Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Pierre MahéJean-Philippe Vert
• Organismes : Xerox Research Centre Europe [Meylan] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Centre de Bioinformatique
• Publié dans Combinatorial Chemistry and High Throughput Screening le 30/10/2020

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Résumé : Support vector machines and kernel methods have recently gained considerable attention in chemoinformatics. They offer generally good performance for problems of supervised classification or regression, and provide a flexible and computationally efficient framework to include relevant information and prior knowledge about the data and problems to be handled. In particular, with kernel methods molecules do not need to be represented and stored explicitly as vectors or fingerprints, but only to be compared to each other through a comparison function technically called a kernel. While classical kernels can be used to compare vector or fingerprint representations of molecules, completely new kernels were developed in the recent years to directly compare the 2D or 3D structures of molecules, without the need for an explicit vectorization step through the extraction of molecular descriptors. While still in their infancy, these approaches have already demonstrated their relevance on several toxicity prediction and structure-activity relationship problems.

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Fichiers liés : surveySVMvirtualscreening.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Olivier LeroyJean-Pierre GangneuxPhilippe MontraversJean-Paul MiraFrançois GouinJean-Pierre SolletJean CarletJacques ReynesMichel RosenheimBernard RegnierOlivier LortholaryNon Renseigné
• Organismes : Service de Réanimation Médicale et des Maladies Infectieuses Signalisation et Réponses aux Agents Infectieux et Chimiques Régulations des équilibres fonctionnels du foie normal et pathologique Département anesthésie-réanimation chirurgicale Institut Cochin Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Universitaire de Nantes = Nantes University Hospital service de réanimation polyvalente Réanimation Médico-Chirurgicale Centre d'infectiologie Necker-Pasteur [CHU Necker] Mycologie moléculaire
• Publié dans Critical Care Medicine le 31/10/2020

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Résumé : OBJECTIVE: To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs). DESIGN: Prospective, observational, national, multicenter study. SETTING: One hundred eighty ICUs in France. PATIENTS: Between October 2005 and May 2006, 300 adult patients with proven invasive Candida infection who received systemic antifungal therapy were included. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: One hundred seven patients (39.5%) with isolated candidemia, 87 (32.1%) with invasive candidiasis without documented candidemia, and 77 (28.4%) with invasive candidiasis and candidemia were eligible. In 37% of the cases, candidemia occurred within the first 5 days after ICU admission. C. albicans accounted for 57.0% of the isolates, followed by C. glabrata (16.7%), C. parapsilosis (7.5%), C. krusei (5.2%), and C. tropicalis (4.9%). In 17.1% of the isolates, the causative Candida was less susceptible or resistant to fluconazole. Fluconazole was the empirical treatment most commonly introduced (65.7%), followed by caspofungin (18.1%), voriconazole (5.5%), and amphotericin B (3.7%). After identification of the causative species and susceptibility testing results, treatment was modified in 86 patients (31.7%). The case fatality ratio in ICU was 45.9% and did not differ significantly according to the type of episode. Multivariate analysis showed that factors independently associated with death in ICU were type 1 diabetes mellitus (odds ratio [OR] 4.51; 95% confidence interval [CI] 1.72-11.79; p = 0.002), immunosuppression (OR 2.63; 95% CI 1.35-5.11; p = 0.0045), mechanical ventilation (OR 2.54; 95% CI 1.33-4.82; p = 0.0045), and body temperature >38.2 degrees C (reference, 36.5-38.2 degrees C; OR 0.36; 95% CI 0.17-0.77; p = 0.008). CONCLUSIONS: More than two thirds of patients with invasive candidiasis in ICU present with candidemia. Non-albicans Candida species reach almost half of the Candida isolates. Reduced susceptibility to fluconazole is observed in 17.1% of Candida isolates. Mortality of invasive candidiasis in ICU remains high.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Mathilde BenhamouNathalie RinchevalCarine RoyViolaine FoltzSylvie RozenbergJean SibiliaThierry SchaeverbekePierre BourgeoisPhilippe H. RavaudBruno Fautrel
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Centre de coordination Département d'épidémiologie, biostatistique et recherche clinique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Physiopathologie des arthrites Service de rhumatologie CHU Pitié-Salpêtrière [AP-HP] Département d'épidémiologie, biostatistique et recherche clinique CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Journal of Rheumatology le 25/10/2020

