Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Jérôme HonnoratStéphanie Cartalat-CarelDamien RicardJean-Philippe CamdessanchéAntoine F. CarpentierVéronique RogemondFrançois ChapuisMichèle AgueraEvelyne DecullierAnne-Marie DucheminFrancesc GrausJean-Christophe Antoine
• Organismes : Équipe Neuro-oncologie et Neuro-inflammation - Neuro-Oncology and Neuro-Inflammation Team Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" Service de neurologie [Paris] Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" Service de Neurologie [CHU de Saint-Étienne] CHU Pitié-Salpêtrière [AP-HP] Équipe Neuro-oncologie et Neuro-inflammation - Neuro-Oncology and Neuro-Inflammation Team Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" Service de soins palliatifs Équipe Neuro-oncologie et Neuro-inflammation - Neuro-Oncology and Neuro-Inflammation Team Service de soins palliatifs Department of Psychiatry Service of Neurology Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques" Service de Neurologie [CHU de Saint-Étienne]
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : OBJECTIVE: Anti-Hu antibodies (Hu-Ab) and anti-CV2/CRMP5 antibodies (CV2/CRMP5-Ab) have been identified in association with paraneoplastic neurological disorders. However, it is not clear whether these antibodies are associated with specific neurological symptoms or are only markers of anti-cancer immune reaction. METHODS: To address this question, 37 patients with CV2/CRMP5-Ab and 324 patients with Hu-Ab were compared. RESULTS: Whereas the age and sex ratio were the same between the two groups, the distribution of neurological symptoms was not. Patients with CV2/CRMP5-Ab presented more frequently cerebellar ataxia, chorea, uveo/retinal symptoms and myasthenic syndrome (Lambert-Eaton myasthenic syndrome LEMS or myasthenia gravis). They also had a better Rankin score. In contrast, dysautonomia, brainstem encephalitis and peripheral neuropathy were more frequent in patients with Hu-Ab. Limbic encephalitis occurred similarly in both groups. Small-cell lung cancer was the most frequently associated tumour in both groups of patients, while malignant thymoma was observed only in patients with CV2/CRMP5-Ab. In particular, patients with CV2/CRMP5-Ab and thymoma developed myasthenic syndrome more frequently, while patients with SCLC developed neuropathies more frequently. Chorea and myasthenic syndrome were only seen in patients with CV2/CRMP5-Ab. The median survival time was significantly longer in patients with CV2/CRMP5-Ab, and this effect was not dependent on the type of tumour. Interpretation: The data demonstrate that in patients with paraneoplastic neurological syndromes, the neurological symptoms and survival vary with both the type of associated onco-neural antibody and the type of tumour.

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Fichiers liés : Honnorat_et_al_.pdf inserm-00321230_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Jean-Philippe EmpanaYves DauvilliersJean-François DartiguesKaren RitchieJerome GariepyXavier JouvenChristophe TzourioPhilippe AmouyelAlain BessetPierre Ducimetiere
• Organismes : AVENIR Team 'Epidemiology of sudden cardiac death'
• Publié dans Stroke le 31/10/2020

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Résumé : Background and Purpose— Excessive daytime sleepiness, one of the most frequent sleep complaints in the elderly, may affect survival, but inconsistent results have been observed in that population so far. We therefore estimated the risk of mortality for excessive daytime sleepiness (EDS) in community-dwelling elderly participating in the Three City Study. Methods— The Three City Study is a French population-based multicenter prospective study including 9294 subjects (60% women) aged ≥65 years at recruitment between 1999 to 2001. At baseline, 8269 subjects rated EDS and nocturnal sleep complaints as never, rare, regular, and frequent in response to an administered questionnaire and provided information on medication use for sleep or anxiety. Hazard ratios (HR) of EDS (regular or frequent) for mortality over 6 years were estimated by a Cox proportional hazard model. Results— At baseline, 18.7% of the study participants had regular or frequent EDS. After 6 years of follow-up, 762 subjects had died including 260 from cancer and 196 from cardiovascular disease. EDS was associated with a significant 33% increased risk of mortality (95% CI: 1.13 to 1.61) after adjustment for age, gender, study center, body mass index, previous cardiovascular disease, Mini Mental State Examination score, and cardiovascular risk factors. Further adjustment for current use of medication for sleep and for depressive symptoms slightly diminished the HRs. EDS was equally predictive of mortality in those who snored loudly and in those who did not. EDS was related to cardiovascular mortality but not to mortality attributable to cancer. Conclusion— EDS might be independently associated with total and cardiovascular mortality in community-dwelling elderly.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Elvire BourgeoisLinh Pham VanMichel SamsonSéverine DiemAnne BarraStéphane RogaJean-Marc GombertElke SchneiderMichel DyPierre GourdyJean-Philippe GirardAndré Herbelin
• Organismes : Cytokines, hématopoïèse et réponse immune Cytokines, hématopoïèse et réponse immune Signalisation et Réponses aux Agents Infectieux et Chimiques Détoxication et réparation tissulaire Cytokines, hématopoïèse et réponse immune Laboratoire d'immunologie [CHU de Poitiers] Institut de pharmacologie et de biologie structurale Laboratoire d'immunologie [CHU de Poitiers] Cytokines, hématopoïèse et réponse immune Cytokines, hématopoïèse et réponse immune Institut de médecine moléculaire de Rangueil Institut de pharmacologie et de biologie structurale Cytokines, hématopoïèse et réponse immune Université Paris Descartes - Paris 5
• Publié dans European Journal of Immunology le 22/10/2020

