Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 10/08/2009
• Auteurs : H. MarchandinCorinne TeyssierJosiane CamposHélène Jean-PierreFrédéric RogerBernard GayJean-Philippe CarlierEstelle Jumas-Bilak
• Organismes : Laboratoire universitaire d'antibiologie Department of Geology and Geophysics Departamento de Geofísica [Santiago] Laboratoire universitaire d'antibiologie Laboratoire de combustion et de détonique Institut de Recherche en Infectiologie de Montpellier Biologie et Génétique des Interactions Plante-Parasite
• Publié dans International Journal of Systematic and Evolutionary Microbiology le 31/10/2020

---

Résumé : Three strains of a hitherto unknown, Gram-negative staining, tiny, anaerobic coccus were collected from human clinical samples originating from skin and soft tissues. The three isolates displayed at least 99.9% identity in 16S rRNA gene sequences and more than 99.8% identity in dnaK gene sequences. The isolates were affiliated to the family Veillonellaceae, the coccobacillus Dialister micraerophilus being the most closely related species but with no more than 91.1% in 16S rRNA gene sequences. Phylogeny based on 16S rRNA gene confirmed that the three strains represent a novel and robust lineage within the current family Veillonellaceae. Similar genomic structure was demonstrated for the three isolates by pulsed-field gel electrophoresis-based analysis. Morphology and metabolic end products, as well as genotypic and phylogenetic data supported the proposal of the novel genus Negativicoccus gen. nov. with the novel species Negativicoccus succinicivorans sp. nov. (type strain ADV 07/08/06-B-1388T (= AIP 149.07T = CIP 109806T = DSM 21255 T = CCUG 56017T) as type species. Phylogenetic analyses based on 16S rRNA gene sequences of members of the phylum Firmicutes and other phyla indicated that the family Veillonellaceae formed a robust lineage clearly separated from those of the classes 'Bacilli', 'Clostridia', Thermolithobacteria and 'Erysipelotrichi' in the phylum Firmicutes. Therefore, we proposed that this family is a class-level taxon in the phylum Firmicutes, for which the name Negativicutes classis nov. is proposed, based on the Gram-negative type of cell wall of its members, with type order Selenomonadales ord. nov. In this order, a novel family, Acidaminococcacae fam. nov., is proposed and description of the family Veillonellaceae is emended.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 06/08/2009
• Auteurs : Jean-Pierre PujolChristos E ChadjichristosF. LegendreCatherine BaugéGallic BeauchefRina AndriamanalijaonaPhilippe GaléraKarim Boumédiene
• Organismes : Université de Caen Normandie Matrice extracellulaire normale et pathologique CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Université de Caen Normandie Matrice extracellulaire normale et pathologique Matrice extracellulaire normale et pathologique Université de Caen Normandie Matrice extracellulaire normale et pathologique Université de Caen Normandie Matrice extracellulaire normale et pathologique Université de Caen Normandie Matrice extracellulaire normale et pathologique Université de Caen Normandie Matrice extracellulaire normale et pathologique Université de Caen Normandie Matrice extracellulaire normale et pathologique Université de Caen Normandie
• Publié dans Connective Tissue Research le 30/10/2020

