Philippe JEAN-PIERRE

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 14/10/2007
• Auteurs : Ibrahim CheddadiPierre SaramitoGraner FrançoisPhilippe MarmottantChristophe Raufaste
• Organismes : Modelling, Observations, Identification for Environmental Sciences Modelling, Observations, Identification for Environmental Sciences Laboratoire de Spectrométrie Physique Laboratoire de Spectrométrie Physique Institut de Recherche sur les Phénomènes Hors Equilibre Laboratoire de Spectrométrie Physique Physique et mécanique des milieux hétérogènes

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 14/10/2007
• Auteurs : Jean-Philippe TardifPeter SturmSébastien Roy
• Organismes : Département d'Informatique et de Recherche Opérationnelle [Montreal] Interpretation and Modelling of Images and Videos Département d'Informatique et de Recherche Opérationnelle [Montreal]

---

Résumé : We present an algorithm for plane-based self-calibration of cameras with radially symmetric distortions given a set of sparse feature matches in at least two views. The projection function of such cameras can be seen as a projection with a pinhole camera, followed by a non-parametric displacement of the image points in the direction of the distortion center. The displacement is a function of the points' distance to the center. Thus, the generated distortion is radially symmetric. Regular cameras, fish-eyes as well as the most popular central catadioptric devices can be described by such a model. Our approach recovers a distortion function consistent with all the views, or estimates one for each view if they are taken by different cameras. We consider a least squares algebraic solution for computing the homography between two views that is valid for rectified (undistorted) point correspondences. We observe that the terms of the function are bilinear in the unknowns of the homography and the distortion coefficient associated to each point. Our contribution is to approximate this non-convex problem by a convex one. To do so, we replace the bilinear terms by a set of new variables and obtain a linear least squares problem. We show that like the distortion coefficients, these variables are subject to monotonicity constraints. Thus, the approximate problem is a convex quadratic program. We show that solving it is sufficient for accurately estimating the distortion parameters. We validate our approach on simulated data as well as on fish-eye and catadioptric cameras. We also compare our solution to three state-of-the-art algorithms and show similar performance.

