Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Philippe BesnardSébastien KoniecznyPierre Marquis
• Organismes : Logique, Interaction, Langue et Calcul Centre National de la Recherche Scientifique Centre de Recherche en Informatique de Lens Centre de Recherche en Informatique de Lens
• Publié dans International Journal of Intelligent Systems le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Karin GérardNicolas BiernePhilippe BorsaAnne ChenuilJean-Pierre Féral
• Organismes : Station Marine d'Endoume Institut des Sciences de l'Evolution de Montpellier Écosystémique des communautés récifales et de leurs usages dans le Pacifique insulaire Station Marine d'Endoume Diversité, évolution et écologie fonctionnelle marine Station Marine d'Endoume Diversité, évolution et écologie fonctionnelle marine
• Publié dans Molecular Phylogenetics and Evolution le 31/10/2020

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Résumé : Smooth-shelled mussels, Mytilus spp., have an antitropical distribution. In the Northern Hemisphere, the M. edulis complex of species is composed of three genetically well delineated taxa: M. edulis, M. galloprovincialis and M. trossulus. In the Southern Hemisphere, morphological characters, allozymes and intron length polymorphisms suggest that Mytilus spp. populations from South America and Kerguelen Islands are related to M. edulis and those from Australasia to M. galloprovincialis. On the other hand, a phylogeny of the 16S rDNA mitochondrial locus demonstrates a clear distinctiveness of southern mussels and suggests that they are related to Mediterranean M. galloprovincialis. Here, we analysed the faster-evolving cytochrome oxidase subunit I locus. The divergence between haplotypes of populations from the two hemispheres was confirmed and was found to predate the divergence between haplotypes of northern M. edulis and M. galloprovincialis. In addition, strong genetic structure was detected among the southern samples, revealing three genetic entities that correspond to (1) South America and Kerguelen Island, (2) Tasmania, (3) New Zealand. Using the trans-Arctic interchange as a molecular clock calibration, we estimated the time since divergence of populations from the two hemispheres to be between 0.5 million years (MY) and 1.3 MY (average 0.84 MY). The contrasting patterns observed for the nuclear and the organelle genomes suggested two alternative, complex scenarios: two trans-equatorial migrations and the existence of differential barriers to mitochondrial and nuclear gene flow, or a single trans-equatorial migration and a view of the composition of the nuclear genome biased by taxonomic preconception.

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Fichiers liés : 2008_Gérard_Mol.Phyl.Evol._pr_Pleistocene separation of mitochondrial lineages of Mytilus spp. mussels from Northern to Southern hemispheres and strong genetic differentiation among southern populations.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/10/2008
• Auteurs : Pierre-Philippe CombesMiren LafourcadeJacques-François ThisseJean-Claude Toutain
• Organismes : Groupement de Recherche en Économie Quantitative d'Aix-Marseille Université de Valenciennes et du Hainaut-Cambrésis Paris-Jourdan Sciences Economiques Paris School of Economics Center of Operation Research and Econometrics [Louvain] Paris-Jourdan Sciences Economiques Paris School of Economics Equipe de recherche sur les marches, l'emploi et la simulation Université Paris 1 Panthéon-Sorbonne

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Résumé : This paper uses a unique database that provides value-added, employment, and population levels for the entire set of French departments for the years 1860, 1930, and 2000. These data cover three sectors: agriculture, manufacturing, and services. This allows us to study the evolution of spatial inequalities within France and to test the empirical relevance of economic geography predictions over the long run. The evidence confirms the existence of a bell-shaped evolution of the spatial concentration of manufacturing and services. In contrast, labor productivity has been converging across departments. Last, our study also confirms the presence of strong agglomeration economies during the full time-period. Market potential during the first sub-period (1860-1930), and higher education during the second (1930-2000), together with sectoral diversity, account for the spatial distribution of these gains.

