Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Cédric CharrierJonathan ClarhautJean-Pierre GessonGuillermina EstiuOlaf WiestJoelle RochePhilippe Bertrand
• Organismes : Synthèse et réactivité des substances naturelles [UMR 6514] Institut de physiologie et biologie cellulaires [UMR 6187] Synthèse et réactivité des substances naturelles [UMR 6514] Department of Chemical and Biomolecular Engineering (Notre Dame, USA) Department of Chemical and Biomolecular Engineering (Notre Dame, USA) Institut de physiologie et biologie cellulaires [UMR 6187] Synthèse et réactivité des substances naturelles [UMR 6514]
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

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Résumé : New benzofuranones were synthesized and evaluated toward NCI-H661 non-small cell lung cancer cells. Benzamide derivatives possessed micromolar antiproliferative and histone deacetylase inhibitory activities and modulate histone H4 acetylation. Hydroxamic acids were found to be potent nanomolar antiproliferative agents and HDAC inhibitors. Computational analysis presented a rationale for the activities of the hydroxamate derivatives. Impact of the HDAC inhibition on the expression of E-cadherin and the SEMA3F tumor suppressor genes revealed new promising compounds for lung cancer treatments.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2009
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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Résumé : Jeanne sans sépulcre et sans portrait, toi qui savais que le tombeau des héros est le cœur des vivants ". C'est avec ces mots qu'André Malraux saluait, le 31 mai 1964, le souvenir de Jeanne d'Arc. À ses yeux, elle était " la seule figure de victoire qui soit une figure de pitié ! ". Jeanne d'Arc nous échappe malgré 20 000 statues publiques sans compter les innombrables représentations en fonte ou en plâtre, près de 800 biographies parues entre 1790 et 1990, une quarantaine de films, des centaines de pièces de théâtre ou de tragédies. Les plus grands ont tenté de percer ce personnage. Verdi, Michelet, Barrès, Péguy ou Malraux s'y sont essayés. Sarah Bernhardt, Michèle Morgan, Ingrid Bergman, Jean Seberg, Madeleine Robinson, Sandrine Bonnaire ou Milla Jovovich lui ont donné leur trait. Quel que soit les efforts, elle continuera à s'esquiver. Elle semble avoir déserté le monde pour gagner un empyrée où elle demeure visible sans pouvoir être saisie. Elle est un personnage de chair devenu une icône, une femme faite une sainte, une guerrière restée une bergère, un chef de guerre n'ayant jamais fait couler elle-même le sang...

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Sébastien BergerFlorian IglésiasPierre BonnetChristophe VoisinGuillaume CassaboisJean‐sébastien LauretClaude DelalandePhilippe Roussignol
• Organismes : Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain
• Publié dans Journal of Applied Physics le 02/11/2020

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Résumé : We report on environmental effects on the optical properties of single-wall carbon nanotubes in a gelatin-based composite material designed to foster their photoluminescence. We show that the dielectric screening of excitons due to the surrounding medium is responsible for a sizeable shift of the luminescence lines, which hardly depends on the tube geometry. In contrast, the temperature dependence from 4 to 300 K of the luminescence is clearly chirality dependent; the first and second excitonic lines shift in opposite directions with a magnitude that can be related quantitatively to a strain-induced modification of the electronic structure due to an expansivity mismatch between the nanotube and the matrix.

