Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Philippe van de PerreGabriella ScarlattiPenny L MooreJean-Pierre MolesNicolas NagotThorkild TylleskärGlenda GrayAmeena Goga
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections IRCCS Ospedale San Raffaele [Milan, Italy] University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections University of Bergen South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] University of Pretoria [South Africa]
• Publié dans Immunity, Inflammation and Disease le 26/10/2020

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Résumé : Passive immunoprophylaxis with broadly neutralizing monoclonal antibodies (bNAbs) could be a game changer in the prevention of human immunodeficiency virus (HIV) acquisition. The prevailing view is that available resources should be focused on identifying a fixed combination of at least three bNAbs for universal use in therapeutic and preventive protocols, regardless of target populations or routes of transmission. HIV transmission through breastfeeding is unique: it involves free viral particles and cell‐associated virus from breast milk and, in the case of acute/recent maternal infection, a viral population with restricted Env diversity. HIV transmission through breastfeeding in high incidence/prevalence areas could potentially be eliminated by subcutaneous administration to all newborns of one or two long‐acting bNAbs with extended breadth, high potency, and effector properties (ADCC, phagocytosis) against circulating HIV strains.

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Fichiers liés : Immunity Inflam Disease - 2024 - Van de Perre - Preventing breast milk HIV transmission using broadly neutralizing.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Luana SpanoCynthia Marie-ClaireOphélia GodinApolline LebrasCindie CourtinJean-Louis LaplancheMarion LeboyerBruno AouizerateAntoine LefrereRaoul BelzeauxPhilippe CourtetEmilie OliéCaroline DubertretRaymund SchwanValérie AubinPaul RouxMircea PolosanLudovic SamalinEmmanuel HaffenB. EtainE. OliéM. LeboyerE. HaffenP. LlorcaV. BarteauS. BensalemO. GodinH. LaouamriK. SouryisS. HotierAmandine PelletierNoémie DrancourtJ. SanchezE. SaliouC. HebbacheJ. PetrucciL. WillaumeE. BourdinF. BellivierB. EtainV. HennionE. MarlingeP. LebardB. AntoniolA. DesageS. GardA. JutantK. MbailaraI. MinoisL. ZanouyC. AbettanL. BardinA. CazalsP. CourtetB. DeffinisD. DucasseM. GachetA. HenrionE. MartinerieF. MolièreB. NoisetteE. OliéG. TarquiniJ. AzorinR. BelzeauxN. CorreardJ. ConsoloniF. GroppiL. LescalierJ. MontantM. RebattuN. ViglianeseR. CohenJ. KahnM. MilazzoO. Wajsbrot-ElgrabliThierry BougerolB. FredembachQ. DenoualA. BertrandA. PouchonM. PolosanL. BrehonG. BonyL. DurandV. FeugaN. KayserChristine PasserieuxP. RouxV. AubinI. CussacM. DupontJ. LoftusI. MedecinC. DubertretN. MazerC. PortalierC. ScognamiglioA. BingP. LaurentC. BealO. BlancT. BonnetD. LacellePierre-Michel LlorcaM. MennetrierL. SamalinM. VayssiéFrank BellivierB Etain
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Optimisation thérapeutique en Neuropsychopharmacologie Optimisation thérapeutique en Neuropsychopharmacologie Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Lariboisière-Fernand-Widal [APHP] GHU AP-HP Nord - Université Paris Cité CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] Université de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Service Psychiatrie Adulte [CHU Clermont-Ferrand] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP]
• Publié dans Translational Psychiatry le 30/10/2020

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Résumé : Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed. Gene expression level of 29 genes, associated with aging or with telomere maintenance, was analyzed in RNA samples from a subsample of 129 individuals. Clustering analyses identified a group of young individuals (mean age 29.64 years), with shorter TL. None of the tested clinical variables were significantly associated with this subgroup. Gene expression level analyses showed significant downregulation of MYC, POT1, and CD27 in the prematurely aged young individuals compared to the young individuals with longer TL. After adjustment only POT1 remained significantly differentially expressed between the two groups of young individuals. This study confirms the existence of a subgroup of young individuals with BD with shortened TL. The observed decrease of POT1 expression level suggests a newly described cellular mechanism in individuals with BD, that may contribute to telomere shortening.

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Fichiers liés : Spano et al 2024.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/03/2024
• Auteurs : Olga ChekhurskaAlmerinda PintoJosé MartinezSébastien DesbureauxRaphaël SoubeyranJoel DorePascal SchlichThibaut LarcherBruno Le BizecBarbara RedlingshoferAllison LocontoPhilippe HéritierSami BouarfaPierre-Alain JayetEtienne LebloisEric SauquetNicolas LamourouxMichel LangBenoît CamenenJean-François HumbertPierre-Olivier MalaterreLaurent PeyrasRémy TourmentMaria-Helena RamosJulien AncelinFrédéric DarbouxFrançois LiboisChristian DuprazJean-François SoussanaVincent BlanfortNassim Ait-MouhebRémi Lombard-LatuneStéphane FournierSylvie LambertYuna Chiffoleau
• Organismes : Direction Appui aux Politiques Publiques Direction Appui aux Politiques Publiques Direction Appui aux Politiques Publiques Centre d'Economie de l'Environnement - Montpellier Centre d'Economie de l'Environnement - Montpellier MICrobiologie de l'ALImentation au Service de la Santé Plateforme Chemosens [Dijon] Centre des Sciences du Goût et de l'Alimentation [Dijon] Physiopathologie Animale et bioThérapie du muscle et du système nerveux Expertise en Anatomie Pathologique Laboratoire d'étude des Résidus et Contaminants dans les Aliments Sciences pour l'Action et le Développement : Activités, Produits, Territoires Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés Technologies et systèmes d'information pour les agrosystèmes Gestion de l'Eau, Acteurs, Usages Paris-Saclay Applied Economics RiverLy - Fonctionnement des hydrosystèmes RiverLy - Fonctionnement des hydrosystèmes RiverLy - Fonctionnement des hydrosystèmes RiverLy - Fonctionnement des hydrosystèmes RiverLy - Fonctionnement des hydrosystèmes Institut d'écologie et des sciences de l'environnement de Paris Gestion de l'Eau, Acteurs, Usages Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Domaine expérimental de Saint-Laurent-de-la-Prée Institut des Géosciences de l’Environnement Paris Jourdan Sciences Economiques Agrosystèmes Biodiversifiés Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Gestion de l'Eau, Acteurs, Usages Réduire, valoriser, réutiliser les ressources des eaux résiduaires Innovation et Développement dans l'Agriculture et l'Alimentation Paris Jourdan Sciences Economiques Innovation et Développement dans l'Agriculture et l'Alimentation

