Philippe JEAN-PIERRE

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2009
• Auteurs : Philippe LerichePierre FrèrePhilippe BlanchardAntonio CravinoJean Roncali
• Organismes : MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Gilles HouvenaeghelClaude NosSylvia GiardHervé MignotteBenjamin EsterniJocelyne JacquemierMax ButtarelliJean-Marc ClasseMonique CohenPhilippe RouanetFrédérique Penault-LlorcaPascal BonnierFrédéric MarchalJean-Rémy GarbayJean FraissePierre MartelEric FondrinierChristine Tunon de LaraJean-Francois Rodier
• Organismes : Institut Paoli-Calmettes Institut Curie [Paris] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Léon Bérard [Lyon] Institut Paoli-Calmettes Institut Paoli-Calmettes Institut Paoli-Calmettes Centre René Gauducheau La Casamance CRLCC Val d'Aurelle - Paul Lamarque Centre Jean Perrin [Clermont-Ferrand] La Conception Centre Alexis Vautrin Centre de Recherche en Automatique de Nancy Institut Gustave Roussy Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Oncopole Claudius Regaud CRLCC - Centre Paul Papin Plateforme de génétique moléculaire des cancers d'Aquitaine Centre Paul Strauss
• Publié dans EJSO - European Journal of Surgical Oncology le 22/10/2020

---

Résumé : Purpose Predictive factors of non-sentinel lymph node (NSN) involvement at axillary lymph node dissection (ALND) have been studied in the case of sentinel node (SN) involvement, with validation of a nomogram. This nomogram is not accurate for SN micrometastasis. The purpose of our study was to determine a nomogram for predicting the likelihood of NSN involvement in breast cancer patients with a SN micrometastasis. Methods We collated 909 observations of SN micrometastases with additional ALND. Characteristics of the patients, tumours and SN were analysed. Results Involvement of SN was diagnosed 490 times (53.9%) with standard staining (HES) and 419 times solely on immunohistochemical analysis (IHC) (46.1%). NSN invasion was observed in 114 patients (12.5%), whereas 62.3% (71) had only one NSN involved and 37.7% (43) two or more NSN involved. In multivariate analysis, significant predictive factors were: tumour size (pT stage ≤10 mm or >11 and ≤20 or >20 mm [odds ratio (OR) 2.1 and 3.43], micrometastases detected by HES or IHC [OR 1.64], presence or absence of lymphovascular invasion (LVI) [OR 1.76], tumour histological type mixed or not [OR 2.64]. The rate and probability of NSN involvement with the model are given for 24 groups, with a representation by a nomogram. Conclusion One group, corresponding to 10.1% of the patients, was associated with a risk of NSN involvement of less than 5%, and five groups, corresponding to 29.8% of the patients, were associated with a risk ≤10%. Omission of ALND could be proposed with minimal risk for a low probability of NSN involvement.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Anna GiustiGaëlle CharronSandra MazeratJd CompainPierre MialaneAnne DolbecqEric RivièreWolfgang WernsdorferRosa Ngo BibouniBineta KeitaLouis NadjoArianna FiloramoJean-Philippe BourgoinTalal Mallah
• Organismes : Institut de Chimie Moléculaire et des Matériaux d'Orsay Institut de Chimie Moléculaire et des Matériaux d'Orsay Institut Lavoisier de Versailles Institut Lavoisier de Versailles Institut de Chimie Moléculaire et des Matériaux d'Orsay Circuits électroniques quantiques Alpes Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay Laboratoire Interfaces et Surfaces d'Oxydes Laboratoire d'Electronique Moléculaire Institut de Chimie Moléculaire et des Matériaux d'Orsay
• Publié dans Angewandte Chemie International Edition le 26/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Séverine RemyPhilippe BlancouLaurent TessonVirginie TardifRégis BrionPierre Joseph RoyerRoberto MotterliniRoberta ForestiMarion PainchautSylvie PoguMarc GrégoireJean-Marie BachIgnacio AnegonChristine Chauveau
• Organismes : Institut National de la Santé et de la Recherche Médicale Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours Immuno-Endocrinologie Cellulaire et Moléculaire Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours Institut National de la Santé et de la Recherche Médicale Northwick Park Institute for Medical Research Northwick Park Institute for Medical Research Immuno-Endocrinologie Cellulaire et Moléculaire Immuno-Endocrinologie Cellulaire et Moléculaire Institut National de la Santé et de la Recherche Médicale Immuno-Endocrinologie Cellulaire et Moléculaire Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Tours
• Publié dans Journal of Immunology le 27/10/2020

