Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/10/2009
• Auteurs : Zsolt JankoJean-Philippe Pons
• Organismes : Interpretation and Modelling of Images and Videos imagine [Marne-la-Vallée] Laboratoire d'Informatique Gaspard-Monge imagine [Marne-la-Vallée] Laboratoire d'Informatique Gaspard-Monge

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Résumé : In this paper, we propose a method for creating a high-quality spatio-temporal texture atlas from a dynamic 3-D model and a set of calibrated video sequences. By adopting an actual spatio-temporal perspective, beyond independent frame-by-frame computations, we fully exploit the very high redundancy in the input video sequences. First, we drastically cut down on the amount of texture data, and thereby we greatly enhance the portability and the rendering efficiency of the model. Second, we gather the numerous different viewpoint/time appearances of the scene, so as to recover from low resolution, grazing views, highlights, shadows and occlusions which affect some regions of the spatio-temporal model. Altogether, our method allows the synthesis of novel views from a small quantity of texture data, with an optimal visual quality throughout the sequence, with minimally visible color discontinuities, and without flickering artifacts. These properties are demonstrated on real datasets.

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Fichiers liés : Janko2009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Olivier Nicolas Pierre-LouisDenis ClayPhilippe Brunet de la GrangeIstvan BlazsekChristophe DesterkeBernadette GuertonCamille BlondeauJean-Valère MalfusonMarie PratAnnelise Bennaceur-GriscelliJean-Jacques LatailladeMarie-Caroline Le Bousse-Kerdilès
• Organismes : Pathologie Cardiovasculaire, toxicité environnementale et envenimations [UR5_3] Institut Cochin Les cellules souches : de leurs niches à leurs applications thérapeutiques Les cellules souches : de leurs niches à leurs applications thérapeutiques Interactions cellules souches-niches : physiologie, tumeurs et réparation tissulaire SFR89 Hôpital Robert Ballanger [Aulnay-sous-Bois] Centre de Transfusion Sanguine des Armées Les cellules souches : de leurs niches à leurs applications thérapeutiques AP-HP - Hôpital Saint-Antoine Modèles de Cellules Souches Malignes et Thérapeutiques Département de biologie et pathologie médicales [Gustave Roussy] Centre de Transfusion Sanguine des Armées Microenvironnement et Physiopathologie de la Differenciation
• Publié dans STEM CELLS le 29/10/2020

