Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2009
• Auteurs : Jean-Philippe GagnéXavier MoreelPierre GagnéYves LabelleArnaud DroitMélissa Chevalier-ParéSylvie BourassaDarin McdonaldMichael J. HendzelClaude PrigentGuy G. Poirier
• Organismes : Axe cancer Institut de Génétique et Développement de Rennes Axe cancer Axe cancer Axe cancer Axe cancer Axe cancer Axe cancer Department of Oncology Department of Oncology Institut de Génétique et Développement de Rennes Axe cancer Proteomics Platform
• Publié dans Journal of Proteome Research le 26/10/2020

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Résumé : Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is responsible for the control of diverse signaling pathways. Several observations suggest that phosphorylation of poly(ADP-ribose) polymerase-1 (PARP-1) regulates its activity. There is also accumulating evidence to suggest the establishment of phosphorylation-dependent assembly of PARP-1-associated multiprotein complexes. Although it is relatively straightforward to demonstrate phosphorylation of a defined target, identification of the actual amino acids involved still represents a technical challenge for many laboratories. With the use of a combination of bioinformatics-based predictions tools for generic and kinase-specific phosphorylation sites, in vitro phosphorylation assays and mass spectrometry analysis, we investigated the phosphorylation profile of PARP-1 and poly(ADP-ribose) glycohydrolase (PARG), two major enzymes responsible for poly(ADP-ribose) turnover. Mass spectrometry analysis revealed the phosphorylation of several serine/threonine residues within important regulatory domains and motifs of both enzymes. With the use of in vivo microirradiation-induced DNA damage, we show that altered phosphorylation at specific sites can modify the dynamics of assembly and disassembly of PARP-1 at sites of DNA damage. By documenting and annotating a collection of known and newly identified phosphorylation sites, this targeted proteomics study significantly advances our understanding of the roles of phosphorylation in the regulation of PARP-1 and PARG.

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Fichiers liés : Gagne_et_al_JPR_.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 30/01/2009
• Auteurs : Stéphanie LacourClaude KirchnerGildas AvoinePierre TrudelEl Hassan BezzaziPhilippe PucheralCaroline ZornNicolas DelvauxClaudine GuerrierJohn Sören PetterssonJean-Jacques LavenueGrégory BeauvaisEstelle DerclayeAdel JomniAntoinette RouvroyGwendal Le GrandGaulord Bauden-HamerelCésar PovédaIsabelle de Lamberterie
• Organismes : Centre d'études sur la coopération juridique internationale [UMR 6224] Centre Inria de l'Université de Bordeaux Centre d'études sur la coopération juridique internationale [UMR 6224] Secured and Mobile Information Systems Parallélisme, Réseaux, Systèmes, Modélisation Département Droit, Économie et Finances Centre d'études sur la coopération juridique internationale [UMR 6224]

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• Type de publi. : Article dans une revue
• Date de publi. : 29/01/2009
• Auteurs : Emmanuel GyanCharles FoussardPhilippe BertrandPatrick MichenetSteven Le GouillChristian C. BerthouHervé MaisonneuveVincent DelwailRémi GressinPhilippe QuittetJean-Pierre VilqueBernard DesablensJérôme JaubertJean-François RaméeNina ArakelyanAntoine ThyssCécile Moluçon-ChabrotRoselyne DelépineNoël N. MilpiedPhilippe ColombatEric Deconinck
• Organismes : Service d'hématologie [Tours] Service d'hématologie Université de Tours Service de pathologie Service d'hématologie Service d'hématologie Service d'hématologie Service Hématologie Service d'hématologie Service d'hématologie Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Laboratoire d'Hématologie [CHU Amiens] Service d'hématologie Service d'hématologie Service d'hématologie Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Service Hématologie Biologique [CHU Clermont-Ferrand] Service d'hématologie [Tours] Service d'hématologie Service d'hématologie [Tours] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
• Publié dans Blood le 28/10/2020

