Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 18/11/2024
• Auteurs : Rodolphe VaillonBasile RouxChristophe LucchesiJean-Philippe PerezPierre-Olivier Chapuis
• Organismes : Équipe Photonique Institut d’Electronique et des Systèmes Micro électronique, Composants, Systèmes, Efficacité Energétique Composants à Nanostructure pour le moyen infrarouge Centre d'Energétique et de Thermique de Lyon Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Matériaux Photonique et Ondes Centre d'Energétique et de Thermique de Lyon

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• Type de publi. : Article dans une revue
• Date de publi. : 16/11/2024
• Auteurs : Omar MotiñoFlavia LambertucciAdrien JosephSylvère DurandGerasimos AnagnostopoulosSijing LiVincent CarbonnierUxía Nogueira-RecaldeLéa MontégutHui ChenFanny AprahamianNitharsshini NirmalathasanMaria Chiara MaiuriFederico PietrocolaDominique VallaCédric LaouénanJean-François GautierLaurent CasteraAnaïs Vallet-PichardTiphaine Vidal-TrécanPauline ManchonValérie ParadisDominique RoulotChristian BoitardBenoît TerrisHélène BihanJean-Baptiste JullaThierry PoynardAngélique BzrustowskiEtienne LargerSébastien CzernichowStanislas PolPierre BedossaChristophe JunotNathalie de PrevilleIsabelle Durand ZaleskiPierre-Emmanuel RautouBernard van BeersMarco DioguardiValérie VilgrainJean-Marie CorreasPhilippe GarteiserJean-Pierre RivelineMark IbbersonIsabelle MartinsGuido Kroemer
• Organismes : Centre de Recherche des Cordeliers Institut Gustave Roussy Universidad de Valladolid = Universidade de Valladolid = Valladolideko Unibertsitatea = University of Valladolid = Université de Valladolid Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Instituto de Investigación Biomédica de A Coruña [La Corogne, Espagne] Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy University of Naples Federico II = Università degli studi di Napoli Federico II Karolinska Institutet = Karolinska Institute [Stockholm] Université Paris Cité Hôpital Beaujon [AP-HP] Infection, Anti-microbiens, Modélisation, Evolution Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique Institut Necker Enfants-Malades Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [AP-HP] Université Paris Cité Hôpital Beaujon [AP-HP] Centre de Recherche des Cordeliers Institut Gustave Roussy Centre de Recherche des Cordeliers Institut Gustave Roussy Cancer Research and Personalized Medicine - CARPEM [Paris]
• Publié dans Cell Death and Differentiation le 29/10/2020

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Résumé : Abstract Acyl-CoA binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular checkpoint of autophagy. Here, we report that patients with histologically confirmed metabolic-associated steatohepatitis (MASH) or liver fibrosis exhibit elevated levels of circulating ACBP/DBI protein as compared to non-affected controls. Plasma ACBP/DBI strongly correlated with the NAFLD and FIB4 scores in patients, and these correlations were independent of age and body mass index. We studied the capacity of a monoclonal antibody (mAb) neutralizing mouse ACBP/DBI to combat active liver disease in several mouse models, in which steatohepatitis had been induced by four different protocols, namely, (i) methionine/choline-deficient diet, (ii) Western style diet (WD) alone, (iii) WD combined with the hepatotoxic agent CCl 4 , and (iv) a combination of CCl 4 injections and oral ethanol challenge. Injections of anti-ACBP/DBI mAb attenuated histological, enzymological, metabolomic and transcriptomic signs of liver damage in these four models, hence halting or reducing the progression of non-alcoholic and alcoholic liver disease. Steatosis, inflammation, ballooning and fibrosis responded to ACBP/DBI inhibition at the preclinical level. Altogether, these findings support a causal role of ACBP/DBI in MASH and liver fibrosis, as well as the possibility to therapeutically target ACBP/DBI.

