Philippe JEAN-PIERRE

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 12/05/2008
• Auteurs : Erwann PoupartGuillaume JollyChristian PerceboisPierre BazexPhilippe PalanqueSandra BasnyatPatrice RabaultLaurent SabatierAurélia Walrawens
• Organismes : Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse] Modèles, Architectures, Composants, Agilité et prOcessus Modèles, Architectures, Composants, Agilité et prOcessus Interactive Critical Systems Interactive Critical Systems SODIFRANCE SODIFRANCE SODIFRANCE

---

Résumé : In this paper, we present a CNES participation through a case study in a research project called DOMINO financed by the French National Research Agency (ANtI) RNTL. This project has started in march 2007 and will end in march 2009, it regroups academics (ENSIETA, IRISA and IR1T), industries and agencies (AIRBUS, CEA, CNES and SODIFRANCE). This project has two main goals: to develop reliable Model Driven Engineering (MDE) components and to build bridges with Domain Specific Languages (DSL). CNES participates in this project through a case study on the reliable design of operational procedures and associated applications. There are two main objectives for this case study: the first is to improve "offline" interoperabiity with the possibility to build import/export tools for any scripting procedure language using meta-modeling technology. The second is to improve efficiency for the production, validation and execution of scripting procedures using operational specifications. It is anticipated that this will result in a reduction of costs and reliability improvement.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 11/05/2008
• Auteurs : Jean Pierre PloteauPatrick GlouannecHervé NoelPhilippe ChauvelonJ.F. Feller
• Organismes : Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 06/05/2008
• Auteurs : F. LoixPierre BadelLaurent OrgéasChristian GeindreauP. BoisseJean-Francis Bloch
• Organismes : Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] Laboratoire sols, solides, structures - risques [Grenoble] Mécanique et Couplages Multiphysiques des Milieux Hétérogènes Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] Mécanique et Couplages Multiphysiques des Milieux Hétérogènes Laboratoire sols, solides, structures - risques [Grenoble]
• Publié dans International Journal of Material Forming le 30/10/2020

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/05/2008
• Auteurs : Olivier ZembJean-Philippe DelgenèsPhilippe LebaronJean-Jacques Godon
• Organismes : Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire d'océanographie biologique de Banyuls Laboratoire de Biotechnologie de l'Environnement [Narbonne]

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Christophe ChiquetPierre-Loic CornutYvonne BenitoGilles ThuretMax MaurinPierre-Olivier LafontaineAndre PechinotKarine PalombiGerard LinaAlain BronPhilippe DenisAnne CarricajoCatherine Creuzot-GarcherJean-Paul RomanetFrancois VandeneschFrench Institutional Endophtalmitis Study Group (friends)
• Organismes : Department of Ophtalmology Department of Ophtalmology Immunité infection vaccination Laboratoire de Bactériologie Department of Ophtalmology Department of Microbiology Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Service d'Ophtalmologie (CHU de Dijon) Laboratoire de bactériologie (CHU Dijon) Department of Ophtalmology Immunité infection vaccination Laboratoire de Bactériologie Service d'Ophtalmologie (CHU de Dijon) Department of Ophtalmology Department of Microbiology Service d'Ophtalmologie (CHU de Dijon) Department of Ophtalmology Immunité infection vaccination Laboratoire de Bactériologie
• Publié dans Investigative Ophthalmology & Visual Science le 31/10/2020

---

Résumé : PURPOSE: To evaluate eubacterial PCR compared with conventional cultures for detection and identification of bacterial agents in ocular samples from patients with acute postcataract endophthalmitis. METHODS: Broad-range eubacterial PCR amplification was used, followed by direct DNA sequencing in ocular samples (aqueous humor, vitreous samples from tap or vitrectomy) from 100 consecutive patients presenting with acute postcataract endophthalmitis. Bacterial cultures were performed on the same ocular samples by using traditional methods (brain-heart infusion broth). RESULTS: At the time of admission, the detection rate was not significantly different between cultures and PCR (38.2% for cultures versus 34.6% for PCR in aqueous humor samples; 54% versus 57% in vitreous from a vitreous tap). In contrast, in the vitreous obtained from vitrectomy, after intravitreous injection of antibiotics, PCR detected bacteria in 70% of the cases, compared with 9% in cultures. By combining PCR and cultures, bacterial identification was obtained in 47% of aqueous humor samples at admission, in 68% of vitreous samples from a vitreous tap at admission, and in 72% of vitreous samples from pars plana vitrectomy. Gram-positive bacteria predominated (94.3%). The concordance between cultures and PCR was 100%. The contamination rate was 2%. CONCLUSIONS: Cultures and eubacterial PCR are complementary techniques for bacterial identification in eyes with acute postcataract endophthalmitis. PCR technique was needed for identification of the involved microbial pathogen in 25% of all the cases. Eubacterial PCR is more effective than cultures in detecting bacteria in vitreous samples from patients with previous intravitreous administration of antibiotics.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Dany GaillardFabienne LaugeretteNicolas DarcelAbdelghani El-YassimiPatricia Passilly-DegraceAziz HichamiNaim Akhtar KhanJean-Pierre MontmayeurPhilippe Besnard
• Organismes : Lipides - Nutrition - Cancer (U866) Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer Institut de biologie et chimie des protéines [Lyon] Centre des Sciences du Goût Centre des Sciences du Goût Physiologie de la Nutrition et du Comportement Alimentaire Lipides et signalisation cellulaire Lipides - Nutrition - Cancer (U866) Centre des Sciences du Goût Lipides et signalisation cellulaire Centre des Sciences du Goût Lipides - Nutrition - Cancer (U866)
• Publié dans FASEB Journal le 25/10/2020