---

Fichiers liés : TardifSturmRoy-iccv2007.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 12/10/2007
• Auteurs : Sabeeha S MerchantSimon E ProchnikOlivier VallonElizabeth H HarrisSteven J KarpowiczGeorge B WitmanAstrid TerryAsaf SalamovLillian K Fritz-LaylinLaurence Maréchal-DrouardWallace F MarshallLiang-Hu QuDavid R NelsonAnton A SanderfootMartin H SpaldingVladimir V KapitonovQinghu RenPatrick FerrisErika LindquistHarris ShapiroSusan M LucasJane GrimwoodJeremy SchmutzPierre CardolHeriberto CeruttiGuillaume ChanfreauChun-Long ChenValérie CognatMartin T CroftRachel DentSusan DutcherEmilio FernándezHideya FukuzawaDavid González-BallesterDiego González-HalphenArmin HallmannMarc HanikenneMichael HipplerWilliam InwoodKamel JabbariMing KalanonRichard KurasPaul A LefebvreStéphane D. LemaireAlexey V LobanovMartin LohrAndrea ManuellIris MeierLaurens MetsMaria MittagTelsa MittelmeierJames V MoroneyJeffrey MoseleyCarolyn NapoliAurora M NedelcuKrishna K NiyogiSergey V NovoselovIan T PaulsenGreg PazourSaul PurtonJean-Philippe RalDiego Mauricio Riaño-PachónWayne RiekhofLinda RymarquisMichael SchrodaDavid L. SternJames UmenRobert WillowsNedra WilsonSara Lana ZimmerJens AllmerJanneke BalkKaterina BisovaChong-Jian ChenMarek EliasKarla GendlerCharles HauserMary Rose LambHeidi LedfordJoanne C LongJun MinagawaM Dudley PageJunmin PanWirulda PootakhamSanja RojeAnnkatrin RoseEric StahlbergAimee M TerauchiPinfen YangSteven BallChris BowlerCarol L DieckmannVadim N GladyshevPamela GreenRichard JorgensenStephen MayfieldBernd Mueller-RoeberSathish RajamaniRichard T SayrePeter BroksteinInna DubchakDavid GoodsteinLeila Hornicky Wayne HuangJinal JhaveriYigong LuoDiego MartínezWing Chi Abby NgauBobby OtillarAlexander PoliakovAaron PorterLukasz SzajkowskiGregory WernerKemin ZhouIgor V GrigorievDaniel S RokhsarArthur R Grossman
• Organismes : Department of Chemistry and Biochemistry Department of Energy / Joint Genome Institute Physiologie membranaire et moléculaire du chloroplaste Department of Biology Department of Chemistry and Biochemistry Department of Cell Biology Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Molecular & Cell Biology [Berkeley] Institut de Biologie Moléculaire des Plantes Department of Biochemistry and Biophysics Biotechnology Research Center Department of Molecular Sciences and Center of Excellence in Genomics and Bioinformatics Department of Plant Biology Department of Genetics, Development, and Cell Biology Genetic Information Research Institute The Institute for Genomic Research Plant Biology Laboratory Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Stanford School of Medicine [Stanford] Stanford School of Medicine [Stanford] Physiologie membranaire et moléculaire du chloroplaste Plant Biology Institute, Department of Life Sciences School of Biological Sciences–Plant Science Initiative Department of Chemistry and Biochemistry Biotechnology Research Center Institut de Biologie Moléculaire des Plantes Department of Plant Sciences Department of Plant and Microbial Biology [Berkeley] Department of Genetics Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Graduate School of Biostudies Department of Plant Biology [Carnegie] Departamento de Genética Molecular, Instituto de Fisiología Celular Department of Cellular and Developmental Biology of Plants Plant Biology Institute, Department of Life Sciences Institute for Plant Biochemistry and Biotechnology Department of Plant and Microbial Biology [Berkeley] Institut Jacques Monod Plant Cell Biology Research Centre, The School of Botany Physiologie membranaire et moléculaire du chloroplaste Department of Plant Biology Institut de biotechnologie des plantes Department of Biochemistry Institut für Allgemeine Botanik Department of Cell Biology and Skaggs Institute for Chemical Biology PCMB and Plant Biotechnology Center Molecular Genetics and Cell Biology Institut für Allgemeine Botanik und Pflanzenphysiologie Department of Molecular and Cellular Biology [University of Arizona] Department of Biological Science Department of Plant Biology [Carnegie] Biology Institute Department of Biology Department of Plant and Microbial Biology [Berkeley] Department of Biochemistry The Institute for Genomic Research Department of Physiology Department of Biology Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 University of Potsdam = Universität Potsdam Department of Medicine Delaware Biotechnology Institute Institute of Biology II/Plant Biochemistry Boyce Thompson Institute [Ithaca] Plant Biology Laboratory Department of Chemistry and Biomolecular Sciences Department of Anatomy and Cell Biology Boyce Thompson Institute [Ithaca] Izmir Ekonomi Universitesi Department of Plant Sciences Institute of Microbiology Biotechnology Research Center Department of Plant Physiology, Faculty of Sciences Biology Institute Bioinformatics Program Department of Biology Department of Plant and Microbial Biology [Berkeley] Department of Chemistry and Biochemistry Institute of Low-Temperature Science Department of Chemistry and Biochemistry Department of Biology Department of Plant Biology [Carnegie] Institute of Biological Chemistry Appalachian State University PCMB and Plant Biotechnology Center Department of Chemistry and Biochemistry Department of Biology Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Institut Jacques Monod Cell Signaling Laboratory Department of Molecular and Cellular Biology [University of Arizona] Department of Biochemistry Delaware Biotechnology Institute Biology Institute Department of Cell Biology and Skaggs Institute for Chemical Biology University of Potsdam = Universität Potsdam Graduate Program in Biophysics PCMB and Plant Biotechnology Center Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Energy / Joint Genome Institute Department of Molecular & Cell Biology [Berkeley] Department of Plant Biology [Carnegie]
• Publié dans Science le 22/10/2020

---

Résumé : Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/10/2007
• Auteurs : Nicolas BellegardePhilippe DessanteJean-Claude VannierPierre Vidal
• Organismes : SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif

---

Résumé : This paper is about a modelling and an optimisation of an electromechanical drive system. The device consists of a DC source, a power converter, a linear actuator and its load. The aim of the system is to drive a load along a linear displacement. The two main objectives are to reduce the actuator volume and the copper losses, which are contrary objectives. Here, we present an analytical modelling of the system and afterwards an optimisation of the linear actuator main dimensions in order to carry out the previous objectives.