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Résumé : Autologous stem cell transplantation (ASCT) as first-line therapy for follicular lymphoma (FL) remains controversial. The multicenter study randomized 172 patients with untreated FL for either immunochemotherapy or high-dose therapy (HDT) followed by purged ASCT. Conditioning was performed with total body irradiation (TBI) and cyclophosphamide. The 9-year overall survival (OS) was similar in the HDT and conventional chemotherapy groups (76% and 80%, respectively). The 9-year progression-free survival (PFS) was higher in the ASCT than the chemotherapy group (64% vs 39%; P = .004). A PFS plateau was observed in the HDT group after 7 years. On multivariate analysis, OS and PFS were independently affected by the per-formance status score, the number of nodal areas involved, and the treatment group. Secondary malignancies were more frequent in the HDT than in the chemotherapy group (6 secondary myelodysplastic syndrome/acute myeloid leukemia and 6 second solid tumor cancers vs 1 acute myeloid leukemia, P = .01). The occurrence of a PFS plateau suggests that a subgroup of patients might have their FL cured by ASCT. However, the increased rate of secondary malignancies may discourage the use of purged ASCT in combination with TBI as first-line treatment for FL. This trial has been registered with ClinicalTrials.gov under identifier NCT00696735.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/01/2009
• Auteurs : Gabriel VasileJean-Philippe OvarlezFrédéric PascalMichel Gay
• Organismes : GIPSA - Signal Images Physique ONERA - The French Aerospace Lab [Toulouse] Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) GIPSA - Signal Images Physique GIPSA-Services

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Résumé : In the context of non-Gaussian polarimetric clutter models, this paper presents an application of the recent advances in the field of Spherically Invariant Random Vectors (SIRV) modelling for coherency matrix estimation in heterogeneous clutter. The complete description of the POLSAR data set is achieved by estimating the span and the normalized coherency independently. The normalized coherency describes the polarimetric diversity, while the span indicates the total received power. The main advantages of the proposed Fixed Point estimator are that it does not require any "a priori" information about the probability density function of the texture (or span) and it can be directly applied on adaptive neighbourhoods. Interesting results are obtained when coupling this Fixed Point estimator with an adaptive spatial support based on the scalar span information. Based on the SIRV model, a new maximum likelihood distance measure is introduced for unsupervised POLSAR classification. The proposed method is tested with airborne POLSAR images provided by the RAMSES system. Results of entropy/alpha/anisotropy decomposition, followed by unsupervised classification, allow discussing the use of the normalized coherency and the span as two separate descriptors of POLSAR data sets.

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Fichiers liés : GVasile_polinsar_2009.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/01/2009
• Auteurs : Sabine HouotGuillaume BodineauJean-Noel RamponAurélia Marcelline MichaudClément PeltreMohamed AnnabiPhilippe CambierPierre BenoitMarie-France DignacSophie GénermontPatricia LavilleClaire-Sophie HaudinDavid MontagneM. Poitrenaud
• Organismes : Environnement et Grandes Cultures Unité Expérimentale d'Amélioration des Arbres Forestiers Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Institut National de la Recherche Agronomique de Tunisie Environnement et Grandes Cultures Environnement et Grandes Cultures Biogéochimie et écologie des milieux continentaux Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Centre de Recherche pour la Propreté et l'Energie

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Résumé : absent

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/01/2009
• Auteurs : Philippe CambierSabine HouotPierre BenoitGuillaume BodineauMarjolaine Bourdat-DeschampsVeronique EtievantJean-Noel RamponJean Pierre PetraudNicolas ProixGiovanni CariaC. FrancouM. Poitrenaud
• Organismes : Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Unité Expérimentale d'Amélioration des Arbres Forestiers Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Physicochimie et Ecotoxicologie des SolS d'Agrosystèmes Contaminés Laboratoire d'Analyses des Sols Laboratoire d'Analyses des Sols Centre de Recherche pour la Propreté et l'Energie Centre de Recherche pour la Propreté et l'Energie

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Résumé : absent

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/01/2009
• Auteurs : Aurélia Marcelline MichaudGuillaume BodineauJean-Noel RamponPhilippe CambierPierre BenoitPierre VachierYves CoquetClaire-Sophie HaudinDavid MontagneM. Le Villio-PoitrenaudDenis D. MontenachPascal ValentinM. ImhoffA. SchaubN. ValentinThierry MorvanSabine Houot
• Organismes : Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Environnement et Grandes Cultures Centre de Recherche pour la Propreté et l'Energie Service d'expérimentation agronomique et viticole Service d'expérimentation agronomique et viticole Mission Recyclage agricole du Haut-Rhin Mission Recyclage agricole du Haut-Rhin Mission Recyclage agricole du Haut-Rhin Sol Agro et hydrosystème Spatialisation Environnement et Grandes Cultures

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Résumé : absent

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2009
• Auteurs : Philippe JonnardKarine Le GuenR. GauvinJean-François Le Berre
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement McGill University = Université McGill [Montréal, Canada] McGill University = Université McGill [Montréal, Canada]
• Publié dans Microscopy and Microanalysis le 28/10/2020