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Résumé : Ce document dit "Recueil de projets d’expertise internationale" complète un premier volume édité en 2021 sur le même type d’activité (https://hal.inrae.fr/hal-04037409). Depuis la création en 2020 de la Direction Générale Déléguée à l’Expertise et l’Appui aux Politiques Publiques (DGDEAPP) il est souligné dans les échanges internes l’importance de mieux connaître, comprendre et "donner à voir" ce que recouvrent ces activités et les produits qui les caractérisent. L’Expertise-projet internationale (EPI) a été définie à travers une note de cadrage élaborée via un groupe d’experts référents. Cette note est accessible sur l’intranet de la DAPP. Au-delà de ce cadrage institutionnel, il semble important et opportun de partager les expériences concrètes, ainsi que la diversité des projets menés par les chercheurs sur cette activité. C’est le but de ce recueil que d’illustrer cette multitude de situations et d’expériences. Ainsi ce document rassemble une quarantaine de projets menés dans plus de 30 pays à travers le monde. On découvre à travers ce recueil un grand nombre d’organisations internationales commanditaires (bailleurs de l’expertise) allant de l’AFD, la FAO, le FIDA, La Banque Mondiale, l’Union Européenne (AEE, JRC), plusieurs agences onusiennes (OMS, PNUD, OMM, UNEP, GEF), l’OCDE, mais aussi des cabinets privés qui font appel à l’expertise scientifique des chercheurs de l’établissement. On y découvre également une grande diversité thématique qu’il est impossible de décrire sans en oublier mais qui vont de la sécurité sanitaire des aliments, des innovations institutionnelles pour une agriculture durable, des dispositifs d’alerte précoce pour prévenir les inondations (CREWS), la valorisation des eaux usées (REUSE), l’économie de la déforestation, les méthodes pour limiter l’impact de l’élevage (MRV), la robotique agricole, des méthodes et outils pour reconsidérer les inégalités, la pauvreté, les structures familiales etc. Si INRAE est aujourd’hui un acteur mondialement reconnu pour la réalisation de projets de recherche dimensionnant et de haut niveau, la montée en puissance des projets d’Expertise Internationale représente un nouveau vecteur de valorisation de ses savoir-faire en renforçant sa visibilité et sa notoriété.

