Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Mathilde Body-MalapelSébastien DharancyDominique BerrebiAlexandre LouvetJean-Pierre HugotDana J PhilpottMarco GiovanniniFabrice ChareyreGilles PagesEmilie GantierStephen E GirardinIrène GarciaSylvie HudaultFiloména ContiPhilippe J SansonettiMathias ChamaillardPierre DesreumauxLaurent DubuquoyPhilippe Mathurin
• Organismes : Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Service d'Anatomie et de Cytologie Pathologiques Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Inflammation intestinale pathologique de l'enfant Department of Immunology Génomique Fonctionnelle des Tumeurs Solides Génomique Fonctionnelle des Tumeurs Solides Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Department of Laboratory Medicine and Pathobiology Université de Genève = University of Geneva Pathogenes et Fonctions des Cellules Epitheliales Polarisees Laboratoire de Biologie Cellulaire Pathogénie Microbienne Moléculaire Collège de France - Chaire Microbiologie et Maladies infectieuses Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition
• Publié dans Laboratory Investigation le 27/10/2020

---

Résumé : The recent discovery of bacterial receptors such as NOD2 that contribute to crosstalk between innate and adaptive immune systems in the digestive tract constitutes an important challenge in our understanding of liver injury mechanisms. The present study focuses on NOD2 functions during liver injury. NOD2, TNF-alpha and IFN-gamma mRNA were quantified using real-time PCR in liver samples from patients and mice with liver injury. We evaluated the susceptibility of concanavalin A (ConA) challenge in NOD2-deficient mice (Nod2-/-) compared to wild-type littermates. We tested the effect of muramyl dipeptide (MDP), the specific activator of NOD2, on ConA-induced liver injury in C57BL/6 mice. We studied the cellular distribution and the role of NOD2 in immune cells and hepatocytes. We demonstrated that NOD2, TNF-alpha and IFN-gamma were upregulated during liver injury in mice and humans. Nod2-/- mice were resistant to ConA-induced hepatitis compared to their wild-type littermates, through reduced IFN-gamma production by immune cells. Conversely, administration of MDP exacerbated ConA-induced liver injury. MDP was a strong inducer of IFN-gamma in freshly isolated human PBMC, splenocytes and hepatocytes. Our study supports the hypothesis that NOD2 contributes to liver injury via a regulatory mechanism affecting immune cells infiltrating the liver and hepatocytes. Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Emilie DubuissonSabine SzuneritsJean-Pierre CairePhilippe LavieSarah Cordier
• Organismes : Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces PSA Peugeot-Citroen PSA Peugeot-Citroen
• Publié dans Journal of Applied Electrochemistry le 02/11/2020

---

Résumé : Electrochemical impedance spectroscopy in 500-1100 μu m large liquid droplets containing chloride and sulphate ions has been used to investigate the local corrosion rate of galvanised steel. The objective was the empirical modelling of the corrosion rate as a function of temperature, electrolyte thickness, and chloride and sulphate concentrations. The first experiments showed that the corrosion time was one of the critical parameters; it was then included in the investigation. An empirical numerical model was obtained for steel and galvanised steel. The statistical model highlighted the respective importance of the five parameters on atmospheric corrosion and gave qualitative results in accordance with the literature. The statistical study also suggested that the corrosion potential was easier to model than corrosion currents.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Benjamin TerrierArnaud JaccardJean-Luc HarousseauRichard DelarueOlivier TournilhacMathilde Hunault-BergerMohamed A. HamidouJacques DantalMarc BernardBernard GrosboisPierre MorelValérie CoiteuxOlivier GisserotPhilippe RodonArnaud HotCaroline ElieVéronique LeblondJean-Paul FermandFadi Fakhouri
• Organismes : Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service d'Hématologie biologique [CHU Limoges] Service d'immuno-hématologie pédiatrique [CHU Necker] Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] Immunointervention dans les allo et xénotransplantations Institut de transplantation et de recherche en transplantation Laboratoire Hubert Curien Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes] Laboratoire de physique des milieux ionisés et applications Service d'immunologie Service de néphrologie pédiatrique [CHU Necker]
• Publié dans Medicine le 28/10/2020

---

Résumé : Immunoglobulin M (IgM)-related amyloidosis remains a rare and little-known complication of monoclonal IgM-associated disorders. We sought to determine the clinical and laboratory presentation, response to treatment, and outcome of patients with IgM-related amyloidosis in the era of new therapeutic approaches. We conducted a retrospective study in 29 French centers to identify patients with monoclonal IgM and biopsy-proven amyloidosis; we reviewed patients' records and collected relevant clinical and laboratory data. We identified 72 patients with IgM-related amyloidosis. Systemic primary amyloidosis (AL) was present in 64, peritumoral AL in 5, and systemic secondary amyloidosis (AA) in 3 patients. A peculiar pattern of relatively frequent lymph node (31%) and lung (17%) involvement was noted in patients with systemic AL amyloidosis. Response to alkylating agents was poor, with a hematologic response in 37%, a complete remission in 0%, and an organ response in 21%. Response to hematopoietic stem cell transplantation showed a hematologic response in 100% with complete remission in 75% and an organ response in 75%. Purine analogs and rituximab induced a hematologic response in 73% and 60%, respectively, with complete remission in 9% and 0% and an organ response in 55% and 0%, respectively. In multivariate analysis, prognostic factors for survival were serum albumin level < or =3.5 g/dL (p = 0.018) and heart involvement (p = 0.0034). Further prospective studies are needed in patients with IgM-related amyloidosis, with special emphasis on treatment options: hematopoietic stem cell transplantation and purine analogs could represent the most effective therapies. The identification of adverse prognostic factors of survival could be useful for those managing and making treatment decisions for these patients.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Loretxu BergouignanCédric LemogneAurélie FoucherEstelle LonginDamien VistoliJean-François AllilairePhilippe Fossati
• Organismes : Vulnérabilité Adaptation et Psychopathologie Centre de Psychiatrie et Neurosciences Centre Hospitalier Universitaire de La Réunion Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
• Publié dans Behaviour Research and Therapy le 24/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 19/02/2008
• Auteurs : Alexis Le FaucheurPierre AbrahamVincent JaquinandiPhilippe BouyéJean Louis SaumetBénédicte Noury-Desvaux
• Organismes : Biologie Neurovasculaire Intégrée Biologie Neurovasculaire Intégrée Cabinet de médecine vasculaire Biologie Neurovasculaire Intégrée Activité Physique, Corps, Sport et Santé
• Publié dans Circulation le 29/10/2020