---

Résumé : In osteoarthritis (OA), interleukin-1 (IL-1) stimulates the expression of metalloproteinases and aggrecanases, which induce cartilage degradation. IL-1 is also capable of reducing the production of cartilage-specific macromolecules, including type II collagen, through modulation of the transcription factors Sp1 and Sp3. Conversely, Transforming growth factor-ß (TGF-β) counteracts with most of the IL-1 deleterious effects and contributes to cartilage homeostasis. However, OA chondrocytes progressively loose the expression of TGF-β type II receptor and become insensitive to the factor. This downregulation is also driven by IL-1. This review provides insights into the molecular mechanisms that underly the interplay between IL-1 and TGF-β in OA cartilage metabolism and enlightens the central role of Sp1 and Sp3 transcription factors in the matrix pathological alterations.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 02/08/2009
• Auteurs : Jean-Gabriel CubySimon L. MorrisPhilip Parr-BurmanMatthew D. LehnertChristopher EvansThierry FuscoPascal JagourelDavid Le MignantRichard M. MyersGérard RoussetHermine SchnetlerJean-Philippe AmansFrançois AssématStephen BeardMathieu CohenNigel A. DipperMarc FerrariÉric GendronJean-Luc GimenezPeter R. HastingsZoltan HubertEmmanuel HugotPhilippe LaporteBrice Le RouxFabrice MadecHelen McgregorTimothy J. MorrisBenoît NeichelMathieu PuechClélia RobertStephen RoltMark SwinbankGordon TalbotWilliam D. TaylorFabrice VidalSébastien VivèsPascal VolaMartyn Wells
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 02/08/2009
• Auteurs : François WildiJean-Luc BeuzitMarkus FeldtDavid MouilletKjetil DohlenPascal PugetA. BaruffoloJulien ChartonPierre BaudozAnthony BoccalettiLyu AbeRiccardo U. ClaudiPhilippe FeautrierThierry FuscoR. G. GrattonNorbert N. HubinMarkus E. KasperMaud LangloisRainer LenzenAlexey PavlovCyril PetitJohan H. PragtPatrick RabouP. R. RoelfsemaMichel SaisseHans-Martin SchmidEric StadlerClaire MoutouMassimo TurattoStéphane UdryRens WatersThomas HenningAnne-Marie LagrangeFarrokh Vakili
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Ingénieurs, Techniciens et Administratifs Laboratoire d'études spatiales et d'instrumentation en astrophysique Ingénieurs, Techniciens et Administratifs Laboratoire d'études spatiales et d'instrumentation en astrophysique Ingénieurs, Techniciens et Administratifs

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2009
• Auteurs : Nicolas Jean-Henri RocheYago Gonzalez VeloLaurent DusseauJérôme BochJean-Roch VailléFrédéric SaignéBruno AzaisGérard AurielEric LorfèvreVincent PougetStephen P. BuchnerJean-Pierre DavidRonan MarecPhilippe Calvel
• Organismes : Institut d’Electronique et des Systèmes Institut d’Electronique et des Systèmes Radiations et composants Institut d’Electronique et des Systèmes Radiations et composants Institut d’Electronique et des Systèmes Radiations et composants Institut d’Electronique et des Systèmes Radiations et composants Institut d’Electronique et des Systèmes Radiations et composants Direction générale de l'armement [France] Direction générale de l'armement [France] Centre National d'Études Spatiales [Toulouse] Laboratoire de l'intégration, du matériau au système NASA Goddard Space Flight Center Laboratoire d'Informatique de Grenoble Thales Alenia Space [Toulouse] Thales Alenia Space [Toulouse]
• Publié dans IEEE Transactions on Nuclear Science le 31/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2009
• Auteurs : Frédéric BernardinMireille BossyClaire ChauvinPhilippe DrobinskiAntoine RousseauTamara Salameh
• Organismes : Laboratoire de Mathématiques Appliquées de Lyon Simuler et calibrer des modèles stochastiques Modelling, Observations, Identification for Environmental Sciences Laboratoire de Météorologie Dynamique (UMR 8539) Modelling, Observations, Identification for Environmental Sciences Laboratoire de Météorologie Dynamique (UMR 8539)
• Publié dans Stochastic Environmental Research and Risk Assessment le 31/10/2020

---

Résumé : In this article, we propose a new stochastic downscaling method: provided a numerical prediction of wind at large scale, we aim to improve the approximation at small scales thanks to a local stochastic model. We first recall the framework of a Lagrangian stochastic model borrowed from S.B. Pope. Then, we adapt it to our meteorological framework, both from the theoretical and numerical viewpoints. Finally, we present some promising numerical results corresponding to the simulation of wind over the Mediterranean Sea.