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Fichiers liés : 39550516.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/11/2024
• Auteurs : Clara De GrootePhilippe TisonStéphanie BertinOlivier CottencinJean-Louis Nandrino
• Organismes : Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193
• Publié dans Psychopathology le 26/10/2020

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Résumé : Beyond the memory deficits classically observed in individuals with alcohol use disorder (IwAUD), research has recently focused on the study of autobiographical memory (AM) processes in IwAUD by analysing the content of AM narratives, and the implications for self-conception have been discussed. However, little is known about how IwAUD subjectively experience autobiographical recall. Thirty-seven IwAUD and 37 control participants were invited to perform an AM task that involved recalling memories for 4 life periods (2 important memories per period). Then, they assessed their subjective experience during AM recall using 6 phenomenological scales evaluating emotional valence, emotional intensity, sensory details, distancing, sharing, and vividness. Anxiety and depression symptoms, interoceptive sensibility, and difficulties in emotion regulation were also measured. The IwAUD experienced greater distancing during AM recall, except during childhood AM recall, indicating that IwAUD are more prone to feeling that the person they are today is different from the person in their retrieved AMs. Very few intergroup differences were observed for AMs from childhood, adolescence-young adulthood, and adulthood, and a greater number of differences were observed for AMs from the last year: the IwAUD experienced AMs with a more negative valence, greater emotional intensity, fewer sensory details, greater distancing, and less sharing. A positive correlation was observed between distancing and interoceptive sensibility in the IwAUD group. Although these results suggest good preservation of autonoetic consciousness in IwAUD, except for more recent AMs, it is insufficient for IwAUD to experience a sense of self-continuity. This difficulty in maintaining a continuous sense of self may constitute a risk for AUD relapse.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/11/2024
• Auteurs : Tom DrossartAlexandre BuffetAli JanbainChris OttolenghiLaurence AmarRossella LibéDelphine DruiCharlotte Lussey-LepoutreMaxence ManciniTimgad LounisArmelle GUENEGOU ARNOUXTchao MéatchiJérôme BertheratNelly BurnichonJudith FavierAnne-Paule Gimenez-RoqueploAnne-Paule Gimenez-RoqueploLaurence AmarGilles ManceauAnne-Marie MadjalianAnne-Laure FauconErika CornuSandrine Laboureau-SoaresIngrid AllixFrédéric IllouzFairouz LalmiAline GauthierBelaïd SekourHervé LefebvreAnne-Françoise CailleuxRomain Le Bolc'HHind BerrahmouneEmmanuel SonnetLaurent DoucetVincent JoulinFrançoise Borson-ChazotHélène LasolleJean-Christophe LifanteLaure MaillardMyriam Decaussin-PetrucciArmelle DelahayeMarie Batisse-LignierDamien BouvierCatherine GodfraindOlivier ChabrePhilippe ChaffanjonNathalie SturmGabriel SchummerJustine CristanteLaure NasseFlora FassioIsabelle RaingeardEmmanuelle GallLaetitia ZerkowskiAnne Marie DupuyFrédérique LlorcyDelphine DruiMaëlle Le BrasAnne-Laure FournierEster LandauElias BarrakBertrand CariouViolette DierryAudrey ErnouldÉric MiralliéCécile CaillardChristophe FerronKarine RenaudinCécile GirardJérôme BertheratLaurence GuignatLionel GroussinGuillaume AssiéRossella