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Résumé : Abstract Identification of prevalent specific markers is crucial to stem/progenitor cell purification. Determinants such as the surface antigens CD34 and CD38 are traditionally used to analyze and purify hematopoietic stem/progenitor cells (HSCs/HPCs). However, the variable expression of these membrane antigens poses some limitations to their use in HSC/HPC purification. Techniques based on drug/stain efflux through the ATP-binding cassette (ABC)G2 pump (side population [SP] phenotype) or on detection of aldehyde dehydrogenase (ALDH) activity have been independently developed and distinguish the SP and ALDHBright (ALDHBr) cell subsets for their phenotype and proliferative capability. In this study, we developed a multiparametric flow cytometric method associating both SP and ALDH activities on human lineage negative (Lin−) bone marrow cells and sorted different cell fractions according to their SP/ALDH activity level. We find that Lin−CD34+CD38Low/− cells are found throughout the spectrum of ALDH expression and are enriched especially in ALDHBr cells when associated with SP functionality (SP/ALDHBr fraction). Furthermore, the SP marker identified G0 cells in all ALDH fractions, allowing us to sort quiescent cells regardless of ALDH activity. Moreover, we show that, within the Lin−CD34+CD38−ALDHBr population, the SP marker identifies cells with higher primitive characteristics, in terms of stemness-related gene expression and in vitro and in vivo proliferative potential, than the Lin−CD34+ CD38−ALDHBr main population cells. In conclusion, our study shows that the coexpression of SP and ALDH markers refines the Lin−CD34+CD38− hematopoietic compartment and identifies an SP/ALDHBr cell subset enriched in quiescent primitive HSCs/HPCs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Mathias BruyandRodolphe ThiébautSylvie Lawson-AyayiPierre JolyAnnie-Jeanne SascoPatrick MerciéJean Luc PellegrinDidier NeauFrançois DabisPhilippe MorlatGeneviève ChêneFabrice Bonnet
• Organismes : Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Epidémiologie et Biostatistique [Bordeaux] Epidémiologie et Biostatistique [Bordeaux] Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Service de médecine interne et maladies infectieuses [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Service de médecine interne et maladies infectieuses [Bordeaux] Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Service de médecine interne et maladies infectieuses [Bordeaux] Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Service de médecine interne et maladies infectieuses [Bordeaux] Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Epidémiologie et Biostatistique [Bordeaux] Coordination Régionale de la lutte contre l'infection due au VIH Service de médecine interne et maladies infectieuses [Bordeaux]
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : BACKGROUND: Human immunodeficiency virus (HIV)-infected patients are at higher risk of malignancies. In addition to traditional determinants, a specific deleterious effect of HIV and immunodeficiency is speculated. We aimed at studying the association between immunological and virological characteristics of HIV-infected patients in care and the risk of acquired immunodeficiency syndrome (AIDS)-defining and non-AIDS-defining malignancies. METHODS: Patients consecutively enrolled in the hospital-based Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine Cohort were included if the duration of follow-up was >3 months during the period 1998-2006. Multivariate modeling used an extended Cox proportional hazards model for time-dependent covariates and delayed entry. RESULTS: The 4194 patients included in the study developed 251 first malignancies during 22,389 person-years. A higher incidence of AIDS-defining malignancies (107 cases) was independently associated with (1) both longer and current exposures to a plasma HIV RNA level >500 copies/mL (hazard ratio [HR], 1.27 per year [P<.001] and 3.30 [P<.001], respectively) and (2) both longer and current exposure to a CD4(+) cell count <200 cells/mm(3) (HR, 1.36 per year [P<.001] and 6.33 [P<.001], respectively). A higher incidence of non-AIDS-defining malignancies (144 cases) was independently associated with longer and current exposure to a CD4(+) cell count <500 cells/mm(3) (HR, 1.13 per year [P=.01] and 2.07 [P<.001], respectively) and male sex (HR, 1.69; P=.02) but not with plasma HIV RNA level (P=.49 and P=.10 for cumulative and current exposures, respectively). CONCLUSIONS: Uncontrolled plasma HIV RNA level was independently associated with a higher likelihood of developing AIDS-defining malignancies, whereas immunosuppression was associated with a higher risk of developing any type of malignancies. Antiretroviral treatment should aim at reaching and maintaining a CD4(+) count >500 cells/mm(3) to prevent the occurrence of malignancy, this should be integrated to malignancy-prevention policies.

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Fichiers liés : inserm-00391182_edited.pdf revised_manuscript.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Philippe ReiffsteckJean Pierre MagnanAbdeldjalil ZadjaouiAbdelmalek Bekkouche
• Organismes : Division Mécanique des Sols des Roches et de la Géologie de l'Ingénieur Direction technique "Géotechnique" Laboratoire Eau et Ouvrages dans Leurs Environnements Laboratoire Eau et Ouvrages dans Leurs Environnements
• Publié dans European Journal of Environmental and Civil Engineering le 29/10/2020

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Résumé : Cet article présente une étude en laboratoire de l'infiltration dans une colonne du sol initialement non saturé. Considérant certaines hypothèses simplificatrices, le phénomène du transfert hydrique est ramené physiquement à un processus décrit par une équation aux dérivées partielles type parabolique détaillée dans un premier temps. Dans un second temps l'article décrit le matériau utilisé dans cette étude. Il donne une description de montage utilisé pour suivre l'infiltration. Les courbes d'infiltration cumulée sont analysées en détail. Les auteurs montrent comment la conductivité hydraulique peut être déduite de ces mesures. L'application aux résultats du modèle de Philip montre une bonne concordance avec les mesures. Enfin, les conditions d'application et les interprétations sont détaillées.

