Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 01/02/2008
• Auteurs : Pierre BomelJean-Philippe DiguetGogniat Guy
• Organismes : Lab-STICC_UBS_CACS_MOCS Lab-STICC_UBS_CACS_MOCS Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192)

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Résumé : Ce procédé de reconfiguration d'un ensemble de composants d'un circuit électronique muni de ressources mémoires internes, ledit circuit étant connecté à un réseau, est caractérisé en ce qu'il comporte une étape de téléchargement de données de configuration dudit ensemble vers les ressources mémoires du circuit électronique à partir d'un serveur connecté audit réseau.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Philippe BonninHaythem DebbabiJean MarianiChristiane Charriaut-MarlangueSylvain Renolleau
• Organismes : Neurobiologie des processus adaptatifs CHU Charles Foix [AP-HP] Service d'explorations fonctionnelles GIS Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs CHU Trousseau [APHP]
• Publié dans Ultrasound in Medicine & Biology le 12/12/2019

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Résumé : A model of ischemic brain injury in 7-day-old rat pups has been developed to study perinatal ischemia. It combines permanent occlusion of the distal left middle cerebral artery (LMCA) and transient occlusion of homolateral common carotid artery (LCCA). At removal of the clip on LCCA, reflow allowed brain reperfusion through cortical anastomoses. In 10 rat pups, we measured blood flow velocities (BFV) in main cerebral arteries with 12-MHz ultrasound imaging. At basal states, peak systolic BFV in proximal LMCA was 16.0 +/- 3.0 cm.s(-1). Occlusion of LMCA did not yield significant modifications. Occlusion of LCCA involved only a decrease in BFV to 9.5 +/- 2.6 cm.s(-1) (p < 0.001). Indeed, LMCA was then supply by the right internal carotid and the vertebral arteries through the circle of Willis. In three rat pups, release of occlusion of LCCA was followed by restoration of BFV in the left internal carotid artery and in LMCA, in seven pups, by a reversed flow in the LICA and lower BFV in LMCA (11.9 +/- 2.3, p < 0.05). BFV returned to basal values from h5 to h48 in all animals. In addition, ultrasound imaging is a useful, reproducible, non invasive, easy-to-repeat, method to assess and monitor arterial cerebral blood flow supply in small animals. It helps to characterize changes occurring during cerebral ischemia and reperfusion, particularly the depth of the hypoperfusion, as well as the variability of reflow. In preclinical studies, this method could help to identify what can be assigned to a neuroprotective treatment and what depends on changes in cerebral blood flow supply. (E-mail: philippe.bonnin@lrb.aphp.fr).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Nathalie ChantretJérôme SalseFrancois SabotArnaud BellecBastien LaubinIvan I. DuboisCarole DossatPierre SourdillePhilippe JoudrierMarie Francoise GautierL. CattolicoMichel BeckertSébastien AubourgJean WeissenbachMichel M. CabochePhilippe LeroyMichel BernardPaul Chalhoub
• Organismes : Diversité et adaptation des plantes cultivées Génétique Diversité et Ecophysiologie des Céréales Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale Génétique Diversité et Ecophysiologie des Céréales Genoscope - Centre national de séquençage [Evry] Genoscope - Centre national de séquençage [Evry] Génétique Diversité et Ecophysiologie des Céréales Développement et amélioration des plantes Développement et amélioration des plantes Genoscope - Centre national de séquençage [Evry] Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale Genoscope - Centre national de séquençage [Evry] Unité de recherche en génomique végétale Génétique Diversité et Ecophysiologie des Céréales Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale
• Publié dans Journal of Molecular Evolution le 28/10/2020

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Résumé : We study here the evolution of genes located in the same physical locus using the recently sequenced Ha locus in seven wheat genomes in diploid, tetraploid, and hexaploid species and compared them with barley and rice orthologous regions. We investigated both the conservation of microcolinearity and the molecular evolution of genes, including coding and noncoding sequences. Microcolinearity is restricted to two groups of genes (Unknown gene-2, VAMP, BGGP, Gsp-1, and Unknown gene-8 surrounded by several copies of ATPase), almost conserved in rice and barley, but in a different relative position. Highly conserved genes between wheat and rice run along with genes harboring different copy numbers and highly variable sequences between close wheat genomes. The coding sequence evolution appeared to be submitted to heterogeneous selective pressure and intronic sequences analysis revealed that the molecular clock hypothesis is violated in most cases

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Jean-Philippe LachauxJulien JungNelly MainyJ. C. DreherOlivier BertrandMonica BaciuLorella MinottiDominique M. HoffmannPhilippe Kahane
• Organismes : IFR des neurosciences de Lyon Processus mentaux et activation cérébrale IFR des neurosciences de Lyon Processus mentaux et activation cérébrale IFR des neurosciences de Lyon Processus mentaux et activation cérébrale Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Processus mentaux et activation cérébrale Dynamique Cérébrale et Cognition Laboratoire de Psychologie et NeuroCognition Dynamique des Reseaux Neuronaux Département de neurologie Département de neurochirurgie Dynamique des Reseaux Neuronaux
• Publié dans Cerebral Cortex le 29/10/2020