---

Fichiers liés : Serra08.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2009
• Auteurs : Candice TrocméHubert MarotteAthan BailletBéatrice Pallot-PradesJérome GarinLaurent GrangePierre MiossecJacques TebibFrançois R. BergerMichael J. NissenRobert JuvinFrançoise MorelPhilippe Gaudin
• Organismes : Groupe de Recherche et d’Étude du Processus Inflammatoire Service d'immunologie et rhumatologie Groupe de Recherche et d’Étude du Processus Inflammatoire Clinique de Rhumatologie Laboratoire de chimie des protéines Groupe de Recherche et d’Étude du Processus Inflammatoire Service d'immunologie et rhumatologie Service d'immunologie et rhumatologie Neurosciences précliniques Service de Rhumatologie Service de Rhumatologie Groupe de Recherche et d’Étude du Processus Inflammatoire Groupe de Recherche et d’Étude du Processus Inflammatoire
• Publié dans Annals of the Rheumatic Diseases le 26/10/2020

---

Résumé : OBJECTIVES: The use of biologicals such as infliximab has dramatically improved the treatment of rheumatoid arthritis (RA). However, factors predictive of therapeutic response need to be identified. A proteomic study was performed prior to infliximab therapy to identify a panel of candidate protein biomarkers of RA predictive of treatment response. METHODS: Plasma profiles of 60 patients with RA (28 non-responders (as defined by the American College of Rheumatology 20% improvement criteria (ACR20)) negative and 32 responders (ACR70 positive) to infliximab) were studied by surface enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS) technology on two types of arrays, an anion exchange array (SAX2) and a nickel affinity array (IMAC3-Ni). Biomarker characterisation was carried out using classical biochemical methods (purification by ammonium sulfate precipitation or metal affinity chromatography) and identification by matrix assisted laser desorption/ionisation time-of-flight (MALDI-TOF) MS analysis. RESULTS: Two distinct protein profiles were observed on both arrays and several proteins were differentially expressed in both patient populations. Five proteins at 3.86, 7.77, 7.97, 8.14 and 74.07 kDa were overexpressed in the non-responder group, whereas one at 28 kDa was increased in the responder population (sensitivity>56%, specificity>77.5%). Moreover, combination of several biomarkers improved the sensitivity and specificity of the detection of patient response to over 97%. The 28 kDa protein was characterised as apolipoprotein A-I and the 7.77 kDa biomarker was identified as platelet factor 4. CONCLUSIONS: Six plasma biomarkers are characterised, enabling the detection of patient response to infliximab with high sensitivity and specificity. Apolipoprotein A-1 was predictive of a good response to infliximab, whereas platelet factor 4 was associated with non-responders.

---

Fichiers liés : Trocme_ApolipoproteinA1.pdf inserm-00382264_edited.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2009
• Auteurs : Hugo BellengerJean-Philippe DuvelMatthieu LengaignePhu Levan
• Organismes : Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire de Météorologie Dynamique (UMR 8539)
• Publié dans Geophysical Research Letters le 25/10/2020

---

Résumé : Using an atmospheric Global Circulation Model (GCM), we study the dynamical response of the tropical atmosphere to large-scale convective perturbations. We hypothesize that such perturbations can be triggered by intraseasonal SST anomalies. We thus compare two ensembles of simulations forced either with actual daily SST fields (high frequency, HF) or with low-pass filtered SST fields (T > 90 days; low frequency, LF). In HF simulations, there is a small increase of seasonal mean precipitation, but a strong and statistically significant increase of the low-level westerly flow. It is argued that it is mostly the "aggregation" of the convection into a few large-scale organized intraseasonal events, and not the intensification of the seasonal mean precipitation, that acts to intensify the low-level westerly flow in the HF simulations. This non-linear behavior shows that a correct representation of intraseasonal variability is required for a correct simulation of the average tropical circulation.

