Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/06/2009
• Auteurs : Jean-Marie DucereAnne HémeryckAlain EstèveMehdi Djafari RouhaniGeorges LandaCyril TropisPhilippe MeniniAndré MaisonnatPierre FauBruno Chaudret
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination

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Résumé : Because of environmental and safety concerns, there is a large need of gas sensing devices. Semiconductor metal oxides, like tin dioxide, are widely used for such applications. In these devices, the gas detection is usually performed by measuring conductivity variations of the oxide sensing layer. Indeed, gas adsorption and surface chemical reactions result in formal electron transfers, modifying the number of charge carriers. In this work, we have performed DFT calculations to characterize different chemical reactions involved in the detection of CO and CO2 by SnO2: CO and CO2 adsorption, SnO2 reduction by CO and its re-oxidation by O2, and the formation of carbonates in the case of CO2. In each case, we have calculated the reaction energy and its activation barrier but also the resulting charge transfer in order to evaluate the sensor electrical response. We find that CO detection is easy thanks to low barrier exothermic reactions and large associated charge transfers. In particular, SnO2 reduction results in the formation of surface oxygen vacancies that formally behave as two electrons in the conduction band. On the other hand, CO2 detection is troublesome due to weakly exothermic reactions and ten times smaller charge transfers. Finally, we study the influence of H2O on the reaction mechanisms and the charge transfers in order to evaluate its interfering capabilities.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/06/2009
• Auteurs : Joffrey MoirouxCecile Le LannMajeed A. SeyahooeiPhilippe VernonJean-Sébastien PierreJoan van BaarenJacques J.M. J.M. van Alphen
• Organismes : Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Institute Biology Leiden Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Paysages, Changements Climatique, Biodiversité

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/06/2009
• Auteurs : Anne HémeryckJean-Marie DucereAlain EstèveMehdi Djafari RouhaniGeorges LandaCyril TropisPhilippe MeniniAndré MaisonnatPierre FauBruno Chaudret
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination

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Résumé : Metal oxides such as tin oxide (SnO 2) are widely used for gas sensing applications, particularly in environmental applications. The change in the resistance of the sensing layer is the detection principle of the gas sensors. The variations of the resistance are due to the charge transfers resulting from the chemical reactions which occur at the surface of the tin dioxide sensitive layer. In this work, a multiscale approach is developed in order to model interactions of SnO 2 with various gases, such as CO and CO 2. Ab initio calculations are systematically used to identify and characterize, at the atomic scale, the chemical reactions occurring at the surface of the sensitive layer of the sensor. Structures and activation energies associated to surface reactions, and charge transfers characteristics of each surface species, are determined. To simulate the sensors behaviour on a wider scale, a mesoscopic model based on the ab initio results and a chemical rate theory technique is developed. This model gives the temporal evolution of the sensors response as a function of external parameters. This methodology, combining ab initio calculations and mesoscopic model, leads to a better understanding of the macroscopic gas sensor behaviour. We identify the SnO 2 reduction by CO, the catalytic oxidation mechanism of CO involving successive reduction and reoxidation of the oxide layer and the tricky detection of CO 2 gas as a function of external parameters like humidity.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/06/2009
• Auteurs : Amaël DelaunoyEmmanuel PradosPau GargalloJean-Philippe PonsPeter Sturm
• Organismes : Interpretation and Modelling of Images and Videos Interpretation and Modelling of Images and Videos Interpretation and Modelling of Images and Videos Centre d'Enseignement et de Recherche en Technologies de l'Information et Systèmes Interpretation and Modelling of Images and Videos

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Résumé : Cet article propose une méthode variationnelle basée sur les maillages pour la reconstruction 3D de scènes (forme et radiance) à partir de plusieurs images. Notre méthode est basée sur les modèles génératifs et minimise l'erreur de reprojection (différence entre une image observée et une image obtenue à partir de la reconstruction) par une descente de gradient. Pour la première fois, nous calculons le gradient de l'erreur de reprojection pour des surfaces non lisses représentées de manière discrète par des maillages triangulés. Le gradient prend correctement en compte les changements de visibilité qui apparaissent lorsque la surface bouge durant l'évolution ; cela force les contours occultants générés par la surface à correspondre parfaitement aux contours apparents dans les images observées. Notre méthode est capable de retrouver la forme et la radiance de diverses scènes.

