Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2008
• Auteurs : Virginie CallotDamien GalanaudYann Le FurSylviane Confort-GounyJean‐philippe RanjevaPatrick J Cozzone
• Organismes : Centre de résonance magnétique biologique et médicale CHU Pitié-Salpêtrière [AP-HP] Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Géoarchitecture : Territoires, Urbanisation, Biodiversité, Environnement Centre de résonance magnétique biologique et médicale Centre de résonance magnétique biologique et médicale Centre de résonance magnétique biologique et médicale
• Publié dans European Journal of Radiology le 22/10/2020

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Résumé : Magnetic resonance spectroscopy (MRS) is proposed in addition to magnetic resonance imaging (MRI) to help in the characterization of brain tumours by detecting metabolic alterations that may be indicative of the tumour class. MRS can be routinely performed on clinical magnets, within a reasonable acquisition time and if performed under adequate conditions, MRS is reproducible and thus can be used for longitudinal follow-up of treatment. MRS can also be performed in clinical practice to guide the neurosurgeon into the most aggressive part of the lesions or to avoid unnecessary surgery, which may furthermore decrease the risk of surgical morbidity.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/08/2008
• Auteurs : Philippe P. SchollhammerJean Talarmin
• Organismes : Chimie, Electrochimie Moléculaires et Chimie Analytique Chimie, Electrochimie Moléculaires et Chimie Analytique

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Résumé : It was a great pleasure for us to accept the invitation of Pierre Braunstein, Editor-in-Chief of the Comptes Rendus Chimie , to guest-edit this thematic issue. We chose to devote it to an exciting field of research, which concerns the production and the oxidation of hydrogen by bio-inspired catalysts. Indeed, the development of economic and ecological processes of hydrogen production/uptake is a major goal in the perspective of a hydrogen economy. This thematic issue, entitled Bio-inspired hydrogen production/uptake catalysis , is dedicated to the chemists' efforts, in this multidisciplinary field at the interface of chemistry and biology, to conceive and to study new molecules inspired by the active sites of the [NiFe] and [FeFe] hydrogenases. The ultimate purpose of these theoretical and experimental studies is to achieve efficient electrocatalysts for the production or the oxidation of hydrogen through a better understanding of the mechanisms implied at the molecular level. We thank Pierre Braunstein very warmly for his invitation, as well as all the colleagues whose contributions allowed the edition of this thematic issue, which, we hope, will contribute to illustrate different aspects of the research performed by chemists in this challenging field.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2008
• Auteurs : Elizabete Rodrigues FerreiraPhilippe BoulangerMichel Destrade
• Organismes : Département de Mathématique [Bruxelles] Département de Mathématique [Bruxelles] Institut Jean Le Rond d'Alembert
• Publié dans Quarterly Journal of Mechanics and Applied Mathematics le 27/10/2020

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Résumé : In the context of the finite elasticity theory, we consider a model for compressible solids called 'compressible neo-Hookean material'. We show how finite-amplitude inhomogeneous plane wave solutions and finite-amplitude unattenuated solutions can combine to form a finite-amplitude Love wave. We take a layer of finite thickness overlying a solid half-space, both made of different prestressed compressible neo-Hookean materials. We derive an exact solution of the equations of motion and boundary conditions and also obtain results for the energy density and the energy flux of the waves. Finally, we investigate the special case when the interface between the layer and the substrate is in a principal plane of the prestrain. A numerical example is given.