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Résumé : It is becoming increasingly clear that attention-demanding tasks engage not only activation of specific cortical regions but also deactivation of other regions that could interfere with the task at hand. At the same time, electrophysiological studies in animals and humans have found that the participation of cortical regions to cognitive processes translates into local synchronization of rhythmic neural activity at frequencies above 40 Hz (so-called gamma-band synchronization). Such synchronization is seen as a potential facilitator of neural communication and synaptic plasticity. We found evidence that cognitive processes can also involve the disruption of gamma-band activity in high-order brain regions. Intracerebral electroencephalograms were recorded in 3 epileptic patients during 2 reading tasks. Visual presentation of words induced a strong deactivation in a broad (20-150 Hz) frequency range in the left ventral lateral prefrontal cortex, in parallel with gamma-band activations within the reading network, including Broca's area. The observed energy decrease in neural signals was reproducible across patients. It peaked around 500 ms after stimulus onset and appeared subject to attention-modulated amplification. Our results suggest that cognition might be mediated by a coordinated interaction between regional gamma-band synchronizations and desynchronizations, possibly reflecting enhanced versus reduced local neural communication.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Antoine JegouFrederic PincetEric PerezJean Philippe WolfAhmed ZiyyatChristine Gourier
• Organismes : Dynamique du cytosquelette et motilité Laboratoire de Physique Statistique de l'ENS Laboratoire de Physique Statistique de l'ENS Service d'Histologie-Embryologie, Biologie de la Reproduction Institut Cochin Laboratoire de Physique Statistique de l'ENS
• Publié dans Langmuir le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Olivier MorelNguyen TranEmmanuel BarrangerBernard FoliguetFrédéric MarchalSylvie ChastantPhilippe JudlinJean-Pierre VillemotOlivier Thiebaugeorges
• Organismes : Centre de Recherche en Automatique de Nancy Centre Alexis Vautrin Centre Hospitalier Régional Universitaire de Nancy Centre de Recherche en Automatique de Nancy Centre Alexis Vautrin Centre Hospitalier Régional Universitaire de Nancy
• Publié dans American Journal of Obstetrics and Gynecology le 26/10/2020

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Résumé : OBJECTIVE: This study was designed to assess the ability of an ultrasound-guided radiofrequency (RF)-driven procedure to induce complete and irreversible cord occlusion using a 90 days fetal sheep model. STUDY DESIGN: Twenty 90 days gestation sheep underwent general anesthesia. The first ten fetuses were exposed under hysterotomy, and RF electrode was inserted visually in the middle of the umbilical cord and deployed. Fetuses were then replaced into the amniotic fluid and RF procedure (average target temperature of 100 degrees C during 10 minutes) was applied. For the next ten fetuses, RF electrode was inserted into the cords under trans-parietal ultrasound guidance and the same RF procedure was applied. Cord occlusion was assessed by Doppler examination (absence of cordonal flows at the end of the procedure and until fetal heart failure occurred) and by subsequent histopathological analysis. RESULTS: Cord occlusion was always complete at Doppler examination at the end of RF procedure for the ten experiments realized under hysterotomy. No cordonal reperfusion was observed until fetal heart failure. Histopathological analysis confirmed cordonal occlusion at the site of impact. Neither cordonal rupture nor cordonal bleeding was observed for any of the ten experiments. When RF electrode was inserted under ultrasound guidance, complete occlusion could be obtained only for 6 of the ten experiments. CONCLUSION: Our results suggest that RF might be an appropriate method for selective termination of pregnancy. Yet, optimal insertion of the electrode is required to engender a complete and irreversible cord occlusion, and ultrasound-guidance training seems necessary before current human application.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Nathalie ChantretJérôme SalseFrançois SabotArnaud BellecBastien LaubinIvan I. DuboisCarole DossatPierre SourdillePhilippe JoudrierMarie-Françoise GautierL. CattolicoMichel BeckertSébastien AubourgJean WeissenbachMichel M. CabochePhilippe LeroyMichel BernardBoulos B. Chalhoub
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
• Publié dans Journal of Molecular Evolution le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Julie LeloupMatthieu LengaigneJean-Philippe Boulanger
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques
• Publié dans Climate Dynamics le 30/10/2020

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Résumé : In this paper, we assess and compare to observations the spatial characteristics of the twentieth Century ENSO SST variability simulated by 23 models of the IPCC-AR4/CMIP3 database. The analysis is confined to the SST anomalies along the equatorial Pacific and is based on the use of a non-linear neural classification algorithm, the Self-Organizing Maps. Systematic biases include a larger than observed proportion for modelled ENSO maximum variability occurring in the Western Pacific. No clear relationship is found between this bias and the characteristics of the modelled mean state bias in the equatorial Pacific. This bias is mainly related to a misrepresentation of both El Niño and La Niña termination phases for most of the models. In contrast, the onset phase is quite well simulated. Modelled El Niño and La Niña peak phases display an asymmetric bias. Whereas the main bias of the modelled El Niño peak is to exhibit a maximum in the western Pacific, the simulated La Niña bias mainly occurs in the central Pacific. In addition, some models are able to capture the observed El Niño peak characteristics while none of them realistically simulate La Niña peaks. It also arises that the models closest to the observations score unevenly in reproducing the different phases, preventing an accurate classification of the models quality to reproduce the overall ENSO-like variability.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Camillo RibiPascal CohenChristian PagnouxAlfred MahrJean-Pierre ArèneDominique LauqueXavier PuéchalPhilippe LetellierPhilippe DelavalJean-François CordierLoïc Guillevin
• Organismes : Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Signalisation et Réponses aux Agents Infectieux et Chimiques Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Cochin [AP-HP] Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
• Publié dans Arthritis and Rheumatism le 27/10/2020