---

Fichiers liés : 5_N.Bellegarde_Supelec.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2007
• Auteurs : C. CombadiereCharles FeumiWilliam RaoulNicole KellerMathieu P RoderoAdeline PézardSophie LavaletteMarianne HoussierLaurent JonetÉmilie PicardPatrice DebréMirna SirinyanPhilippe DeterreTania FerroukhiSalomon-Yves CohenDominique ChauvaudJean-Claude JeannySylvain ChemtobFrancine Behar-CohenFlorian Sennlaub
• Organismes : Immunologie cellulaire et tissulaire CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Immunologie cellulaire et tissulaire Immunologie cellulaire et tissulaire Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Immunologie cellulaire et tissulaire CHU Pitié-Salpêtrière [AP-HP] Department of Pediatrics, Ophthalmology and Pharmacology Immunologie cellulaire et tissulaire Immunologie cellulaire et tissulaire Centre d'Angiographie et de Laser Service d'ophtalmologie [Hôtel-Dieu - Paris] Centre de Recherche des Cordeliers Department of Pediatrics, Ophthalmology and Pharmacology Centre de Recherche des Cordeliers Service d'ophtalmologie [Hôtel-Dieu - Paris] Centre de Recherche des Cordeliers
• Publié dans Journal of Clinical Investigation le 24/10/2020

---

Résumé : The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 (CX3CR1) and that homozygosity for the CX3CR1 M280 allele, which is associated with impaired cell migration, increases the risk of AMD. In humans with AMD, MCs accumulated in the subretinal space at sites of retinal degeneration and choroidal neovascularization (CNV). In CX3CR1-deficient mice, MCs accumulated subretinally with age and albino background and after laser impact preceding retinal degeneration. Raising the albino mice in the dark prevented both events. The appearance of lipid-bloated subretinal MCs was drusen-like on funduscopy of senescent mice, and CX3CR1-dependent MC accumulation was associated with an exacerbation of experimental CNV. These results show that CX3CR1-dependent accumulation of subretinal MCs evokes cardinal features of AMD. These findings reveal what we believe to be a novel pathogenic process with important implications for the development of new therapies for AMD.

---

Fichiers liés : Combadiere_JCI_07.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2007
• Auteurs : Estelle Jumas-BilakJean-Philippe CarlierHélène Jean-PierreFrancine MoryCorinne TeyssierBernard GayJosiane CamposH. Marchandin
• Organismes : Laboratoire universitaire d'antibiologie Laboratoire de Bactériologie Department of Geology and Geophysics Institut de Recherche en Infectiologie de Montpellier Facultat de Fisica, Departament Universitari d'Optica Laboratoire universitaire d'antibiologie Laboratoire de Bactériologie
• Publié dans International Journal of Systematic and Evolutionary Microbiology le 31/10/2020

---

Résumé : Eleven strains of a hitherto unknown, Gram-negative, anaerobic coccus were recovered from various human clinical samples of patients hospitalized in two geographically distant French hospitals. These strains displayed the morphology and growth characteristics of those related to the genus Acidaminococcus. The clinical isolates shared at least 99.9 and 99.7 % of their nucleotide positions in the 16S and 23S rRNA gene sequences, respectively. They displayed 95.6 and 88.9 % 16S and 23S rRNA gene sequence similarities, respectively, with Acidaminococcus fermentans. The 16S rRNA-based phylogeny revealed that all the clinical isolates grouped in a statistically well supported cluster separate from A. fermentans. Enzymic activity profiles as well as metabolic end product patterns, including propionic acid production, differentiated the novel bacteria from A. fermentans. Finally, phenotypic, genotypic and phylogenetic data, including large-scale chromosome structure and DNA G+C content, supported the proposal of a novel species of the genus Acidaminococcus, for which the name Acidaminococcus intestini sp. nov. is proposed. The type strain is ADV 255.99(T) (=AIP 283.01(T)=CIP 108586(T)=CCUG 50930(T)).