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Fichiers liés : wp200854.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/10/2008
• Auteurs : Jean-Philippe AntoineLuc BabouletAlain BublexPierre ChabardGeorge DupinGuillemette Morel JournelCatherine de Smet
• Organismes : L'Observatoire de la condition suburbaine L'Observatoire de la condition suburbaine L'Observatoire de la condition suburbaine

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Fichiers liés : MC_BRAUP_AAP_2004_BOU_TXT1_BD.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Ronan CariouJean-Philippe AntignacDaniel ZalkoAlain BerrebiJean-Pierre CravediDaniel MaumePhilippe MarchandFabrice MonteauAnne RiuFrançois AndreBruno Le Bizec
• Organismes : Laboratoire d'étude des Résidus et Contaminants dans les Aliments Métabolisme et Xénobiotiques Laboratoire d'étude des Résidus et Contaminants dans les Aliments
• Publié dans Chemosphere le 29/10/2020

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Résumé : A French monitoring study was initiated to evaluate the exposure of fetus and newborn to brominated flame retardants (BFR). A previously developed multi-residue analytical method was used for measuring the main classes of BFR (tetrabromobisphenol-A, and tri- to decabomodiphenyl ethers) in various human biological matrices. Analyzed samples (maternal and cord serum, adipose tissue and breast milk) were collected from 93 volunteer women during caesarean deliveries. TBBPA was detected in 44% of the analyzed breast milk samples, at levels varying from 0.06 to 37.34 ng g(-1) lipid weight, but was not detected in adipose tissue. This compound was also detected in 30% of the analyzed serum samples, with similar average values in maternal and cord serum (154 pg g(-1) fresh weight versus 199 pg g(-1) fresh weight, respectively). The interpretation of the collected data permitted the demonstration of (1) a significant exposure to TBBPA both for mothers and fetuses and (2) a possible risk of overexposure of newborns through breastfeeding.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Jean-Philippe RerolleElisa MunteanuMireille DrouetJean-Christophe SzelagBéatrice ChamptiauxFatima YagoubiPierre-Marie PreuxJean-Claude AldigierYann Le Meur
• Organismes : Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Service d'Immunologie et immunogénétique [CHU Limoges] Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations
• Publié dans Nephrology Dialysis Transplantation le 01/11/2020

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Résumé : BACKGROUND: The type 1 plasminogen activator inhibitor (PAI-1) is involved in the development of fibrosis, and its intrarenal expression is increased in interstitial fibrosis and tubular atrophy (IFTA). Moreover, a 4G/5G polymorphism of the PAI-1 gene has been described associating 4G haplotype with higher PAI-1 plasma activity. We investigated the relationship between the donor and recipient PAI-1 polymorphism and kidney graft survival. METHODS: The PAI-1 genotype was determined for both the 304 donors and the 337 corresponding recipients. In recipients, PAI-1 antigen levels were also determined. We compared 4G/4G donors versus donors with other genotypes. RESULTS: Donor or recipient genotype did not influence the PAI-1 plasma level in recipients. Actuarial kidney graft survival was significantly reduced in the 4G/4G donor group (107 months versus 147.5 months, P = 0.013), while recipient PAI-1 genotype did not show any influence on graft survival. Moreover, graft loss due to IFTA proved significantly higher in the 4G/4G donor group (13% versus 6%, P = 0.03). Multivariate analysis showed that the significant independent variables associated with graft loss were the donor 4G/4G genotype, acute clinical rejection and donor age. CONCLUSION: Our study suggests that donor PAI-1 polymorphism influences kidney graft survival and that the donor 4G/4G genotype is an independent risk factor for graft loss. Prospective studies are needed to confirm these results.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Emilie AllardFrançois HindréCatherine Passirani-MalleretLaurent LemaireNicolas LepareurNicolas NoiretPhilippe MeneiJean-Pierre Benoit
• Organismes : Ingénierie de la vectorisation particulaire Ingénierie de la vectorisation particulaire Ingénierie de la vectorisation particulaire Ingénierie de la vectorisation particulaire Centre de Médecine Nucléaire Synthèses et activations de biomolécules Ingénierie de la vectorisation particulaire Service de neurochirurgie [CHU Angers] Ingénierie de la vectorisation particulaire
• Publié dans European Journal of Nuclear Medicine and Molecular Imaging le 30/10/2020