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Fichiers liés : FV-2024-Brochure-expertise-n2-PDF-interactif.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Nowell PhelpsRosie SingletonBin ZhouRachel HeapAnu MishraJames BennettChristopher PaciorekVictor Pf LhosteRodrigo Carrillo-LarcoGretchen StevensAndrea Rodriguez-MartinezHonor BixbyJames BenthamMariachiara Di CesareGoodarz DanaeiArchie RaynerAna Barradas-PiresMelanie CowanStefan SavinLeanne RileyCarlos Aguilar-SalinasJennifer BakerAmina BarkatZulfiqar BhuttaFrancesco BrancaRoberta CaixetaSarah CuschieriFarshad FarzadfarShubash GanapathyNayu IkedaVioleta IotovaAndre KengneYoung-Ho KhangAvula LaxmaiahHsien-Ho LinJun MaJean Claude N MbanyaJ Jaime MirandaRajendra PradeepaFernando Rodríguez-ArtalejoMaroje SorićMaria TurleyLimin WangKaren Webster-KerrJulie AarestrupLeandra Abarca-GómezMohsen Abbasi-KangevariZiad AbdeenShynar AbdrakhmanovaSuhaila Abdul GhaffarHanan Abdul RahimZulfiya AbdurrahmonovaNiveen Abu-RmeilehJamila Abubakar GarbaBenjamin Acosta-CazaresIshag AdamMarzena AdamczykRobert AdamsSeth Adu-AfarwuahWichai AekplakornKaosar AfsanaShoaib AfzalValirie AgborImelda AgdeppaJavad Aghazadeh-AttariÅsa ÅgrenHassan AguenaouCharles AgyemangMohamad Hasnan AhmadNoor Ani AhmadAli AhmadiNaser AhmadiNastaran AhmadiImran AhmedSoheir AhmedWolfgang AhrensGulmira AitmurzaevaKamel AjlouniHazzaa Al-HazzaaHalima Al-HinaiBadreya Al-LahouJawad Al-LawatiRajaa Al-RaddadiDeena Al AsfoorHuda Al HouraniNawal Al QaoudMonira AlaroujFadia AlbuhairanShahla AldhukairMaryam AldwairjiSylvia AlexiusMohamed AliAnna AlievaAbdullah AlkandariAla'A AlkerwiButhaina AlkhatibKristine AllinShaker AlomaryHusam AlomirahArwa AlshangitiMar Alvarez-PedrerolEman AlyDeepak AmarapurkarPilar Amiano EtxezarretaJohn AmoahNorbert AmougouPhilippe AmouyelLars Bo AndersenSigmund AnderssenOdysseas AndroutsosLars ÄngquistRanjit Mohan AnjanaAlireza Ansari-MoghaddamElena AnufrievaHajer Aounallah-SkhiriJoana AraújoInger AriansenTahir ArisRaphael ArkuNimmathota ArlappaKrishna AryalNega AssefaThor AspelundFelix AssahBatyrbek AssembekovMaria Cecília F AssunçãoMay Soe AungCorreia Júnior Marco Aurélio de ValoisJuha AuvinenMária AvdičováShina AviKishwar AzadAna AzevedoMohsen Azimi-NezhadFereidoun AziziBontha BabuFlora BacopoulouMaja Bæksgaard JørgensenAzli BaharudinSuhad BahijriIzet BajramovicMarta BakacsNagalla BalakrishnaYulia BalanovaMohamed BamoshmooshMaciej BanachJosé BanegasJoanna BaranRafał BaranCarlo BarbagalloValter Barbosa FilhoAlberto BarcelóMaja BaretićJoaquin BarnoyaLena BarreraMarta BarretoAluisio Jd BarrosMauro Virgílio Gomes BarrosAnna BartosiewiczAbdul BasitJoao Luiz BastosIqbal BataAnwar BatiehaAline BatistaRosangela BatistaZhamilya BattakovaLouise BaurPascal BayauliRobert BeagleholeSilvia Bel-SerratAntonisamy BelavendraHabiba Ben RomdhaneTheodora BenedekJudith BenedicsMikhail BenetGilda Estela Benitez RolandiMichaela BenzevalElling BereNicolas BergerIngunn Holden BerghYemane BerhaneSalim BerkinbayevAntonio Bernabe-OrtizGailute BernotieneXimena Berrios CarrasolaHeloísa BettiolManfred BeutelAugustin BeybeyJorge BezerraAroor BhagyalaxmiSumit BharadwajSantosh BhargavaHongsheng BiYufang BiDaniel BiaKatia BiaschElysée Claude Bika LeleMukharram BikbovBihungum BistaDusko BjelicaAnne BjerregaardPeter BjerregaardEspen BjertnessMarius BjertnessCecilia BjörkelundKatia BlochAnneke BlokstraMoran Blychfeld MagnazuSimona BoMartin BobakLynne BoddyBernhard BoehmJolanda Ma BoerJose BoggiaElena BogovaCarlos BoissonnetStig BojesenMarialaura BonaccioVanina BongardAlice Bonilla-VargasMatthias BoppHerman BorghsSteve BotombaRupert Ra BournePascal BovetKhadichamo BoymatovaLien BraeckeveltLutgart BraeckmanMarjolijn Ce BragtTasanee BraithwaiteImperia BrajkovichJuergen BreckenkampJoão BredaHermann BrennerLizzy BrewsterGarry BrianYajaira BriceñoLacramioara BrinduseBettina Bringolf-IslerMiguel BritoSinead BrophyJohannes BrugGraziella BrunoAnna BuggeMarta BuoncristianoGenc BurazeriCon BurnsAntonio Cabrera de LeónJoseph CacciottoloHui CaiTilema CamaChristine CameronJosé CamolasGünay CanAna Paula C CândidoFelicia CañeteMario CapanzanaNaděžda ČapkováEduardo CapuanoRocco CapuanoVincenzo CapuanoMarloes CardolViviane CardosoAxel CarlssonEsteban CarmuegaJoana CarvalhoJosé CasajúsFelipe CasanuevaMaribel CasasErtugrul CelikcanLaura CensiMarvin Cervantes-LoaizaJuraci CesarParinya ChamnanSnehalatha ChamukuttanAngelique ChanQueenie ChanFadi CharcharMarie-Aline CharlesHimanshu ChaturvediNish ChaturvediNorsyamlina Che Abdul RahimMiao Li CheeChien-Jen ChenFangfang ChenHuashuai ChenLong-Sheng ChenShuohua ChenZhengming ChenChing-Yu ChengYiling ChengBahman CheraghianAngela ChetritEkaterina Chikova-IscenerMai Jm ChinapawAnne ChinnockArnaud ChioleroShu-Ti ChiouAdela Chirita-EmandiMaría-Dolores ChirlaqueBelong ChoKaare ChristensenDiego ChristofaroJerzy ChudekRenata CifkovaMichelle CiliaEliza CintezaMassimo CirilloFrank ClaessensPhilip ClareJanine ClarkeEls ClaysEmmanuel CohenCosmin