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Résumé : OBJECTIVE: To compare rheumatologists' prescription for first disease modifying antirheumatic drug (DMARD) in early rheumatoid arthritis (RA) in real-life settings with 2 clinical practice guidelines (CPG), the French Society of Rheumatology/STPR 2004 and EULAR/ESCISIT 2007, and thus assess the gap between practices and guidelines. Method. ESPOIR was a French multicenter cohort study of 813 patients with early arthritis between 2002 and 2005. "Definite" and "probable" RA were defined according to ACR criteria and the level of diagnostic certainty. The objectives were to assess conformity between the observed first-line DMARD prescribed for those patients and the DMARD recommended in the guidelines; and to conduct a mail survey of patients' usual rheumatologists to investigate the reasons for their nonconformity with guidelines. RESULTS: In total 627 patients with definite or probable RA were identified. Conformity rates were 58% for STPR guidelines and 54% for EULAR guidelines. At 6 months, 83 (34%) patients with early RA did not receive any DMARD. Main determinants associated with conformity to guidelines were disease activity and presence of severity-predictive factors. The main reason leading to a discrepancy between guidelines and daily practice appeared to be diagnostic uncertainty, i.e., the difficulty to reliably assess RA diagnosis as early as the first visits to the rheumatologist. CONCLUSION: There is a substantial gap between CPG and rheumatologists' daily practice concerning the first DMARD to prescribe in early RA. This is explained mainly by diagnostic uncertainty. More attention should be paid in future guidelines to the diagnostic difficulties of early RA.

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Fichiers liés : inserm-00380632_edited.pdf 081024-article_ESPOIR.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Thomas FalguièresPierre-Philippe LuyetJean Gruenberg
• Organismes : Université de Genève = University of Geneva Université de Genève = University of Geneva Université de Genève = University of Geneva
• Publié dans Experimental Cell Research le 25/10/2020

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Résumé : Along the degradation pathway, endosomes exhibit a characteristic multivesicular organization, resulting from the budding of vesicles into the endosomal lumen. After endocytosis and transport to early endosomes, activated signaling receptors are incorporated into these intralumenal vesicles through the action of the ESCRT machinery, a process that contributes to terminate signaling. Then, the vesicles and their protein cargo are further transported towards lysosomes for degradation. Evidence also shows that intralumenal vesicles can undergo "back-fusion" with the late endosome limiting membrane, a route exploited by some pathogens and presumably followed by proteins and lipids that need to be recycled from within the endosomal lumen. This process depends on the late endosomal lipid lysobisphosphatidic acid and its putative effector Alix/AIP1, and is presumably coupled to the invagination of the endosomal limiting membrane at the molecular level via ESCRT proteins. In this review, we discuss the intra-endosomal transport routes in mammalian cells, and in particular the different mechanisms involved in membrane invagination, vesicle formation and fusion in a space inaccessible to proteins known to control intracellular membrane traffic.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Sylvain RaffaeleEmmanuelle Maria BayerDavid LafargeStéphanie CluzetSylvie German-RetanaTamy BoubekeurNathalie Leborgne-CastelJean-Pierre CardeJeannine LherminierElodie NoirotSatiat-Jeunemaitre BéatriceJeanny Laroche-TraineauPatrick MoreauThomas OttAndrew J MaulePhilippe ReymondFrançoise Simon-PlasEdward E FarmerJean-Jacques BessouleSébastien Mongrand
• Organismes : Processus d'Action des Enseignants : Déterminants et Impacts Laboratoire Traitement et Communication de l'Information Plante - microbe - environnement : biochimie, biologie cellulaire et écologie Plante - microbe - environnement : biochimie, biologie cellulaire et écologie Institut des sciences du végétal Laboratoire de biogenèse membranaire Laboratoire des interactions plantes micro-organismes Laboratoire de biogenèse membranaire Laboratoire de biogenèse membranaire
• Publié dans The Plant cell le 27/10/2020

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Résumé : Remorins (REMs) are proteins of unknown function specific to vascular plants. We have used imaging and biochemical approaches and in situ labeling to demonstrate that REM clusters at plasmodesmata and in approximately 70-nm membrane domains, similar to lipid rafts, in the cytosolic leaflet of the plasma membrane. From a manipulation of REM levels in transgenic tomato (Solanum lycopersicum) plants, we show that Potato virus X (PVX) movement is inversely related to REM accumulation. We show that REM can interact physically with the movement protein TRIPLE GENE BLOCK PROTEIN1 from PVX. Based on the localization of REM and its impact on virus macromolecular trafficking, we discuss the potential for lipid rafts to act as functional components in plasmodesmata and the plasma membrane.

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Fichiers liés : publi09-lipm-001_rafaelle_remorin_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Guilhem ArrachartGaëlle CreffHubert WadepohlChristophe BlancChristian BonhommeFlorence BabonneauBruno AlonsoJean-Louis BantigniesCarole CarcelJoël  j. E. MoreauPhilippe Dieudonné-GeorgeJean-Louis SauvajolDominique MassiotMichel Wong Chi Man
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Australian Nuclear Science and Technology Organisation [Australie] Laboratoire des colloïdes, verres et nanomatériaux Anorganisch-Chemisches Institut der Universität Heidelberg Laboratoire des colloïdes, verres et nanomatériaux Laboratoire de Chimie de la Matière Condensée de Paris Laboratoire de Chimie de la Matière Condensée de Paris Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Laboratoire des colloïdes, verres et nanomatériaux Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Laboratoire des colloïdes, verres et nanomatériaux Laboratoire des colloïdes, verres et nanomatériaux Conditions Extrêmes et Matériaux : Haute Température et Irradiation Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
• Publié dans Chemistry - A European Journal le 29/10/2020

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Résumé : The hydrolysis and condensation of a silylated derivative of ureidopyrimidinone led to nanostructured hybrid silica, such as that depicted, as clearly shown by powder XRD studies. The nanostructuring was directly related to molecular recognition through hydrogen bonding. By combining FTIR, solution and solid-state NMR spectroscopic data, the transcription of the hydrogen-bonding networks from the precursor to the final product was clearly evidenced.