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Fichiers liés : 11.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/06/2009
• Auteurs : Maxime SermesantFlorence BilletRadomir ChabiniokTommaso MansiPhani ChinchapatnamPhilippe MoireauJean-Marc PeyratKawal S. RhodeMatt GinksPier LambiaseSimon ArridgeHervé DelingetteMichel SorineC.A. RinaldiDominique ChapelleReza RazaviNicholas Ayache
• Organismes : Analysis and Simulation of Biomedical Images Analysis and Simulation of Biomedical Images Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems Modeling, analysis and control in computational structural dynamics Analysis and Simulation of Biomedical Images Centre for Medical Image Computing Modeling, analysis and control in computational structural dynamics Analysis and Simulation of Biomedical Images Division of Imaging Sciences Division of Imaging Sciences The Heart Hospital [London] Centre for Medical Image Computing Analysis and Simulation of Biomedical Images SIgnals and SYstems in PHysiology & Engineering Department of cardiology [Guy's and St. Thomas ' hospitals] [London] Modeling, analysis and control in computational structural dynamics Division of Imaging Sciences NIHR Biomedical Research Centre [London] Analysis and Simulation of Biomedical Images

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Résumé : Cardiac resynchronisation therapy (CRT) has been shown to be an effective adjunctive treatment for patients with dyssynchronous ventricular contraction and symptoms of the heart failure. However, clinical trials have also demonstrated that up to 30% of patients may be classified as non-responders. In this article, we present how the personalisation of an electromechanical model of the myocardium could help the therapy planning for CRT. We describe the four main components of our myocardial model, namely the anatomy, the electrophysiology, the kinematics and the mechanics. For each of these components we combine prior knowledge and observable parameters in order to personalise these models to patient data. Then the acute effects of a pacemaker on the cardiac function are predicted with the in silico model on a clinical case. This is a proof of concept of the potential of virtual physiological models to better select and plan the therapy.

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• Type de publi. : Rapport
• Date de publi. : 03/06/2009
• Auteurs : Reto KrummenacherIoan TomaChristophe HamerlingJean-Pierre LorreFrançoise BaudeVirginie LegrandPhilippe MerleCristian RuzCarlos PedrinaciDong LiuTomas Pariente Lobo
• Organismes : Active objects, semantics, Internet and security Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis Adaptive Distributed Applications and Middleware Active objects, semantics, Internet and security Knowledge Media Institute Knowledge Media Institute

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Edouard TuaillonDiane ValéaPierre BecquartYassine Al TabaaNicolas MedaKarine BollorePhilippe Van de PerreJean-Pierre Vendrell
• Organismes : Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Centre Muraz [Bobo-Dioulasso, Burkina Faso] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Centre Muraz [Bobo-Dioulasso, Burkina Faso] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Institut de recherche en biothérapie
• Publié dans Journal of Immunology le 27/10/2020

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Résumé : While secretory Abs have been extensively explored in human breast milk, the existence, features, and functions of B lymphocytes remain largely unexplored in this compartment. We analyzed breast milk and blood lymphocytes from 21 lactating women, including 12 HIV-1-infected mothers. Breast milk B cells displayed a phenotype of class-switched memory B cells, with few IgD+ memory and naive B cells. We observed that breast milk B lymphocytes bore a unique profile of adhesion molecules (CD44+, CD62L−, α4β7+/−, α4β1+). Higher percentages of activated B cells (CD38+), large-sized B cells, plasmablasts, and plasma cells (CD19+, CD20low/−, CD27high, CD138+) were found as compared with blood. This indicates that a significant proportion of breast milk B cells underwent terminal plasma cell differentiation. We also observed a higher frequency of cells secreting Ig spontaneously in breast milk. Among these cells, IgG-secreting cells predominated over IgA-secreting cells as measured by Ig ELISPOT assays. Specific Ab-secreting cells were investigated following polyclonal activation using the CD40L ligation. Finally, the detection of anti-HIV-1-secreting cells demonstrates the existence of B cells specific to HIV-1 Ag in breast milk from HIV-1-infected women. Breast milk B cells display a phenotype strikingly different from blood, are primed to secrete Abs, and have a mucosal homing profile similar to B cells located in gut-associated lymphoid tissue.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : France Tuffery-GiraudChristophe BéroudFrance LeturcqRabah Ben YaouDalil HamrounLaurence Michel-CalemardPierre MoizardRafaelle BernardMireille CosséePierre BoisseauMartine BlayauIsabelle CreveauxAnne Guiochon-MantelBérengère de MartinvillePhilippe PhilippeNicole MonnierÉric BiethPhilippe KHAU VAN KIENFrançois-Olivier DesmetVéronique HumbertclaudeJean-Claude KaplanJamel ChellyMireille ClaustresSylvie Tuffery-GiraudChristophe PhilippePhilippe Khau van Kien
• Organismes : Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Service de biochimie et de génétique moléculaire [CHU Cochin] Institut de génétique humaine Centre de Biologie et Pathologie Est [Bron] Génétique Médicale et Génomique Fonctionnelle Service de génétique médicale Physiopathologie et pharmacologie cellulaires et moléculaires Service de génétique clinique [Rennes] Laboratoire de Biochimie Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique Canaux calciques , fonctions et pathologies Service Génétique Médicale [CHU Toulouse] Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Institut de génétique humaine Laboratoire de Biochimie et Génétique Moléculaire Human Molecular Genetics Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique Centre Hospitalier Universitaire de Nîmes
• Publié dans Human Mutation le 26/10/2020