LibéAnne JouinotMeriama SaidiKarine PerlemoineMathilde SibonyBenoît TerrisBéatrice ParfaitCharlotte Lussey-LepoutreSuzanne LarocheChristel JublancVirginie GrouthierChristophe TresalletPr Fabrice MenegauxGabrielle DeniziautGenevieve HerveIsabelle BrocheriouJean-Yves DelattreInes DetraitAntoine TabarinMagalie HaissaguerreAmandine GaliootMarie PuertoIsabelle GuilhemAgathe GuenegoAnnabelle EsvantAndréa ManuntaBernard GoichotMichel VixDidier MutterHervé LangPietro AddeoPeggy Renoult PierreLise CrinièreSerge GuyétantGaëlle FromontFranck BruyéreBenjamin Faivre d'ArcierCéline BourbaoEric BaudinSophie LeboulleuxJulien HadouxLivia Lamartina
• Organismes : Paris-Centre de Recherche Cardiovasculaire CIC - HEGP CIC - HEGP Reference Center for Inborn Errors of Metabolism, Necker University Hospital, APHP and University of Paris Cité, Paris, France. Hôpital Européen Georges Pompidou [APHP] Institut Cochin Hôpital Cochin [AP-HP] Institut du Thorax [CHU Nantes] Groupe de recherche clinique Tumeurs Thyroïdiennes CHU Pitié-Salpêtrière [AP-HP] Hopital Saint-Louis [AP-HP] CIC - HEGP Unité de Recherche Clinique et Centre Investigation Clinique-Epidémiologie Hôpital Européen Georges Pompidou [APHP] Institut Cochin Hôpital Cochin [AP-HP] CIC - HEGP Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] CIC - HEGP Université Paris Cité CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé : Abstract Context and Objective Identifying the risk of malignancy and genetic status in primary paraganglioma or pheochromocytoma (PPGL) is a key challenge. The aim was to assess the diagnostic accuracy of genomic, metabolomic and histopathological biomarkers for predicting metastatic and genetic status. Design, Setting, and Patients COMETE-TACTIC is a prospective study (NCT02672020) conducted from November 2015 to March 2019 across 16 referral centers. Tumor samples and liquid biopsies from 231 consecutive patients with PPGL were collected. Main Outcome Measures Germline and somatic genetic status were determined by next-generation sequencing, SDHB, SDHA and CA9 immunohistochemistries were performed on tumor tissues. TERT promoter methylation was assessed by pyrosequencing. Metabolomic profile and circulating miRNAs were measured in liquid biopsies by gas chromatography MS/MS and TaqMan assay quantified by droplet digital PCR, respectively. Results Tumor analysis outperformed germline analysis for determining genetic status. Positive SDHA and SDHB staining combined with negative CA9 labeling indicated the absence of SDHx and VHL variants. Plasma succinate levels above 4.94 µM identified SDHx mutation carriers with 65% sensitivity and 92% specificity [area under the receiver operating characteristic curve (AUC-ROC) 0.82, 95% confidence interval (CI) 0.70-0.93]. Among circulating miRNAs, miR-483-5p was the best classifier of metastatic status (AUC-ROC 0.64, 95%CI 0.52-0.77). A sum of dinucleotide methylation rate of TERT promoter CpGs above 42% predicted metastatic status (AUC-ROC 0.75, 95% CI 0.65-0.85). Multivariate analyses showed that biomarker combinations significantly predicted SDHx status (AUC-ROC 0.99, 95% CI 0.98-1.00) and metastatic potential (AUC-ROC 0.93, 95% CI 0.84-1). Conclusion Circulating miR-483-5p, plasma succinate, TERT promoter methylation, and SDHB immunostaining are valuable for PPGL risk stratification. Combining biomarkers with clinical data provides excellent diagnostic accuracy for metastatic patients (AUC-ROC 0.97, 95%CI 0.93-1).

