Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 23/11/2009
• Auteurs : Julien DambrinePhilippe HochRaphaël KuateJérôme LohéacJérôme MetralBernard RebourcetLisl Weynans
• Organismes : Institut de Mathématiques de Bordeaux DAM Île-de-France Laboratoire Jacques-Louis Lions Laboratoire de Spectrométrie Physique Equations aux Dérivées Partielles DAM Île-de-France DAM Île-de-France Institut de Mathématiques de Bordeaux Modélisation, contrôle et calcul
• Publié dans ESAIM: Proceedings le 25/10/2020

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Résumé : Numerous systems of conservation laws are discretized on Lagrangian meshes where cells nodes move with matter. For complex applications, cells shape or aspect ratio often do not insure sufficient accuracy to provide an acceptable numerical solution and use of ALE technics is necessary. Here we are interested with conduction phenomena depending on velocity derivatives coming from the resolution of gas dynamics equations. For that, we propose the study of a mock of second order turbulent mixing model combining an elliptical part and an hyperbolic kernel. The hyperbolic part is approximated by finite-volume centered scheme completed by a remapping step see [7]. A major part of this paper is the discretization of the anisotropic parabolic equation on polygonal distorted mesh. It is based on the scheme described in [9] ensuring the positivity of the numerical solution. We propose an alternative based on the partitioning of polygons in triangles. We show some preliminary results on a weak coupling of hydrodynamics and parabolic equation whose tensor diffusion coefficient depends on Reynolds stresses.

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Fichiers liés : cemracsproceding.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/11/2009
• Auteurs : Hugues GirardSandrine PerruchasCeline GessetMarc ChaigneauLaetitia VieilleJean-Charles ArnaultPhilippe BergonzoJean-Pierre BoilotThierry Gacoin
• Organismes : Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de physique de la matière condensée Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de Physique des Interfaces et des Couches Minces Centre Sciences des Processus Industriels et Naturels Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de physique de la matière condensée Laboratoire de physique de la matière condensée
• Publié dans ACS Applied Materials & Interfaces le 01/11/2020

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Résumé : Nanodiamond (ND) seeding is a well-established route toward the CVD (chemical vapor deposition) synthesis of diamond ultrathin films. This method is based on the deposition onto a substrate of diamond nanoparticles which act as pre-existing sp$^3$ seeds. Here, we report on a straightforward method to disperse diamond nanoparticles on a substrate by taking advantage of the electrostatic interactions between the nanodiamonds and the substrate surface coated with a cationic polymer. This layer-by-layer deposition technique leads to reproducible and homogeneous large-scale nanoparticle deposits independent of the substrate’s nature and shape. No specific functionalization of the nanoparticles is required, and low concentrated solutions can be used. The density of ND on the substrate can be controlled, as shown by in situ ATR-FTIR (attenuated total reflection Fourier transform infrared) analysis and QCM (quartz crystal microbalance) measurements. Highly dense and compact ND deposits can be obtained, allowing CVD growth of nanocrystalline diamond ultrathin films (70 nm) on various substrates. The synthesis of 3D structured and patterned diamond thin films has also been demonstrated with this method.

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Fichiers liés : article_HuguesGirard_Applied Materials and Interfaces_2009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/11/2009
• Auteurs : Christiane Copie-BergmanPhilippe GaulardKaren LeroyJosette BriereMaryse BaiaJean-Philippe JaisGilles A. SallesFrançoise BergerCorinne HaiounHervé TillyJean François J.F. EmileAlison H. BanhamNicolas MounierChristian GisselbrechtPierre FeugierBertrand CoiffierThierry J. Molina
• Organismes : Groupe Henri Mondor-Albert Chenevier Institut Mondor de Recherche Biomédicale Groupe Henri Mondor-Albert Chenevier Institut Mondor de Recherche Biomédicale Groupe Henri Mondor-Albert Chenevier Institut Mondor de Recherche Biomédicale Service d'anatomo-pathologie [Paris] Groupe Henri Mondor-Albert Chenevier Institut Mondor de Recherche Biomédicale Service d'informatique médicale et biostatistiques [CHU Necker] Département de pathologie Université Claude Bernard Lyon 1 Département de pathologie Groupe Henri Mondor-Albert Chenevier Institut Mondor de Recherche Biomédicale Service d'hématologie clinique Service d'Hématologie Service d'anatomie pathologique [CHU Ambroise-Paré] Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Nuffield Department of Clinical Laboratory Sciences Service d'onco-hématologie Service d'hématologie-oncologie adultes Service d'Hématologie [CHRU Nancy] Département de pathologie Département de Pathologie
• Publié dans Journal of Clinical Oncology le 01/11/2020

