Philippe JEAN-PIERRE

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/12/2008
• Auteurs : Fabrice BethuelPhilippe GravejatJean-Claude Saut
• Organismes : Laboratoire Jacques-Louis Lions CEntre de REcherches en MAthématiques de la DEcision Laboratoire de Mathématiques d'Orsay

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Résumé : This paper presents recent results concerning the existence and qualitative properties of travelling wave solutions to the Gross-Pitaevskii equation posed on the whole space R^N. Unlike the defocusing nonlinear Schrödinger equations with null condition at infinity, the presence of non-zero conditions at infinity yields a rather rich and delicate dynamics. We focus on the case N = 2 and N = 3, and also briefly review some classical results on the one-dimensional case. The works we survey provide rigorous justifications to the impressive series of results which Jones, Putterman and Roberts established by formal and numerical arguments.

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Fichiers liés : BGS-survey-end.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2008
• Auteurs : Pierre‐philippe LuyetThomas FalguièresVéronique PonsAsit K PattnaikJean Gruenberg
• Organismes : Université de Genève = University of Geneva Université de Genève = University of Geneva Université de Genève = University of Geneva University of Nebraska–Lincoln Université de Genève = University of Geneva
• Publié dans Traffic le 22/10/2020

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Résumé : Like other enveloped viruses, vesicular stomatitis virus infects cells through endosomes. There, the viral envelope undergoes fusion with endosomal membranes, thereby releasing the nucleocapsid into the cytoplasm and allowing infection to proceed. Previously, we reported that the viral envelope fuses preferentially with the membrane of vesicles present within multivesicular endosomes. Then, these intra-endosomal vesicles (containing nucleocapsids) are transported to late endosomes, where back-fusion with the endosome limiting membrane delivers the nucleocapsid into the cytoplasm. In this study, we show that the tumor susceptibility gene 101 (Tsg101) subunit of the endosomal sorting complexes required for transport (ESCRT)-I complex, which mediates receptor sorting into multivesicular endosomes, is dispensable for viral envelope fusion with endosomal membranes and viral RNA transport to late endosomes but is necessary for infection. Our data indicate that Tsg101, in contrast to the ESCRT-0 component Hrs, plays a direct role in nucleocapsid release from within multivesicular endosomes to the cytoplasm, presumably by controlling the back-fusion process. We conclude that Tsg101, through selective interactions with its partners including Hrs and Alix, may link receptor sorting and lysosome targeting to the back-fusion process involved in viral capsid release.

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Fichiers liés : Traffic - 2008 - Luyet - The ESCRT‐I Subunit TSG101 Controls Endosome‐to‐Cytosol Release of Viral RNA.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/11/2008
• Auteurs : Carlo Abi ChahineNathalie ChaignaudJean-Philippe KotowiczJean-Pierre Pécuchet
• Organismes : Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes

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Résumé : Document indexation is an essential task achieved by archivists or automatic indexing tools. To retrieve relevant documents to a query, keywords describing this document have to be carefully chosen. Archivists have to find out the right topic of a document before starting to extract the keywords. For an archivist indexing specialized documents, experience plays an important role. But indexing documents on different topics is much harder. This article proposes an innovative method for an indexing support system. This system takes as input an ontology and a plain text document and provides as output contextualized keywords of the document. The method has been evaluated by exploiting Wikipedia's category links as a termino-ontological resources.

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Fichiers liés : latex8.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/11/2008
• Auteurs : Nasissatou Ingrid TraoreGuy BarlesChristine GeorgelinJean René LicoisJaap J. van MilgenLucile MontagneFrederic GlasserPierre NoziereHélène FouilletPhilippe Lescoat
• Organismes : Unité de Recherches Avicoles Laboratoire de Mathématiques et Physique Théorique Laboratoire de Mathématiques et Physique Théorique Systèmes d'élevage, nutrition animale et humaine Systèmes d'élevage, nutrition animale et humaine Unité de Recherches sur les Herbivores Unité de Recherches sur les Herbivores Unité de Recherches Avicoles

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Résumé : absent

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/11/2008
• Auteurs : Bernadette BanrezesPhilippe AndreyEugénie CanonThierry Sainte-BeuveJosé‐manuel CancelaJean-Pierre Ozil
• Organismes : Biologie du développement et reproduction Neurobiologie de l'Olfaction et de la Prise Alimentaire Biologie du développement et reproduction Biologie du développement et reproduction Laboratoire de neurobiologie cellulaire et moléculaire Institut de Neurobiologie Alfred Fessard - Laboratoire de Physiologie Nerveuse Biologie du développement et reproduction