---

Résumé : Background— The maximal walking distance (MWD) performed on a treadmill test remains the “gold standard” in estimating the walking capacity of patients who have peripheral arterial disease with intermittent claudication, although treadmills are not accessible to most physicians. We hypothesized that global positioning system (GPS) recordings could monitor community-based outdoor walking and provide valid information on walking capacity in patients with peripheral arterial disease. Methods and Results— We studied 24 patients (6 women) with arterial claudication (median [25th to 75th percentile] values: 57 years old [48 to 67 years], 169 cm tall [164 to 172 cm], weight 81 kg [71 to 86 kg], and ankle-brachial index 0.64 [0.56 to 0.74]). MWD on the treadmill was 184 m (144 to 246 m), which was compared with the results of self-reported MWD, the distance score from the Walking Impairment Questionnaire, MWD observed during a 6-minute walking test, and MWD measured over a GPS-recorded unconstrained outdoor walk in a public park. Self-reported MWD, Walking Impairment Questionnaire distance score, 6-minute walking test score, and GPS-measured MWD were 300 m (163 to 500 m), 28% (15% to 47%), 405 m (338 to 441 m), and 609 m (283 to 1287 m), respectively. The best correlation with MWD on the treadmill test was obtained with the MWD measured by the GPS (Spearman r =0.81, P <0.001). Conclusions— Outdoor walking capacity measured by a low-cost GPS is a potentially innovative way to study the walking capacity of patients with peripheral arterial disease. It opens new perspectives in the study of walking capacity for vascular patients with claudication under free-living conditions or for physicians who do not have a treadmill.

---

Source

---

• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 12/02/2008
• Auteurs : David ChavalariasJean-Philippe Cointet
• Organismes : Centre de Recherche en Epistémologie Appliquée Institut des Systèmes Complexes - Paris Ile-de-France Centre de Recherche en Epistémologie Appliquée

---

Résumé : We propose a series of methods to represent the evolution of a field of science at different levels: namely micro, meso and macro levels. We use a previously introduced asymmetric measure of paradigmatic proximity between terms that enable us to extract structure from a large publications database. We apply our set of methods on a case study from the Complex Systems Community through the mapping of more than 400 Complex Systems Science concepts indexed from a database as large as several millions of journal papers. We will first recapitulate the main properties of our asymmetric proximity measure. Then we show how salient paradigmatic fields can be embedded into a 2-dimensional visualization into which the terms are plotted according to their relative specificity and generality index. This meso-level helps us producing macroscopic maps of the field of science studied featuring the former paradigmatic fields.

---

Fichiers liés : CointetChavalariasNHMV1.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 08/02/2008
• Auteurs : Suzana P SalcedoMaría Ines MarchesiniHugues LelouardEmilie FugierGilles JollyStéphanie BalorAlexandre MullerNicolas N. LapaqueOlivier DemariaLena AlexopoulouDiego J ComerciRodolfo A UgaldePhilippe PierreJean-Pierre Gorvel
• Organismes : Centre d'Immunologie de Marseille - Luminy Instituto de Investigaciones Biotecnológicas [San Martín] Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Instituto de Investigaciones Biotecnológicas [San Martín] Instituto Nacional de Tecnología Industrial Instituto de Investigaciones Biotecnológicas [San Martín] Instituto Nacional de Tecnología Industrial Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy
• Publié dans PLoS Pathogens le 27/10/2020

---

Résumé : Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops, dendritic cells from ileal Peyer's patches become infected and constitute a cell target for this pathogen. In vitro, we found that Brucella replicates within dendritic cells and hinders their functional activation. In addition, we identified a new Brucella protein Btp1, which down-modulates maturation of infected dendritic cells by interfering with the TLR2 signaling pathway. These results show that intracellular Brucella is able to control dendritic cell function, which may have important consequences in the development of chronic brucellosis.

---

Fichiers liés : journal.ppat.0040021.PDF

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/02/2008
• Auteurs : Andrzej RybakGisèle BoiteuxPierre AlcouffePhilippe CassagnauGérard SeytreYevgen MamunyaMaksym Iurzhenko
• Organismes : Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Institute of Macromolecular Chemistry of NAS of Ukraine Institute of Macromolecular Chemistry of NAS of Ukraine

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2008
• Auteurs : Hélène MauryKarine Le GuenJean-Michel AndréZ. WangJia DongFrançoise BridouFranck DelmottePhilippe Jonnard
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Institute of Precision Optical Engineering, Department of Physics Institute of Precision Optical Engineering [Shangai] Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire de Chimie Physique - Matière et Rayonnement

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2008
• Auteurs : Hélène MauryPhilippe JonnardKarine Le GuenJean-Michel AndréFranck DelmotteFrançoise BridouMarie-Françoise Ravet-KrillStephano NanaronneNicola Mahne
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratorio Nazionale TASC Laboratorio Nazionale TASC

---

Source