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Résumé : PURPOSE: Lipid nanocapsules (LNC) entrapping lipophilic complexes of (188)Re ((188)Re(S(3)CPh)(2)(S(2)CPh) [(188)Re-SSS]) were investigated as a novel radiopharmaceutical carrier for internal radiation therapy of malignant gliomas. The present study was designed to evaluate the efficacy of intra-cerebral administration of (188)Re-SSS LNC by means of convection-enhanced delivery (CED) on a 9L rat brain tumour model. METHODS: Female Fischer rats with 9L glioma were treated with a single injection of (188)Re-SSS LNC by CED 6days after cell implantation. Rats were put into random groups according to the dose infused: 12, 10, 8 and 3Gy in comparison with blank LNC, perrhenate solution (4Gy) and non-treated animals. The radionuclide brain retention level was evaluated by measuring (188)Re elimination in faeces and urine over 72h after the CED injection. The therapeutic effect of (188)Re-SSS LNC was assessed based on animal survival. RESULTS: CED of (188)Re perrhenate solution resulted in rapid drug clearance with a brain T (1/2) of 7h. In contrast, when administered in LNC, (188)Re tissue retention was greatly prolonged, with only 10% of the injected dose being eliminated at 72h. Rat median survival was significantly improved for the group treated with 8Gy (188)Re-SSS LNC compared to the control group and blank LNC-treated animals. The increase in the median survival time was about 80% compared to the control group; 33% of the animals were long-term survivors. The dose of 8Gy proved to be a very effective dose, between toxic (10-12Gy) and ineffective (3-4Gy) doses. CONCLUSIONS: These findings show that CED of (188)Re-loaded LNC is a safe and potent anti-tumour system for treating malignant gliomas. Our data are the first to show the in vivo efficacy of (188)Re internal radiotherapy for the treatment of brain malignancy.

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Fichiers liés : Allard_Rhenium188.pdf inserm-00343438_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Jean-Claude DesportBenoît MarinBenoit FunalotPierre-Marie PreuxPhilippe Couratier
• Organismes : Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Laboratoire de Biostatistique et d'Informatique Médicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Biomolécules Thérapies anti-tumorales Service d'Immunologie et immunogénétique [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Laboratoire de Biostatistique et d'Informatique Médicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de Neurologie [CHU Limoges]
• Publié dans Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders le 26/10/2020

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Résumé : Malnutrition is a well-known independent survival factor in ALS patients. Total body impedance analysis (BIA) has been validated for the measurement of fat-free mass. Another physical value obtained by BIA is phase angle (PA) that has been proposed to be an index of malnutrition or a survival prognostic factor in several diseases. We measured PA in a sample of 168 ALS patients and analysed the relationships between PA and neurological, respiratory and nutritional status, and determined whether PA is an independent prognostic factor for survival in ALS. BIA was performed using an Analycor3 instrument with surface electrodes at 50 kHz and 800 microA. PA was obtained using the formula: PA =arctan (Xc/R) (in degrees) where Xc is the body reactance and R the bioelectric resistance. Relationships between quantitative variables were assessed by linear correlation coefficients and through univariate and multivariate linear regression analyses. To assess the prognostic role of PA on survival of patients, we performed survival analyses based on the Kaplan-Meier method using the log rank test, and on univariate and multivariate Cox proportional hazard model. Baseline time was time from multidisciplinary visit (T1) to death or censoring time. PA was always significantly lower in ALS patients than in healthy control subjects published in the literature. PA was lower in our ALS malnourished patients than in non-malnourished patients (3.3+/-1.1 degrees versus 2.5+/-0.6 degrees , p =0.003). In multivariate linear regression analysis, manual muscle testing (p<0.0001), vital capacity (p<0.001), fat-free mass (p<0.0001), time between initial signs and T1 (p<0.002) and age (p<0.001) were independently significantly linked with PA and explained 48% of PA variation. The survival of ALS patients from T1 was significantly linked with PA after adjustment on BMI, CV and time between initial signs and multidisciplinary visit, clinical form, age and sex. Patients with a PA <2.5 degrees had a significantly poorer survival rate than patients with a PA >2.5 degrees . We concluded that in ALS patients, PA is greatly decreased. It is related to the nutritional status of patients, and is also an independent prognostic factor of survival.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Ibrahim CheddadiPierre SaramitoChristophe RaufastePhilippe MarmottantGraner François
• Organismes : Modelling, Observations, Identification for Environmental Sciences Equations aux Dérivées Partielles Modelling, Observations, Identification for Environmental Sciences Equations aux Dérivées Partielles Physique et mécanique des milieux hétérogènes Laboratoire de Spectrométrie Physique Laboratoire de Spectrométrie Physique Institut de Recherche sur les Phénomènes Hors Equilibre Laboratoire de Spectrométrie Physique
• Publié dans European Physical Journal E: Soft matter and biological physics le 01/11/2020