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2007
• Auteurs : Benoît RousseauLudovic MénardValérie HaurieDanièle TarasJean-Frédéric BlancFrançois Moreau-GaudryPhilippe MetzlerMichel HuguesSandrine BoyaultSylvie LemièreXavier CanronPierre CostetMichael ColeCharles BalabaudPaulette Bioulac-SageJessica Zucman-RossiJean Rosenbaum
• Organismes : Fibrose hépatique et cancer du foie Fibrose hépatique et cancer du foie Fibrose hépatique et cancer du foie Fibrose hépatique et cancer du foie Fibrose hépatique et cancer du foie Service d'Hépato-Gastro-Entérologie Transfert de Genes a Visee Therapeutique Dans les Cellules Souches Fibrose hépatique et cancer du foie Fibrose hépatique et cancer du foie Génomique Fonctionnelle des Tumeurs Solides Mecanismes Moleculaires de l'Angiogenese Mecanismes Moleculaires de l'Angiogenese Animalerie spécialisée Department of Pharmacology and of Genetics Fibrose hépatique et cancer du foie Service d'Hépato-Gastro-Entérologie Fibrose hépatique et cancer du foie Service d'Hépato-Gastro-Entérologie Génomique Fonctionnelle des Tumeurs Solides Fibrose hépatique et cancer du foie
• Publié dans Hepatology le 30/10/2020

---

Résumé : Using a proteomic analysis of human hepatocellular carcinoma (HCC), we identified the overexpression in 4 tumors of RuvB-like 2 (RUVBL2), an ATPase and putative DNA helicase known to interact with beta-catenin and cellular v-myc myelocytomatosis viral oncogene homolog (c-myc). RUVBL2 expression was further analyzed in tumors with quantitative reverse-transcription polymerase chain reaction analysis and immunohistochemistry; in addition, RUVBL2 expression in a HuH7 cell line was silenced by small interfering RNA or increased with a lentiviral vector. RUVBL2 messenger RNA overexpression was confirmed in 72 of 96 HCC cases, and it was associated with poorly differentiated tumors (P = 0.02) and a poor prognosis (P = 0.02) but not with beta-catenin mutations or c-myc levels. Although RUVBL2 was strictly nuclear in normal hepatocytes, tumoral hepatocytes exhibited additional cytoplasmic staining. There was no mutation in the coding sequence of RUVBL2 in 10 sequenced cases. Silencing RUVBL2 in HuH7 HCC cells reduced cell growth (P < 0.001) and increased apoptosis, as shown by DNA fragmentation (P < 0.001) and caspase 3 activity (P < 0.005). This was associated with an increased expression of several proapoptotic genes and with an increased conformational activation of Bak-1 and Bax. On the other hand, HuH7 cells with an overexpression of RUVBL2 grew better in soft agar (P < 0.03), had increased resistance to C2 ceramide-induced apoptosis (P < 0.001), and gave rise to significantly larger tumors when injected into immunodeficient Rag2/gammac mice (P = 0.016). CONCLUSION: RUVBL2 is overexpressed in a large majority of HCCs. RUVBL2 overexpression enhances tumorigenicity, and RUVBL2 is required for tumor cell viability. These results argue for a major role of RUVBL2 in liver carcinogenesis.

---

Fichiers liés : Rousseau.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2007
• Auteurs : Emmanuelle LacazeJean-Philippe MichelMichel AlbaMichel Goldmann
• Organismes : Institut des Nanosciences de Paris Institut des Nanosciences de Paris Laboratoire Léon Brillouin Institut des Nanosciences de Paris
• Publié dans Physical Review E : Statistical, Nonlinear, and Soft Matter Physics [2001-2015] le 01/11/2020

