Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Jean‐sébastien LauretGurvan MagadurValérie AlainPhilippe RoussignolChristophe VoisinEmmanuelle DeleporteJacques A. Delaire
• Organismes : Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires

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Résumé : Tailoring the properties of carbon nanotubes by functionalizing their side-wall is an important point towards the realization of carbon nanotube-based optoelectronic or electronic devices. Interactions between nanotubes and porphyrin molecules have attracted much attention for about five years [1-8]. We report here on "p-stacking" functionalization of CoMoCaT nanotubes with hydrosoluble porphyrins (TPPS). The mutual influence on electronic properties of both porphyrins molecules and nanotubes is studied by optical absorption, photoluminescence and excitation of photoluminescence spectroscopy in both species optical transitions energy range. The optical absorption spectrum of porphyrins adsorbed on nanotubes exhibits a 120 meV red shift of the Soret band. The porphyrin-nanotube complex shows a 99% quenching of the TPPS emission. In contrast with previous studies photoluminescence intensity of the nanotubes is enhanced in presence of porphyrins. Moreover this enhancement is much better when the excitation energy is in resonance with the “p-stacked" porphyrin absorption band. This reveals the existence of an excitation transfer from the porphyrin molecules to the nanotube.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Philippe BertusJan SzymoniakErwann JeanneauTibor DocsaPal GergelyJean-Pierre PralySébastien Vidal
• Organismes : Unité de chimie organique moléculaire et macromoléculaire Institut de Chimie Moléculaire de Reims Institut de Chimie Moléculaire de Reims Université Claude Bernard Lyon 1 University of Debrecen University of Debrecen Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
• Publié dans Bioorganic and Medicinal Chemistry Letters le 28/10/2020

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Résumé : The synthesis of carbohydrate-based glycogen phosphorylase inhibitors is attractive for potential applications in the treatment of type 2 diabetes. A titanium-mediated synthesis led to a benzoylated C-glucosylated cyclopropylamine intermediate, which underwent a benzoyl migration to afford the corresponding 2-hydroxy-C-glycoside. X-ray crystallographic studies revealed a unit cell composed of four molecules as pairs of dimers connected through two hydrogen bonds. The deprotection of the benzoate esters under Zemplén conditions afforded a glycogen phosphorylase inhibitor candidate displaying weak inhibition toward glycogen phosphorylase (16% at 2.5 mM).

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• Type de publi. : Article dans une revue
• Date de publi. : 27/12/2007
• Auteurs : Isabelle MermetFrançois M. KleinclaussAliette MarandinJean Sébastien GuérriniRégis AngoninPierre TiberghienPhilippe SaasFrançois Aubin
• Organismes : Département de dermatologie Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Département de dermatologie Service d'Anatomie pathologique [CHRU Besançon] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Département de dermatologie
• Publié dans Transplantation le 25/10/2020

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Résumé : Although previous studies have demonstrated the efficient modulatory effects of ultraviolet radiation B (UVB) on cutaneous graft-versus-host disease (GVHD), most animal research on GVHD has been performed in murine models of acute GVHD. Here, we studied the preventive effect of UVB radiation on the occurrence of chronic sclerodermatous (Scl) GVHD in a murine model. Scl GVHD was induced by transplanting lethally irradiated BALB/c mice with B10.D2 bone marrow and spleen cells. Recipient mice were exposed to UVB before or after bone marrow and spleen cell infusion. Histological and clinical evaluation of GVHD was performed, in association with the characterization of epidermal Langerhans cells. UVB irradiation of recipients after, and more remarkably before, transplantation induced a decrease of Scl GVHD severity associated with epidermal Langerhans cells depletion. We conclude that UVB irradiation of recipient before or after transplantation has a preventive effect on cutaneous Scl GVHD and may represent an effective strategy for prevention of Scl GVHD.

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• Type de publi. :
• Date de publi. : 26/12/2007
• Auteurs : Vincent CoudercPhilippe LeprouxVincent TombelainePierre-Alain ChampertSébastien FévrierAlain BarthélémyJean-Louis AugusteJean-Marc Blondy
• Organismes : PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/12/2007
• Auteurs : Jean-Philippe TarelSio Song IengPierre Charbonnier
• Organismes : Division Exploitation-Signalisation-Éclairage Division Exploitation-Signalisation-Éclairage Centre d'études techniques de l'équipement Est

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Résumé : Automatic road markings detection is a central point in road scene analysis from images. Its applications concern as well the inventory of lane marking types on a road network, as the design of driver assistance systems on-board vehicles. We here describe a model and an estimation algorithm which account for the geometric specificity and variability of the markings and, above all, which are robust to the numerous perturbations that can be observed in real-world images.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/12/2007
• Auteurs : L. LavisseJean-Marie JouvardJ.P. GallienP. BergerDominique GreveyNaudy Philippe
• Organismes : Laboratoire Interdisciplinaire Carnot de Bourgogne Laboratoire Interdisciplinaire Carnot de Bourgogne Laboratoire Pierre Süe Laboratoire Pierre Süe Laboratoire Interdisciplinaire Carnot de Bourgogne VALDUC
• Publié dans Applied Surface Science le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 11/12/2007
• Auteurs : Jean-Philippe RegnauxKaveh SaremiJon MarehbianBernard BusselBruce H Dobkin
• Organismes : Department of Neurology Physiologie et physiopathologie de la motricité chez l'homme Department of Neurological Rehabilitation
• Publié dans Journal of Neurologic Rehabilitation le 27/10/2020