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Résumé : IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, given that purified iNKT cells express the T1/ST2 receptor constitutively and respond to IL-33 by in vitro expansion and functional activation. Conversely to the expected pro-Th2 effect, IL-33 induced a preferential increase in IFN-gamma rather than IL-4 production upon TCR engagement that depended on endogenous IL-12. Moreover, in combination with the pro-inflammatory cytokine IL-12, IL-33 enhanced IFN-gamma production by both iNKT and NK cells. Taken together these data support the conclusion that IL-33 can contribute as a co-stimulatory factor to innate cellular immune responses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Philippe MadelineJean-Marc Moriceau
• Organismes : Espaces et Sociétés Centre de recherche d'histoire quantitative
• Publié dans L'Histoire le 28/10/2020

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Résumé : Pierre Lebugle, petit paysan de Normandie, a tenu de 1942 à 1971 un carnet où se mêlent comptes domestiques et propos intimes. L'histoire rurale prend grâce à lui un nouveu relief.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : David RudraufJean-Philippe LachauxAntonio DamasioSylvain BailletLaurent HuguevilleJacques MartinerieHanna DamasioBernard Renault
• Organismes : Neurosciences cognitives et imagerie cérébrale Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Brain and Creativity Institute and Dornsife Cognitive Neuroimaging Center Laboratoire de neurosciences cognitives et d'imagerie cérébrale Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans International Journal of Psychophysiology le 31/10/2020

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Résumé : In a MEG experiment, we imaged the early dynamics of the human cerebral cortex during the induction of emotion by visual stimuli. We tested the hypothesis that early cortical responses would correlate with the emotional competence of visual stimuli and subsequent subjective ratings of feeling in a set of specific target regions important for somatosensory, attentional, and motivational functions, just after initial visual and appraisal related cortical responses to picture presentation. Relative to the neutral condition, cortical responses, during the 350-500 ms phase of the MEG evoked response, were stronger for both pleasant and unpleasant stimuli in the orbitofrontal cortex, ventromedial prefrontal cortex, anterior cingulate and somatosensory cortices. These responses, which correlated with subjective ratings of arousal, emerged after an initial spreading of cortical activity from early visual cortex (70-200 ms) to the ventral visual stream, temporopolar and orbitofrontal regions (200-350 ms), higher for emotionally competent stimuli than for neutral in the 200-350 ms window, in a manner compatible with an appraisal function. Heart beats occurring during the first 500 ms post stimulus showed longer intervals for unpleasant than for neutral stimuli relative to the preceding beat. The results support the hypothesis of a sequence of processing regarding the emergence of feelings and suggest that, even in the early phase of feeling induction, actual body responses to the inducing stimuli could be represented in the brain.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/04/2009
• Auteurs : Groupe CiameIsabelle Augé-BlumMireille BayartMartine WahlGuy BenoitEric BenoitLaurent CauffriezPh. CharpentierAndré ChovinJoseph CiccotelliBlaise ConrardJean-Michel DranguetEric FaeDenis Genon-CatalotJean-Marc ThirietJoseph Weexsteen
• Organismes : CITI Centre of Innovation in Telecommunications and Integration of Service Systèmes Tolérants aux Fautes Laboratoire Electronique, Ondes et Signaux pour les Transports Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) Systèmes Tolérants aux Fautes Institut National de l'Environnement Industriel et des Risques Institut National de l'Environnement Industriel et des Risques Laboratoire de Conception et d'Intégration des Systèmes GIPSA - Signal et Automatique pour le Diagnostic et la Surveillance