---

Résumé : We study ultrathin films of 8CB in planar anchoring on a MoS(2) inorganic substrate. We evidence an anchoring breakage for 60-nm-thick films, in favor of the homeotropic anchoring at the air interface. This allows one to determine the 8CB-MoS(2) smectic anchoring energy. We then demonstrate for films thinner than 60 nm that, under the homeotropic bulk, an intermediate film remains in planar anchoring, associated with a melting of the smectic layers close to the substrate. Such a melting could be general for planar or tilted anchorings and we show that, for strong anchorings, the anchoring energy can be driven by the deformations of this intermediate nematic film.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2007
• Auteurs : Thierry BlanchonJeanne-Marie BréchotPhilippe A. GrenierGilbert R. FerrettiEtienne LemariéBernard MilleronDominique ChaguéFrançois LaurentYves MartinetCatherine Beigelman-AubryFrançois BlanchonMarie-Pierre RevelSylvie FriardMartine Rémy-JardinManuela VasileNicola SantelmoAlain LecalierPatricia LefébureDenis Moro-SibilotJean-Luc BretonMarie-France CaretteChristian BrambillaFrançois FournelAlexia KiefferGuy FrijaAntoine FlahaultGroup Depiscan
• Organismes : Epidémiologie des maladies infectieuses et modélisation CHU Tenon [AP-HP] Hôpital Avicenne [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut d'oncologie/développement Albert Bonniot de Grenoble Hôpital Bretonneau CHU Tenon [AP-HP] CH Belfort-Montbéliard Physiopathologie de la réactivite bronchique et vasculaire Centre Hospitalier Régional Universitaire de Nancy CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier de Meaux [Meaux-sur-Marne] Hôpital Européen Georges Pompidou [APHP] Hôpital Foch [Suresnes] Hôpital Albert Calmette Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Henri Duffaut (Avignon) Institut d'oncologie/développement Albert Bonniot de Grenoble CH Belfort-Montbéliard CHU Tenon [AP-HP] Institut d'oncologie/développement Albert Bonniot de Grenoble Epidémiologie des maladies infectieuses et modélisation Epidémiologie des maladies infectieuses et modélisation Hôpital Européen Georges Pompidou [APHP] Epidémiologie des maladies infectieuses et modélisation CHU Tenon [AP-HP]
• Publié dans Lung Cancer le 27/10/2020

---

Résumé : BACKGROUND: Lung cancer has the highest mortality-rate per cancer, with an overall 5-year survival <15%. Several non-randomized studies pointed out the high sensitivity of low dose computed tomography (LDCT) to detect early stage lung cancer. In France, Depiscan, a pilot RCT of LDCT versus chest X-ray (CXR), started on October 2002 to determine the feasibility of enrollment by general practitioners (GPs), investigations and diagnostic procedures by university hospital radiologists and multidisciplinary teams, data management by centralized clinical research assistants, and anticipate the future management of a large national trial. METHODS: GPs and occupational physicians (OPs) selected and enrolled 1000 subjects in 1 year. Eligible subjects were asymptomatic males or females aged 50-75 years with a current or former cigarette smoking history of >/=15 cigarettes per day for at least 20 years (former smokers having quit <15 years prior to enrollment). Based to randomization, annual LDCT or CXR screenings were planned at baseline and annually for 2 years. RESULTS: Between October 2002 and December 2004, 765 subjects were enrolled by 89 out of the 232 participating GPs and OPs. Complete clinical and imaging baseline data were available for 621 individuals out of the 765 enrolled, due to 144 noncompliant subjects who withdrew their consent. At least one nodule was detected in 152 out of 336 subjects (45.2%) in the LDCT screening, versus 21 out of 285 subjects (7.4%) in the CXR screening arm. Eight lung cancers were detected in the LDCT arm and one in the CXR arm. DISCUSSION: This pilot trial allows estimating that non-calcified nodules are 10 [6.36-17.07] times more often detected from LDCT than from CXR. However enrollment by GPs was more difficult than expected with 41% active investigators and a high rate (19%) of noncompliant patients. This experience speaks to the need for a high level of GPs formation and a large, coordinated clinical research team in such a trial. Trial registration number: 02526.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2007
• Auteurs : Philippe Verheyde
• Organismes : Institutions et Dynamiques Historiques de l'Economie

---

Source