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 14/11/2024
• Auteurs : Chantal LeroyerFrédérique DurandPierre MilleVincent BernardYannick Le DigolPhilippe Poirier
• Organismes : Ministère de la Culture Centre de Recherche en Archéologie, Archéosciences, Histoire Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Centre de Recherche sur l'Environnement et l'Aménagement Centre de Recherche en Archéologie, Archéosciences, Histoire Dendrotech Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier

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• Type de publi. : Article dans une revue
• Date de publi. : 12/11/2024
• Auteurs : P. AdrichP. BlumerG. CaratschM. ChungPierre CladéP. CominiP. CrivelliO. DalkarovP. DebuA. DouilletD. DrapierP. FroelichNabil GarroumSaïda Guellati-KhélifaJ. GuyomardPaul-Antoine HervieuxLaurent HilicoPaul IndelicatoS. JonsellJean-Philippe KarrB. KimS. KimE.-S. KimY. KoT. KosinskiN. KurodaB.M. LataczB. LeeH. LeeJ. LeeE. LimL. LiszkayD. LunneyGiovanni ManfrediB. MansouliéM. MatusiakV. NesvizhevskyF. NezS. NiangBen OhayonK. ParkNancy PaulP. PérezC. RegenfusSerge ReynaudCorentin RoumegouJ.-Y. RousséY. SacquinG. SadowskiJ. SarkisyanM. SatoF. Schmidt-KalerM. StaszczakK. SzymczykT. TanakaB. TuchmingB. VallageAnatoli VoroninD.P. van der WerfA. WelkerD. WongS. WronkaY. YamazakiK.-H. YooPauline Yzombard
• Organismes : National Center for Nuclear Research Institute for Particle Physics and Astrophysics [ETH Zürich] Institute for Particle Physics and Astrophysics [ETH Zürich] Ulsan National Institute of Science and Technology Laboratoire Kastler Brossel Institut de Recherches sur les lois Fondamentales de l'Univers Institute for Particle Physics and Astrophysics [ETH Zürich] CERN [Genève] Institut de Recherches sur les lois Fondamentales de l'Univers Université d'Évry-Val-d'Essonne Laboratoire Kastler Brossel Laboratoire Kastler Brossel Stockholm University Department of Physics [Stockholm] Angström Laboratory Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Kastler Brossel Laboratoire Kastler Brossel Laboratoire commun de métrologie LNE-CNAM Laboratoire Kastler Brossel Institut de Physique et Chimie des Matériaux de Strasbourg Université d'Évry-Val-d'Essonne Laboratoire Kastler Brossel Laboratoire Kastler Brossel Department of Physics [Stockholm] Laboratoire Kastler Brossel Université d'Évry-Val-d'Essonne Korea Basic Science Institute Department of Physics and Astronomy [Seoul] Korea University [Seoul] Institute for Basic Science [Daejeon] National Centre for Nuclear Research [Otwock] The University of Tokyo Institut de Recherches sur les lois Fondamentales de l'Univers Seoul National University [Seoul] Department of Physics and Astronomy [Seoul] Institute for Basic Science [Daejeon] Korea University [Seoul] Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Recherches sur les lois Fondamentales de l'Univers National Centre for Nuclear Research [Otwock] Institut Laue-Langevin Laboratoire Kastler Brossel Laboratoire de Physique des 2 Infinis Irène Joliot-Curie CERN [Genève] Institute for Particle Physics and Astrophysics [ETH Zürich] Institute for Basic Science [Daejeon] Department of Physics and Astronomy [Seoul] Laboratoire Kastler Brossel Institut de Recherches sur les lois Fondamentales de l'Univers Institute for Particle Physics and Astrophysics [ETH Zürich] Laboratoire Kastler Brossel Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institute for Particle Physics and Astrophysics [ETH Zürich] The University of Tokyo Institut für Physik [Mainz] National Centre for Nuclear Research [Otwock] National Centre for Nuclear Research [Otwock] The University of Tokyo Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers CERN [Genève] Department of Physics [Swansea] CERN [Genève] Department of Physics and Astronomy [Seoul] National Centre for Nuclear Research [Otwock] Saitama University Ulsan National Institute of Science and Technology Laboratoire Kastler Brossel
• Publié dans European Physical Journal C: Particles and Fields le 23/10/2020

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Résumé : We report on the first production of an antihydrogen beam by charge exchange of 6.1 keV antiprotons with a cloud of positronium in the GBAR experiment at CERN. The 100 keV antiproton beam delivered by the AD/ELENA facility was further decelerated with a pulsed drift tube. A 9 MeV electron beam from a linear accelerator produced a low energy positron beam. The positrons were accumulated in a set of two Penning–Malmberg traps. The positronium target cloud resulted from the conversion of the positrons extracted from the traps. The antiproton beam was steered onto this positronium cloud to produce the antiatoms. We observe an excess over background indicating antihydrogen production with a significance of 3–4 standard deviations.

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Fichiers liés : s10052-024-13515-w.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/11/2024
• Auteurs : Bastien LaperrousazBenoît LevastMathieu FontaineStéphane NanceyPierre DechelotteJoel DorePhilippe Lehert
• Organismes : MaaT Pharma [Lyon] MaaT Pharma [Lyon] MaaT Pharma [Lyon] Service d'Hépatologie et de Gastroentérologie [Lyon] Hospices Civils de Lyon Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Centre International de Recherche en Infectiologie Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service de Nutrition [CHU Rouen] MetaGenoPolis MICrobiologie de l'ALImentation au Service de la Santé UCL Crypto Group University of Melbourne
• Publié dans BMC Gastroenterology le 01/11/2020