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• Type de publi. :
• Date de publi. : 01/10/2009
• Auteurs : Hélène BlanchardMaëla KloarecSabine D’andreaStéphanie DavalVincent RiouxPhilippe P. LegrandFrédérique Pédrono
• Organismes : Université Paris-Saclay AgroParisTech Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Génétique, Environnement et Protection des Plantes Institut Agro Rennes Angers Nutrition, Métabolismes et Cancer

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Maxime CrépelHendrik IsbarnUmberto CapitanioDaniel LibermanClaudio JeldresMaxine SunShahrokh F ShariatHugues WidmerPhilippe ArjaneMarkus GraefenFrancesco MontorsiJean-Jacques PatardPaul PerrottePierre I. Karakiewicz
• Organismes : Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Martini-Clinic Cancer Prognostics and Health Outcome Unit Department of Urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Division of Urology Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Martini-Clinic Department of urology Service d'urologie [Rennes] = Urology [Rennes] Institut de Génétique et Développement de Rennes Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans Urology le 26/10/2020

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Résumé : OBJECTIVES: To test whether renal cell carcinoma (RCC) histologic subtypes (HSs) affect cancer-specific mortality after nephron-sparing surgery (NSS). HSs are considered of prognostic value in RCC. For example, the papillary HS might confer a worse prognosis, and, at some centers, only radical nephrectomy is performed for the papillary HS. METHODS: We used univariate and multivariate Cox regression models to study patients with Stage T1N0M0 RCC treated with NSS (n = 1205) from 1988 to 2004. The data were taken from 9 Surveillance, Epidemiology, and End Results registries. RESULTS: At 36 months after NSS, the cancer-specific mortality rate was 97.8%, 100%, and 97.4% for a clear cell, chromophobe, and papillary RCC HS, respectively. On univariate and multivariate analyses, no statistically significant differences were recorded with regard to the HS. CONCLUSIONS: Despite the suggested more aggressive phenotype of the papillary HS, we found no difference among the papillary, chromophobe, and clear cell variants. Thus, the diagnosis of one HS vs another HS should not deter from the use of NSS when cancer-specific mortality is considered as an endpoint.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Jean-Charles PreiserPhilippe DevosSergio Ruiz-SantanaChristian MélotDjillali AnnaneJohan GroeneveldGaetano IapichinoXavier Maurice LeverveGérard NitenbergPierre SingerJan WernermanMichael JoannidisAdela StecherRené Chioléro
• Organismes : Department of General Intensive Care Department of General Intensive Care Department of Intensive Care Department of Intensive Care AP-HP - Hôpital Raymond Poincaré Intensive Care Medicine Unit Department of Anaesthesia and Intensive Care Clinique de réanimation médicale Laboratoire de bioénergétique fondamentale et appliquée Département d'anesthésie, réanimation et pathologie infectieuse General Intensive Care Department and Institute for Nutrition Research Department of Anesthesiology and Intensive Care Medicine Department of Intensive Care Department of Anaesthesia and Intensive Care Service de médecine intensive adulte
• Publié dans Intensive Care Medicine le 27/10/2020

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Résumé : PURPOSE: An optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU mortality of intensive insulin therapy (IIT) with an intermediate glucose control. METHODS: Adult patients admitted to the 21 participating medico-surgical ICUs were randomized to group 1 (target BG 7.8-10.0 mmol/L) or to group 2 (target BG 4.4-6.1 mmol/L). RESULTS: While the required sample size was 1,750 per group, the trial was stopped early due to a high rate of unintended protocol violations. From 1,101 admissions, the outcomes of 542 patients assigned to group 1 and 536 of group 2 were analysed. The groups were well balanced. BG levels averaged in group 1 8.0 mmol/L (IQR 7.1-9.0) (median of all values) and 7.7 mmol/L (IQR 6.7-8.8) (median of morning BG) versus 6.5 mmol/L (IQR 6.0-7.2) and 6.1 mmol/L (IQR 5.5-6.8) for group 2 (p < 0.0001 for both comparisons). The percentage of patients treated with insulin averaged 66.2 and 96.3%, respectively. Proportion of time spent in target BG was similar, averaging 39.5% and 45.1% (median (IQR) 34.3 (18.5-50.0) and 39.3 (26.2-53.6)%) in the groups 1 and 2, respectively. The rate of hypoglycaemia was higher in the group 2 (8.7%) than in group 1 (2.7%, p < 0.0001). ICU mortality was similar in the two groups (15.3 vs. 17.2%). CONCLUSIONS: In this prematurely stopped and therefore underpowered study, there was a lack of clinical benefit of intensive insulin therapy (target 4.4-6.1 mmol/L), associated with an increased incidence of hypoglycaemia, as compared to a 7.8-10.0 mmol/L target. (ClinicalTrials.gov # NCT00107601, EUDRA-CT Number: 200400391440).