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Fichiers liés : destrade_42_preprint.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2008
• Auteurs : Fabienne LesueurMahaut de LichyMichel BarroisGuillermo DurandJohny BombledMarie-Francoise AvrilAgnès ChompretFrançoise BoitierGilbert M LenoirMonique BaccardBertrand BacholletPascaline BerthetValérie BonadonaJean-Marie BonnetblancJacqueline Chevrant-BretonJean-Francois CunyStéphane DalleMichèle DelaunayLiliane DemangeJulie De QuatrebarbesJean-François DoréMarc FrénayJean-Pierre FrickerMarion Gauthier-VillarsPaul GestaSophie GiraudPhilippe GorryFlorent GrangeAndrew GreenLaetitia HuiartNicolas JaninPascal JolyDelphine KerobChristine LassetDominique LerouxJean-Marc LimacherMichel LongySandrine MansardKarine MarrouTanguy Martin-DenavitChristine MateusEve MaubecLaurence Olivier-FaivreVincent OrlandiniPascal PujolBruno SassolasDominique Stoppa-LyonnetLuc ThomasPierre VabresLaurence VenatEwa Hainaut-WierzbickaHelene ZattaraBrigitte Bressac-de Paillerets
• Organismes : Génomes et cancer Institut Gustave Roussy Vectorologie et transfert de gènes Service de Génétique [Villejuif] Hématopoïèse normale et pathologique Service de Dermatologie [CHU Cochin] Département de médecine oncologique [Gustave Roussy] Université Claude Bernard Lyon 1 Hôpital Michallon Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Equipe de Recherche Médicale Appliquée Service de Dermatologie [Rennes] = Dermatology [Rennes] Service de Dermatologie et Allergologie [CHRU Nancy] Institut de Génomique Fonctionnelle Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Oncogénèse et progression tumorale Groupe de Recherche en Economie Théorique et Appliquée Hôpital universitaire Robert Debré [Reims] Luxembourg Institute of Health Biostatistiques santé [LBBE] Hôpital pasteur [Colmar] CHU Estaing [Clermont-Ferrand] Service de dermatologie [Gustave Roussy] Service de dermatologie [Avicenne] Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) Centre Hospitalier Régional Universitaire [Montpellier] Département de Médecine Interne et Pneumologie [Brest] Pathologie moléculaire des cancers Laboratoire Electronique, Informatique et Image [UMR6306] Institut Gustave Roussy
• Publié dans British Journal of Cancer le 29/10/2020

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Résumé : Mutations in two genes encoding cell cycle regulatory proteins have been shown to cause familial cutaneous malignant melanoma (CMM). About 20% of melanoma-prone families bear a point mutation in the CDKN2A locus at 9p21, which encodes two unrelated proteins, p16(INK4a) and p14(ARF). Rare mutations in CDK4 have also been linked to the disease. Although the CDKN2A gene has been shown to be the major melanoma predisposing gene, there remains a significant proportion of melanoma kindreds linked to 9p21 in which germline mutations of CDKN2A have not been identified through direct exon sequencing. The purpose of this study was to assess the contribution of large rearrangements in CDKN2A to the disease in melanoma-prone families using multiplex ligation-dependent probe amplification. We examined 214 patients from independent pedigrees with at least two CMM cases. All had been tested for CDKN2A and CDK4 point mutation, and 47 were found positive. Among the remaining 167 negative patients, one carried a novel genomic deletion of CDKN2A exon 2. Overall, genomic deletions represented 2.1% of total mutations in this series (1 of 48), confirming that they explain a very small proportion of CMM susceptibility. In addition, we excluded a new gene on 9p21, KLHL9, as being a major CMM gene.

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Fichiers liés : 6604470.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2008
• Auteurs : Jean-Bernard PouvreauMichèle MorançaisFrédéric TaranPhilippe RosaLaurent DufosséFabienne GuérardSerge PinJoel FleurencePierre Pondaven
• Organismes : Laboratoire de biologie et pathologie végétales Mer, molécules et santé EA 2160 Mer, molécules et santé EA 2160 Service de Chimie Bio-Organique et de Marquage Mer, molécules et santé EA 2160 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments Laboratoire ANTiOX Institut Rayonnement Matière de Saclay (DRF) Service de Chimie Moléculaire Mer, molécules et santé EA 2160 Mer, molécules et santé EA 2160
• Publié dans Journal of Agricultural and Food Chemistry le 02/11/2020

