Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Serge-Thierry LekounoungouMathieu PetrissansJean-Pierre JacquotÉric GelhayePhilippe Gerardin
• Organismes : Laboratoire d’Etude et de Recherche sur le Matériau Bois Laboratoire d’Etude et de Recherche sur le Matériau Bois Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Laboratoire d’Etude et de Recherche sur le Matériau Bois
• Publié dans Wood Science and Technology le 27/10/2020

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Résumé : Effect of heat treatment on extracellular enzymes involved in wood degradation by Trametes versicolor was investigated. Heat-treated and untreated beech blocks were exposed to T. versicolor on malt-agar medium and extracellular enzymatic activities investigated. A strong ABTS oxidizing activity has been detected during the first stage of colonization in both cases, while cellulase activities are mainly detected in the case of untreated beech wood. Further investigations carried out on holocellulose, isolated using sodium chlorite delignification procedure and subjected to heat treatment or not, indicate that commercially available cellulases and xylanases are able to hydrolyse untreated holocellulose, while heat-treated holocellulose was not affected. All these data suggest that chemical modifications of wood components during heat treatment disturb enzymatic system involved in wood degradation.

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• Type de publi. :
• Date de publi. : 01/01/2009
• Auteurs : Vincent BadeauDaniel BerthaultCecile BlancChristophe BougetIsabelle ChuineJacques CourdilleDenis CouvetPhilippe-Jacques DuboisJean-Luc DupoueyCécile EdelistMichel GalliotPhilippe GoulletquerEmmanuel GrittiPhilippe GrosMaryline LoquetLuc MauchampPierre MeignienMichel MetaisVanessa NuzzoBertrand ReyssetMarie-Christine SalmonaBernard SalvatNirmala Séon-MassinEmmanuel ThiryWilfried ThuillerJacques TrouvilliezLaetitia TufferyPierre Zagatti
• Organismes : Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture Centre National de la Recherche Scientifique Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Muséum national d'Histoire naturelle Ligue pour la Protection des Oiseaux Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Muséum national d'Histoire naturelle Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Institut Français de Recherche pour l'Exploitation de la Mer Centre National de la Recherche Scientifique Institut Français de Recherche pour l'Exploitation de la Mer Ministère de l’Alimentation, de l'Agriculture et de la Pêche Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Ligue pour la Protection des Oiseaux Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Université de Perpignan Via Domitia Office national de l'eau et des milieux aquatiques Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Centre National de la Recherche Scientifique Muséum national d'Histoire naturelle Ministère de l'Ecologie, de l'Energie, du Développement Durable et de la Mer Physiologie de l'Insecte : Signalisation et Communication

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Fichiers liés : partie_5_annexes_des_rapports_thematiques_AnnexeF_1.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2009
• Auteurs : Pierre DelattreJean-Philippe Melis
• Organismes : Centre de Biologie pour la Gestion des Populations Services déconcentrés d'appui à la recherche - Montpellier

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2009
• Auteurs : Jean-Pierre BarraquéPhilippe Senac
• Organismes : Identités, Territoires, Expressions, Mobilités France, Amériques, Espagne, Sociétés, Pouvoirs, Acteurs

