Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Christelle RaffaitinHenri GinJean‐philippe EmpanaCatherine HelmerClaudine BerrChristophe TzourioFlorence PortetJean-François DartiguesAnnick AlpérovitchPascale Barberger-Gateau
• Organismes : Epidémiologie et Biostatistique [Bordeaux] Université Sciences et Technologies - Bordeaux 1 Université Sciences et Technologies - Bordeaux 1 Neuropsychiatrie : recherche épidémiologique et clinique Epidémiologie et Biostatistique [Bordeaux] Neuropsychiatrie : recherche épidémiologique et clinique Neuroépidémiologie Neuropsychiatrie : recherche épidémiologique et clinique Epidémiologie et Biostatistique [Bordeaux] Neuroépidémiologie Epidémiologie et Biostatistique [Bordeaux]
• Publié dans Diabetes Care le 01/11/2020

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Résumé : OBJECTIVE: Associations between metabolic syndrome and its individual components with risk of incident dementia and its different subtypes are inconsistent. RESEARCH DESIGN AND METHODS: The 7,087 community-dwelling subjects aged > or =65 years were recruited from the French Three-City (3C) cohort. Hazard ratios (over 4 years) of incident dementia and its subtypes (vascular dementia and Alzheimer's disease) and association with metabolic syndrome (defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria) and its individual components (hypertension, large waist circumference, high triglycerides, low HDL cholesterol, and elevated fasting glycemia) were estimated in separate Cox proportional hazard models. RESULTS: Metabolic syndrome was present in 15.8% of the study participants. The presence of metabolic syndrome increased the risk of incident vascular dementia but not Alzheimer's disease over 4 years, independent of sociodemographic characteristics and the apolipoprotein (apo) Eepsilon4 allele. High triglyceride level was the only component of metabolic syndrome that was significantly associated with the incidence of all-cause (hazard ratio 1.45 [95% CI 1.05-2.00]; P = 0.02) and vascular (2.27 [1.16-4.42]; P = 0.02) dementia, even after adjustment of the apoE genotype. Diabetes, but not impaired fasting glycemia, was significantly associated with all-cause (1.58 [1.05-2.38]; P = 0.03) and vascular (2.53 [1.15-5.66]; P = 0.03) dementia. CONCLUSIONS: The observed relation between high triglycerides, diabetes, and vascular dementia emphasizes the need for detection and treatment of vascular risk factors in older individuals in order to prevent the likelihood of clinical dementia.

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Fichiers liés : Smet_Dem_accepte_141008.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Adeline BertolaVanessa DeveauxStéphanie BonnafousDéborah RousseauRodolphe AntyAbdelilah WakkachMoncef DahmanJoan TordjmanKarine ClémentSiobhán E McquaidKeith N FraynPierre-Michel HuetJean GugenheimSophie LotersztajnYannick Le Marchand-BrustelAlbert TranPhilippe Gual
• Organismes : Centre méditérannéen de médecine moléculaire Institut Mondor de Recherche Biomédicale Signalisation moléculaire et obésité Transduction du Signal : Signalisation Calcique et Phosphorylation Génétique, physiopathologie et ingénierie du tissu osseux Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Oxford Centre for Diabetes, Endocrinology and Metabolism Environnement et Grandes Cultures Service de Chirurgie Digestive / Centre de Transplantation Hépatique [CHU Nice] Institut Mondor de Recherche Biomédicale Centre méditérannéen de médecine moléculaire Digestive Center
• Publié dans Diabetes le 01/11/2020