---

Fichiers liés : 2009GL039584.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/08/2009
• Auteurs : Nadezda SukhorukovaAndrew StranieriBahadorreza OfoghiPeter VamplewM. SaleemLiping MaAdrien UgonJulien UgonNial MueckeHélène AmielCarole PhilippeAhmed Bani-MustafaShamsul HudaMarcello BertoliPierre LévyJean-Gabriel Ganascia
• Organismes : Agents Cognitifs et Apprentissage Symbolique Automatique Agents Cognitifs et Apprentissage Symbolique Automatique

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2009
• Auteurs : Marie VidailhetJerome YelnikChristelle LagrangeValérie FraixDavid GrabliStéphane ThoboisPierre BurbaudMarie-Laure WelterJin Xie-BrustolinMaria-Clara Coelho BragaClaire ArdouinVirginie CzerneckiHélène KlingerStephan ChabardesEric SeigneuretPatrick MertensEmmanuel CunySoledad NavarroPhilippe CornuAlim-Louis BenabidJean-Francois Le BasDidier DormontMarc HermierKathy DujardinSerge BlondPierre KrystkowiakAlain DestéeEric BardinetYves AgidPaul KrackEmmanuel BroussollePierre PollakNon Renseigné
• Organismes : Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm UM des troubles du mouvement Grenoble Institut des Neurosciences Département de neurologie Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Physiologie et physiopathologie de la signalisation cellulaire Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm CHU Pitié-Salpêtrière [AP-HP] Service de neurologie Grenoble Institut des Neurosciences UM des troubles du mouvement Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Université Claude Bernard Lyon 1 Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences Département de neurochirurgie Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Physiologie et physiopathologie de la signalisation cellulaire CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information RMN biomédicale : de la cellule à l'homme Grenoble Institut des Neurosciences CHU Pitié-Salpêtrière [AP-HP] Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Service de neuroradiologie [Lyon] Département de neurologie [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Service de neurologie [Amiens] Département de neurologie [Lille] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] CHU Pitié-Salpêtrière [AP-HP] Grenoble Institut des Neurosciences Département de neurologie Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Grenoble Institut des Neurosciences Département de neurologie
• Publié dans The Lancet Neurology le 27/10/2020

---

Résumé : BACKGROUND: Cerebral palsy (CP) with dystonia-choreoathetosis is a common cause of disability in children and in adults, and responds poorly to medical treatment. Bilateral pallidal deep brain stimulation (BP-DBS) of the globus pallidus internus (GPi) is an effective treatment for primary dystonia, but the effect of this reversible surgical procedure on dystonia-choreoathetosis CP, which is a subtype of secondary dystonia, is unknown. Our aim was to test the effectiveness of BP-DBS in adults with dystonia-choreoathetosis CP. METHODS: We did a multicentre prospective pilot study of BP-DBS in 13 adults with dystonia-choreoathetosis CP who had no cognitive impairment, little spasticity, and only slight abnormalities of the basal ganglia on MRI. The primary endpoint was change in the severity of dystonia-choreoathetosis after 1 year of neurostimulation, as assessed with the Burke-Fahn-Marsden dystonia rating scale. The accuracy of surgical targeting to the GPi was assessed masked to the results of neurostimulation. Analysis was by intention to treat. FINDINGS: The mean Burke-Fahn-Marsden dystonia rating scale movement score improved from 44.2 (SD 21.1) before surgery to 34.7 (21.9) at 1 year post-operatively (p=0.009; mean improvement 24.4 [21.1]%, 95% CI 11.6-37.1). Functional disability, pain, and mental health-related quality of life were significantly improved. There was no worsening of cognition or mood. Adverse events were related to stimulation (arrest of the stimulator in one patient, and an adjustment to the current intensity in four patients). The optimum therapeutic target was the posterolateroventral region of the GPi. Little improvement was seen when the neurostimulation diffused to adjacent structures (mainly to the globus pallidus externus [GPe]). INTERPRETATION: Bilateral pallidal neurostimulation could be an effective treatment option for patients with dystonia-choreoathetosis CP. However, given the heterogeneity of motor outcomes and the small sample size, results should be interpreted with caution. The optimum placement of the leads seemed to be a crucial, but not exclusive, factor that could affect a good outcome. FUNDING: National PHRC; Cerebral Palsy Foundation: Fondation Motrice/APETREIMC; French INSERM Dystonia National Network; Medtronic.

---

Source