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Fichiers liés : PLT-VoisinJAP.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Corinne Le QuéréMichael RaupachJ. CanadellGregg MarlandLaurent BoppPhilippe CiaisThomas ConwayScott DoneyRichard A. FeelyPru FosterPierre FriedlingsteinKevin GurneyRichard A. HoughtonJoanna HouseChris HuntingfordPeter LevyMark LomasJoseph MajkutNicolas MetzlJean OmettoGlen PetersIain Colin PrenticeJames RandersonSteven RunningJorge L. SarmientoUte SchusterStephen SitchTaro TakahashiNicolas ViovyGuido van der WerfF. Ian Woodward
• Organismes : British Antarctic Survey Commonwealth Scientific and Industrial Research Organisation [Australia] Commonwealth Scientific and Industrial Research Organisation [Australia] Division of Environmental Sciences Mid Sweden University Laboratoire des Sciences du Climat et de l'Environnement Laboratoire des Sciences du Climat et de l'Environnement National Oceanic and Atmospheric Administration Woods Hole Oceanographic Institution NOAA Pacific Marine Environmental Laboratory [Newport] School of Earth Sciences [Bristol] Laboratoire des Sciences du Climat et de l'Environnement Department of Earth, Atmospheric, and Planetary Sciences [West Lafayette] Woods Hole Research Center Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry Centre for Ecology & Hydrology - Bush Estate NERC Centre of Ecology and Hydrology Department of Animal and Plant Sciences [Sheffield] Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Instituto Nacional de Pesquisas Espaciais [Sao José dos Campos, Brasil] = National Institute for Space Research [Sao José dos Campos, Brazil] Center for International Climate and Environmental Research [Oslo] University of Bristol [Bristol] Montana State University Atmospheric and Oceanic Sciences Program [Princeton] University of East Anglia [Norwich] University of Exeter Lamont-Doherty Earth Observatory Laboratoire des Sciences du Climat et de l'Environnement Faculty of Earth and Life Sciences [Amsterdam] Department of Animal and Plant Sciences [Sheffield]
• Publié dans Nature Geoscience le 26/10/2020

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Résumé : Efforts to control climate change require the stabilization of atmospheric CO₂ concentrations. This can only be achieved through a drastic reduction of global CO₂ emissions. Yet fossil fuel emissions increased by 29% between 2000 and 2008, in conjunction with increased contributions from emerging economies, from the production and international trade of goods and services, and from the use of coal as a fuel source. In contrast, emissions from land-use changes were nearly constant. Between 1959 and 2008, 43% of each year's CO₂ emissions remained in the atmosphere on average; the rest was absorbed by carbon sinks on land and in the oceans. In the past 50 years, the fraction of CO₂ emissions that remains in the atmosphere each year has likely increased, from about 40% to 45%, and models suggest that this trend was caused by a decrease in the uptake of CO₂ by the carbon sinks in response to climate change and variability. Changes in the CO₂ sinks are highly uncertain, but they could have a significant influence on future atmospheric CO₂ levels. It is therefore crucial to reduce the uncertainties.

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Fichiers liés : LeQuere2009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Julien CharreauYan ChenStuart A. GilderLaurie BarrierStéphane DominguezRomain AugierŞevket ŞenJean‐philippe AvouacAudrey GallaudQingchen WangFabien Graveleau
• Organismes : Institut des Sciences de la Terre d'Orléans Centre de Recherches Pétrographiques et Géochimiques Institut des Sciences de la Terre d'Orléans Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Géosciences Montpellier Institut des Sciences de la Terre d'Orléans Paléobiodiversité et paléoenvironnements Caltech Division of Geological and Planetary Sciences Institut des Sciences de la Terre d'Orléans Institute of Geology and Geophysics [Beijing] Géosciences Montpellier
• Publié dans Tectonics le 22/10/2020

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Résumé : The Tian Shan Mountains constitute central Asia's longest and highest mountain range. Understanding their Cenozoic uplift history thus bears on mountain building processes in general, and on how deformation has occurred under the influence of the India-Asia collision in particular. In order to help decipher the uplift history of the Tian Shan, we collected 970 samples for magnetostratigraphic analysis along a 4571-m-thick section at the Jingou River (Xinjiang Province, China). Stepwise alternating field and thermal demagnetization isolate a linear magnetization component that is interpreted as primary. From this component, a magnetostratigraphic column composed of 67 polarity chrons are correlated with the reference geomagnetic polarity timescale between ~1 Ma and ~23.6 Ma, with some uncertainty below ~21 Ma. This correlation places precise temporal control on the Neogene stratigraphy of the southern Junggar Basin and provides evidence for two significant stepwise increases in sediment accumulation rate at ~16–15 Ma and ~11–10 Ma. Rock magnetic parameters also undergo important changes at ~16–15 Ma and ~11–10 Ma that correlate with changes in sedimentary depositional environments. Together with previous work, we conclude that growth history of the modern Tian Shan Mountains includes two pulses of uplift and erosion at ~16–15 Ma and ~11–10 Ma. Middle to upper Tertiary rocks around the Tian Shan record very young (<~5 Ma) counterclockwise paleomagnetic rotations, on the order of 15° to 20°, which are interpreted as because of strain partitioning with a component of sinistral shear that localized rotations in the piedmont.