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• Type de publi. : Article dans une revue
• Date de publi. : 21/11/2008
• Auteurs : Nicolas MaubourguetAnnick LesneJean-Pierre ChangeuxUwe MaskosPhilippe Faure
• Organismes : Neurobiologie Intégrative des Systèmes Cholinergiques Institut des Hautes Études Scientifiques Neurobiologie Intégrative des Systèmes Cholinergiques Neurobiologie Intégrative des Systèmes Cholinergiques Neurobiologie Intégrative des Systèmes Cholinergiques
• Publié dans PLoS Computational Biology le 27/10/2020

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Résumé : Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta2-containing nAChRs (beta2-/-) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or "stops". These stops are associated with a scanning of the environment in wild-type mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific "decision moment" that is reduced in beta2-/- mutant mice, suggesting an important role of beta2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals.

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Fichiers liés : journal.pcbi.1000229.PDF

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/11/2008
• Auteurs : Stéphane BosseMarie-Line GrimaG. KenfackCédric Dumez-ViouP. PicardJacques PezzaniPatrice RenaudChristophe TaffoureauLaurent DenisAndrée CoffreI. ThomasStephen A. TorchinskyJean-Michel MartinÉric GérardWillem van DrielAlain LecacheuxPierre ColomAlain KerdraonRodolphe WeberPhilippe RavierR. Feliachi
• Organismes : Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Unité Scientifique de la Station de Nançay Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Physique stellaire et galactique Unité Scientifique de la Station de Nançay Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Physique stellaire et galactique Unité Scientifique de la Station de Nançay Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Physique stellaire et galactique Unité Scientifique de la Station de Nançay Laboratoire d'études spatiales et d'instrumentation en astrophysique Unité Scientifique de la Station de Nançay Laboratoire d'études spatiales et d'instrumentation en astrophysique Unité Scientifique de la Station de Nançay Laboratoire d'études spatiales et d'instrumentation en astrophysique Unité Scientifique de la Station de Nançay Institut PRISME Institut PRISME Institut PRISME

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Résumé : Nançay radio astronomy station teams are involved in several aspects of the Research and Development (R&D) for radio astronomy detectors and systems: i) Microelectronics: Low Noise Amplifiers (LNA), receiver on chip and

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/11/2008
• Auteurs : Jean-Philippe MaletYves DurandAlexandre RemaîtreOlivier MaquairePierre EtcheversGilbert Guyomarc’hMichel DéquéL. van Beek
• Organismes : Institut de physique du globe de Strasbourg Centre national de recherches météorologiques Ecole et Observatoire des Sciences de la Terre Littoral, Environnement, Télédétection, Géomatique Centre national de recherches météorologiques Centre national de recherches météorologiques Centre national de recherches météorologiques Faculty of Geosciences,

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• Type de publi. : Article dans une revue
• Date de publi. : 14/11/2008
• Auteurs : Khaled BenkaliPierre MarquetJean-Philippe RerolleYannick LemeurLouis Noël Gastinel
• Organismes : Pharmacologie des Immunosuppresseurs et de la Transplantation Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service de néphrologie et de transplantation Pharmacologie des Immunosuppresseurs et de la Transplantation
• Publié dans BMC Genomics le 01/11/2020

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Résumé : ABSTRACT: BACKGROUND: LC-MALDI-TOF/TOF analysis is a potent tool in biomarkers discovery characterized by its high sensitivity and high throughput capacity. However, methods based on MALDI-TOF/TOF for biomarkers discovery still need optimization, in particular to reduce analysis time and to evaluate their reproducibility for peak intensities measurement. The aims of this methodological study were: (i) to optimize and critically evaluate each step of urine biomarker discovery method based on Nano-LC coupled off-line to MALDI-TOF/TOF, taking full advantage of the dual decoupling between Nano-LC, MS and MS/MS to reduce the overall analysis time; (ii) to evaluate the quantitative performance and reproducibility of nano-LC-MALDI analysis in biomarker discovery; and (iii) to evaluate the robustness of biomarkers selection. RESULTS: A pool of urine sample spiked at increasing concentrations with a mixture of standard peptides was used as a specimen for biological samples with or without biomarkers. Extraction and nano-LC-MS variabilities were estimated by analyzing in triplicates and hexaplicates, respectively. The stability of chromatographic fractions immobilised with MALDI matrix on MALDI plates was evaluated by successive MS acquisitions after different storage times at different temperatures. Low coefficient of variation (CV%: 10-22%) and high correlation (R2 > 0.96) values were obtained for the quantification of the spiked peptides, allowing quantification of these peptides in the low fentomole range, correct group discrimination and selection of "specific" markers using principal component analysis. Excellent peptide integrity and stable signal intensity were found when MALDI plates were stored for periods of up to 2 months at +4degreesC. This allowed storage of MALDI plates between LC separation and MS acquisition (first decoupling), and between MS and MSMS acquisitions while the selection of inter-group discriminative ions is done (second decoupling). Finally the recording of MSMS spectra to obtain structural information was focused only on discriminative ions in order to minimize analysis time. CONCLUSION: Contrary to other classical approaches with direct online coupling of chromatographic separation and on the flight MS and/or MSMS data acquisition for all detected analytes, our dual decoupling strategy allowed us to focus on the most discriminative analytes, giving us more time to acquire more replicates of the same urine samples thus increasing detection sensitivity and mass precision.

