Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Annabelle CesaroAbakar Abakar-MahamatPatrick BrestSandra LassalleEric SelvaJérôme FilippiXavier HébuterneJean-Pierre HugotAlain DoglioFranck GallandPhilippe NaquetValérie Vouret-CraviariBaharia MograbiPaul M Hofman
• Organismes : Infection bactérienne, inflammation, et carcinogenèse digestive Infection bactérienne, inflammation, et carcinogenèse digestive Immunité muqueuse et vaccination Infection bactérienne, inflammation, et carcinogenèse digestive Infection bactérienne, inflammation, et carcinogenèse digestive Immunité muqueuse et vaccination Immunité muqueuse et vaccination Infection bactérienne, inflammation, et carcinogenèse digestive Immunité muqueuse et vaccination Inflammation intestinale pathologique de l'enfant Infection bactérienne, inflammation, et carcinogenèse digestive Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Infection bactérienne, inflammation, et carcinogenèse digestive Immunité muqueuse et vaccination Infection bactérienne, inflammation, et carcinogenèse digestive Immunité muqueuse et vaccination
• Publié dans AJP - Gastrointestinal and Liver Physiology le 26/10/2020

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Résumé : The acute phase of Crohn's disease (CD) is characterized by a large afflux of polymorphonuclear leukocytes (PMNL) into the mucosa and by the release of TNF-alpha. Conversion of inactive TNF-alpha into an active form requires the cleavage of a transmembrane TNF-alpha precursor by the TNF-alpha-converting enzyme (ADAM17), a protease mainly regulated by the tissue inhibitor of metalloproteinase 3 (TIMP3). The aim of the present study was to investigate in an in vitro model of PMNL transepithelial migration and in the intestinal mucosa of patients with CD the expression and regulation of ADAM17 and TIMP3 in intestinal epithelial cells (IEC). ADAM17 and TIMP3 expression was analyzed by Western blotting, RT-PCR, confocal microscopy, and immunohistochemistry by using the T84 model and digestive biopsies. ADAM17 expression in IEC was increased at a posttranscriptional level during the early phase (from 2 to 4 h) of PMNL transepithelial migration whereas TIMP3 was only increased 24 h later. TNF-alpha induced an early upregulation of ADAM17 in T84 cells, whereas PMNL adhesion, H(2)O(2), or epithelial tight junction opening alone did not affect the amount of ADAM17. Immunohistochemistry of intestinal biopsies revealed that strong expression of ADAM17 was associated with a high activity of CD. In contrast, TIMP3 was very poorly expressed in these biopsies. ADAM17 and TIMP3 profiling did not correlated with the NOD2/CARD15 status. The ADAM17 activity was higher both in the early phase of PMNL transepithelial migration and in active CD. These results showed early posttranscriptional upregulation of ADAM17 in IEC linked to PMNL transepithelial migration and a high activity of CD.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Shah Nawaz BurokurAbdelwaheb OurirJean-Pierre DanielPhilippe RatajczakAndré De Lustrac
• Organismes : Laboratoire Energétique Mécanique Electromagnétisme Institut Langevin - Ondes et Images (UMR7587) Ecole Nationale de l'Aviation Civile Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique IEF
• Publié dans Microwave and Optical Technology Letters le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Laurent ZiniJean-Jacques PatardUmberto CapitanioArnaud MejeanArnauld VillersAlexandre de La TailleVincenzo FicarraMaxime CrépelRoberto BertiniLaurent J. SalomonGregory VerhoestPaul PerrotteKarim BensalahPhilippe ArjaneJacques BiserteFrancesco MontorsiPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Service d'urologie Institut de Génétique et Développement de Rennes Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Department of urology Service d'urologie Département d'urologie Service d'urologie [Mondor] Department of Oncological and Surgical Sciences Service d'urologie [Rennes] = Urology [Rennes] Department of urology Service d'urologie [Mondor] Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcomes Unit Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcomes Unit Département d'urologie Department of urology Cancer Prognostics and Health Outcome Unit
• Publié dans EJSO - European Journal of Surgical Oncology le 22/10/2020

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Résumé : PURPOSE: The objective was to define the trends of PN use over time at six tertiary care European centers. METHODS: Data were retrieved from institutional databases for patients treated with either PN or radical nephrectomy (RN) for stages T(1-2)N(0)M(0) renal cell carcinoma (RCC) between 1987 and 2007. For purpose of temporal trend analyses patients were divided into five equally sized groups according to the date of surgery. Categorical and multivariable logistic regression analyses assessed predictors of PN use. RESULTS: Overall 597 (31.7%) patients were treated with PN. Overall, a 4.5-fold increase of PN was recorded. The absolute increases were 41.7-86.3%, 14.9-69.3% and 8.1-35.3% for lesions < or = 2 cm, 2.1-4 cm and 4.1-7 cm (chi-square trend test p<0.001), respectively. In multivariable logistic regression models, decreasing tumor size, younger age, more contemporary date of surgery, male gender and institutional PN rate represented independent predictors of the individual probability of treatment with PN. Lack of data from community hospitals limits the generalizability of our findings. CONCLUSION: Based on data from six tertiary care centers, the contemporary rate of PN ranges from 86 to 35% for renal masses < or = 2 cm to 4.1-7 cm and is indicative of excellent quality of care.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Estelle EscudierPhilippe DuquesnoyJean-François PaponSerge Amselem
• Organismes : Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Institut Mondor de Recherche Biomédicale Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans Paediatric Respiratory Reviews le 02/11/2020

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Résumé : Cilia are evolutionarily conserved structures that play key roles in diverse cell types. Motile cilia are involved in the most prominent ciliopathy called primary ciliary dyskinesia (PCD) that combines respiratory symptoms, male infertility, and, in nearly 50% cases, situs inversus. The diagnosis of PCD relies on the identification of ciliary abnormalities that mainly concern outer and/or inner dynein arms (ODA, IDA). PCD is a genetic condition, usually inherited as an autosomal recessive trait. To date, six genes have been clearly implicated in PCD. Two "major" genes, DNAI1 and DNAH5, underlie PCD in nearly half of the patients with ODA defects, whereas RPGR, DNAH11 and TXNDC3 are implicated in rare families with specific phenotypes (retinitis pigmentosa, abnormal beating of structurally normal cilia, and situs ambiguous, respectively). The relative contribution of DNAI2 is currently being assessed. In all the other patients with ODA or other ultrastructural defects, the causative genes remain to be identified.

