Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/12/2008
• Auteurs : Martine EckertMitsuhiro HayashibeDavid GuiraudPierre-Brice WieberPhilippe Fraisse
• Organismes : IMERIR Artificial movement and gait restoration Artificial movement and gait restoration Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems Artificial movement and gait restoration

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Résumé : Mathematical models of the skeletal muscle can support the development of neu-roprotheses to restore functional movements in individuals with motor deficien-cies by the means of Functional Electrical Stimulation (FES). Since many years, numerous skeletal muscle models have been proposed to express the relationship between muscle activation and generated force. One of them (Makssoud et al [2]-[3]), integrates the Hill model [5] and the physiological one based on Huxley work [4] allowing the muscle activation under FES. We propose in this paper an impro-vement of this model by modifying the activation part. These improvements are highlighted through the HuMAnS toolbox [1] using a 3D biomechanical model of human named Human 36. This article describes this toolbox and the software implementation of the model. Then, we present the results of the simulation.

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Fichiers liés : Summary.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2008
• Auteurs : Jean-Marc BarretAnna KruczynskiStéphane VispéJean-Philippe AnnereauViviane BrelYves GuminskiJean-Guy DelcrosAmélie LansiauxNicolas GuilbaudThierry ImbertChristian Bailly
• Organismes : Centre de Recherche en Oncologie Expérimentale Centre de Recherche en Oncologie Expérimentale Centre de Recherche en Oncologie Expérimentale Centre de Recherche en Oncologie Expérimentale Centre de Recherche en Oncologie Expérimentale Division de Chimie Médicinale III Institut de Génétique et Développement de Rennes Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche en Oncologie Expérimentale Division de Chimie Médicinale III Centre de Recherche en Oncologie Expérimentale
• Publié dans Cancer Research le 29/10/2020

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Résumé : The polyamine transport system (PTS) is an energy-dependent machinery frequently overactivated in cancer cells with a high demand for polyamines. We have exploited the PTS to selectively deliver a polyamine-containing drug to cancer cells. F14512 combines an epipodophyllotoxin core-targeting topoisomerase II with a spermine moiety introduced as a cell delivery vector. The polyamine tail supports three complementary functions: (a) facilitate formulation of a water-soluble compound, (b) increase DNA binding to reinforce topoisomerase II inhibition, and (c) facilitate selective uptake by tumor cells via the PTS. F14512 is 73-fold more cytotoxic to Chinese hamster ovary cells compared with CHO-MG cells with a reduced PTS activity. A decreased sensitivity of L1210 leukemia cells to F14512 was observed in the presence of putrescine, spermidine, and spermine. In parallel, the spermine moiety considerably enhances the drug-DNA interaction, leading to a reinforced inhibition of topoisomerase II. The spermine tail of F14512 serves as a cell delivery vehicle as well as a DNA anchor, and this property translates at the cellular level into a distinct pharmacologic profile. Twenty-nine human solid or hematologic cell lines were used to characterize the high cytotoxic potential of F14512 (median IC50 of 0.18 micromol/L). Finally, the potent antitumor activity of F14512 in vivo was evidenced with a MX1 human breast tumor xenograft model, with partial and complete tumor regressions. This work supports the clinical development of F14512 as a novel targeted cytotoxic drug and sheds light on the concept of selective delivery of drugs to tumor cells expressing the PTS.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2008
• Auteurs : Jean-Philippe TarelSio Song IengPierre Charbonnier
• Organismes : Division Exploitation-Signalisation-Éclairage Division Exploitation-Signalisation-Éclairage Centre d'études techniques de l'équipement Est
• Publié dans Advances in Data Analysis and Classification le 25/10/2020

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Résumé : We consider the problem of multiple fitting of linearly parametrized curves, that arises in many computer vision problems such as road scene analysis. Data extracted from images usually contain non-Gaussian noise and outliers, which makes classical estimation methods ineffective. In this paper, we first introduce a family of robust probability density functions which appears to be well-suited to many real-world problems. Also, such noise models are suitable for defining continuation heuristics to escape shallow local minima and their robustness is devised in terms of breakdown point. Second, the usual Iterative Reweighted Least Squares (IRLS) robust estimator is extended to the problem of robustly estimating sets of linearly parametrized curves. The resulting, non convex optimization problem is tackled within a Lagrangian approach, leading to the so-called Simultaneous Robust Multiple Fitting (SRMF) algorithm, whose global convergence to a local minimum is proved using results from constrained optimization theory.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/12/2008
• Auteurs : Pierre CharbonnierJean-Philippe TarelSio Song Ieng
• Organismes : Centre d'études techniques de l'équipement Est Laboratoire Exploitation, Perception, Simulateurs et Simulations Laboratoire Exploitation, Perception, Simulateurs et Simulations

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Résumé : Schématiquement, résoudre un problème inverse revient à essayer de restituer la réalité à partir d'une image partielle et/ou brouillée. Les problèmes inverses constituent un domaine foisonnant; les applications sont multiples, les problématiques diverses et les méthodes utilisées forcément variées. Cet ouvrage collectif réalise un état de l'art sur différentes techniques inverses utilisées au sein du réseau scientifique et technique du Ministère de l'écologie, de l'énergie, du développement durable et de l'aménagement du territoire, dans le cadre de la mécanique et du génie civil en particulier. On y aborde des problèmes inverses divers : identification de paramètres mécaniques d'un compacteur, de paramètres modaux, d'un système discret hystérétique, identification des causes, détection et reconnaissance d'images, optimisation de mur anti-bruit, détermination d'hétérogénéités et aussi plusieurs problèmes de tomographie appliqués à la géophysique et à l'auscultation d'ouvrages d'art. Les méthodes de résolution numérique proposées vont des méthodes maintenant classiques d'optimisation dans le cadre régulier ou convexe, aux méthodes dites métaheuristiques de minimisation globale pour lesquelles est joint un cederom contenant une boîte à outil en langage Scilab.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2008
• Auteurs : Laurent ZiniPaul PerrotteClaudio JeldresUmberto CapitanioDaniel PharandPhilippe ArjaneSteven LapointeFrancesco MontorsiJean-Jacques PatardPierre I. Karakiewicz
• Organismes : Service d'urologie [Rennes] = Urology [Rennes] Institut de Génétique et Développement de Rennes Cancer Prognostics and Health Outcome Unit
• Publié dans BJU International le 28/10/2020