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Résumé : BackgroundMultiple studies have evaluated fecal microbiota transfer (FMT) in patients with ulcerative colitis (UC) using single-donor (SDN) and multidonor (MDN) products. Systematic review and meta-analysis were performed to compare the safety of SDN and MDN products.MethodsSystematic searches were performed in Web of Science, Scopus, PubMed, and Orbit Intelligence to identify studies that compared FMT products manufactured using SDN or MDN strategies against control treatment in patients with UC. Fifteen controlled studies were selected for meta-analysis (11 randomized controlled trials and 4 controlled cohort trials). Safety of each treatment type was assessed using the counts of adverse events and serious adverse events using fixed- and random-effects models. Significance of the indirect difference between FMT preparations was assessed using a network approach. Benefit-risk ratios were calculated by multiplicative utility model, incorporating geometric mean of risk ratios (RRs) of efficacy and safety.ResultsSafety data was collected for a total of 587 patients (193 exposed to SDN products, 114 exposed to MDN products and 280 exposed to control treatment). The 12 studies showed similar overall safety event counts for MDN and SDN versus placebo (RRs: 0.90 and 1.09, respectively [P = 0.206 and P = 0.420, respectively]). Results indicated similar risk of safety events for MDN compared to SDN (RR: 0.83, P = 0.159). Positive benefit-risk ratios were demonstrated for MDN and SDN versus placebo (RRs: 1.70 and 1.16, respectively [P = 0.003 and P = 0.173, respectively]). MDN had a greater benefit-risk ratio compared to SDN (RR: 1.46, P = 0.072).ConclusionSimilar safety profiles were observed for MDN and SDN strategies. Alongside previously described superior efficacy, treatment with MDN has greater benefit-risk ratio than SDN in patients with UC. Further development of MDN FMT treatment for UC should be considered.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/11/2024
• Auteurs : Raghiatou BaldéLambert AssoumouChristine KatlamaBaptiste AbbarPierre DelobelThierry AllegreArmelle LavoleAlain MakinsonOlivia Zaegel-FaucherLaurent GreillierCathia SouliéMarianne VeyriMathilde BertheauMichèle Algarte GeninSéverine GibowskiAnne-Geneviève MarcelinKevin BihanMarine BaronDominique CostagliolaOlivier LambotteJean-Philippe Spano
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier d'Aix en Provence [Aix-en-Provence] CHU Tenon [AP-HP] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Département Maladies Infectieuses et Tropicales [CHRU Montpellier] Aix Marseille Université Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM] Multidisciplinary Oncology and Therapeutic Innovations Unit / Service d’Oncologie Multidisciplinaire et d’Innovations Thérapeutiques Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique ANRS - Maladies infectieuses émergentes Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] ANRS - Maladies infectieuses émergentes CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Institut Pierre Louis d'Epidémiologie et de Santé Publique Service de Médecine interne - Immunologie clinique [Kremlin-Bicêtre] Université Paris-Saclay CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique

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Résumé : Background: immune checkpoint inhibitors (ICIs) have been a major advance in cancer management. However, we still lack prospective real-world data regarding their usage in people with HIV infection (PWH). Materials and methods: the ANRS-CO24-OncoVIHAC study (NCT03354936) is an ongoing prospective observational cohort study in France of PWH with cancer treated with ICI. We assessed the incidence of grade ≥3 immune-related adverse events (irAEs). All grade ≥3 irAEs were reviewed by an Event Review. Results: between 17 January 2018 and 5 December 2023, 150 participants were recruited from 33 sites and 140 were included in this analysis. At the data cut-off date of 5 December 2023, median follow-up was 9.2 months (IQR 3.9–18.3), with a total of 126.2 person-years. Median age was 59 years (IQR 54–64) and 111 (79.3%) were men. Median time since HIV diagnosis was 25 years (12–31), median duration on ARV was 19.5 years (7.7–25.4) and the CD4 nadir was 117/µl (51–240). ICI regimens comprised anti-programmed cell death protein 1 (PD1) for 111 (79.3%) participants, anti-programmed death-ligand 1 (PDL1) for 25 (17.9%), a combination of anti-PD1 and anti-human cytotoxic T-lymphocyte-associated protein 4 (CTLA4) for three (2.1%), and anti-PD1 along with anti-vascular endothelial growth factor (VEGFR) for one (0.7%). The most frequent cancers were lung (n = 65), head/neck (n = 15), melanoma (n = 12), liver (n = 11) and Hodgkin lymphoma (n = 9). During follow-up, a total of 34 grade ≥3 irAEs occurred in 20 participants, leading to an incidence rate of 26.9 per 100 person-years. The Kaplan-Meier estimates of the proportion of participants with at least one episode of grade ≥3 irAEs were 13.8% at 6 months, 15.0% at 12 months and 18.7% at 18 months. One treatment-related death due to myocarditis was reported (0.7%). Multivariable analysis of cumulative incidence showed that participants with time since HIV diagnosis >17 years (incidence rate ratio [IRR] 4.66, p = 0.002), with CD4 <200 cells/µl (IRR 4.39, p < 0.0001), with positive cytomegalovirus (CMV) serology (IRR 2.76, p = 0.034), with history of cancer surgery (IRR 3.44, p = 0.001) had a higher risk of incidence of grade ≥3 irAEs. Conclusions: this study showed that the incidence of a first episode of grade ≥3 irAE was 15.0% (95% CI 9.6–22.9) at 1 year and the cumulative incidence of all severe irAE episodes was 26.9 per 100 person-years. Low CD4 count, positive CMV serology, history of cancer surgery and a longer time since HIV diagnosis were associated with the occurrence of severe irAEs.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/11/2024
• Auteurs : Cassandra NormandinFrédéric FrappartLuc BourrelFabien BlarelSylvain BiancamariaJean-Pierre WigneronLéonie GalenonEmilie BernardLudovic CoulonBertrand LubacVincent MarieuVincent VantrepotteBinh Pham-DucHuy Toan DoCatherine PrigentFilipe AiresDai YamazakiPhilippe Ciais
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Géosciences Environnement Toulouse Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Interactions Sol Plante Atmosphère Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'études en Géophysique et océanographie spatiales Environnements et Paléoenvironnements OCéaniques Environnements et Paléoenvironnements OCéaniques Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Vietnam Academy of Science and Technology [Hanoi] Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres University of Tokyo [Kashiwa Campus] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans Science of the Total Environment le 29/10/2020