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Résumé : PURPOSE: To evaluate the prognostic value of cell of origin immunohistochemical markers and BCL2, BCL6, and c-MYC translocations in a homogeneous cohort of patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). PATIENTS AND METHODS: Patients with CD20+ DLBCL were enrolled in the randomized LNH98-5 and 01-5B Groupe d'Etude des Lymphomes de l'Adulte trials. Paraffin-embedded tumor samples of 119 patients treated with R-CHOP were analyzed by immunohistochemistry for CD10, BCL6, MUM1/IRF4, LMO2, and forkhead box protein P1 (FOXP1) expression and for BCL2, BCL6, and c-MYC breakpoints by fluorescence in situ hybridization (FISH) on tissue microarray. RESULTS: LMO2 expression and BCL2 breakpoint were associated with the germinal center (GC) subtype defined by Hans' algorithm, respectively (P < .0001; P = .0002) whereas FOXP1 expression and BCL6 breakpoint were associated with the non-germinal center (non-GC) subtype (P = .008 and P = .0001, respectively). The immunohistochemical markers analyzed independently, GC/non-GC phenotype and BCL2 breakpoint did not predict overall survival (OS). BCL6 breakpoint was significantly associated with an unfavorable impact on OS (P = .04). Interestingly, an immunoFISH index, defined by positivity for at least two of three non-GC markers (FOXP1, MUM1/IRF4, BCL6 breakpoint) was significantly associated with a shorter 5-year OS rate (44%; 95% CI, 28 to 60 v 78%; 95% CI, 59 to 89; P = .01) which was independent (P = .04) of the age-adjusted International Prognostic Index (P = .04) in multivariate analysis. CONCLUSION: Our study demonstrates that combining immunohistochemistry with FISH allows construction of an immunoFISH index that significantly predicts survival in elderly DLBCL patients treated with R-CHOP.

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Fichiers liés : REVISED-MS-98-5-JCO-10-4-09.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/11/2009
• Auteurs : Bertrand DelezoideHervé Le BorgnePierre-Alain MoëllicDavid GorisseFrédéric PreciosoIacopo VivarelliBernard MerialdoPhilippe-Henri GosselinLionel GranjonDenis PellerinMichèle RombautHervé BredinLionel KoenigHélène LachambreElie El KhouryBoris MansencalYifan ZhouJenny Benois-PineauHervé JégouStéphane AyacheBahjat SafadiGeorges QuénotJonathan FabrizioMatthieu CordHervé GlotinZhongqiu ZhaoEmilie DumontBertrand Augereau
• Organismes : Laboratoire d'Intégration des Systèmes et des Technologies Laboratoire d'Intégration des Systèmes et des Technologies Laboratoire d'Intégration des Systèmes et des Technologies Equipes Traitement de l'Information et Systèmes Equipes Traitement de l'Information et Systèmes Eurecom [Sophia Antipolis] Eurecom [Sophia Antipolis] MIDI GIPSA-Services GIPSA - Architecture, Géométrie, Perception, Images, Gestes GIPSA - Architecture, Géométrie, Perception, Images, Gestes Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Centre National de la Recherche Scientifique Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Learning and recognition in vision Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Machine Learning and Information Retrieval Equipes Traitement de l'Information et Systèmes Machine Learning and Information Retrieval Laboratoire des Sciences de l'Information et des Systèmes Laboratoire des Sciences de l'Information et des Systèmes Laboratoire des Sciences de l'Information et des Systèmes SIC

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Résumé : The IRIM group is a consortium of French teams working on Multimedia Indexing and Retrieval. This paper describes our participation to the TRECVID 2009 High Level Features detection task. We evaluated a large number of different descriptors (on TRECVID 2008 data) and tried different fusion strategies, in particular hierarchical fusion and genetic fusion. The best IRIM run has a Mean Inferred Average Precision of 0.1220, which is significantly above TRECVID 2009 HLF detection task median performance. We found that fusion of the classification scores from different classifier types improves the performance and that even with a quite low individual performance, audio descriptors can help.