CojocaruSandra Colorado-YoharLaura-María Compañ-GabucioHans ConcinSusana ConfortinCyrus CooperTara CoppingerEva CorpeleijnLilia Yadira CortésSimona CostanzoDominique CottelChris CowellCora CraigAmelia CrampinAmanda CrossAna CrujeirasJuan CruzTamás CsányiSemánová CsillaAlexandra CucuLiufu CuiFelipe CureauEwelina Czenczek-LewandowskaGraziella d'ArrigoEleonora d'OrsiAlanna da SilvaLiliana DacicaChristina DahmJean DallongevilleAlbertino DamascenoCamilla DamsgaardRachel DanknerThomas DantoftParasmani DasguptaSaeed DastgiriLuc DauchetKairat DavletovFrancisco de Assis Guedes de VasconcelosMaria Alice Altenburg de AssisGuy de BackerDirk de BacquerJaco de BacquerJeroen de BontAmalia de CurtisPatrícia de Fragas HinnigGiovanni de GaetanoStefaan de HenauwPilar de Miguel-EtayoJan-Walter de NevePaula Duarte de OliveiraDavid de RidderKarin de RidderSusanne de RooijAna Carolina Mgn de SáDelphine de SmedtMohan DeepaAlexander DeevVincent Jr DegennaroHélène DelisleFrancis DelpeuchStefaan DemarestElaine DennisonKatarzyna DereńValérie DeschampsRuslan DevrishovMeghnath DhimalAugusto Di CastelnuovoJuvenal Soares Dias-Da-CostaMaría Elena Díaz-SánchezAlejandro DiazPedro Díaz FernándezMaría Pilar Díez RipollésZivka DikaShirin DjalaliniaVisnja DjordjicHa Tp DoAnnette DobsonLiria DominguezMaria Benedetta DonatiChiara DonfrancescoGuanghui DongYanhui DongSilvana DonosoAngela DöringMaria DorobantuAhmad Reza DorostyMarcus DörrKouamelan DouaNico DraganoWojciech DrygasShufa DuJia Li DuanCharmaine DuantePriscilla DubozVesselka DulevaVirginija DulskieneSamuel DumithAnar DushpanovaTerence DwyerAzhar DyussupovaVilnis DzerveElzbieta Dziankowska-ZaborszczykNarges EbrahimiGuadalupe EcheverríaRicky EddieEbrahim EftekharVasiliki EfthymiouEruke EgbagbeRobert EggertsenSareh EghtesadGabriele EibenUlf EkelundMohammad El-KhateebLaila El AmmariJalila El AtiDenise Eldemire-ShearerPaul ElliottOfem EnangRonit EndeveltReina Engle-StoneRajiv ErasmusCihangir EremGul ErgorLouise EriksenJohan ErikssonJorge Escobedo-de la PeñaSaeid EslamiAli EsmaeiliAlun EvansRoger EvansDavid FaehGuy FagherazziIldar FakhradiyevAlbina FakhretdinovaCaroline FallElnaz FaramarziMojtaba FarjamVictoria Farrugia Sant'AngeloYosef FarziMohammad Reza FattahiAsher FawwadWafaie FawziFrancisco Felix-RedondoTrevor FergusonRomulo FernandesDaniel Fernández-BergésDaniel FerranteThomas FerraoGerson FerrariMarika FerrariMarco FerrarioCatterina FerreccioHaroldo FerreiraEldridge FerrerJean FerrieresThamara Hubler FigueiróAnna FijalkowskaGünther FinkMauro FisbergKrista FischerLeng Huat FooMaria ForsnerEdward FottrellHeba FouadDamian FrancisMaria Do Carmo FrancoZlatko FrasBrooklyn FraserGuillermo FronteraFlavio FuchsSandra FuchsIsti FujiatiYuki FujitaMatsuda FumihikoViktoriya FurdelaTakuro FurusawaStefan Adela GabrielaZbigniew GaciongMihai GafencuManuel Galán CuestaAndrzej GalbarczykSonya GalchevaHenrike GalenkampDaniela GaleoneMyriam GalfoFabio GalvanoJingli GaoPei GaoManoli Garcia-De-La-HeraMaría José García MéridaMarta García SolanoDickman GaretaSarah GarnettJean-Michel GaspozMagda GasullAdroaldo Cesar Araujo GayaAnelise Reis GayaAndrea GazzinelliUlrike GehringHarald GeigerJohanna GeleijnseRonnie GeorgeEva GerdtsEbrahim GhaderiSeyyed-Hadi GhamariAli GhanbariErfan GhasemiOana-Florentina Gheorghe-FroneaAlessandro GialluisiSimona GiampaoliFrancesco GianfagnaChristian GiegerTiffany GillJonathan GiovannelliGlen GironellaAleksander GiwercmanKonstantinos GkiourasNatalya GlushkovaRamesh GodaraJustyna GodosSibel GogenMarcel GoldbergDavid GoltzmanGeorgina GómezJesús Humberto Gómez GómezLuis GomezSantiago GómezAleksandra GomulaBruna Gonçalves Cordeiro da SilvaHelen GonçalvesMauer GonçalvesAna González-AlvarezDavid Gonzalez-ChicaEsther González-GilMarcela Gonzalez-GrossMargot González-LeonJuan González-RivasClicerio González-VillalpandoMaría-Elena González-VillalpandoAngel GonzalezFrederic GottrandAntonio Pedro GraçaDušan GrafnetterAneta GrajdaMaria GrammatikopoulouEdward GreggRonald GregorMaria João GregórioElse Karin GrøholtAnders GrøntvedGiuseppe GrossoGabriella GrudenDongfeng GuViviana GuajardoEmanuela Gualdi-RussoPilar Guallar-CastillónAndrea GualtieriElias GudmundssonVilmundur GudnasonMaëlenn GuerchetRamiro GuerreroIdris GuessousAndre GuimaraesUnjali GujralMartin GullifordJohanna GunnlaugsdottirMarc GunterXiu-Hua GuoYin GuoPrakash GuptaRajeev GuptaOye GurejeMirjana GurinovićEnrique Gutiérrez GonzálezLaura GutierrezFelix GutzwillerXinyi GweeSeongjun HaFarzad HadaeghCharalambos HadjigeorgiouRosa HaghshenasHamid HakimiJytte HalkjærIan HambletonBehrooz HamzehWillem HanekomDominique HangeAbu Am HanifSari HantunenJie HaoCarla Menêses HardmanLouise HardyRachakulla Hari KumarTina Harmer LassenJavad HarooniSeyed Mohammad Hashemi-ShahriMaria HassapidouJun HataTeresa HaugsgjerdAlison HayesJiang HeYuan HeYuna HeRegina Heidinger-FelsőMargit HeierMirjam HeinenTatjana HejgaardMarleen Elisabeth HendriksRafael dos Santos HenriqueAna HenriquesLeticia Hernandez