---

Résumé : The sense of taste informs the body about the quality of ingested foods. Tastant-mediated signals are generated by a rise in free intracellular calcium levels ([Ca(2+)]i) in the taste bud cells and then are transferred to the gustatory area of brain via connections between the gustatory nerves (chorda tympani and glossopharyngeal nerves) and the nucleus of solitary tract in the brain stem. We have recently shown that lingual CD36 contributes to fat preference and early digestive secretions in the mouse. We show here that 1) the induction of an increase in [Ca(2+)]i by linoleic acid is CD36-dependent in taste receptor cells, 2) the spontaneous preference for or conversely conditioned aversion to linoleic acid requires intact gustatory nerves, and 3) the activation of gustatory neurons in the nucleus of the solitary tract elicited by a linoleic acid deposition on the tongue in wild-type mice cannot be reproduced in CD36-null animals. We conclude that the CD36-mediated perception of long-chain fatty acids involves the gustatory pathway, suggesting that the mouse may have a "taste" for fatty foods. This system would constitute a potential physiological advantage under conditions of food scarcity by leading the mouse to select and absorb fatty foods. However, it might also lead to a risk of obesity and associated diseases in a context of constantly abundant food.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Marie-Christine C PicotAudrey JaussentPhilippe KahaneArielle CrespelPhilippe GélisseEdouard HirschPhilippe DerambureSimon DupontElisabeth LandréFrancine ChassouxLuc ValtonJean Pierre VignalChristian MarchalAline RougierClément LamyFrançois SemahArnaud BirabenAlexis ArzimanoglouJérome PetitPhilippe ThomasDorine NeveuPhilippe Ryvlin
• Organismes : Unité de biostatistiques et épidémiologie Unité de biostatistiques et épidémiologie Grenoble Institut des Neurosciences Service de neurophysiopathologie de l'épilepsie Service d'explorations neurologiques et épileptologie Service d'explorations neurologiques et épileptologie Service de Neurologie [Strasbourg] Service de neurophysiologie clinique CHU Pitié-Salpêtrière [AP-HP] Service de neuro-chirurgie Service de neuro-chirurgie Département Neurologie [CHU Toulouse] Service de neurologie [CHRU Nancy] Service de neurologie Service de neurochirurgie CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Rennes] Service de neurologie pédiatrique et maladies métaboliques Service de neurologie Service de neurologie Unité de biostatistiques et épidémiologie Unité de Neurologie Fonctionnelle et d'Épileptologie
• Publié dans Neurochirurgie le 22/10/2020

---

Résumé : PURPOSE: To compare resective surgery and medical therapy in a cost-effectiveness analysis in a multicenter cohort of adult patients with partial intractable epilepsy. POPULATION AND METHODS: Adult patients with partial, medically intractable, potentially operable epilepsy were eligible and followed every year over five years. Effectiveness was defined as one year without seizure. The long-term costs and effectiveness were extrapolated over the patients' lifetime with a Markov model. Productivity (indirect costs) and quality of life (QOLIE-31, SEALS) were also assessed. Changes before and after surgery were compared between the two groups. RESULTS: Two hundred and eighty-nine patients were included (119 with surgery, 161 medically treated, six not eligible, three lost to follow-up). One year after surgery, 81% of the patients were seizure-free; at two and three years, this rate was 78%. In the medical group, these rates were 10, 18, and 15%, respectively. The cost of the explorations was euro 8464; including surgery, it was euro 19,700. In the medical group, the average annual direct costs were between 3500 and euro 6000. At two years after surgery, the annual direct cost decreased to euro 2768, at three years, it was euro 1233, predominately antiepileptic drug costs. Surgery became cost-effective between seven and eight years. In the surgical group, all the quality-of-life scores improved at one year after surgery and were stable during the second and third years. CONCLUSION: Surgical therapy was cost-effective at the middle term even though indirect costs were not considered.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Philippe DeschampsDelphine GuillebeaultJimi DevassineDavid DauvilleeSophie HaebelMartin SteupAlain BuléonJean-Luc PutauxMarie-Christine SlomiannyChristophe ColleoniAline DevinCharlotte PlanckeStanislas TomavoEvelyne DerelleHervé MoreauSteven Ball
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Laboratoire d'océanographie biologique de Banyuls Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Center of Mass Spectrometry of Biopolymers and Plant Physiology Plant Physiology, Institute of Biochemistry and Biology Institut National de la Recherche Agronomique, Centre de Recherches Agroalimentaires Centre de Recherches sur les Macromolécules Végétales Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Laboratoire d'océanographie biologique de Banyuls Laboratoire d'océanographie biologique de Banyuls Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans Eukaryotic Cell le 30/10/2020

