Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Etienne SamainJonathan WeickPatrick VranckenFranck ParaDominique AlbaneseJocelyn ParisJean-Marie TorreCheng ZhaoPhilippe GuillemotIsabelle Petitbon
• Organismes : Laboratoire Gemini Géoazur Laboratoire Gemini Géoazur Laboratoire Gemini Institut des Matériaux, de Microélectronique et des Nanosciences de Provence Laboratoire Gemini Laboratoire Gemini Laboratoire Gemini Laboratoire Gemini Chinese Academy of Sciences [Changchun Branch] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse]
• Publié dans International Journal of Modern Physics D le 25/10/2020

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Résumé : The new generation of optical time transfer will allow the synchronization of remote ultra stable clocks and the determination of their performances over intercontinen-tal distances. The principle of T2L2 (Time Transfer by Laser Link) is based on the techniques of satellite laser ranging coupled with time-frequency metrology. It consists of synchronizing ground and space clocks using short laser pulses travelling between ground clocks and satellite equipment. The instrument will be integrated on the ocean altimetry satellite Jason-2 that is scheduled for launch in 2008. a The experiment should enhance the performance of time transfer by one or two magnitudes compared to existing microwave techniques such as GPS and Two-Way Satellite Time and Frequency Transfer (TWSTFT).

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Fichiers liés : 2008_International Journal of Modern Physics D.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Nicolas MangoldAline GendrinBrigitte GondetStéphane Le MouélicCathy Quantin-NatafV. AnsanJean-Pierre BibringYves LangevinPhilippe MassonGerhard Neukum
• Organismes : Interactions et dynamique des environnements de surface Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Interactions et dynamique des environnements de surface Interactions et dynamique des environnements de surface Institut d'astrophysique spatiale Institut d'astrophysique spatiale Interactions et dynamique des environnements de surface
• Publié dans Icarus le 30/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre RaboissonDominique SchultzChristian MullerJean-Marie ReimundGuillaume PinnaRomain MathieuPhilippe BernardQuoc-Tuan DoRenee DesjarlaisHélène JustianoClaire LugnierJean-Jacques Bourguignon
• Organismes : Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Cooltech Applications Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen] Institut de Biologie Intégrative de la Cellule Centre de Recherches Pétrographiques et Géochimiques Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
• Publié dans European Journal of Medicinal Chemistry le 31/10/2020

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Résumé : A series of 8-substituted pyrazolo[1,5-a]-1,3,5-triazines were considered as a bioisosteric replacement for the 9-substituted adenine derivatives resulting in the discovery of 8-(2-methoxybenzyl)-4-(N-methylamino)-2-n-propylpyrazolo[1,5-a]-1,3,5-triazine (14d) and 2-trifluoromethyl-8-(2-methoxybenzyl)-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine (14e) as a new structural class of potent phosphodiesterase type 4 inhibitors (IC50 = 13 nM and 11 nM, respectively) with high isoenzyme selectivity. An original tandem of reactions involving a palladium-mediated cross-coupling reaction (PMCCR) of the readily available 8-iodo-2-methyl-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazine (11a) and arylboronic acids or alkynes followed by the displacement of the N-methyl-N-phenylamino group constitute the key steps in a novel synthetic approach developed herein. The treatment of 11a–c with n-BuLi and selected aldehydes represents an interesting alternative to the PMCCR for the synthesis of benzylic derivatives 14a–i. Preliminary biological testing has shown that compounds 14d and 14e strongly inhibit LPS-induced TNFα release from human mononuclear cells from healthy subjects. These two compounds were selected for further biological evaluation. Some derivatives belonging to the series of pyrazolo[1,5-a]-1,3,5 triazines act as adenine bioisosteres and present potent and selective PDE4 inhibitory properties.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jeremy GuendouzPierre BuffièreJuan CachoMyriam CarrèreJean-Philippe Delgenès
• Organismes : VEOLIA France Laboratoire de Génie Civil et d'Ingénierie Environnementale VEOLIA France VEOLIA France Laboratoire de Biotechnologie de l'Environnement [Narbonne]
• Publié dans Water Science and Technology le 26/10/2020

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Résumé : Two experiments were undertaken in three different experimental set-ups in order to compare them: an industrial 21-m(3) pilot reactor, a new 40-l laboratory pilot reactor and bmp type plasma bottles. Three consecutive batch dry digestion tests of municipal solid waste were performed under mesophilic conditions with the same feedstock in all vessels. Biogas and methane production at the end of the tests were similar (around 200m(3) CH4STP/tVS) for both pilot reactors and were different from the bottle tests. The dynamics of methane production and VFA accumulation concurred. However, the maximal levels of VFA transitory accumulation varied between reactors and between runs in a same reactor. Ammonia levels were similar in both reactors. These results show that the new reactor accurately imitates the conditions found in the larger one. Adaptation of microorganisms to the waste and operating conditions was also pointed out along the consecutive batches. Thermophilic semi-continuous tests were performed in both reactors with similar conditions. The methane production efficiencies were similar.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Jean-Pierre CharpyDidier CarnetPhilip BastablePhilippe de La Grange
• Organismes : Centre Interlangues - Texte, Image, Langage Centre Interlangues - Texte, Image, Langage