---

Résumé : Heme oxygenase-1 (HO-1) exerts its functions via the catabolism of heme into carbon monoxide (CO), Fe2+, and biliverdin, as well as by depletion of free heme. We have recently described that overexpression of HO-1 is associated with the tolerogenic capacity to dendritic cells (DCs) stimulated by LPS. In this study, we demonstrate that treatment of human monocyte-derived DCs with CO blocks TLR3 and 4-induced phenotypic maturation, secretion of proinflammatory cytokines, and alloreactive T cell proliferation, while preserving IL-10 production. Treatment of DCs with biliverdin, bilirubin, and deferoxamine or replenishing intracellular heme stores had no effect on DC maturation. HO-1 and CO inhibited LPS-induced activation of the IFN regulatory factor 3 pathway and their effects were independent of p38, ERK, and JNK MAPK. HO-1 and CO treatment also inhibited mouse DC maturation in vitro and mouse DC immunogenic properties in vivo, as shown by adoptive cell transfer in a transgenic model of induced diabetes. Thus, for the first time, our data show that CO treatment inhibits DC immunogenicity induced by TLR ligands and that blockade of IFN regulatory factor 3 is associated with this effect.

---

Source

---

• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2009
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2009
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Philippe Martin
• Organismes : Religions et croyances
• Publié dans Spee Jahrbuch le 27/01/2014

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2009
• Auteurs : Christelle MariaisFlorence MichauJean-Philippe Pernin
• Organismes : Modèles et Technologies pour l’Apprentissage Humain Modèles et Technologies pour l’Apprentissage Humain Modèles et Technologies pour l’Apprentissage Humain

---

Résumé : no abstract

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Denis MullemanJean-Camille MéricGilles PaintaudEmilie DucourauCharlotte Magdelaine-BeuzelinJean-Pierre ValatPhilippe Goupille
• Organismes : Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
• Publié dans Arthritis Research and Therapy le 27/10/2020

---

Résumé : INTRODUCTION: Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS: RA patients routinely treated with infliximab were included in an observational open-label study. On visit 1 (V1), according to the disease activity, a preliminary therapeutic decision was selected among four therapeutic options and a blood sample was collected to measure trough serum infliximab concentration. The final therapeutic decision, based on both disease activity and serum infliximab concentration assessed at V1, was applied at the following infusion (V2). Clinical and biological evaluations were performed at V3 and V4 and compared with those at V1. RESULTS: We included 24 patients. The final therapeutic decision differed from the preliminary decision for 12 patients (50%). For patients with increased infliximab dosage at V2, mean disease activity score for 28 joints (DAS28) decreased by about 20% at V3 or V4 as compared with V1 (P < 0.05). Decreased DAS28 was correlated with increased serum infliximab concentration (P < 0.02). CONCLUSIONS: The measurement of infliximab trough concentration modifies the therapeutic decision for RA patients and helps improve control of disease activity. Therapeutic drug monitoring of infliximab in RA may be useful for individual dosage adjustment.

---

Fichiers liés : mulleman_AR_T_2009.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Mathieu KoehlLionel BombrunMichel GayEmmanuel TrouvéPhilippe BolonJean-Marie NicolasGabriel VasileIvan PetillotTania LandesP. Grussenmeyer
• Organismes : Modèles et simulation pour l'architecture, l'urbanisme et le paysage GIPSA - Signal Images Physique GIPSA - Signal Images Physique GIPSA-Services Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire Traitement et Communication de l'Information GIPSA - Signal Images Physique Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Equipe Photogrammétrie et Géomatique Modèles et simulation pour l'architecture, l'urbanisme et le paysage
• Publié dans Traitement du Signal le 23/10/2020

---

Résumé : Measurements of glacier surface velocity have been performed on the French Alps Argentière's glacier for more than ten years. Completed by precise other measurements done during the MEGATOR experimentations, the surface velocity could be calculated on one reference point located on the glacial accumulation area. The knowledge of this particular surface velocity allows solving the ambiguity of displacement fields derived from pairs of interferometric synthetic aperture radar (SAR) images acquired by ERS-1/2 satellites. These interferograms provide the surface velocity over large areas. The obtained values are then compared with in-situ precise geodetic measurements of local surface velocities. The similar obtained results permit to validate the described process.

---

Source