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Fichiers liés : benkali_k_bmc_genomics.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 13/11/2008
• Auteurs : Luc MalletMircea PolosanNematollah JaafariNicolas BaupMarie-Laure WelterDenys FontaineSophie Tezenas Du MontcelJérôme YelnikIsabelle ChéreauChristophe ArbusSylvie RaoulBruno AouizeratePhilippe DamierStephan ChabardèsVirginie CzerneckiClaire ArdouinMarie-Odile KrebsEric BardinetPatrick ChaynesPierre BurbaudPhilippe CornuPhilippe DerostThierry BougerolBenoit BatailleVianney MatteiDidier DormontBertrand DevauxMarc VérinJean-Luc HouetoPierre PollakAlim-Louis BenabidYves AgidPaul KrackBruno MilletAntoine PelissoloNon Renseigné
• Organismes : Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm Service de Psychiatrie Immunologie antivirale systémique et cérébrale Centre Hospitalier Sainte-Anne [Paris] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm CHU Pitié-Salpêtrière [AP-HP] Service de Neurochirurgie CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CIC AP-HP (pitie-Salpetriere)/inserm Service Psychiatrie Adulte [CHU Clermont-Ferrand] Service Anatomie et cytologie pathologiques [CHU Toulouse] Service de physiologie Clinique neurologique Grenoble Institut des Neurosciences Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] UM des troubles du mouvement Centre Hospitalier Sainte-Anne [Paris] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière Service Neurochirurgie [CHU Toulouse] Physiologie et physiopathologie de la signalisation cellulaire CHU Pitié-Salpêtrière [AP-HP] Fondation FondaMental [Créteil] Clinique Universitaire de Psychiatrie Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Sainte-Anne [Paris] Université Paris Descartes - Paris 5 Service de Neurologie [Rennes] = Neurology [Rennes] Service de neurologie [CHU de Poitiers] Grenoble Institut des Neurosciences Département de neurologie Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information CHU Pitié-Salpêtrière [AP-HP] Grenoble Institut des Neurosciences Département de neurologie Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes] Service de psychiatrie CHU Pitié-Salpêtrière [AP-HP]
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : BACKGROUND: Severe, refractory obsessive-compulsive disorder (OCD) is a disabling condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for the treatment of movement disorders, has been proposed as a therapeutic option. METHODS: In this 10-month, crossover, double-blind, multicenter study assessing the efficacy and safety of stimulation of the subthalamic nucleus, we randomly assigned eight patients with highly refractory OCD to undergo active stimulation of the subthalamic nucleus followed by sham stimulation and eight to undergo sham stimulation followed by active stimulation. The primary outcome measure was the severity of OCD, as assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), at the end of two 3-month periods. General psychopathologic findings, functioning, and tolerance were assessed with the use of standardized psychiatric scales, the Global Assessment of Functioning (GAF) scale, and neuropsychological tests. RESULTS: After active stimulation of the subthalamic nucleus, the Y-BOCS score (on a scale from 0 to 40, with lower scores indicating less severe symptoms) was significantly lower than the score after sham stimulation (mean [+/-SD], 19+/-8 vs. 28+/-7; P=0.01), and the GAF score (on a scale from 1 to 90, with higher scores indicating higher levels of functioning) was significantly higher (56+/-14 vs. 43+/-8, P=0.005). The ratings of neuropsychological measures, depression, and anxiety were not modified by stimulation. There were 15 serious adverse events overall, including 1 intracerebral hemorrhage and 2 infections; there were also 23 nonserious adverse events. CONCLUSIONS: These preliminary findings suggest that stimulation of the subthalamic nucleus may reduce the symptoms of severe forms of OCD but is associated with a substantial risk of serious adverse events. (ClinicalTrials.gov number, NCT00169377.)

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