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Résumé : UMD-DMD France is a knowledgebase developed through a multicenter academic effort to provide an up-to-date resource of curated information covering all identified mutations in patients with a dystrophinopathy. The current release includes 2,411 entries consisting in 2,084 independent mutational events identified in 2,046 male patients and 38 expressing females, which corresponds to an estimated number of 39 people per million with a genetic diagnosis of dystrophinopathy in France. Mutations consist in 1,404 large deletions, 215 large duplications, and 465 small rearrangements, of which 39.8% are nonsense mutations. The reading frame rule holds true for 96% of the DMD patients and 93% of the BMD patients. Quality control relies on the curation by four experts for the DMD gene and related diseases. Data on dystrophin and RNA analysis, phenotypic groups, and transmission are also available. About 24% of the mutations are de novo events. This national centralized resource will contribute to a greater understanding of prevalence of dystrophinopathies in France, and in particular, of the true frequency of BMD, which was found to be almost half (43%) that of DMD. UMD-DMD is a searchable anonymous database that includes numerous newly developed tools, which can benefit to all the scientific community interested in dystrophinopathies. Dedicated functions for genotype-based therapies allowed the prediction of a new multiexon skipping (del 45-53) potentially applicable to 53% of the deleted DMD patients. Finally, such a national database will prove to be useful to implement the international global DMD patients' registries under development.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Gilles PaintaudJean-Camille MericDenis MullemanEmilie DucourauCharlotte Magdelaine-BeuzelinJean-Pierre ValatPhilippe Goupille
• Organismes : Génétique, immunothérapie, chimie et cancer Génétique, immunothérapie, chimie et cancer Génétique, immunothérapie, chimie et cancer Génétique, immunothérapie, chimie et cancer Génétique, immunothérapie, chimie et cancer
• Publié dans Fundamental & Clinical Pharmacology le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Barbara BournetAnny SouquePierre SenesseEric AssenatMarc BarthetNathalie LesavreAriane AubertDermot O'ToolePascal HammelPhilippe LevyPhilippe RuszniewskiMichèle BouissonJean EscourrouPierre CordelierLouis Buscail
• Organismes : Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil CRLCC Val d'Aurelle - Paul Lamarque CRLCC Val d'Aurelle - Paul Lamarque Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil
• Publié dans Endoscopy le 22/10/2020

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Résumé : BACKGROUND AND STUDY AIMS: Differential diagnosis between pancreatic adenocarcinoma (PADC) and pseudotumoral forms of chronic pancreatitis remains difficult. Mutation of KRAS oncogene is present in 75% to 95% of PADC. This study aimed to evaluate whether the combined analysis of KRAS mutation with cytopathological findings from endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) might improve discrimination between PADC and chronic pancreatitis. PATIENTS AND METHODS: This prospective multicenter study included 178 patients with solid pancreatic masses (men 104, women 74; mean age 64.5 years). Cytopathological examination and KRAS mutation analysis (codon-12 and codon-13, restriction fragment length polymorphism [RFLP] and direct sequencing) were performed on EUS-FNAB material. Final diagnoses were obtained on EUS-FNAB analysis and/or a second biopsy and/or clinical follow-up and/or surgery: PADC, n = 129; chronic pancreatitis, n = 27; other pancreatic neoplasms, n = 16; and benign lesions, n = 6. RESULTS: KRAS status analysis was successful in all EUS-FNAB samples. Codon-12 KRAS point mutation was found in 66% of PADC samples. No case of chronic pancreatitis displayed KRAS mutation. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of cytopathology alone for diagnosis of PADC versus chronic pancreatitis were 83%, 100%, 100%, 56% and 86%, respectively. When KRAS mutation analysis was combined with cytopathology, these values reached 88%, 100%, 100%, 63% and 90% respectively. CONCLUSION: Although the value of KRAS analysis in addition to EUS-FNAB is limited for distinguishing pancreatic mass lesions, when chronic pancreatitis presented as a pseudotumor a negative finding (wild-type KRAS), was useful in strongly suggesting a benign lesion.

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