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Fichiers liés : PCD_Review_Escudier.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Philippe Jean-BaptisteElise FourréJean-Luc CharlouJean-Pierre DonvalThierry Corrège
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables
• Publié dans Estuarine, Coastal and Shelf Science le 22/10/2020

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Fichiers liés : publication-6457.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Marie-Pierre ChauzatPatrice CarpentierAnne-Claire MartelStéphanie BougeardNicolas CougoulePhilippe PortaJulie LachaizeFrançois MadecMichel AubertJean-Paul Faucon
• Organismes : Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Direction du végétal et de l'environnement Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches avicoles, porcines et piscicoles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches avicoles, porcines et piscicoles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles
• Publié dans Environmental Entomology le 24/10/2020

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Résumé : A 3-yr field survey was carried out in France, from 2002 to 2005, to study honey bee (Apis mellifera L.) colony health in relation to pesticide residues found in the colonies. This study was motivated by recent massive losses of honey bee colonies, and our objective was to examine the possible relationship between low levels of pesticide residues in apicultural matrices (honey, pollen collected by honey bees, beeswax) and colony health as measured by colony mortality and adult and brood population abundance. When all apicultural matrices were pooled together, the number of pesticide residue detected per sampling period (four sampling periods per year) and per apiary ranged from 0 to 9, with the most frequent being two (29.6%). No pesticide residues were detected during 12.7% of the sampling periods. Residues of imidacloprid and 6- chloronicotinic acid were the most frequently detected in pollen loads, honey, and honey bee matrices. Several pairs of active ingredients were present concurrently within honey bees and in pollen loads but not in beeswax and honey samples. No statistical relationship was found between colony mortality and pesticide residues. When pesticide residues from all matrices were pooled together, a mixed model analysis did not show a significant relationship between the presence of pesticide residues and the abundance of brood and adults, and no statistical relationship was found between colony mortality and pesticide residues. Thus, although certain pesticide residues were detected in apicultural matrices and occasionally with another pesticide residual, more work is needed to determine the role these residues play in affecting colony health.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/05/2009
• Auteurs : Magali DuvailAlexandre RuasPhilippe MoisyJean-Pierre SimoninOlivier BernardPhilippe Guilbaud
• Organismes : Département de recherche sur les procédés pour la mine et le recyclage du combustible Laboratoire de Chimie des Actinides Département de recherche sur les procédés pour la mine et le recyclage du combustible PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX Département de recherche sur les procédés pour la mine et le recyclage du combustible

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/05/2009
• Auteurs : Pierre GuillotPascal PhilippeCorinne BerlandJean-François Bercher
• Organismes : NXP Semiconductors NXP Semiconductors Electronique, Systèmes de communication et Microsystèmes Laboratoire des signaux et systèmes Laboratoire d'Informatique Gaspard-Monge

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Résumé : Ce papier démontre la faisabilité d’une référence haute fréquence pour les architectures RF. Il présente la conception d’un circuit oscillant à 2GHz réalisé en technologie CMOS 65nm. Les deux principales innovations sont les performances en terme de stabilité (bruit de phase de -128dBc/Hz à 100kHz de la porteuse) et en précision (implémentation d’une banque de capacité ayant un pas de 0.4ppm) de l’oscillateur. Sa consommation est optimisée (0.9mW). Il est suivi d’un diviseur faible bruit (-140dBc/Hz à 100kHz de la porteuse) délivrant un signal à 500MHz.

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Fichiers liés : guillot_jnm_2009.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 18/05/2009
• Auteurs : Ion IturbePhilippe RouxBarbara NicolasJean VirieuxJerome I. Mars
• Organismes : GIPSA - Signal Images Physique Laboratoire de Géophysique Interne et Tectonophysique GIPSA - Signal Images Physique Laboratoire de Géophysique Interne et Tectonophysique GIPSA - Signal Images Physique

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Résumé : In underwater acoustics, ray tomography is the classical method used to estimate velocity variations, but recently. Travel-Time Sensitivity Kernels (TSK) approaches have been developed. In this paper, we deal with TSK for two source-receive arrays in an acoustic waveguide for shallow water tomography. As a first step, we show that separation of the different raypaths is improved by using a recently proposed new array processing [time-delay double beamforming (DBF) algorithm]. DBF consists of changing the 3-D data space from source depth, receiver depth and time into a new 3-D space related to ray propagation expressed by the beamformed variables, source angle, receive angle and time. As a consequence, each eigenray of the multipath propagation for a source-receiver couple can be identified and separated through DBF. In this context of DBF, the TSK is no longer point-to-point as usual, but relies on all source-receiver time series. Kernels are computed using the fact that the processed signal is a linear combination of time-delayed signals between all sources and receivers. Results in simulated data and in real datasets recorded in an ultrasonic tank prove that combination of TSK and DBF increases the resolution and robustness performance of shallow-water acoustic tomography.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/05/2009
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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