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Résumé : OBJECTIVE: Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications in dietary murine models. We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis. RESEARCH DESIGN AND METHODS: OPN and CD44 expressions were studied in 52 morbidly obese patients and in mice. Cellular studies were performed in HepG2 cells. RESULTS: Hepatic OPN and CD44 expressions were strongly correlated with liver steatosis and insulin resistance in obese patients and mice. This increased OPN expression could be due to the accumulation of triglycerides, since fat loading in HepG2 promotes OPN expression. In contrast, OPN expression in adipose tissue (AT) was enhanced independently of insulin resistance and hepatic steatosis in obese patients. The elevated OPN expression in AT was paralleled with the AT macrophage infiltration, and both phenomena were reversed after weight loss. The circulating OPN level was slightly elevated in obese patients and was not related to liver steatosis. Further, AT did not appear to secrete OPN. In contrast, bariatric surgery-induced weight loss induced a strong increase in circulating OPN. CONCLUSIONS: The modestly elevated circulating OPN levels in morbidly obese patients were not related to liver steatosis and did not appear to result from adipose tissue secretion. In subcutaneous AT, expression of OPN was directly related to macrophage accumulation independently from liver complications. In contrast, hepatic OPN and CD44 expressions were related to insulin resistance and steatosis, suggesting their local implication in the progression of liver injury.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Isabelle GriffoulBruno GiraudeauDenis MullemanClaude-Laurent BenhamouJean-Pierre ValatPhilippe Goupille
• Organismes : Centre d’Investigation Clinique [Tours] CIC 1415 Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
• Publié dans Joint Bone Spine le 31/10/2020

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Résumé : The advent of TNF antagonists has had a revolutionary impact on the treatment of ankylosing spondylitis (AS). However, whether the benefits recorded in controlled trials are replicated in everyday practice has not been extensively evaluated. Objectives: To evaluate the effectiveness of infliximab in patients with axial spondyloarthropathies, to identify factors associated with the treatment response, and to assess fulfillment of modified New York criteria and compliance with guidelines about using TNF antagonists. Methods: Retrospective review of patients given infliximab for axial spondyloarthropathy between 2001 and 2003. Disease activity, motion limitation, laboratory tests, and the 6-week response rate were recorded. Results: Of the 86 included patients (48 women and 38 men, mean age, 44 +/- 11 years), 37% responded to infliximab therapy. Uveitis and C-reactive protein elevation at baseline predicted a response. Only 53% of patients met modified New York criteria and only 23% met ASAS criteria for starting TNF antagonist therapy. Conclusion: Infliximab was less effective in our patients with axial spondyloarthropathy than expected based on the results of controlled trials. However, many patients did not meet New York criteria for AS and/or ASAS criteria for TNF antagonist therapy. Therefore, our results do not challenge the usefulness of TNF antagonists in axial AS. Our patients were treated before the development of guidelines for TNF antagonist therapy and before the introduction of magnetic resonance imaging as an evaluation tool in AS. Strict criteria should be used to decide when TNF antagonist therapy is appropriate in patients with spondyloarthropathies. (C) 2008 Elsevier Masson SAS. All rights reserved.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Delphine DeboisKassem HamzeVincent GuerineauJean-Pierre Le CaërI Barry HollandPhilippe LopesJamal OuazzaniSimone J SérorAlain BrunelleOlivier Laprévote
• Organismes : Institut de génétique et microbiologie [Orsay] Institut de génétique et microbiologie [Orsay] Institut de génétique et microbiologie [Orsay]
• Publié dans Proteomics le 25/10/2020

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Résumé : No abstracts.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Carine ChaduteauPhilippe Jean-BaptisteElise FourréJean-Luc CharlouJean-Pierre Donval
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables
• Publié dans Geochemistry, Geophysics, Geosystems le 25/10/2020

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Résumé : During the ZaïRov2 cruise of the ZaïAngo project (1998-2000) on the passive Congo-Angola margin, several gravity cores were analyzed for helium isotopic composition of sedimentary pore waters in two cold fluid seepage zones: the Astrid slide area and the Regab giant pockmark. Gas concentration and isotopic composition are presented along with thermal data in terms of the origin and circulation of fluids. Helium isotope data lie on a mixing line between bottom seawater and an almost pure radiogenic. Helium and temperature vertical profiles are well described by the classic diffusion-advection equation. On the basis of He profiles, we estimate the advection rate on the rim of the pockmark between 1.2 and 2.3 mm/a. The He flux derived for a pure diffusive regime (2.4 Â 10 À8 mol/m 2 /a) can favorably be compared to literature data and contrasts with the flux computed close to the pockmark center (1.9 Â 10 À7 mol/m 2 /a). Helium depth profiles turned to be more sensitive to advection rate than temperature profiles are.