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Fichiers liés : IRIMatTRECVID2009.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/11/2009
• Auteurs : Fabrice LegeaiJean-Pierre GauthierFrançois CousseransEmmanuelle d'AlençonOlivier CollinJacques NicolasPhilippe FournierDenis Tagu
• Organismes : Biological systems and models, bioinformatics and sequences Biologie des organismes et des populations appliquées à la protection des plantes Biologie des organismes et des populations appliquées à la protection des plantes Biologie Intégrative et Virologie des Insectes [Univ. de Montpellier II] Biologie Intégrative et Virologie des Insectes [Univ. de Montpellier II] Biological systems and models, bioinformatics and sequences Biological systems and models, bioinformatics and sequences Biologie Intégrative et Virologie des Insectes [Univ. de Montpellier II] Biologie des organismes et des populations appliquées à la protection des plantes

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Résumé : Genome annotation includes any features mapped on the genome, including protein coding genes and their multiples mRNA, pseudogenes, transposons and repeats, non-coding RNAs, SNPs, or similarities to other genomes. While many of these features can be automatically locally predicted by sophisticated software packages based on sequence or structure comparisons, setting up centralized a boinformatic warehouse is crucial to organize, display, and distribute all these data, and facilitates their handling by non skilled bio-analyst. It also provides the opportunity to unite a broad community for curating gene models and gathering manual and functional annotations, which is an essential step to attain a basal data quality. AphidBase (http://www.aphidbase.org) is a comprehensive information system dedicated to aphids. It has been set up to safely centralize, manage, mine, disseminate and promulgate data generated by International Aphid Genomics Consortium (IAGC). It allowed an international community dispersed at many sites to produce a robust and comprehensive annotation of the pea aphid genome. Lepido-DB (http://www.inra.fr/lepidodb) is a centralized bioinformatic resource that was first developed to facilitate the comparative genomics of two major lepidopteran pests, the noctuid moths Helicoverpa armigera and Spodoptera frugiperda, by the analyzis of syntenic relationships and genome rearrangements of 15 pairs of BACs sequences and their corresponding colinear regions extracted from 10 Bombyx mori chromosomes. These systems were constructed using open source software tools from the Generic Model Organism Database (GMOD, http://www.gmod.org) including several Chado instances and genome browsers (Gbrowse and Cmap), gene and protein reports, Apollo, an application for the manual curation, and various other tools such as a a blast search and a full text search facilities. At a a larger scope, ensuing the AphidBase and LepidoDB experience, this system will be extended to definitely support complete genomes sequencing or resequencing, annotation projects, or any other project based on deep sequencing strategies (expression profiling by RNA-Seq, variability studies, ChIP-Seq, ...) for various Insect pest species. And, to ensure that all these resources were fully exploited by the community, this expansion would be accompanied by gathering many new biological data such as phenotypes, ontologies and atlas.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/11/2009
• Auteurs : Yann H. KerrFrançois CabotPhilippe RichaumePhilippe WaldteufelWigneron J.-P.Achim HahneSuzanne Mecklenburg
• Organismes : Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère ESTER - LATMOS Écologie fonctionnelle et physique de l'environnement Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency

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Résumé : The SMOS mission aims at allowing a frequent and global monitoring of two geophysical parameters: Soil Mois- ture and sea surface Salinity. These two quantities are key variables for climate studies, weather forecast and water resources management. To achieve this goal, a two dimensional interferometer operating at L band was developed and eventually launched on November 2 2009. The SMOS mission aims at providing a global frequent coverage of the globe with a spatial resolution of 43 km on average (27 km max).

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Fichiers liés : 39347_20100907032152378_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/11/2009
• Auteurs : Philippe BalbianiFahima Cheikh AliliPierre-Cyrille HeamOlga Kouchnarenko
• Organismes : Logique, Interaction, Langue et Calcul Centre National de la Recherche Scientifique Logique, Interaction, Langue et Calcul Combination of approaches to the security of infinite states systems Combination of approaches to the security of infinite states systems

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Résumé : Composition of Web services consists of the interleaving of the sequence of actions executed by the elementary services in accordance with a client specification. We model Web services as automata executing actions and also sending and receiving messages. This paper provides a theoretical study for three service composition problems, and in particular for the problem of computing a Boolean formula which exactly characterises the conditions required for services to answer the client's request. New complexity results are established for these problems within the framework of service composition with constraints.