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Résumé : Le présent volume consacré à l’habitat pyrénéen au cours des périodes médiévale et moderne est le fruit de la collaboration de plusieurs universités espagnoles (universités du Pays Basque-UPV ; publique de Navarre-UPN ; de Saragosse, de Gérone) et françaises (universités de Perpignan Via domitia, de Toulouse-Le Mirail, de Pau et des Pays de l’Adour). C’est en effet au sein de RESOPYR, un réseau d’universités franco-espagnoles réunies autour d’un projet commun élaboré dans le cadre de la Communauté de travail des Pyrénées (CTP), qu’il a été préparé. Il regroupe une vingtaine de contributions concernant la montage pyrénéenne et son piémont, de l’Atlantique à la Méditerranée, depuis le Moyen Âge jusqu’à nos jours. Ce volume aborde les problèmes de l’habitat et s’organise autour de trois cadres principaux ; certains articles traitent de la naissance et de la mise en place des villages ; d’autres envisagent les différentes modes de hiérarchisation et de fonctionnement de l’habitat dans un modèle communautaire qui n’est jamais égalitaire ; enfin, les derniers analysent la remise en cause de ce modèle communautaire et sa rupture définitive au profit d’un accaparement individuel. Ouvrage publié avec le soutien des organismes suivants : Universitat de Girona ; Universidad del País Vasco-Euskal Herriko Unibertsitatea ; Universidad Pública de Navarra-Nafarroako Unibertsitate Publikoa ; Universidad de Zaragoza ; Universités de Perpignan Via Domitia, de Pau et des Pays de l’Adour et de Toulouse ; Région Midi-Pyrénées ; Communauté de travail des Pyrénées.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Yuqiao Y. GuPhilippe LucasJean-Pierre J.-P. Rospars
• Organismes : Physiologie de l'Insecte : Signalisation et Communication Physiologie de l'Insecte : Signalisation et Communication Physiologie de l'Insecte : Signalisation et Communication Unité de biométrie et intelligence artificielle de Jouy INRA - Mathématiques et Informatique Appliquées
• Publié dans PLoS Computational Biology le 27/10/2020

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Résumé : A biophysical model of receptor potential generation in the male moth olfactory receptor neuron is presented. It takes into account all pre-effector processes-the translocation of pheromone molecules from air to sensillum lymph, their deactivation and interaction with the receptors, and the G-protein and effector enzyme activation-and focuses on the main post-effector processes. These processes involve the production and degradation of second messengers (IP3 and DAG), the opening and closing of a series of ionic channels (IP3-gated Ca2+ channel, DAG-gated cationic channel, Ca2+-gated Cl- channel, and Ca2+-and voltage-gated K+ channel), and Ca2+ extrusion mechanisms. The whole network is regulated by modulators (protein kinase C and Ca2+-calmodulin) that exert feedback inhibition on the effector and channels. The evolution in time of these linked chemical species and currents and the resulting membrane potentials in response to single pulse stimulation of various intensities were simulated. The unknown parameter values were fitted by comparison to the amplitude and temporal characteristics (rising and falling times) of the experimentally measured receptor potential at various pheromone doses. The model obtained captures the main features of the dose-response curves: the wide dynamic range of six decades with the same amplitudes as the experimental data, the short rising time, and the long falling time. It also reproduces the second messenger kinetics. It suggests that the two main types of depolarizing ionic channels play different roles at low and high pheromone concentrations; the DAG-gated cationic channel plays the major role for depolarization at low concentrations, and the Ca2+-gated Cl- channel plays the major role for depolarization at middle and high concentrations. Several testable predictions are proposed, and future developments are discussed.

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Fichiers liés : 35677_20100915035704745_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Mathieu SchusterPhilippe DuringerJean-François GhienneClaude RoquinPierre SepulchreAbderamane MoussaA.-E. LebatardHassan Taisso MackayeAndossa LikiusPatrick VignaudMichel Brunet
• Organismes : Institut de physique du globe de Strasbourg Institut de physique du globe de Strasbourg Institut de physique du globe de Strasbourg Institut de physique du globe de Strasbourg Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation du climat Institut de physique du globe de Strasbourg Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Université de N'Djaména Université de N'Djaména Laboratoire de paléontologie, évolution, paléoécosystèmes, paléoprimatologie [UMR 7262] Institut international de paléoprimatologie, paléontologie humaine : Évolution et paléoenvironnement [UMR 6046] Collège de France - Chaire Paléontologie Humaine
• Publié dans Comptes Rendus. Géoscience le 29/07/2021

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Résumé : Since the mid 1990s, the Mission paléoanthropologique francotchadienne (MPFT) conducts yearly paleontological field investigations of the Miocene-Pliocene of the Chad Basin. This article synthesizes some of the results of the MPFT, with focus on the Chad Basin development during the Neogene. We propose an overview of the depositional paleoenvironments of this part of Africa at different scales of time and space, based on a multidisciplinary approach (sedimentary geology, geomorphology, geophysic, numerical simulations and geochronology). The Miocene-Pliocene paleoenvironments are examined through the sedimentary archives of the early hominids levels and the Holocene Lake Mega-Chad episode illustrates the last major paleoenvironmental change in this area. The sedimentary record of the Chad Basin since the Late Miocene can be schematized as the result of recurrent interactions from lake to desert environments.