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Résumé : OBJECTIVE: To assess the efficacy of systemic corticosteroids (CS) alone as first-line treatment in patients with Churg-Strauss syndrome (CSS) without poor-prognosis factors, as defined by the Five-Factors Score (FFS), and to compare the efficacy and safety of oral azathioprine (AZA) versus intravenous pulse cyclophosphamide (CYC) as adjuvant immunosuppressive therapy for treatment failure or relapse. METHODS: This multicenter, prospective, randomized, open-label therapeutic trial included 72 patients with newly diagnosed CSS (FFS of 0) treated with CS alone. At treatment failure or relapse, patients were randomized to receive 6 months of oral AZA or 6 pulses of CYC. Analyses were performed according to an intent-to-treat strategy. RESULTS: The mean +/- SD followup was 56.2 +/- 31.7 months. Among the 72 patients studied, 93% achieved remission with CS therapy alone, and 35% relapsed, mainly during the first year of treatment. Among the 19 patients randomized to additional immunosuppression because of treatment failure or relapse, 5 of 10 receiving AZA and 7 of 9 receiving pulse CYC achieved remission, but the difference was not statistically significant. Survival rates in all patients at 1 and 5 years were 100% and 97%, respectively. At the end of followup, 79% of the patients whose disease was in remission required low-dose CS therapy, mainly to control respiratory disease. CS-related adverse events were observed in 31% of the 72 patients. CONCLUSION: In CSS patients with an FFS of 0, survival was excellent, confirming the predictive value of the FFS in this disease. First-line therapy with CS achieved remission in most patients, but relapses were common, and one-third of them required additional immunosuppressive therapy. AZA or pulse CYC was fairly effective in treating CS-resistant disease or major relapses. Over the long term, most patients continued to take oral CS, which might explain the high rate of CS-related adverse events.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : A. JeandrotJean-Louis RichardChristophe CombescureNathalie JourdanS. FingeMichel RodierPierre CorbeauAlbert SottoJean-Philippe Lavigne
• Organismes : Laboratoire de bactériologie, virologie et parasitologie Service des maladies de la nutrition et de diabétologie Département de l'information médicale Service des maladies métaboliques et endocriniennes Service d'immunologie Service des maladies métaboliques et endocriniennes Service d'immunologie Systèmes de sécrétion de type IV et virulence bactérienne Laboratoire de bactériologie, virologie et parasitologie Systèmes de sécrétion de type IV et virulence bactérienne
• Publié dans Diabetologia le 01/11/2020

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Résumé : AIMS/HYPOTHESIS: Infection of diabetic foot ulcers is common; at early stages it is difficult to differentiate between non-infected ulcers (or those colonised with normal flora) and ulcers infected with virulent bacteria that lead to deterioration. This pilot study aimed to assess the diagnostic accuracy of inflammatory markers as an aid to making this distinction. METHODS: We included 93 diabetic patients who had an episode of foot ulcer and had not received antibiotics during the 6 months preceding the study. Ulcers were classified as infected or uninfected, according to the Infectious Diseases Society of America-International Working Group on the Diabetic Foot classification. Diabetic patients without ulcers (n = 102) served as controls. C-reactive protein (CRP), orosomucoid, haptoglobin and procalcitonin were measured together with white blood cell and neutrophil counts. The diagnostic performance of each marker, in combination (using logistic regression) or alone, was assessed. RESULTS: As a single marker, CRP was the most informative for differentiating grade 1 from grade 2 ulcers (sensitivity 0.727, specificity 1.000, positive predictive value 1.000, negative predictive value 0.793) with an optimal cut-off value of 17 mg/l. In contrast, white blood cell and neutrophil counts were not predictive. The most relevant combination derived from the logistic regression was the association of CRP and procalcitonin (AUC 0.947), which resulted in a significantly more effective determination of ulcer grades, as shown by comparing receiver operating characteristic curves. CONCLUSIONS/INTERPRETATION: Measurement of only two inflammatory markers, CRP and procalcitonin, might be of value for distinguishing between infected and non-infected foot ulcers in subgroups of diabetic patients, to help ensure the appropriate allocation of antibiotic treatment. Nevertheless, external validation of the diagnostic value of procalcitonin and CRP in diabetic foot ulcers is needed before routine use can be recommended.

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Fichiers liés : PCT-Diabetologia2007.pdf

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