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• Type de publi. : Article dans une revue
• Date de publi. : 02/11/2009
• Auteurs : Pierre-Francois BiardAnnabelle CouvertChristophe RennerPhilippe ZozorSébastien BassivièreJean-Pierre Levasseur
• Organismes : Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Water Research Center Water Research Center Water Research Center Veolia Eau (Paris)
• Publié dans Water Practice and Technology le 22/10/2020

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Résumé : Recently, the development of a high voidage contactor, named Aquilair Plus™, has demonstrated high efficiency for chemical scrubbing of hydrogen sulphide. Liquid and gas phases flow at co-current and high velocity, leading to a great dispersion of the liquid and then to an enhancement of the mass transfer rate by comparison with classical packed towers. This study focused on the results which obtained at semi-industrial scale with the Aquilair PlusTM process on a waste water treatment plant located in France. The scrubbing liquid consisted of a sodium hypochlorite alkaline solution. At once, pressure drop, H2S removal and reagents consumption were followed. The influence of the superficial gas velocity, liquid-to-gas mass ratio (L/G), pH, hypochlorite concentration of the scrubbing liquid and H2S inlet concentration was characterised. H2S removal percentages higher than 90% could be easily achieved with a moderate pressure drop (< 40 mbar). Both hydrodynamic and chemical conditions proved to influence performances. Reagents consumptions slightly higher than the predicted ones were measured.

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Fichiers liés : Biard_et_al_H2S_removal_final.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/11/2009
• Auteurs : Philippe BalbianiFahima Cheikh AliliPierre-Cyrille HeamOlga Kouchnarenko
• Organismes : Logique, Interaction, Langue et Calcul Centre National de la Recherche Scientifique Logique, Interaction, Langue et Calcul Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Combination of approaches to the security of infinite states systems

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Résumé : Composition of Web services consists of the interleaving of the sequence of actions executed by the elementary services in accordance with a client specification. We model Web services as automata executing actions and also sending and receiving messages. This paper provides a theoretical study for three service composition problems, and in particular for the problem of computing a Boolean formula which exactly characterises the conditions required for services to answer the client s request. New complexity results are established for these problems within the framework of service composition with constraints.

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Fichiers liés : bchk10_ij.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2009
• Auteurs : Alejandro Piris-GimenezJean-Philippe CorreGrégory JouvionThomas CandelaHuot KhunPierre L. Goossens
• Organismes : Toxines et Pathogénie Bactérienne Toxines et Pathogénie Bactérienne Histotechnologie et Pathologie Toxines et Pathogénie Bactérienne Histotechnologie et Pathologie Toxines et Pathogénie Bactérienne
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : BACKGROUND: The Bacillus anthracis poly-gamma-D-glutamate capsule is essential for virulence. It impedes phagocytosis and protects bacilli from the immune system, thus promoting systemic dissemination. METHODS: To further define the virulence mechanisms brought into play by the capsule, we characterized the interactions between encapsulated nontoxinogenic B. anthracis and its host in vivo through histological analysis, perfusion, and competition experiments with purified capsule. RESULTS: Clearance of encapsulated bacilli from the blood was rapid (>90% clearance within 5 min), with 75% of the bacteria being trapped in the liver. Competition experiments with purified capsule polyglutamate inhibited this interaction. At the septicemic phase of cutaneous infection with spores, the encapsulated bacilli were trapped in the vascular spaces of the liver and interacted closely with the liver endothelium in the sinusoids and terminal and portal veins. They often grow as microcolonies containing capsular material shed by the bacteria. CONCLUSION: We show that, in addition to its inhibitory effect on the interaction with the immune system, the capsule surrounding B. anthracis plays an active role in mediating the trapping of the bacteria within the liver and may thus contribute to anthrax pathogenesis. Because other microorganisms produce polyglutamate, it may also represent a general mechanism of virulence or in vivo survival.

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Fichiers liés : Piris-gimenez-JID.pdf

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