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• Type de publi. :
• Date de publi. : 01/01/2009
• Auteurs : Pierre Loïc CornutGilles ThuretCatherine Creuzot-GarcherMax MaurinAndré PéchinotAlain Marie BronJean-Paul RomanetPhilippe DenisFrancois VandeneschChristophe Chiquet
• Organismes : CHU Dijon FLAveur, VIsion et Comportement du consommateur CHU Dijon FLAveur, VIsion et Comportement du consommateur
• Publié dans Investigative Ophthalmology & Visual Science le 21/03/2023

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Résumé : Purpose: : To correlate the presenting clinical ophthalmic features with the bacterial identification in 100 patients with acute post catarcat endophthalmitis enrolled in the FRench Instutionnal ENdophthalmitis Study (FRIENDS). Methods: : Demographic data, past medical history and initial eye examination were recorded in a standardized form in 100 patients with acute endophthalmitis after cataract extraction (< 6 weeks) in a prospective multicenter study. Relationship between microbiological identification (using conventional cultures and panbacterial PCR) and clinical factors at baseline was studied using univariate (ANOVA). Results: : 100 patients were hospitalized for endophthalmitis treatment with a mean delay of 8±7.5 (SD) days (range: 2-31 days) after the cataract surgery, complicated by capsular rupture in 19% of the cases. Main symptoms were loss of vision (95%) frequently limited to light perception (32%), and pain (75%). More frequent clinical signs were hypopion (72%), cyclitic membrane (77.5%) and absence of fundus visibility (90%). As compared with Staphylococcus species, the identification of Streptococcus species was more frequently identified (p<0.05) in male and diabetic patients, with initial visual acuity limited to light perceptions and a painfull eye. The Staphylococcus aureus and lugdunensis group differed from other coagulase negative Staphylococcus group (p<0.05) for the height of hypopion. Conclusions: : The baseline features of acute endophthalmitis after cataract surgery in the era of phacoemulsification are similar to those reported in the EVS 10 years ago. The presenting characteristics of acute post cataract endophthalmitis differ according to the infecting organism. The association between clinical factors at baseline and bacteria identified using cultures and/or eubacterial PCR does not appear sufficiently predictive to guide empiric intraocular antibiotic therapy. However our results suggest that other baseline characteristics than initial visual acuity may be useful to detect presumed infected patients with a virulent species needing a more aggressive therapeutic approach.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Khaled BenkaliAurelie PrémaudNicolas PicardJean-Philippe RerolleOlivier ToupanceGuillaume HoizeyAlain TurcantFlorence VillemainYannick LemeurPierre MarquetAnnick Rousseau
• Organismes : Groupe d'Étude des Interactions Hôte-Pathogène
• Publié dans Clinical Pharmacokinetics le 30/10/2020

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Résumé :