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Résumé : Among microalgae, the marine diatom Haslea ostrearia has the distinctive feature of synthesizing and releasing, into the surrounding environment, a blue-green polyphenolic pigment called marennine. The oyster-breeding industry commonly makes use of this natural phenomenon for the greening of oysters grown in the ponds of the French Atlantic coast. This article reports the in vitro antioxidant properties of pure marennine. Two kinds of evaluation systems were adopted to test the antioxidative activity of marennine: antioxidant capacity assays (β-carotene and thymidine protection assays and iron reducing power assay) and free radical scavenging assays (DPPH·, O2·-, and HO·). In almost all cases, marennine exhibited significantly higher antioxidative and free radical scavenging activities than natural and synthetic antioxidants commonly used in food, as shown by comparing median effective concn. (EC50) values, for each test independently. This medium mol. wt. polyphenol (around 10 kDa) from microalgae is thus a potentially useful natural antioxidant. Because of its blue-coloring property and water soly., it could also be used as a natural food-coloring additive. [on SciFinder(R)]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/07/2008
• Auteurs : F. LoixPierre BadelLaurent OrgéasChristian GeindreauP. BoisseJean-Francis Bloch
• Organismes : Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/07/2008
• Auteurs : Ibrahim CheddadiGraner FrançoisPhilippe MarmottantChristophe RaufastePierre Saramito
• Organismes : Modelling, Observations, Identification for Environmental Sciences Equations aux Dérivées Partielles Laboratoire de Spectrométrie Physique Laboratoire de Spectrométrie Physique Institut de Recherche sur les Phénomènes Hors Equilibre Laboratoire de Spectrométrie Physique Physique et mécanique des milieux hétérogènes Modelling, Observations, Identification for Environmental Sciences Equations aux Dérivées Partielles

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Résumé : We present a numerical simulation based on a tensorial elastoviscoplastic model that includes a viscous drag and compare it to experimental measurements on liquid foams trapped between two glass plates in a bidimensional cylindrical Couette geometry, both in stationary and transient regimes. The main features of the model are elasticity up to a plastic yield stress and viscoelasticity above. The numerical modelling bases on a small set of standard material parameters that could be fully characterised. Shear localisation as well as fine transient observations are reproduced and are found to be in good agreement with experimental measurements. The plasticity appears to be the fundamental mechanism of the localisation of the flow. The present approach can be extended from liquid foams to similar materials such as emulsions, colloids or wet granular materials that exhibit localisation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/07/2008
• Auteurs : Jean-Philippe AntoniPierre FrankhauserCécile TannierSamy Youssoufi
• Organismes : Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049)

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Résumé : The first part of the paper is centered on the phenomena of urban growth, in order to set the rules for a sustainable scenario of urban development. Then we enter the core of the paper that is the comparison of models. For each of the three compared models, we describe its main theoretical characteristics, the chosen parameters, and the obtained results. In section 6, heterogeneity of the produced results is discussed, and we highlight the points of interest and the lacks of the three models. Here we show that results we obtained feed debates about urban growth management. Finally, concluding remarks at the end of the paper address the general topic of the evaluation of the quality of simulation results.

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Fichiers liés : DDSS2008-25.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/07/2008
• Auteurs : Benoît MosserJean-Tristan BueyClaude CatalaThierry AppourchauxStéphane CharpinetPhilippe MathiasJean-Pierre Maillard
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Ingénieurs, Techniciens et Administratifs Pôle Planétologie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Ingénieurs, Techniciens et Administratifs Pôle Planétologie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Ingénieurs, Techniciens et Administratifs Pôle Planétologie du LESIA

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/07/2008
• Auteurs : Kauzar Saleh ContellGilles BouletYann H. KerrPhilippe MaisongrandePhilippe RichaumeWigneron J.-P.Steven DelwartRocco PancieraJeffrey Walker
• Organismes : Department of geography Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement European Space Research and Technology Centre University of Melbourne University of Melbourne

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Fichiers liés : Abstract_Saleh_IGARRS08_1.pdf

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