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Fichiers liés : 2007TC002137.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Julien AmalricP. Hubert MutinGilles GuerreroArnaud PoncheAlbert SottoJean-Philippe Lavigne
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut de Chimie et des Surfaces et Interfaces Systèmes de sécrétion de type IV et virulence bactérienne Systèmes de sécrétion de type IV et virulence bactérienne Laboratoire de bactériologie
• Publié dans Journal of Materials Chemistry le 25/10/2020

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Résumé : Titanium and stainless steel substrates were modified by grafting with mercaptododecyl phosphonic acid (MDPA) followed by reaction with silver nitrate (AgNO3), in order to investigate the potential of phosphonate self-assembled monolayers functionalized by silver thiolate species as antibacterial nanocoatings for inorganic biomaterials. The samples were characterized by Fourier transform infrared (FTIR) spectroscopy in grazing-incidence mode, water contact angle measurements, and X-ray photoelectron spectroscopy (XPS). The influence of the surface modification on bacterial adhesion and biofilm growth was investigated in vitro using E. coli, P. aeruginosa, S. epidermidis, and S. aureus strains. The stability of the the monolayer in blood-mimicking medium was examined. Despite their very low silver content, MDPA+AgNO3 monolayers strongly decreased bacterial adhesion (>99.9% reduction in the number of viable adherent bacteria) and biofilm formation in comparison to the bare substrates.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Jérôme VialardJean-Philippe DuvelMichael J. McphadenPascale Bouruet-AubertotBrian WardErica KeyDenis BourrasR. WellerP. J. MinnettAlain WeillChristophe CassouLaurence EymardT. FristedtClaude BasdevantYves DandonneauOlaf DuteilTakeshi IzumoClément de Boyer MontégutSébastien MassonFrancis MarsacChristophe MenkesSean C. Kennan
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire de Météorologie Dynamique (UMR 8539) NOAA Pacific Marine Environmental Laboratory [Newport] Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Old Dominion University [Norfolk] ESTER - LATMOS Woods Hole Oceanographic Institution University of Miami [Coral Gables] ESTER - LATMOS Centre Européen de Recherche et de Formation Avancée en Calcul Scientifique Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Swedish Defence Research Agency [Stockholm] Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Frontier Research Center for Global Change Frontier Research Center for Global Change Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Thons tropicaux et écosystèmes pélagiques : taxies, interactions et stratégies d'exploitation Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques National Institute of Water and Atmospheric Research [Wellington]
• Publié dans Bulletin of the American Meteorological Society le 26/10/2020

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Résumé : The Vasco–Cirene program explores how strong air–sea interactions promoted by the shallow thermocline and high sea surface temperature in the Seychelles–Chagos thermocline ridge results in marked variability at synoptic, intraseasonal, and interannual time scales. The Cirene oceanographic cruise collected oceanic, atmospheric, and air–sea flux observations in this region in January–February 2007. The contemporaneous Vasco field experiment complemented these measurements with balloon deployments from the Seychelles. Cirene also contributed to the development of the Indian Ocean observing system via deployment of a moor-ing and 12 Argo profilers.Unusual conditions prevailed in the Indian Ocean during January and February 2007, following the Indian Ocean dipole climate anomaly of late 2006. Cirene measurements show that the Seychelles–Chagos thermocline ridge had higher-than-usual heat content with subsurface anomalies up to 7°C. The ocean surface was warmer and fresher than average, and unusual eastward currents prevailed down to 800 m. These anomalous conditions had a major impact on tuna fishing in early 2007. Our dataset also sampled the genesis and maturation of Tropical Cyclone Dora, including high surface temperatures and a strong diurnal cycle before the cyclone, followed by a 1.5°C cooling over 10 days. Balloonborne instruments sampled the surface and boundary layer dynamics of Dora. We observed small-scale structures like dry-air layers in the atmosphere and diurnal warm layers in the near-surface ocean. The Cirene data will quantify the impact of these finescale features on the upper-ocean heat budget and atmospheric deep convection.