Objectives: The aims of this study were (i) to investigate the population pharmacokinetics of tacrolimus in renal transplant recipients, including the influence of biological and pharmacogenetic covariates; and (ii) to develop a Bayesian estimator able to reliably estimate the individual pharmacokinetic parameters and inter-dose area under the blood concentration-time curve (AUC) from 0 to 12 hours (AUC12) in renal transplant patients. Methods: Full pharmacokinetic profiles were obtained from 32 renal transplant patients at weeks 1 and 2, and at months 1, 3 and 6 post-transplantation. The population pharmacokinetic analysis was performed using the nonlinear mixed-effect modelling software NONMEM® version VI. Patients’ genotypes were characterized by allelic discrimination for PXR −25385C>T genes. Results: Tacrolimus pharmacokinetics were well described by a two-compartment model combined with an Erlang distribution to describe the absorption phase, with low additive and proportional residual errors of 1.6 ng/mL and 9%, respectively. Both the haematocrit and PXR −25385C>T single nucleotide polymorphism (SNP) were identified as significant covariates for apparent oral clearance (CL/F) of tacrolimus, which allowed improvement of prediction accuracy. Specifically, CL/F decreased gradually with the number of mutated alleles for the PXR −25385C>T SNP and was inversely proportional to the haematocrit value. However, clinical criteria of relevance, mainly the decrease in interindividual variability and residual error, led us to retain only the haematocrit in the final model. Maximum a posteriori Bayesian forecasting allowed accurate prediction of the tacrolimus AUC12 using only three sampling times (at 0 hour [predose] and at 1 and 3 hours postdose) in addition to the haematocrit value, with a nonsignificant mean AUC bias of 2% and good precision (relative mean square error = 11%). Conclusion: Population pharmacokinetic analysis of tacrolimus in renal transplant recipients showed a significant influence of the haematocrit on its CL/F and led to the development of a Bayesian estimator compatible with clinical practice and able to accurately predict tacrolimus individual pharmacokinetic parameters and the AUC12.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Maëlenn GuerchetDismand Stephan HouinatoMoussiliou Noël ParaïsoNicolas von AhsenPhilippe NubukpoMarkus OttoJean-Pierre ClémentPierre-Marie PreuxJean-François Dartigues
• Organismes : Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Unité d'Enseignement et de Recherche de Neurologie Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Hôpital Psychiatrique La Valette Centre de Mémoire de Ressources et de Recherches [Limoges] Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Epidémiologie et Biostatistique [Bordeaux]
• Publié dans Dementia and Geriatric Cognitive Disorders le 01/11/2020

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Résumé : BACKGROUND/AIMS: Dementia is increasing as a priority public health problem because of the ageing of the world population. Our goal was to estimate dementia and cognitive impairment prevalence in an elderly population of rural Benin. METHODS: In a door-to-door survey, elderly people aged 65 years and above were screened using the Community Screening Interview for Dementia and the Five-Word Test. RESULTS: The prevalence of cognitive impairment was 10.4% and that of dementia was 2.6%. Age, current depressive disorder and absence of the APOE epsilon2 allele were significantly associated with cognitive impairment. CONCLUSION: Prevalence of dementia and cognitive impairment appears to be lower in this study than in developed countries.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Jean-Daniel ParisA. StohlP. NédélecM.Yu. ArshinovM.V. PanchenkoV.P. ShmargunovKathy S. LawB.D. BelanPhilippe Ciais
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Norwegian Institute for Air Research Laboratoire d'aérologie V.E. Zuev Institute of Atmospheric Optics V.E. Zuev Institute of Atmospheric Optics V.E. Zuev Institute of Atmospheric Optics TROPO - LATMOS V.E. Zuev Institute of Atmospheric Optics Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC
• Publié dans Atmospheric Chemistry and Physics le 31/10/2020

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Résumé : We present airborne measurements of carbon dioxide (CO2), carbon monoxide (CO), ozone (O3), equivalent black carbon (EBC) and ultra fine particles over North-Eastern Siberia in July 2008 performed during the YAK-AEROSIB/POLARCAT experiment. During a "golden day" (11 July 2008) a number of biomass burning plumes were encountered with CO concentration enhancements of up to 500 ppb relative to a background of 90 ppb. Number concentrations of aerosols in the size range 3.5–200 nm peaked at 4000 cm−3 and the EBC content reached 1.4 μg m−3. These high concentrations were caused by forest fires in the vicinity of the landing airport in Yakutsk where during the descent measurements in fresh smoke could be made. We estimate a combustion efficiency of 90±3% based on CO and CO2 measurements. The emission factor of CO emitted was 59.6±15.2 g CO per kilogram of dry matter burned, suggesting an increase in the average northern hemispheric CO concentration of 3.0–7.2 ppb per million hectares of Siberian forest burned. For BC, we estimate an emission factor of 0.52±0.07 g BC kg−1, comparable to values reported in the literature. The emission ratio of ultra-fine particles (3.5–200 nm) was 26 cm−3 (ppb CO)−1, consistent with other airborne studies.

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Fichiers liés : acp-9-9315-2009.pdf

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