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Résumé : OBJECTIVES: To examine the cancer-specific survival of patients treated with nephrectomy and compared it to that of patients managed without surgery. PATIENTS AND METHODS: Of 43,143 patients with renal cell carcinoma (RCC) identified in the 1988-2004 Surveillance, Epidemiology and End Results database, 7068 had locally advanced RCC and with no distant metastasis. These patients had a nephrectomy (6786, 96.0%) or no surgical therapy (282, 4.0%). Multivariable Cox regression models, and matched and unmatched Kaplan-Meier survival analyses, were used to compare the effect of nephrectomy vs non-surgical therapy on cancer-specific survival. Also, competing-risks regression models adjusted for the effect of other-cause mortality. Covariates and matching variables consisted of age, gender, tumour size and year of diagnosis. RESULTS: The 1-, 2-, 5- and 10-year cancer-specific survival of patients who had nephrectomy was 88.9%, 88.1%, 68.6% and 57.5%, vs 44.8%, 30.6%, 14.5% and 10.6% for non-surgical therapy. In multivariable analyses, relative to nephrectomy, non-surgical therapy was associated with a 5.8-fold higher rate of cancer-specific mortality (P < 0.001). Non-surgical therapy was also associated with a 5.1-fold higher rate of cancer-specific mortality in matched analyses (P < 0.001). Finally, competing-risks regression confirmed the statistical significance of the variable defining treatment type (nephrectomy vs non-surgical therapy) in multivariable and matched analyses (P < 0.001). CONCLUSION: Relative to non-surgical treatment, nephrectomy improves the cancer-specific survival of patients with locally advanced RCC; our findings await prospective confirmation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2008
• Auteurs : Loïc de PontualPhilippe OvetchkineDiana RodriguezAudrey GrantAnne PuelJacinta BustamanteSabine PlancoulaineLaurent YonaPierre‐yves LienhartDanièle DehesdinMichel HuerreRégis TournebizePhilippe SansonettiLaurent AbelJean Laurent Casanova
• Organismes : Laboratory of Human Genetics of Infectious Diseases Laboratory of Human Genetics of Infectious Diseases
• Publié dans Clinical Infectious Diseases le 30/10/2020

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/12/2008
• Auteurs : Fabrice BethuelPhilippe GravejatJean-Claude Saut
• Organismes : Laboratoire Jacques-Louis Lions CEntre de REcherches en MAthématiques de la DEcision Laboratoire de Mathématiques d'Orsay

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Résumé : This paper presents recent results concerning the existence and qualitative properties of travelling wave solutions to the Gross-Pitaevskii equation posed on the whole space R^N. Unlike the defocusing nonlinear Schrödinger equations with null condition at infinity, the presence of non-zero conditions at infinity yields a rather rich and delicate dynamics. We focus on the case N = 2 and N = 3, and also briefly review some classical results on the one-dimensional case. The works we survey provide rigorous justifications to the impressive series of results which Jones, Putterman and Roberts established by formal and numerical arguments.

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Fichiers liés : BGS-survey-end.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/11/2008
• Auteurs : Carlo Abi ChahineNathalie ChaignaudJean-Philippe KotowiczJean-Pierre Pécuchet
• Organismes : Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes

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Résumé : Document indexation is an essential task achieved by archivists or automatic indexing tools. To retrieve relevant documents to a query, keywords describing this document have to be carefully chosen. Archivists have to find out the right topic of a document before starting to extract the keywords. For an archivist indexing specialized documents, experience plays an important role. But indexing documents on different topics is much harder. This article proposes an innovative method for an indexing support system. This system takes as input an ontology and a plain text document and provides as output contextualized keywords of the document. The method has been evaluated by exploiting Wikipedia's category links as a termino-ontological resources.

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Fichiers liés : latex8.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/11/2008
• Auteurs : Bernadette BanrezesPhilippe AndreyEugénie CanonThierry Sainte-BeuveJosé‐manuel CancelaJean-Pierre Ozil
• Organismes : Biologie du développement et reproduction Neurobiologie de l'Olfaction et de la Prise Alimentaire Biologie du développement et reproduction Biologie du développement et reproduction Laboratoire de neurobiologie cellulaire et moléculaire Institut de Neurobiologie Alfred Fessard Biologie du développement et reproduction

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/11/2008
• Auteurs : Nasissatou Ingrid TraoreGuy BarlesChristine GeorgelinJean René LicoisJaap J. van MilgenLucile MontagneFrederic GlasserPierre NoziereHélène FouilletPhilippe Lescoat
• Organismes : Unité de Recherches Avicoles Laboratoire de Mathématiques et Physique Théorique Laboratoire de Mathématiques et Physique Théorique Systèmes d'élevage, nutrition animale et humaine Systèmes d'élevage, nutrition animale et humaine Unité de Recherches sur les Herbivores Unité de Recherches sur les Herbivores Unité de Recherches Avicoles

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Résumé : absent

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