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Fichiers liés : 2007GC001897.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Samuel DequiedtMaud LelièvreClaudy JolivetNicolas P. A. SabyManuel P MartinJean ThioulousePierre-Alain MaronChristophe MougelNicolas Chemidlin Prévost-BouréDominique ArrouaysPhilippe LemanceauLionel Ranjard
• Organismes : Microbiologie Centre des Sciences du Goût InfoSol InfoSol InfoSol Evolution, adaptation et comportement [LBBE] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Ecologie quantitative et évolutive des communautés [LBBE] Microbiologie Microbiologie Microbiologie InfoSol Microbiologie Microbiologie
• Publié dans Étude et Gestion des Sols le 02/11/2020

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Fichiers liés : 28066_20091120110351004_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Jérôme VialardJean-Philippe DuvelMichael J. McphadenPascale Bouruet-AubertotBrian WardErica KeyDenis BourrasR. WellerP. J. MinnettAlain WeillChristophe CassouLaurence EymardT. FristedtClaude BasdevantYves DandonneauOlaf DuteilTakeshi IzumoClément de Boyer MontégutSébastien MassonFrancis MarsacChristophe MenkesSean C. Kennan
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques ESTER - LATMOS ESTER - LATMOS Centre Européen de Recherche et de Formation Avancée en Calcul Scientifique Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Thons tropicaux et écosystèmes pélagiques : taxies, interactions et stratégies d'exploitation Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques
• Publié dans Bulletin of the American Meteorological Society le 26/10/2020

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Fichiers liés : %5B15200477%20-%20Bulletin%20of%20the%20American%20Meteorological%20Society%5D%20Supplement%20to%20Cirene%3A%20Air%E2%80%94Sea%20Interactions%20in%20the%20Seychelles%E2%80%94Chagos%20Thermocline%20Ridge%20Region.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : T. MeasC. AmbonvilleChristine Bellanné‐chantelotS.. BeaufilsPhilippe MassinB. VialettesH. GinJosé TimsitB. BauduceauLouis BernardE. BertinJ.-F. BlickleJ. Cahen-VarsauxA. CaillebaR.W. SpringerPascal CathébrasGuillaume CarpentierP. ChedinT. CreaBrigitte DelemerDanièle Dubois-LaforgueF. DucheminPierre-Henri DucluzeauBéatrice BouhanickL. DusselierT. GabreauA. GrimaldiBruno GuerciV. JacquinE. KaloustianEtienne LargerA. Lecleire-ColletF. LorenziniJ. LouisJ. MaussetArnaud MuratS. Nadler-FluteauF. OlivierVeronique Paquis-FlucklingerD. Paris-BockelI. RaynaudYves ReznikJean-Pierre RivelineS. SchneebeliE. SonnetAgnès Sola-GazagnesJ-L ThomasB. TrabulsiM. VirallyP. GuillausseauMarie Laloi-Michelin
• Organismes : CHU Saint-Antoine [AP-HP] Service de chirurgie orthopédique et traumatologique, centre hospitalier universitaire Nutrition, obésité et risque thrombotique Université de Bordeaux Centre Hospitalier Universitaire de Bordeaux Service de diabétologie [CHU Cochin] Service d'Endocrinologie Service des Maladies Infectieuses Université de Tours Hôpital universitaire Robert Debré [Reims] Max-Planck-Institut für Kernphysik Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Service d'Endocrinologie - Diabète - Nutrition [Reims] Université Sorbonne Paris Cité Institut Cochin Service de diabétologie [CHU Cochin] Université Paris Descartes - Paris 5 Hôpital Cochin [AP-HP] Stress Oxydant et Pathologies Métaboliques Centre Hospitalier Universitaire de Toulouse CH Belle-Isle ELASIS Service de Diabétologie, Nutrition et Maladies métaboliques [CHRU Nancy] CH de Compiègnes Angiogénèse embryonnaire et pathologique Université Paris Descartes - Paris 5 Ecologie Systématique et Evolution Groupement Hospitalier Lyon-Est INSERM U782 Service de génétique médicale Instabilité génétique : maladies rares et cancers Centre Hospitalier Universitaire [Strasbourg] Unité sous contrat aromatase et oestrogènes dans les gonades des mammifères Centre Hospitalier Universitaire Centre de Recherche des Cordeliers Department of diabetes and endocrinology Service d'Endocrinologie CHU Lariboisière-François Widal Hôpital Lariboisière-Fernand-Widal [APHP]
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé :

Context: Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes with a matrilineal transmission, sensorineural hearing loss, and macular pattern dystrophy due to an A to G transition at position 3243 of mitochondrial DNA (mtDNA) (m.3243A>G). The phenotypic heterogeneity of MIDD may be the consequence of different levels of mutated mtDNA among mitochondria in a given tissue.