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Fichiers liés : Preiser-IntCareMed-2009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : J. C. YeeA. UdalskiT. SumiSubo DongS. KozłowskiJ. C. BirdAndrew ColeD. HigginsJ. MccormickL. A. G. MonardD. PolishookA. ShporerO. SpectorM. K. SzymańskiM. KubiakGrzegorz PietrzyńskiI. SoszyńskiO. SzewczykK. UlaczykŁ. WyrzykowskiR. PoleskiW. AllenM. BosG. W. ChristieD. L. DepoyJ. D. EastmanB. S. GaudiA. GouldC. HanS. KaspiC.-U. LeeF. MalliaA. MauryD. MaozT. NatuschB.-G. ParkR. W. PoggeR. SantalloF. AbeI. A. BondA. FukuiK. FurusawaJ. B. HearnshawS. HosakaY. ItowK. KamiyaA. V. KorpelaP. M. KilmartinW. LinC. H. LingS. MakitaK. MasudaY. MatsubaraN. MiyakeY. MurakiM. NagayaK. NishimotoK. OhnishiY. C. PerrottN. J. RattenburyT. SakoTo. SaitoL. SkuljanD. J. SullivanW. L. SweatmanP. J. TristramP. C. M. YockM. D. AlbrowV. BatistaP. FouquéJean-Philippe BeaulieuD. P. BennettA. CassanJohan ComparatC. CouturesS. DietersJ. GreenhillK. HorneN. KainsD. KubasRoland MartinJ. MenziesJ. WambsganssAmy J. WilliamsM. Zub
• Organismes : The Ohio State University [Columbus] Laboratoire Astrophysique de Toulouse-Tarbes Institut d'Astrophysique de Paris Astronomische Rechen-Institut [Heidelberg]
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : We analyze the extreme high-magnification microlensing event OGLE-2008-BLG-279, which peaked at a maximum magnification of A ~ 1600 on 2008 May 30. The peak of this event exhibits both finite-source effects and terrestrial parallax, from which we determine the mass of the lens, Ml = 0.64 ± 0.10 M sun, and its distance, Dl = 4.0 ± 0.6 kpc. We rule out Jupiter-mass planetary companions to the lens star for projected separations in the range 0.5-20 AU. More generally, we find that this event was sensitive to planets with masses as small as 0.2 \;M_\oplus \simeq 2 \;M_{Mars} with projected separations near the Einstein ring (~3 AU).

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2009
• Auteurs : Jean-Philippe DubusChristophe GonzalesPatrice Perny
• Organismes : DECISION DECISION DECISION

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Résumé : This paper is devoted to preference-based recommendation or configuration in the context of multiagent (or multicriteria) decision making. More precisely, we study the use of decomposable utility functions in the search for Choquet-optimal solutions on combinatorial domains. We consider problems where the alternatives (feasible solutions) are represented as elements of a product set of finite domains and evaluated according to different points of view (agents or criteria) leading to different objectives. Assuming that objectives take the form of GAI-utility functions over attributes, we investigate the use of GAI networks to determine efficiently an element maximizing an overall utility function defined by a Choquet integral.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Giovanni LughezzaniClaudio JeldresHendrik IsbarnPaul PerrotteShahrokh F. ShariatMaxine SunHugues WidmerPhilippe ArjaneFrancois PeloquinDaniel PharandJean-Jacques PatardMarkus GraefenFrancesco MontorsiPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Martini-Clinic Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Service d'urologie [Rennes] = Urology [Rennes] Institut de Génétique et Développement de Rennes Martini-Clinic Department of urology Cancer Prognostics and Health Outcome Unit
• Publié dans The Journal of Urology le 27/10/2020

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Résumé : PURPOSE: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. MATERIALS AND METHODS: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. RESULTS: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p <0.001). Cubic spline analysis showed that tumor size was virtually linearly related to the synchronous metastasis rate. Stratification by histological subtype in patients treated with nephrectomy revealed that clear cell renal cell cancer was most frequently associated with synchronous metastasis. Finally, tumor size was an independent predictor of synchronous metastasis in multivariate regression models adjusted for age, gender, histological subtype and year of diagnosis quartiles. CONCLUSIONS: Our study confirms that tumor size is an important determinant of the likelihood of synchronous metastasis in patients with T1a and T1b renal cell cancer. The synchronous metastasis rate directly increases with increasing tumor size. Even patients with small renal masses are at risk for synchronous metastasis and patients with clear cell renal cell cancer are at highest risk.

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