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Résumé :

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Fichiers liés : 1-s2.0-S0048969724054093-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/11/2024
• Auteurs : Annicet-Clotaire DikoumbaPierre Philippe Mbehang NguemaLeresche Even Doneilly Oyaba YindaRoméo Wenceslas LendambaJean Constan Obague MbeangGuy Roger Ndong AtomeZinga-Koumba Christophe RolandSylvain GodreuilRichard Onanga
• Organismes : Centre Interdisciplinaire de Recherches Médicales de Franceville Institut de Recherche en Ecologie Tropicale Centre Interdisciplinaire de Recherches Médicales de Franceville Centre de Recherches Médicales de Lambaréné Institut de Recherche en Ecologie Tropicale Departement de Chimie Institut de Recherche en Ecologie Tropicale Département de Bactériologie-Virologie [CHRU Montpellier] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Centre Interdisciplinaire de Recherches Médicales de Franceville
• Publié dans Antibiotics le 24/10/2020

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Résumé : Background: In Gabon, studies on the characterization of extended-spectrum beta-lactamase-producing Escherichia coli in young children with diarrhoea are almost nonexistent. The objective was to evaluate the prevalence of antibiotic resistance to extended-spectrum beta-lactamase-producing Escherichia coli in children at public hospitals in Franceville, Gabon. Methods: Seventy diarrhoea faecal samples were collected from children aged 0–5 years. The culture and isolation of colonies were carried out on MacConkey agar. The colonies were identified using VITEK 2. The determination of the extended-spectrum beta-lactamase’s profiles was accomplished using the double disk method. The identification of phylogroups and pathotypes was performed by PCR. Identification of the ESBL genes was performed by sequencing. Results: A total of 26 strains of Escherichia coli (33.0%) were identified from 78 bacterial isolates. Twenty (77.0%) Escherichia coli strains carried extended-spectrum beta-lactamases blaCTX-M-15 and 5.0% carried blaSHV-12 subtypes. Phylogroup D (62.0%) was predominant, followed by B1 (12.0%), B2 (8.0%) and E (4.0%). The bacterial pathogens causing diarrhoea were enterohemorrhagic E. coli (12.0%), typical enteropathogenic Escherichia coli (8.0%), atypical enteropathogenic Escherichia coli (4.0%), Enteroaggregative Escherichia coli (4.0%) and enteroinvasive E. coli (4.0%). Conclusions: This study showed a high prevalence of extended-spectrum beta-lactamase, Escherichia coli of phylogroup D and pathotype enterohemorrhagic Escherichia coli in children under 5 years old in public hospitals in Franceville, most probably due to the misuse or inappropriate consumption of beta-lactams.

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Fichiers liés : antibiotics-13-01059.pdf

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