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Résumé : The valence states of Mg-Al alloys are compared to those of reference materials ~pure Mg and Al metals, and intermetallics!. Two methods based on X-ray emission spectroscopy are proposed to determine the phases and their proportion: first, by analyzing the Al valence spectra of the Mg-rich alloys and the Mg valence spectra of the Al-rich alloys; second, by fitting with a linear combination of the reference spectra the Al spectra of the Al-rich alloys and the Mg spectra of the Mg-rich alloys. This enables us to determine that Al and Al3Mg2 are present in the 0-43.9 wt% Al composition range and Mg and Al12Mg17 are present in the 62.5-100 wt% Al composition range. In the 43.9-62.5% Al range, the alloy is single phase and an underestimation of the Al content of the alloy can be estimated from the comparison of the bandwidth of the alloy spectrum to the bandwidths of the reference spectra.

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Fichiers liés : AlMg_MM.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/01/2009
• Auteurs : Vladimir KorobovLaurent HilicoJean-Philippe Karr
• Organismes : Bogoliubov Laboratory of Theoretical Physics [Dubna] Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry)
• Publié dans Physical Review A : Atomic, molecular, and optical physics [1990-2015] le 02/11/2020

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Résumé : The m alpha6 m/M-order corrections to the hyperfine splitting in the H2+ ion are calculated. That allows a reduction of the uncertainty in the frequency intervals between hyperfine sublevels of a given rovibrational state to about 10 ppm. The results are in good agreement with the high-precision experiment carried out by Jefferts (Phys. Rev. Lett. 23, 1476 (1969)).

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• Type de publi. : Article dans une revue
• Date de publi. : 02/01/2009
• Auteurs : Fabrice JaffréPhilippe BonninJacques CallebertHaythem DebbabiVincent SetolaStéphane DolyLaurent MonassierBertrand MettauerBurns C. BlaxallJean-Marie LaunayLuc Maroteaux
• Organismes : Institut du Fer à Moulin Service de Physiologie–Explorations Fonctionnelles Centre de Recherche Cardiovasculaire de Lariboisiere Biologie des maladies à prions et régulations cellulaires Service de Physiologie–Explorations Fonctionnelles Centre de Recherche Cardiovasculaire de Lariboisiere Institut du Fer à Moulin Institut du Fer à Moulin Régulation nerveuse de la fonction cardiovasculaire Service de Cardiologie Cardiovascular Research Institute Biologie des maladies à prions et régulations cellulaires Institut du Fer à Moulin
• Publié dans Circulation Research le 29/10/2020

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Résumé : By mimicking sympathetic stimulation in vivo, we previously reported that mice globally lacking serotonin 5-HT(2B) receptors did not develop isoproterenol-induced left ventricular hypertrophy. However, the exact cardiac cell type(s) expressing 5-HT(2B) receptors (cardiomyocytes versus noncardiomyocytes) involved in pathological heart hypertrophy was never addressed in vivo. We report here that mice expressing the 5-HT(2B) receptor solely in cardiomyocytes, like global 5-HT(2B) receptor-null mice, are resistant to isoproterenol-induced cardiac hypertrophy and dysfunction, as well as to isoproterenol-induced increases in cytokine plasma-levels. These data reveal a key role of noncardiomyocytes in isoproterenol-induced hypertrophy in vivo. Interestingly, we show that primary cultures of angiotensinogen null adult cardiac fibroblasts are releasing cytokines on stimulation with either angiotensin II or serotonin, but not in response to isoproterenol stimulation, demonstrating a critical role of angiotensinogen in adrenergic-dependent cytokine production. We then show a functional interdependence between AT(1)Rs and 5-HT(2B) receptors in fibroblasts by revealing a transinhibition mechanism that may involve heterodimeric receptor complexes. Both serotonin- and angiotensin II-dependent cytokine production occur via a Src/heparin-binding epidermal growth factor-dependent transactivation of epidermal growth factor receptors in cardiac fibroblasts, supporting a common signaling pathway. Finally, we demonstrate that 5-HT(2B) receptors are overexpressed in hearts from patients with congestive heart failure, this overexpression being positively correlated with cytokine and norepinephrine plasma levels. Collectively, these results reveal for the first time that interactions between AT(1) and 5-HT(2B) receptors coexpressed by noncardiomyocytes are limiting key events in adrenergic agonist-induced, angiotensin-dependent cardiac hypertrophy. Accordingly, antagonists of 5-HT(2B) receptors might represent novel therapeutics for sympathetic overstimulation-dependent heart failure.

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Fichiers liés : CircRes104_113_Jaffre.pdf

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