CadenaSauli HerralaMarianella Herrera-CuencaVictor HerreraIsabelle Herter-AeberliKarl-Heinz HerzigRamin HeshmatBarbara HeudeAllan HillSai Yin HoSuzanne HoMichael HobbsDoroteia HöfelmannMichelle HoldsworthReza HomayounfarClara HomsEmiel HoogendijkWilma HopmanAndrea Rvr HorimotoClaudia HormigaBernardo HortaLeila HoutiChristina HowittThein Thein HtayAung Soe HtetMaung Maung Than HtikeYonghua HuJosé María HuertaIlpo Tapani HuhtaniemiLaetitia HuiartConstanta Huidumac PetrescuAbdullatif HusseiniChinh Nguyen HuuInge HuybrechtsNahla HwallaJolanda HyskaLicia IacovielloEllina IakupovaJesús IbarluzeaMohsen IbrahimNorazizah Ibrahim WongJannicke IglandChinwuba IjomaM Arfan IkramCarmen IñiguezVilma IrazolaTakafumi IshidaGodsent IsiguzoMuhammad IslamSheikh Mohammed Shariful IslamDuygu IslekTill IttermannIvaila Ivanova-PandourskaMasanori IwasakiTuija JääskeläinenRod JacksonJeremy JacobsMichel JadoulTazeen JafarBakary JallowKenneth JamesKazi JamilKonrad JamrozikNataša JanAnna JanssonImre JanszkyEdward JanusJuel JaraniGerald JarnigMarjo-Riitta JarvelinGrazyna JasienskaAna JelakovićBojan JelakovićGarry JenningsChao Qiang JiangRamon JimenezKarl-Heinz JöckelMichel JoffresJari JokelainenJost JonasJitendra JonnagaddalaLars Jøran KjerpesethTorben JørgensenPradeep JoshiRohina JoshiJosipa JosipovićFarahnaz JoukarJacek JóźwiakDebra JudgeAnne JuoleviGregor JurakIulia Jurca SiminaVesna JuresaRudolf KaaksFelix KaducuAgnes KadvanAnthony KafatosMónika KajEero KajantieNatia KakutiaDaniela KállayováZhanna KalmatayevaOfra Kalter-LeiboviciYves KameliKodanda KanalaSrinivasan KannanEfthymios KapantaisEva KaraglaniArgyro KarakostaLine KårhusKhem KarkiOmat KarlssonAdoubi Kassi AnicetPhilippe KatchungaMarzieh KatibehJoanne KatzPeter KatzmarzykJussi KauhanenPrabhdeep KaurMaryam KavousiGyulli KazakbaevaFrançois KazeBenson KazembeCalvin KeUlrich KeilLital Keinan BokerSirkka Keinänen-KiukaanniemiRoya KelishadiCecily KelleherHan Cg KemperMaryam KeramatiAlina KerimkulovaMathilde KerstingTimothy KeyYousef Saleh KhaderArsalan KhaledifarDavood KhaliliBahareh KheiriMotahareh KheradmandAlireza KhosraviIlse Msl KhouwUrsula Kiechl-KohlendorferSophia KiechlStefan KiechlJaphet KillewoHyeon Chang KimJeongseon KimJenny KindblomAndrew 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ViswanathanMihaela VladulescuTiina VlasoffDorja VocanecPeter VollenweiderHenry VölzkeGeorgia VourliAri VoutilainenMartine VrijheidTanja Gm VrijkotteSilvije VuletićAlisha WadeThomas WaldhörJanette WaltonElvis Oa WambiyaWan Mohamad Wan BebakarWan Nazaimoon Wan MohamudRildo de Souza Wanderley JúniorChongjian WangHuijun WangMing-Dong WangNingli WangQian WangXiangjun WangYa Xing WangYing-Wei WangS Goya WannametheeNicholas WarehamOlivia WarthaAdelheid WeberNiels WedderkoppDaniel WeghuberWenbin WeiAneta WeresBo WernerLeo WestburyPeter WhincupLars WichstrømKremlin WickramasingheKurt WidhalmIndah WidyaheningAndrzej WięcekPhilipp WildRainford WilksJohann WilleitPeter WilleitJulianne WilliamsTom WilsgaardJames WirthBogdan WojtyniakMeseret WoldeyohannesKathrin WolfRoy Wong-McclureAndrew WongEmily WongJyh Eiin WongTien Yin WongJean WooMark WoodwardFrederick WuHon-Yen WuJianfeng WuLi Juan WuShouling WuJustyna WyszyńskaHaiquan XuLiang XuNor Azwany YaacobUruwan YamborisutLi YanWeili YanLing YangXiaoguang YangYang YangNazan YardimTabara YasuharuMartha Yépez GarcíaPanayiotis YiallourosAgneta YngveMoein YoosefiAkihiro YoshiharaYoto YotovQi Sheng YouSan-Lin YouNovie Younger-ColemanYu-Ling YuYunjiang YuSafiah Md YusofAhmad Faudzi YusoffLuciana ZaccagniVassilis ZafiropulosAhmad ZainuddinSeyed Rasoul ZakaviFarhad ZamaniSabina ZambonAntonis ZampelasHana ZamrazilováMaria Elisa ZapataAbdul Hamid ZargarKo Ko ZawAyman ZayedTomasz ZdrojewskiMagdalena ŻegleńKristyna ZejglicovaTajana Zeljkovic VrkicYi ZengAndrea ZentaiBing ZhangLuxia ZhangZhen-Yu ZhangDong ZhaoMing-Hui ZhaoWenhua ZhaoYanitsa ZhechevaShiqi ZhenWei ZhengYingfeng ZhengBekbolat ZholdinMaigeng ZhouDan ZhuPaul ZimmetMarie ZinsEmanuel ZittYanina ZocaloNada ZoghlamiJulio Zuñiga CisnerosMonika ZuziakMajid EzzatiPierre-Marie Preux
• Organismes : University of Chinese Academy of Sciences [Beijing] Shanghai Institute of Biochemistry and Cell Biology [Shanghai, China] University of Newcastle Imperial College London Imperial College London Imperial College London Imperial College London Imperial College London University of Kent [Canterbury] Middlesex University [London] Harvard T.H. Chan School of Public Health Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] European Atherosclerosis Society [Göteborg, Sweden] Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] University of Malta [Malta] Tehran University of Medical Sciences Seoul National University [Seoul] Epidémiologie des Maladies Chroniques en zone tropicale Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Institut de Recherche pour le Développement Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans The Lancet le 02/11/2020