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Résumé : In this paper, a numerical simulation based on a tensorial elastoviscoplastic model is compared to experimental measurements on liquid foams for a bidimensional Couette flow, both in stationary and transient cases. The main features of of the model are elasticity up to a plastic yield stress and viscoelasticity above. The numerical modelling bases on a small set of standard material parameters that could be fully characterised. Shear localisation as well as fine transient observations are reproduced and are found to be in good agreement with experimental measurements. The effect of the friction of plates is taken into account. The plasticity appears to be the fundamental mechanism of the localisation of the flow. Finally, the present approach could be extended from liquid foams to similar materials such as emulsions, colloids or wet granular materials, that exhibits localisations.

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Fichiers liés : epje.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2008
• Auteurs : Jean-Philippe JaisCorine HaiounThierry J. MolinaDavid S. RickmanAurélien de ReyniesFrançoise BergerChristian GisselbrechtJosette BrièreFélix ReyesPhilippe GaulardPierre FeugierEric LabouyrieHervé TillyChristian BastardBertrand CoiffierGilles A. SallesKaren Leroy
• Organismes : Service d'informatique médicale et biostatistiques [CHU Necker] Service d'hématologie clinique Département de Pathologie "Cartes d'Identité des Tumeurs " "Cartes d'Identité des Tumeurs " Service d'Anatomo-Pathologie Laboratoire de biologie et modélisation de la cellule Service d'hématologie-oncologie adultes Service d'anatomo-pathologie [Paris] Service d'hématologie clinique Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Service d'Hématologie [CHRU Nancy] Service d'Anatomie et Cytologie Pathologiques Service d'Hématologie Service de génétique oncologique Service d'hématologie [Centre Hospitalier Lyon Sud - HCL] Laboratoire de biologie et modélisation de la cellule Service d'hématologie [Centre Hospitalier Lyon Sud - HCL] Laboratoire de biologie et modélisation de la cellule Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor]
• Publié dans Leukemia le 25/10/2020

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Résumé : Gene expression profiles have been associated with clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with anthracycline-containing chemotherapy. Using Affymetrix HU133A microarrays, we analyzed the lymphoma transcriptional profile of 30 patients treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and 23 patients treated with rituximab (R)-CHOP in the Groupe d'Etude des Lymphomes de l'Adulte clinical centers. We used this data set to select transcripts showing an association with progression-free survival in all patients or showing a differential effect in the two treatment groups. We performed real-time quantitative reverse transcription-PCR in the 23 R-CHOP samples of the screening set and an additional 44 R-CHOP samples set to evaluate the prognostic significance of these transcripts. In these 67 patients, the level of expression of 16 genes and the cell-of-origin classification were significantly associated with overall survival, independently of the International Prognostic Index. A multivariate model comprising four genes of the cell-of-origin signature (LMO2, MME, LPP and FOXP1) and two genes related to immune response, identified for their differential effects in R-CHOP patients (APOBEC3G and RAB33A), demonstrated a high predictive efficiency in this set of patients, suggesting that both features affect outcome in DLBCL patients receiving immunochemotherapy.

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Fichiers liés : revised_manuscript_with_figures.pdf

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