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• Type de publi. : Autre publication
• Date de publi. : 01/05/2009
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Amalia TroussonSophie BernardPatrice X PetitPhilippe LiereAntoine PianosKhadija El HadriJean-Marc A. LobaccaroM. Said GhandourMichel RaymondjeanMichael SchumacherCharbel Massaad
• Organismes : Régulation de la transcription et maladies génétiques Régulation de la transcription et maladies génétiques Service de radiologie pédiatrique Institut de biologie et chimie des protéines [Lyon] Laboratoire Astrophysique de Toulouse-Tarbes Stéroides et système nerveux : physiopathologie moléculaire et clinique Stéroides et système nerveux : physiopathologie moléculaire et clinique Vieillissement Cellulaire Intégré et Inflammation Génétique, Reproduction et Développement Physiologie et physiopathologie Stéroïdes et système nerveux : physiopathologie moléculaire et clinique Faculté de Médecine Paris-Sud Régulation de la transcription et maladies génétiques
• Publié dans Journal of Neurochemistry le 25/10/2020

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Résumé : In several neurodegenerative diseases of the CNS, oligodendrocytes are implicated in an inflammatory process associated with altered levels of oxysterols and inflammatory enzymes such as secreted phospholipase A2 (sPLA2). In view of the scarce literature related to this topic, we investigated oxysterol effects on these myelinating glial cells. Natural oxysterol 25-hydroxycholesterol (25-OH; 1 and 10 muM) altered oligodendrocyte cell line (158N) morphology and triggered apoptosis (75% of apoptosis after 72 h). These effects were mimicked by 22(S)-OH (1 and 10 muM) which does not activate liver X receptor (LXR) but not by a synthetic LXR ligand (T0901317). Therefore, oxysterol-induced apoptosis appears to be independent of LXR. Interestingly, sPLA2 type IIA (sPLA2-IIA) over-expression partially rescued 158N cells from oxysterol-induced apoptosis. In fact, 25-OH, 24(S)-OH, and T0901317 stimulated sPLA2-IIA promoter and sPLA2 activity in oligodendrocyte cell line. Accordingly, administration of T0901317 to mice enhanced sPLA2 activity in brain extracts by twofold. Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 muM) and by LXR beta at basal oxysterol concentration. Finally, GC coupled to mass spectrometry established that oligodendrocytes contain oxysterols and express their biosynthetic enzymes, suggesting that they may act through autocrine/paracrine mechanism. Our results show the diversity of oxysterol signalling in the CNS and highlight the positive effects of the LXR/PXR pathway which may open new perspectives in the treatment of demyelinating and neurodegenerative diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2009
• Auteurs : Amélie Carbonnelle-PuscianChristiane Copie-BergmanMaryse BaiaNadine Martin-GarciaYves AlloryCorinne HaiounAnne CrémadesIssam Abd-AlsamadJean-Pierre FarcetPhilippe GaulardFlavia CastellanoValérie Molinier-Frenkel
• Organismes : Département de pathologie [Mondor] Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Service d'hématologie clinique Institut Mondor de Recherche Biomédicale Service d'Anatomo-Pathologie Institut Mondor de Recherche Biomédicale Service d'immunologie biologique Département de pathologie [Mondor] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Service d'immunologie biologique Institut Mondor de Recherche Biomédicale Service d'immunologie biologique
• Publié dans Leukemia le 25/10/2020

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Résumé : We previously reported a strong IL4I1 gene expression in primary mediastinal B-cell lymphoma (PMBL) and recently identified the protein as a secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, which inhibits T-cell proliferation in vitro. Here, we analyzed the pattern of IL4I1 protein expression in 315 human lymphoid and non-lymphoid malignancies. Besides PMBL, IL4I1 expression in tumors was very frequent. IL4I1 was detected in tumor-associated macrophages from most of the tumors and in neoplastic cells from follicular lymphoma, classic and nodular lymphocyte predominant Hodgkin lymphomas and small lymphocytic lymphoma, three of which are germinal center derived. IL4I1-positive tumor cells were also detected in rare cases of solid cancers, mainly mesothelioma. The enzymatic activity paralleled protein expression, suggesting that IL4I1 is functional in vivo. Depending on the tumor type, IL4I1 may impact on different infiltrating lymphocyte populations with consequences on tumor evolution. In the particular case of follicular lymphoma cells, which are susceptible to antitumor cytotoxic T cells killing but depend on interactions with local T helper cells for survival, a high level of IL4I1 expression seems associated with the absence of bone marrow involvement and a better outcome. These findings plead for an evaluation of IL4I1 as a prognosis factor.

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Fichiers liés : inserm-00392067_edited.pdf Equipe09_LeukemiaHAL.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 27/04/2009
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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