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Résumé : Summary Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m²) and obesity (BMI ≥30 kg/m²). For school- aged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.

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Fichiers liés : Worldwide-trends-in-underweight-and-obesity-from-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Fabien NoguéMathilde CaussePhilippe DebaekeAnnabelle DéjardinStéphane LemariéGuy RichardPeter RogowskyCarole Caranta
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Génétique et Amélioration des Fruits et Légumes AGroécologie, Innovations, teRritoires Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt Laboratoire d'Economie Appliquée de Grenoble Direction de l'Expertise scientifique collective, de la Prospective et des Etudes Reproduction et développement des plantes Collège de Direction
• Publié dans iScience le 17/01/2019

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Résumé : Meeting the challenges of agroecological transition in a context of climate change requires the use of various strategies such as biological regulations, adapted animal and plant genotypes, diversified production systems, and digital technologies. Seeds and plants, through plant breeding, play a crucial role in driving these changes. The emergence of genome editing presents a new opportunity in plant breeding practices. However, like any technological revolution involving living organisms, it is essential to assess its potential contributions, limits, risks, socio-economic implications, and the associated controversies. This article aims to provide a comprehensive review of scientific knowledge on genome editing for agroecological transition, drawing on multidisciplinary approaches encompassing biological, agronomic, economic, and social sciences.

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Fichiers liés : 1-s2.0-S2589004224003808-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Naïl BenallegueFabien RollotS WiertlewskiRomain CaseyMarc DebouverieAnne KerbratJérôme de SèzeJonathan CironAurelie RuetPierre LabaugeElisabeth MaillartHélène ZéphirCaroline PapeixGilles DeferChristine Lebrun-FrénayThibault MoreauEric BergerBruno StankoffPierre ClavelouOlivier HeinzlefJean PelletierEric ThouvenotAbdullatif Al KhedrBertrand BourreOlivier CasezPhilippe CabreAbir WahabLaurent MagySandra VukusicDavid-Axel Laplaud
• Organismes : Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology CIC Plurithématique de Nantes Université Claude Bernard Lyon 1 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CIC Plurithématique de Nantes Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Université Claude Bernard Lyon 1 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Service de Neurologie [Rennes] = Neurology [Rennes] Neuroimagerie: méthodes et applications Hôpitaux Universitaires de Strasbourg CIC Strasbourg Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Hospitalier Universitaire de Bordeaux Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] CHU Pitié-Salpêtrière [AP-HP] Hôpital Roger Salengro [Lille] Lille Neurosciences & Cognition - U 1172 Service de neurologie [Hôpital Fondation Adolphe de Rothschild] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Service de Neurologie [CHRU Besançon] CHU Saint-Antoine [AP-HP] CHU Clermont-Ferrand Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Hôpital de la Timone [CHU - APHM] Centre de résonance magnétique biologique et médicale Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle CHU Amiens-Picardie CHU Rouen Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Hôpital Henri Mondor CHU Limoges Université Claude Bernard Lyon 1 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology CIC Plurithématique de Nantes
• Publié dans JAMA neurology le 24/10/2020

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Résumé : Importance: Moderately effective therapies (METs) have been the main treatment in pediatric-onset multiple sclerosis (POMS) for years. Despite the expanding use of highly effective therapies (HETs), treatment strategies for POMS still lack consensus.Objective: To assess the real-world association of HET as an index treatment compared with MET with disease activity.Design, setting, and participants: This was a retrospective cohort study conducted from January 1, 2010, to December 8, 2022, until the last recorded visit. The median follow-up was 5.8 years. A total of 36 French MS centers participated in the Observatoire Français de la Sclérose en Plaques (OFSEP) cohort. Of the total participants in OFSEP, only treatment-naive children with relapsing-remitting POMS who received a first HET or MET before adulthood and at least 1 follow-up clinical visit were included in the study. All eligible participants were included in the study, and none declined to participate.Exposure: HET or MET at treatment initiation.Main outcomes and measures: The primary outcome was the time to first relapse after treatment. Secondary outcomes were annualized relapse rate (ARR), magnetic resonance imaging (MRI) activity, time to Expanded Disability Status Scale (EDSS) progression, tertiary education attainment, and treatment safety/tolerability. An adapted statistical method was used to model the logarithm of event rate by penalized splines of time, allowing adjustment for effects of covariates that is sensitive to nonlinearity and interactions.Results: Of the 3841 children (5.2% of 74 367 total participants in OFSEP), 530 patients (mean [SD] age, 16.0 [1.8] years; 364 female [68.7%]) were included in the study. In study patients, both treatment strategies were associated with a reduced risk of first relapse within the first 2 years. HET dampened disease activity with a 54% reduction in first relapse risk (adjusted hazard ratio [HR], 0.46; 95% CI, 0.31-0.67; P < .001) sustained over 5 years, confirmed on MRI activity (adjusted odds ratio [OR], 0.34; 95% CI, 0.18-0.66; P = .001), and with a better tolerability pattern than MET. The risk of discontinuation at 2 years was 6 times higher with MET (HR, 5.97; 95% CI, 2.92-12.20). The primary reasons for treatment discontinuation were lack of efficacy and intolerance. Index treatment was not associated with EDSS progression or tertiary education attainment (adjusted OR, 0.51; 95% CI, 0.24-1.10; P = .09).Conclusions and relevance: Results of this cohort study suggest that compared with MET, initial HET in POMS was associated with a reduction in the risk of first relapse with an optimal outcome within the first 2 years and was associated with a lower rate of treatment switching and a better midterm tolerance in children. These findings suggest prioritizing initial HET in POMS, although long-term safety studies are needed.