---

Résumé : The nature of the cytoplasmic pathway of starch biosynthesis was investigated in the model heterotrophic dinoflagellate Crypthecodinium cohnii. The storage polysaccharide granules were shown to be composed of both amylose and amylopectin fractions with a chain length distribution and crystalline organization very similar to those of green algae and land plant starch. Preliminary characterization of the starch pathway demonstrated that C. cohnii contains multiple forms of soluble starch synthases and one major 110-kDa granule-bound starch synthase. All purified enzymes displayed a marked substrate preference for UDP-glucose. At variance with most other microorganisms, the accumulation of starch in the dinoflagellate occurs during early and mid-log phase, with little or no synthesis witnessed when approaching stationary phase. In order to establish a genetic system allowing the study of cytoplasmic starch metabolism in eukaryotes, we describe the isolation of marker mutations and the successful selection of random recombinant populations after homothallic crosses.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Anne Louchet-ChauvetYann Le DuFabien BretenakerThierry ChanelièreFabienne GoldfarbIvan LorgeréJean-Louis Le GouëtOlivier Guillot-NoëlPhilippe Goldner
• Organismes : Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire Aimé Cotton Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI) Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI)
• Publié dans Physical Review B: Condensed Matter and Materials Physics (1998-2015) le 02/11/2020

---

Résumé : A thulium-doped crystal is experimentally shown to be an excellent candidate for broadband quantum storage in a solid-state medium. For the first time, nuclear spin coherence is optically excited, detected and characterized in such a crystal. The lifetime of the spin coherence -- the potential storage entity -- is measured by means of Raman echo to be about 300~$\mu$s over a wide range of ground state splittings. This flexibility, attractive for broadband operation, and well fitted to existing quantum sources, results from the simple hyperfine structure, contrasting with Pr- and Eu- doped crystals.

---

Fichiers liés : PRB77-195110louchet_Raman echo.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2008
• Auteurs : Marianne ZellerClaudia KorandjiJean-Claude GuillandPierre SicardCatherine VergelyLuc LorgisJean-Claude BeerLaurence DuvillardAnne-Cécile LagrostDaniel MoreauPhilippe GambertYves CottinLuc Rochette
• Organismes : Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5) Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5) Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5) Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5) Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon]
• Publié dans Arteriosclerosis, Thrombosis, and Vascular Biology le 27/10/2020

---

Résumé : Objective-Asymmetrical dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthases. From a prospective cohort of patients with acute myocardial infarction (MI), we aimed to analyze the predictive value of circulating ADMA concentrations on prognosis. Methods and Results-Blood samples from 249 consecutive patients hospitalized for acute MI Ͻ24 hours were taken on admission. Serum levels of ADMA and its stereoisomer, symmetrical dimethylarginine (SDMA), were determined using high-performance liquid chromatography. The independent predictors of ADMA were glomerular filtration rate, female sex, and SDMA (R 2 ϭ0. 25). Baseline ADMA levels were higher in patients who had died than in patients who were alive at 1 year follow-up (1.23 [0.98 to 1.56] versus 0.95 [0.77 to 1.20] mol/L, PϽ0.001). By Cox multivariate analysis, the higher tertile of ADMA (median [interquartile range]: 1.45 [1.24 to 1.70] mol/L) was a predictor for mortality (Hazard Ratio [95% CI], 4.83 [1.59 to 14.71]), when compared to lower tertiles, even when adjusted for potential confounders, such as acute therapy, biological, and clinical factors. Conclusion-Our study suggests that the baseline ADMA level has a strong prognostic value for mortality after MI, beyond traditional risk factors and biomarkers.

---

Source