix_3788.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Stéphanie WeissChristine CarapitoJessica Cleiss-ArnoldSandrine KoechlerEvelyne TurlinJean-Yves CoppéeMichael HeymannValérie KuglerMagalie StauffertStéphane CruveillerClaudine MédigueAlain van DorsselaerPhilippe BertinFlorence Arsène-Ploetze
• Organismes : Génétique moléculaire, génomique, microbiologie Laboratoire de Spectrométrie de Masse BioOrganique [Strasbourg] Institut Pluridisciplinaire Hubert Curien Génétique moléculaire, génomique, microbiologie Génétique moléculaire, génomique, microbiologie Génétique des Génomes Bactériens Puces à ADN (Plate-Forme 2) Génétique moléculaire, génomique, microbiologie Institut de biologie et chimie des protéines [Lyon] Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Génétique moléculaire, génomique, microbiologie Genoscope - Centre national de séquençage [Evry] Structure et évolution des génomes - UMR 8030 Génomique métabolique Genoscope - Centre national de séquençage [Evry] Structure et évolution des génomes - UMR 8030 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Institut Pluridisciplinaire Hubert Curien Laboratoire de Spectrométrie de Masse BioOrganique [Strasbourg] Compartimentation et dynamique cellulaires Génétique moléculaire, génomique, microbiologie Génétique moléculaire, génomique, microbiologie
• Publié dans Biochimie le 28/10/2020

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Résumé : The arsenite-oxidizing strain Herminiimonas arsenicoxydans proteome was investigated with gel electrophoresis and tandem mass spectrometry analyses. The comparison of experimental and theoretical M(r) and pI, as well as that of peptide sequences identified by MS and predicted protein sequences, allowed the correction of five protein annotations. More importantly, the functional analysis of SDS- and 2D-PAGE proteome maps obtained in the presence of arsenic, combined with partial transcriptomic results indicate that H. arsenicoxydans expressed genes and proteins required not only for arsenic detoxification or stress response but also involved in motility, exopolysaccharide synthesis, phosphate import or energetic metabolism. This study provides therefore new insights into the adaptation processes of H. arsenicoxydans in response to arsenic.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/02/2009
• Auteurs : Philippe ChrétiennePierre FouilhouxEric GourdinJean Mathieu Segura
• Organismes : Recherche Opérationnelle Recherche Opérationnelle Recherche Opérationnelle

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Résumé : Nous nous intéressons au problème de localisation d’équipements dans un réseau lorsque l’on désire affecter des produits et des clients à ces équipements. Ce problème intervient dans la distribution de contenu, comme celle d’un catalogue de films dans le service de vidéo à la demande (VoD) destinés à des utilisateurs de ce service et à travers le réseau d’un opérateur internet. Les équipements à positionner dans le réseau sont des disques durs, appelés des caches, où l’on peut stocker un nombre limité de films. Les caches doivent être répartis dans le réseau de manière à permettre un accès rapide lors de la distribution des films aux clients. La solution de ce problème consiste donc, tout à la fois, à placer les caches, ainsi qu’affecter les films sur ces caches, de sorte à ce que chaque client ait accès à la totalité des films du catalogue. Dans ce contexte de distribution de films, le coût de raccordement des clients aux caches sont plus important pour des films dits "populaires" que pour les films peu demandés. Dès lors, les objectifs sont de minimiser le coût de raccordement des clients aux caches, ainsi que le coût d’installation de ces caches.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Sophie LimouSigrid Le ClercCédric CoulongesWassila CarpentierChristian DinaOlivier DelaneauTaoufik LabibLieng TaingRob SladekChristiane DeveauRojo RatsimandresyMatthieu MontesJean-Louis SpadoniJean-Daniel LelièvreYves LévyAmu TherwathFrançois SchächterFumihiko MatsudaIvo GutPhillippe FroguelJean-François DelfraissySerge HercbergJean-François Zagury
• Organismes : Chaire de Bioinformatique Agence Nationale de Recherches sur le Sida et les Hépatites Virales Institut Mondor de Recherche Biomédicale Institut de Génomique d'Evry Centre National de Génotypage Chaire de Bioinformatique Agence Nationale de Recherches sur le Sida et les Hépatites Virales Institut Mondor de Recherche Biomédicale Chaire de Bioinformatique Agence Nationale de Recherches sur le Sida et les Hépatites Virales Plateforme Post-génomique de la Pitié-Salpêtrière Agence Nationale de Recherches sur le Sida et les Hépatites Virales Institut Pasteur de Lille Institut de biologie de Lille - UMS 3702 Chaire de Bioinformatique Chaire de Bioinformatique Institut Mondor de Recherche Biomédicale Chaire de Bioinformatique McGill University and Genome Quebec Innovation Centre Agence Nationale de Recherches sur le Sida et les Hépatites Virales Chaire de Bioinformatique Chaire de Bioinformatique Chaire de Bioinformatique Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Université Paris Diderot - Paris 7 Chaire de Bioinformatique Etudes génomiques trans-ethniques des maladies multifactorielles Institut de Génomique d'Evry Centre National de Génotypage Institut de biologie de Lille - UMS 3702 Institut Pasteur de Lille Imperial College London ANRS France Recherche Nord & sud Sida-hiv hépatites Unité de Recherche en Epidémiologie Nutritionnelle Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité Centre de Recherche en Nutrition Humaine d'Ile-de-France UFR Santé, Médecine et Biologie Humaine Chaire de Bioinformatique ANRS France Recherche Nord & sud Sida-hiv hépatites Institut Mondor de Recherche Biomédicale
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 275 human immunodeficiency virus (HIV) type 1-seropositive nonprogressor patients in relation to a control group of 1352 seronegative individuals in a genomewide association study (GWAS). The strongest association was obtained for HCP5 rs2395029 (P=6.79x10(-10); odds ratio, 3.47) and was possibly linked to an effect of sex. Interestingly, this single-nucleotide polymorphism (SNP) was in high linkage disequilibrium with HLA-B, MICB, TNF, and several other HLA locus SNPs and haplotypes. A meta-analysis of our genomic data combined with data from the previously conducted Euro-CHAVI (Center for HIV/AIDS Vaccine Immunology) GWAS confirmed the HCP5 signal (P=3.02x10(-19)) and identified several new associations, all of them involving HLA genes: MICB, TNF, RDBP, BAT1-5, PSORS1C1, and HLA-C. Finally, stratification by HCP5 rs2395029 genotypes emphasized an independent role for ZNRD1, also in the HLA locus, and this finding was confirmed by experimental data. The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection.

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