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Fichiers liés : jamaneurology_benallegue_2024_oi_230102_1707244155.42328.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Thibaut CouchouxTristan JaouenChristelle Melodelima-GonindardPierre BaseilhacArthur BranchuNicolas ArfiRichard AzizaNicolas Barry DelongchampsFranck BladouFlavie BratanSerge BrunellePierre ColinJean-Michel CorreasFrançois CornudJean-Luc DescotesPascal EschwègeGaelle FiardBénédicte GuillaumeRémi GrangeNicolas GrenierHervé LangFrédéric LefèvreBernard MalavaudClément MarcelinPaul MoldovanNicolas MottetPierre MozerEric PotironDaniel PortalezPhilippe PuechRaphaele Renard-PennaMatthieu RoumiguiéCatherine RoyMarc-Olivier TimsitThibault TricardArnauld VillersJochen WalzSabine DebeerAdeline MansuyFlorence Mège-LechevallierMyriam Decaussin-PetrucciLionel BadetMarc ColombelAlain RuffionSébastien CrouzetMuriel RabilloudRémi SouchonOlivier Rouvière
• Organismes : Hôpital Edouard Herriot [CHU - HCL] Laboratoire des applications thérapeutiques des ultrasons / Application des ultrasons à la thérapie Laboratoire d'Ecologie Alpine Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital Saint Joseph Saint Luc Service Radiologie et imagerie médicale - Rangueil / Larrey [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Institut Necker Enfants-Malades Service d'urologie [CHU Cochin] CHU de Bordeaux Pellegrin [Bordeaux] Hôpital Saint Joseph Saint Luc Institut Paoli-Calmettes École, mutations, apprentissages Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Laboratoire d'Imagerie Biomédicale [Paris] Service Maladies infectieuses et tropicales [AP-HP Hôpital Cochin] Service d'urologie [CHU Grenoble] Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Service d'urologie [CHU Grenoble] BCL, équipe Linguistique de l’énonciation Service de Radiologie [CHU Saint-Etienne] CHU de Bordeaux Pellegrin [Bordeaux] Service d'Urologie [Strasbourg] Département de Radiologie adultes [CHRU Nancy] Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole CHU de Bordeaux Pellegrin [Bordeaux] Hôpital Edouard Herriot [CHU - HCL] Service d'Urologie - Andrologie [CHU Saint-Etienne] CHU Pitié-Salpêtrière [AP-HP] Clinique urologique [CHU de Nantes] Service Radiologie et imagerie médicale - Rangueil / Larrey [CHU Toulouse] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche Clinique Onco-Urologie Prédictive Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse] Service de radiologie [Strasbourg] Hôpital Européen Georges Pompidou [APHP] Service d'Urologie [Strasbourg] Centre Hospitalier Régional Universitaire [CHU Lille] Service Radiologie et imagerie médicale - Rangueil / Larrey [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Service d'urologie [CHU Cochin] Service d'urologie [CHU Cochin] Service d'Urologie - Andrologie [CHU Saint-Etienne] Université Claude Bernard Lyon 1 Université Claude Bernard Lyon 1 Université Claude Bernard Lyon 1 Département biostatistiques et modélisation pour la santé et l'environnement [LBBE] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Biostatistiques santé [LBBE] Laboratoire des applications thérapeutiques des ultrasons / Application des ultrasons à la thérapie Laboratoire des applications thérapeutiques des ultrasons / Application des ultrasons à la thérapie
• Publié dans European Urology Oncology le 02/11/2020