Objective: The aim of the present study was thus to ascertain the correlation between the severity of the phenotype in patients with MIDD and the level of heteroplasmy in the blood leukocytes.

Participants: The GEDIAM prospective multicenter register was initiated in 1995. Eighty-nine Europid patients from this register, with MIDD and the mtDNA 3243A>G mutation, were included. Patients with MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) or with mitochondrial diabetes related to other mutations or to deletions of mtDNA were excluded.

Results: A significant negative correlation was found between levels of heteroplasmy and age of the patients at the time of sampling for molecular analysis, age at the diagnosis of diabetes, and body mass index. After adjustment for age at sampling for molecular study and gender, the correlation between heteroplasmy levels and age at the diagnosis of diabetes was no more significant. The two other correlations remained significant. A significant positive correlation between levels of heteroplasmy and HbA1c was also found and remained significant after adjustment for age at molecular sampling and gender.

Conclusions: These results support the hypothesis that heteroplasmy levels are at least one of the determinants of the severity of the phenotype in MIDD.

Heteroplasmy levels are at least one of the determinants of the severity of the phenotype of maternally inherited diabetes and deafness.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2009
• Auteurs : Masatoshi FunabashiDavid ChavalariasJean-Philippe Cointet
• Organismes : Centre de Recherche en Epistémologie Appliquée Centre de Recherche en Epistémologie Appliquée Institut des Systèmes Complexes - Paris Ile-de-France Réseau National des Systèmes Complexes Centre de Recherche en Epistémologie Appliquée Transformations Sociales et Politiques liées aux Vivants Institut des Systèmes Complexes - Paris Ile-de-France

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Philippe StempfléT. DjilaliRichard Kouitat NjiwaMarthe RousseauEvelyne LopezXavier Bourrat
• Organismes : Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Institut Jean Lamour Ecole Nationale Supérieure des Mines de Nancy Biologie des organismes marins et écosystèmes Biologie des organismes marins et écosystèmes Institut des Sciences de la Terre d'Orléans
• Publié dans Tribology Letters le 25/10/2020

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Résumé : Sheet nacre is a natural biocomposite with a multiscale structure including a mineral phase of calcium carbonate (97 wt.%) and two organic matrices (3 wt.%). The mineral phase is constituted by an arrangement of CaCO3 biocrystal nanograins (ca 40 nm in size) drowned in an ‘‘intracrystalline'' organic matrix (4 nm thick) in order to form a microsized flat organomineral aragonite platelet. These platelets are themselves surrounded by an ‘‘intercrystalline'' organic matrix (40 nm thick) building up a very tough materials. This microarchitecture referred to as ‘‘bricks and mortar'' nacre structure, is mainly studied for the creation of new organic/inorganic hybrid materials. Currently, only little is known about the nacre mechanical behaviour under dynamical loading and more particularly under tribological conditions which involve shocks and thermal effects simultaneously. This paper brings out the thermal-induced damage mechanisms effect on the wear of sheet nacre by the assessment of the thermal component of the friction with a scanning thermal microscope. Results reveal that the mean contact pressure is the main driving force involved in the degradation of the organic constituents. For the lowest mean contact pressure (\0.4 MPa), wear is rather weak because the friction-induced thermal component is not sufficient for degrading the organic matrices. In contrast, beyond 0.4 MPa, the friction-induced contact temperature rises up over the melting point of the organic matrices, and may even reach the temperature of the aragonite– calcite phase transformation increasing dramatically the wear of sheet nacre.

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Fichiers liés : 2009_Stempfle_etal_TribologyLetters_version_hal.pdf

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