Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Rasmus AbildgrenJean-Philippe DiguetPierre BomelGogniat GuyPeter KochYannick Le Moullec
• Organismes : Center for Embedded Software Systems [Aaborg] Lab-STICC_UBS_CACS_MOCS Lab-STICC_UBS_CACS_MOCS Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192) Center for Embedded Software Systems [Aaborg] Center for Embedded Software Systems [Aaborg]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Karine LacombeJoël GozlanAnders BoydPierre-Yves BoëllePhilippe BonnardJean-Michel MolinaPatrick MiailhesCaroline Lascoux-CombeLawrence SerfatyFabien ZoulimPierre-Marie Girard
• Organismes : Epidémiologie des maladies infectieuses et modélisation CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Epidémiologie des maladies infectieuses et modélisation Epidémiologie des maladies infectieuses et modélisation CHU Tenon [AP-HP] Service de maladies infectieuses et tropicales [Saint-Louis] Physiopathologie moléculaire et nouveaux traitements des hépatites virales Service d'hépatologie et de gastroentérologie Service de Médecine Interne [Saint-Louis] CHU Saint-Antoine [AP-HP] Physiopathologie moléculaire et nouveaux traitements des hépatites virales Service d'hépatologie et de gastroentérologie Epidémiologie des maladies infectieuses et modélisation CHU Saint-Antoine [AP-HP]
• Publié dans Antiviral Therapy le 24/10/2020

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Résumé : BACKGROUND: Characteristics and factors influencing viral decay under tenofovir (TDF) and adefovir (ADV) need to be determined in HIV-HBV-coinfected patients. METHODS: This open-label study compared the HBV dynamics in 85 HIV-HBV-coinfected patients initiating an antiretroviral regimen, either including TDF or associated with ADV. The first 6-month change in viral load was analysed using mixed linear models. The adjusted hazards ratio, comparing the rates of undetectable HBV DNA between treatments, was calculated using a Cox proportional hazard model. RESULTS: The HBV DNA decay, adjusted for baseline HBV viral load was more pronounced in patients treated with TDF than with ADV at 12 months (66% versus 53%, P=0.0001). Patients in the TDF group presented a steeper slope of decline at 1.1 (95% confidence interval [CI] 0.9-1.3), compared with 0.8 (95% CI 0.6-1.0) in the ADV group (P=0.036). The mean time to HBV DNA undetectability was 19.3 months (95% CI 16.7-22.0) with TDF and 25.9 months (95% CI 21.1-30.7) with ADV. When adjusted for hepatitis B virus e antigen, HBV DNA and alanine aminotransferase levels at baseline, the influence of treatment on time to HBV DNA undetectability remained in favour of TDF versus ADV (hazard ratio=2.79, 95% CI 1.05-7.40, P=0.039) CONCLUSIONS: TDF influenced more strongly the early-phase HBV DNA kinetics than ADV. This is associated with a sustained antiviral activity in the TDF group, in which patients reached the threshold of HBV undetectability at a faster rate and in a larger proportion than those taking ADV.

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Fichiers liés : ADV_TDF_figure_2_REVISED.pdf ADV_TDF_figure_1_REVISED.pdf ADV_TDF_figure_3_REVISED.pdf ADV_TDF_HAL.pdf ADV_TDF_tables_REVISED.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2008
• Auteurs : Jean-René MoricePhilippe ViolierYves Perret-GentilAlain LottinJean-Pierre Poussou
• Organismes : Espaces et Sociétés Espaces et Sociétés

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Résumé :

La dynamique des lieux touristiques littoraux

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2008
• Auteurs : Jean CorneloupPhilippe Bourdeau
• Organismes : Pacte, Laboratoire de sciences sociales Pacte, Laboratoire de sciences sociales

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Julien RéthoréJean-Philippe TinnesStéphane RouxJean-Yves BuffiereFrançois Hild
• Organismes : Laboratoire de Mécanique et Technologie Matériaux, ingénierie et science [Villeurbanne] Laboratoire de Mécanique et Technologie Matériaux, ingénierie et science [Villeurbanne] Laboratoire de Mécanique et Technologie
• Publié dans Comptes Rendus. Mécanique le 17/10/2021

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Résumé : A correlation algorithm is proposed to measure full three-dimensional displacement fields in a three-dimensional domain. The chosen kinematic basis for this measurement is based on continuous finite-element shape functions. It is furthermore proposed to account for the presence of strong discontinuities, similarly to extended finite element schemes, with a suited enrichment of the kinematics with discontinuities supported by a (crack) surface. An optimization of the surface geometry is proposed based on correlation residuals. The procedure is applied to analyze one loading cycle of a fatigue-cracked nodular graphite cast iron sample by using computed tomography pictures. Subvoxel crack openings are revealed and measured.