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Résumé : L'évolution conjointe des capteurs, des actionneurs et des réseaux de terrain a conduit à la mise en place de systèmes d'automatisation à intelligence distribuée, pour lesquels la fonction communication a une place importante. Cet ouvrage souhaite apporter une aide aux concepteurs de ces systèmes commandés en réseaux en proposant une analyse approfondie de la fonction "communication" avec une vision "sûreté de fonctionnement" et/ou "sécurité". Les critères de sûreté de fonctionnement des principaux réseaux industriels (Profibus, Can, ASI, ...) sont présentés, ainsi que l'évolution vers les réseaux de sécurité et les réseaux sans fil. La problématique de la sécurité est présentée au travers différents domaines d'application (sécurité des machines, ferroviaire, domotique).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Laurent ZiniPaul PerrotteUmberto CapitanioClaudio JeldresAlain DuclosPhilippe ArjaneArnauld VillersFrancesco MontorsiJean-Jacques PatardPierre I. Karakiewicz
• Organismes : Service d'urologie Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Département d'urologie Department of urology Institut de Génétique et Développement de Rennes Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans BJU International le 28/10/2020

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Résumé : OBJECTIVES: To assess whether, in contemporary patients with renal cell carcinoma (RCC), access to nephrectomy is the same between the Blacks and Whites, and that there is no difference in mortality after stratification for treatment type. PATIENTS AND METHODS: The effect of race has received little attention in RCC; only two reports have addressed and suggested the presence of racial disparities, including access to nephrectomy and survival after nephrectomy, where Black patients were disadvantaged relative to Whites. We used the Surveillance, Epidemiology and End Results data from 12 516 patients of all stages diagnosed and treated for RCC between 2000 and 2004. The effect of race (Black vs White) on nephrectomy rate was addressed in logistic regression and binomial regression models, and Cox regression models tested the effect of race on overall survival. RESULTS: Black patients were 50% less likely to have a nephrectomy than their White counterparts. However, race had no effect on overall survival when the entire cohort was assessed, as well as in subgroups of patients with or without nephrectomy. CONCLUSIONS: Although race is a determinant of access to nephrectomy, it should not be interpreted as a barrier to care, as survival was unaffected by race in patients having a nephrectomy or not. Instead, race might represent a proxy of comorbidity and life-expectancy, which represent surgical selection criteria for nephrectomy.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/04/2009
• Auteurs : Philippe KeckhutAlain HauchecorneChantal ClaudB. FunatsuJaya Prakas RajuV. CharyuluMarion MarchandSlimane BekkiHassan BencherifJean-Marie Perrin
• Organismes : STRATO - LATMOS STRATO - LATMOS Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS STRATO - LATMOS Laboratoire de physique de l'atmosphère Observatoire de Haute-Provence

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Résumé : The long-term cooling of the middle atmosphere as well as the atmospheric response to solar activity, result to radiative forcing, ozone chemistry and many dynamical feedbacks. The long-term monitoring as well as process studies require both ground-based and satellite observations. Temperature lidar provide reliable data, and long enough data series to evaluate satellite information and the quality of the measurement continuity from space while satellites allow to estimate the representativeness and sampling effects associated with lidar series. Planetary waves (and associated stratospheric warming) and mesospheric inversions induce the largest variability in this domain. However, atmospheric tides are also an important issue for both long-term monitoring and vertical coupling processes. Tides are investigated with lidar in the frame of the CAWSES tidal campaigns that are compared with different models such as dynamical, CTM, and CCM and SABER satellite. Comparisons show good agreements with models on the vertical and temporal behavior with however some differences on waves amplitudes.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2009
• Auteurs : Laurent ZiniPaul PerrotteClaudio JeldresUmberto CapitanioAlain DuclosMartine Jolivet-TremblayPhilippe ArjaneFrançois PéloquinDaniel PharandArnauld VillersFrancesco MontorsiJean-Jacques PatardPierre I. Karakiewicz
• Organismes : Service d'urologie Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Service d'urologie Department of urology Institut de Génétique et Développement de Rennes Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans BJU International le 28/10/2020

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Résumé : OBJECTIVE: To examine population-based rates of cancer-specific and other-cause mortality after either non-surgical management (NSM) or nephrectomy, in patients with small renal masses, as several reports from selected institutions support the applicability of surveillance in patients with small renal masses, but there are no population-based studies confirming the general applicability of this therapy. PATIENTS AND METHODS: Of 43 143 patients with renal cell carcinoma identified in the 1988-2004 Surveillance, Epidemiology and End Results database, 10 291 had localized small renal masses (

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• Type de publi. : Article dans une revue
• Date de publi. : 28/03/2009
• Auteurs : David BrevetMagali Gary-BoboLaurence RaehmSébastien RicheterOuahiba HocineKassem AmroBernard LoockPierre CouleaudCéline FrochotAlain MorèrePhilippe MaillardMarcel GarciaJean-Olivier Durand
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut de recherche en cancérologie de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Conception, synthèse et vectorisation de biomolécules Département de Chimie Physique des Réactions Département de Chimie Physique des Réactions Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] Conception, synthèse et vectorisation de biomolécules Institut de recherche en cancérologie de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
• Publié dans Chemical Communications le 29/10/2020

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Résumé : Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.

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Fichiers liés : chemcommun-2009_Gary-Bobo_M_Co-Auteur.pdf

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