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Résumé : OBJECTIVE: . Two commercial robotic devices, the Gait Trainer (GT) and the Lokomat (LOKO), assist task-oriented practice of walking. The gait patterns induced by these motor-driven devices have not been characterized and compared. METHODS: . A healthy participant chose the most comfortable gait pattern on each device and for treadmill (TM) walking at 1, 2 (maximum for the GT), and 3 km/h and over ground at similar speeds. A system of accelerometers on the thighs and feet allowed the calculation of spatiotemporal features and accelerations during the gait cycle. RESULTS: . At the 1 and 2 km/h speed settings, single-limb stance times were prolonged on the devices compared with overground walking. Differences on the LOKO were decreased by adjusting the hip and knee angles and step length. At the 3 km/h setting, the LOKO approximated the participant's overground parameters. Irregular accelerations and decelerations from toe-off to heel contact were induced by the devices, especially at slower speeds. CONCLUSIONS: . The LOKO and GT impose mechanical constraints that may alter leg accelerations-decelerations during stance and swing phases, as well as stance duration, especially at their slower speed settings, that are not found during TM and overground walking. The potential impact of these perturbations on training to improve gait needs further study.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/12/2007
• Auteurs : Xavier ChardonCyrille RigolotChristine BaratteAlain-Hervé Le GallS. EspagnolRoger Martin-ClouaireJean-Pierre RellierChristelle RaisonJean-Claude PoupaPhilippe Faverdin
• Organismes : Production du lait Institut de l'élevage Systèmes d'Elevage, Nutrition Animale et Humaine Institut du Porc Production du lait Institut de l'élevage Institut du Porc Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) Institut de l'élevage Unité de recherche d'Économie et Sociologie Rurales Production du lait

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2007
• Auteurs : Karine Le GuenHélène MauryJean-Michel AndréPhilippe JonnardAurélie HardouinFranck DelmotteMarie-Françoise Ravet-Krill
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop
• Publié dans Applied Physics Letters le 01/11/2020

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Résumé : The use of Cr/Sc multilayer interferential mirrors (MIMs) in optical systems such as x-ray microscopes or telescopes have been reported for the water window (between C K- and O K-absorption edges). However, their possibilities in spectroscopic application have never been described in the literature. The purpose of the paper is to report for the first time on the performances of Cr/Sc MIMs as Bragg dispersive devices for the analysis in wavelength dispersive spectrometry of samples containing N or Sc atoms. The possibility to distinguish the chemical state of the emitting N or Sc atoms is evidenced by using Johan-type and double-crystal spectrometers.

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Fichiers liés : 00575878.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Jean-René PallandreEmilie BrillardGilles CréhangeAmandine RadlovicJean-Paul Remy-MartinPhilippe SaasPierre-Simon RohrlichXavier B. PivotXiang LingPierre TiberghienChristophe Borg
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service de Radiothérapie [CHRU Besançon] Service de Radiothérapie [CHRU Besançon] Service de Radiothérapie [CHRU Besançon] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'Oncologie Médicale [CHRU Besançon] Section of Molecular Hematology and Therapy Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'Oncologie Médicale [CHRU Besançon]
• Publié dans Journal of Immunology le 27/10/2020

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Résumé : Immunological tolerance is maintained by specialized subsets of T cells including CD4(+)CD25(+)FOXP3(+) regulatory cells (Treg). Previous studies established that Treg thymic differentiation or peripheral conversion depend on CD28 and Lck signaling. Moreover, foxp3 gene transfer in murine CD4(+)CD25(-) T lymphocytes results in the acquisition of suppressive functions. However, molecular pathways leading to FOXP3 expression remain to be described. In this study, we investigated the molecular events driving FOXP3 expression. We demonstrated that CD28 activation in CD4(+)CD25(-) T lymphocytes leads to STAT3 Tyr(705) phosphorylation in an Lck-dependent manner. STAT3 neutralization during naive peripheral CD4(+)CD25(-) T cell conversion into Treg through costimulation with TCR/CD28 and TGF-beta1, decreased FOXP3 expression, prevented the acquisition of suppressive functions and restored the ability of the converted lymphocytes to produce IL-2 and IFN-gamma. Furthermore, we observed that STAT3 ablation using small interfering RNA strategies inhibited FOXP3 expression and suppressive functions among naturally differentiated CD4(+)CD25(+) T lymphocytes, suggesting a direct role of STAT3 in Treg phenotype and function maintenance. CD4(+)CD25(+) T lymphocytes transduced with specific STAT3 small interfering RNA were devoid of suppressive functions and failed to control the occurrence of acute graft-vs-host disease. Finally, STAT3 inhibition in CD4(+) lymphocytes enhanced the anti-tumor immunity conferred by a lymphocyte adoptive transfer. In summary, our findings determine that STAT3 is critical in the molecular pathway required for FOXP3 expression. STAT3 modulation should be taken into account when assessing how regulatory T cells contribute to inflammatory diseases and tumor immunosurveillance.

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