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Fichiers liés : CRmeca14-ccsd.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Marc MalletVéronique PontCathy LiousseLaurent GomesJacques PelonSimon OsborneJames HaywoodJean-Claude RogerPhilippe DubuissonArmand MariscalValérie ThouretPhilippe Goloub
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Laboratoire d'aérologie Centre national de recherches météorologiques Service d'aéronomie United Kingdom Met Office [Exeter] United Kingdom Met Office [Exeter] Laboratoire de météorologie physique Observatoire de Physique du Globe de Clermont-Ferrand Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Laboratoire d'aérologie Laboratoire d'aérologie Laboratoire d’Optique Atmosphérique - UMR 8518
• Publié dans Journal of Geophysical Research: Atmospheres le 24/10/2020

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Résumé : The purpose of this work is to investigate the direct radiative forcing of aerosols over the supersite of Djougou (northern Benin) during the African Monsoon Multidisciplinary Analyses dry season experiment. We focus our simulations on the top of atmosphere, bottom of atmosphere, and atmosphere radiative forcings. During the dry season period, Sun photometer measurements indicate a rather turbid atmosphere with a mean aerosol optical depth for the overall period of 0.78 ± 0.24 (at 440 nm). The aerosol absorption coefficient estimated at the surface ranged between 2.3 and 37.3 Mm−1 (mean value 15.2 ± 10.6 Mm−1 at 520 nm) and the scattering coefficient between 44.5 and 232.3 Mm−1 (mean 145 ± 59 Mm−1 at 520 nm). This leads to a single scattering albedo of between 0.81 and 0.98 (at 520 nm) with a mean (and standard deviation) value of 0.91 ± 0.05, indicating moderately absorbing aerosols. In parallel, micropulse lidar measurements indicate the presence of two distinct aerosol layers, with a first one located between the surface and 1 km and a second one located above 1.5–4.0 km. On the basis of surface and aircraft observations, sunphotometer measurements, lidar profiles, and Moderate Resolution Imagaing Spectroradiometer sensor an estimation of the daily clear sky direct radiative forcing has been estimated for the 17–24 January 2006 period. Simulations indicate that aerosols reduce significantly the solar energy reaching the surface (mean ΔFBOA = −61.5 W/m2) by reflection to space (mean ΔFTOA = −18.4 W/m2) but predominantly by absorption of the solar radiation into the atmosphere (mean ΔFATM = +43.1 W/m2). The mean heating rate at the surface and within the elevated biomass burning layer is considerably enhanced by 1.50 and 1.90 K day−1, respectively.

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Fichiers liés : Mallet_et_al-2008-Journal_of_Geophysical_Research__Solid_Earth_(1978-2012).pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Marie KempfRegine BaraducHenri BonnabauMichel BrunH. CharbonJacques CroizéMarie-Claude DemachyPierre-Yves DonnioPhilippe DupontThierry FosseLaurent GibelAlain GravetTahar HadouFarida HamdadJean-Louis KoeckG. LauransJeanne MaugeinAndre PéchinotMarie-Cécile PloyJosette RaymondAlain RosMicheline Roussel-DelvallezChristine SegondsMichel VergnaudVeronique Vernet-GarnierM. WeberEmmanuelle VaronAgnes LepoutrePhilippe Lanotte
• Organismes : Groupe d'Étude des Interactions Hôte-Pathogène

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Vincent VidalXing MeiPhilippe Decaudin
• Organismes : Virtual environments for animation and image synthesis of natural objects Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées Virtual environments for animation and image synthesis of natural objects
• Publié dans Journal of graphics tools le 06/11/2014

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Résumé : Interactive volume rendering methods such as texture-based slicing techniques and ray casting have been well developed in recent years. The rendering performance is generally restricted by the volume size, the fill-rate, and the texture fetch speed of the graphics hardware. For most 3D data sets, a fraction of the volume is empty, which will reduce the rendering performance without specific optimization. In this paper, we present a simple kd-tree-based space partitioning scheme to efficiently remove the empty spaces from the volume data sets at the preprocessing stage. The splitting rule of the scheme is based on a simple yet effective cost function evaluated through a fast approximation of the bounding volume of the nonempty regions. The scheme culls a large number of empty voxels and encloses the remaining data with a small number of axis-aligned bounding boxes, which are then used for interactive rendering. The number of boxes is controlled by halting criteria. In addition to its simplicity, our scheme requires little preprocessing time and improves the rendering performance significantly.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-Pierre LevraudEmma Colucci-GuyonMichael ReddGeorges LutfallaPhilippe Herbomel
• Organismes : Macrophages et Développement de l'Immunité Macrophages et Développement de l'Immunité Huntsman Cancer Institute [Salt Lake City] Dynamique des interactions membranaires normales et pathologiques Macrophages et Développement de l'Immunité
• Publié dans Methods in Molecular Biology le 25/10/2020

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Résumé : Among vertebrate model species, the zebrafish embryo combines at an unprecedented level optical accessibility with easy genetic manipulation. As such, it is gaining recognition as a powerful model to study innate immunity. In this chapter, we provide a protocol for the generation of zebrafish embryos deficient in a protein of interest for innate immune signaling using antisense morpholino oligonucleotides, the systemic or local infection of these embryos with bacteria, and the assessment of various aspects of the following immune response with emphasis on microscopic observation. This example can be easily adapted to study the role of other genes, either knocked down or overexpressed, and in response to any other challenge, from purified microbial compounds to pathogenic viruses. This protocol is aimed at people not necessarily familiar with zebrafish biology and handling.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Christophe VoisinFlorian IglésiasSébastien BergerPierre BonnetGuillaume CassaboisPhilippe RoussignolJean‐sébastien Lauret
• Organismes : Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire

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