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Fichiers liés : 2008bams2499.1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Tsevi MazehPascal GutermanSuzanne AigrainS. ZuckerN. GrinbergA. AlapiniRoi AlonsoMichel AuvergneMauro BarbieriPierre BargeP. BordéFrançois BouchyHans J. DeegR. de la RezaMagali DeleuilRudolf DvorakAnders EriksonMalcolm C. FridlundPhilippe GondoinLaurent JordaHelmut LammerAlain LégerAntoine LlebariaPierre MagainClaire MoutouMarc OllivierM. PätzoldFrédéric PontDidier QuelozHeike RauerDaniel RouanR. SaboJean SchneiderGünther Wuchterl
• Organismes : John Radcliffe Hospital [Oxford University Hospital] Laboratoire d'Astrophysique de Marseille University of Exeter Tel Aviv University Tel Aviv University University of Exeter Laboratoire d'Astrophysique de Marseille Laboratoire d'études spatiales et d'instrumentation en astrophysique Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Institut d'astrophysique spatiale Observatoire de Haute-Provence Instituto de Astrofisica de Canarias Observatório Nacional/MCTI Laboratoire d'Astrophysique de Marseille Institut für Astronomie, Universität Wien DLR Institut für Planetenforschung Research and Scientific Support Department, ESA-ESTEC Research and Scientific Support Department, ESA-ESTEC Laboratoire d'Astrophysique de Marseille Osterreichische Akademie der Wissenschaften = Académie autrichienne des sciences Institut d'astrophysique spatiale Laboratoire d'Astrophysique de Marseille Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire d'Astrophysique de Marseille Institut d'astrophysique spatiale Rheinisches Institut für Umweltforschung University of Exeter Observatoire Astronomique de l'Université de Genève DLR Institut für Planetenforschung Laboratoire Univers et Théories Laboratoire d'études spatiales et d'instrumentation en astrophysique Tel Aviv University Technical University of Berlin / Technische Universität Berlin Laboratoire Univers et Théories
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : This paper presents an analysis that searched for systematic effects within the CoRoT exoplanet field light curves. The analysis identified a systematic effect that modified the zero point of most CoRoT exposures as a function of stellar magnitude. We could find this effect only after preparing a set of learning light curves that were relatively free of stellar and instrumental noise. Correcting for this effect, rejecting outliers that appear in almost every exposure, and applying SysRem, reduced the stellar RMS by about 20%, without attenuating transit signals.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2009
• Auteurs : Laurent HussonJean-Pierre BrunPhilippe YamatoClaudio Faccenna
• Organismes : Géosciences Rennes Géosciences Rennes Géosciences Rennes Dipartimento di Scienze Geologiche [Roma TRE]
• Publié dans Geophysical Journal International le 25/10/2020

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Résumé : The burial-exhumation cycle of crustal material in subduction zones can either be driven by the buoyancy of the material, by the surrounding flow, or by both. High pressure and ultrahigh pressure rocks are chiefly exhumed where subduction zones display transient behaviours, which lead to contrasted flow regimes in the subduction mantle wedge. Subduction zones with stationary trenches (mode I) favour the burial of rock units, whereas slab rollback (mode II) moderately induces an upward flow that contributes to the exhumation, a regime that is reinforced when slab dip decreases (mode III). Episodic regimes of subduction that involve different lithospheric units successively activate all three modes and thus greatly favour the exhumation of rock units from mantle depth to the surface without need for fast and sustained erosion.

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Fichiers liés : husson-gji.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2009
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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