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Résumé : Background and objective: Prostate multiparametric magnetic resonance imaging (MRI) shows high sensitivity for International Society of Urological Pathology grade group (GG) ≥2 cancers. Many artificial intelligence algorithms have shown promising results in diagnosing clinically significant prostate cancer on MRI. To assess a region-of-interest-based machine-learning algorithm aimed at characterising GG ≥2 prostate cancer on multiparametric MRI. Methods: The lesions targeted at biopsy in the MRI-FIRST dataset were retrospectively delineated and assessed using a previously developed algorithm. The Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) score assigned prospectively before biopsy and the algorithm score calculated retrospectively in the regions of interest were compared for diagnosing GG ≥2 cancer, using the areas under the curve (AUCs), and sensitivities and specificities calculated with predefined thresholds (PIRADSv2 scores ≥3 and ≥4; algorithm scores yielding 90% sensitivity in the training database). Ten predefined biopsy strategies were assessed retrospectively. Key findings and limitations: After excluding 19 patients, we analysed 232 patients imaged on 16 different scanners; 85 had GG ≥2 cancer at biopsy. At patient level, AUCs of the algorithm and PI-RADSv2 were 77% (95% confidence interval [CI]: 70-82) and 80% (CI: 74-85; p = 0.36), respectively. The algorithm's sensitivity and specificity were 86% (CI: 76-93) and 65% (CI: 54-73), respectively. PI-RADSv2 sensitivities and specificities were 95% (CI: 89-100) and 38% (CI: 26-47), and 89% (CI: 79-96) and 47% (CI: 35-57) for thresholds of ≥3 and ≥4, respectively. Using the PI-RADSv2 score to trigger a biopsy would have avoided 26-34% of biopsies while missing 5-11% of GG ≥2 cancers. Combining prostate-specific antigen density, the PI-RADSv2 and algorithm's scores would have avoided 44-47% of biopsies while missing 6-9% of GG ≥2 cancers. Limitations include the retrospective nature of the study and a lack of PI-RADS version 2.1 assessment. Conclusions and clinical implications: The algorithm provided robust results in the multicentre multiscanner MRI-FIRST database and could help select patients for biopsy. Patient summary: An artificial intelligence-based algorithm aimed at diagnosing aggressive cancers on prostate magnetic resonance imaging showed results similar to expert human assessment in a prospectively acquired multicentre test database.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Benjamin de ValenceMarion DelauneYann NguyenVincent JachietMaël HeibligAlexis JeanStanislas Riescher TuczkiewiczPierrick HennetonPhilippe GuilpainNicolas SchleinitzGuillaume Le GuennoHervé LobbesValentin LacombeSamuel ArdoisEstibaliz LazaroVincent LangloisRoderau OuthJulien VinitJean-Philippe MartellosioPaul DeckerThomas MoulinetYannick DieudonnéAdrien BigotLouis TerriouAlexandre VlakosBaptiste de MalepradeGuillaume DenisJonathan BronerMarie KostineSebastien HumbertFrancois LifermannMaxime SamsonSusann PechuzalAchille AoubaOlivier KosmiderJeremie DionSylvie GrosleronRim BourguibaBenjamin TerrierSophie Georgin-LavialleOlivier FainArsène MékinianMarjolaine MorgandThibault ComontJérome HadjadjIsabelle MelkiPierre FenauxLionel AdesAlexandra AudemardMikael EbboYvan JamillouxOdile Beyne RauzyAlexandre BelotRaphaël BorieAlexis MathianLaurent ArnaudFrançois ChassetJean-David BouazizPierre SujobertYgal BenhamouGaetan SauvetreKhalil El-KarouiFrançois Rodrigues
• Organismes : Immuno-Biologie des Lymphomes [CIRI] Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] CHU Estaing [Clermont-Ferrand] Institut Pascal
• Publié dans Annals of the Rheumatic Diseases le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Gilles NevezGaelle GuillermJean-Philippe TalarminDorothée QuinioXavier IriartPierre-Luc LissillourSchéhérazade RezigMarie-Sarah FangousMarion RantyLaetitia BodenesCécile AubronMarie-Anne CouturierSolène Le Gal
• Organismes : Université de Brest Université d'Angers Université de Brest Centre Hospitalier Intercommunal de Cornouaille Université de Brest Institut Toulousain des Maladies Infectieuses et Inflammatoires Service de Parasitologie et Mycologie [CHU Toulouse] Université de Brest Université de Brest Centre Hospitalier Intercommunal de Cornouaille Université de Brest Université de Brest Université de Brest Université de Brest Université de Brest
• Publié dans Journal of Medical Mycology = Journal de Mycologie Médicale le 31/10/2020

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Résumé : Hormographiella aspergillata is a basidiomycete exceptionally involved in invasive fungal infections (IFI). We report a case of H. aspergillata pulmonary infection in a 30-year-old female in a context of pancytopenia and relapsed of acute myeloid leukemia (AML). She presented with fever, thoracic pain, left pleural effusion and pneumonia, diagnosed on chest X-ray and CT-scan. Direct examination of a bronchoalveolar lavage (BAL) specimen performed on day (d) 10 was negative, while the culture was positive on d30. H. aspergillata was suspected, considering macroscopic and microscopic examination. Its identification was confirmed using Microflex® Bruker mass spectrometry and pan-fungal (PF)-PCR assay followed by DNA sequencing. After this initial diagnosis, the patient was monitored for 2.8 years. She was treated with liposomal amphotericin B and/or voriconazole until switching to isavuconazole on d298 due to side-effects. This antifungal treatment was maintained until d717 and then discontinued, the patient being considered as cured. Over this follow-up period, the patient was submitted to recurrent pulmonary sampling. Each time, cultures were negative, while PF - PCR assays and DNA sequencing confirmed the presence of H. aspergillata. The present case-report is the 32nd observation of H. aspergillata invasive infection showing that this IFI is still infrequent. Fifteen have occurred in patients with AML, which appears as the most frequent underlying disease favoring this IFI. Six recent case-reports in addition to ours highlight PF-PCR assays and DNA sequencing as relevant diagnostic tools that must be included in routine diagnosis and monitoring of IFI, specifically those due to rare basidiomycetes.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2024
• Auteurs : Sindy SimIgor Lima MaldonadoPierre CastelnauLaurent BarantinWissam El-HageFrédéric AnderssonJean-Philippe Cottier
• Organismes : Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry CHU Trousseau [Tours] Imaging, Brain & Neuropsychiatry
• Publié dans Journal de Neuroradiologie / Journal of Neuroradiology le 26/10/2020

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