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• Type de publi. : Autre publication
• Date de publi. : 01/01/2008
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Jean-Marie AubyPhilippe TerneyreJean-Bernard AubyPierre Bon
• Organismes : Centre d’Étude et de Recherche sur le Droit Administratif et la Réforme de l’État Université de Pau et des Pays de l'Adour École de Droit de Sciences Po (Sciences Po) Droit public comparé - Droit international et Droit européen Droits International, Comparé et Européen / Institut d'études ibériques et ibérico-américaines (IE2IA)

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Résumé : Manifestation du caractère dérogatoire du droit administratif, les biens de l’administration obéissent à des règles propres, qu’elles portent sur leurs statuts, leurs modes d’acquisition ou la façon d’y conduire des travaux. Maintenant dans sa quatrième édition, le Précis de Droit administratif des biens analyse les évolutions sensibles de ce droit au cours des dernières, notamment grâce à l'enrichissement du droit administratif des contrats, à la préoccupation croissante de valoriser économiquement le patrimoine public ainsi qu'aux incidences de la Convention européenne des droits de l'homme en matière d'expulsion.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Loïc MaisonnassePhilippe MulhemÉric GaussierJean-Pierre Chevallet
• Organismes : Distribution, Recherche d'Information et Mobilité Laboratoire d'Informatique de Grenoble Modélisation et Recherche d’Information Multimédia [Grenoble] Modélisation et Recherche d’Information Multimédia [Grenoble] Modélisation et Recherche d’Information Multimédia [Grenoble]

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Elodie Françoise VerhaegheAurélien FraysseJean-Luc Guerquin-KernTing-Di WuGuillaume DevèsCharles MioskowskiCatherine LeblancOrtega RYves AmbroisePhilippe Potin
• Organismes : Institut de Biologie et de Technologies de Saclay Chimie Nucléaire Analytique et Bio-environnementale laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff] Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff]
• Publié dans Journal of Biological Inorganic Chemistry le 31/10/2020

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Résumé : Brown algal kelp species are the most efficient iodine accumulators among all living systems, with an average content of 1.0% of dry weight in Laminaria digitata. The iodine distributions in stipe and blade sections from L. digitata were investigated at tissue and subcellular levels. The quantitative tissue mapping of iodine and other trace elements (Cl, K, Ca, Fe, Zn, As and Br) was provided by the proton microprobe with spatial resolutions down to 2 mum. Chemical imaging at a subcellular resolution (below 100 nm) was performed using the secondary ion mass spectrometry microprobe. Sets of samples were prepared by both chemical fixation and cryofixation procedures. The latter prevented the diffusion and the leaching of labile inorganic iodine species, which were estimated at around 95% of the total content by neutron activation analysis. The distribution of iodine clearly shows a huge, decreasing gradient from the meristoderm to the medulla. The contents of iodine reach very high levels in the more external cell layers, up to 191 +/- 5 mg g(-1) of dry weight in stipe sections. The peripheral tissue is consequently the main storage compartment of iodine. At the subcellular level, iodine is mainly stored in the apoplasm and not in an intracellular compartment as previously proposed. This unexpected distribution may provide an abundant and accessible source of labile iodine species which can be easily remobilized for potential chemical defense and antioxidative activities. According to these imaging data, we proposed new hypotheses for the mechanism of iodine storage in L. digitata tissues.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-Baptiste PierreThierry HuguetPhilippe BarreChristian HuygheBernadette Julier
• Organismes : Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité mixte de recherche interactions plantes-microorganismes École nationale supérieure agronomique de Toulouse Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères
• Publié dans TAG Theoretical and Applied Genetics le 01/11/2020

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Résumé : Adaptation to the environment and reproduction are dependent on the date of flowering in the season. The objectives of this paper were to evaluate the effect of photoperiod on flowering date of the model species for legume crops, Medicago truncatula and to describe genetic architecture of this trait in multiple mapping populations. The effect of photoperiod (12 and 18 h) was analysed on eight lines. Quantitative variation in three recombinant inbred lines (RILs) populations involving four parental lines was evaluated, and QTL detection was carried out. Flowering occurred earlier in long than in short photoperiods. Modelling the rate of progression to flowering with temperature and photoperiod gave high R-2, with line-specific parameters that indicated differential responses of the lines to both photoperiod and temperature. QTL detection showed a QTL on chromosome 7 that was common to all populations and seasons. Taking advantage of the multiple mapping populations, it was condensed into a single QTL with a support interval of only 0.9 cM. In a bioanalysis, six candidate genes were identified in this interval. This design also indicated other genomic regions that were involved in flowering date variation more specifically in one population or one season. The analysis on three different mapping populations detected more QTLs than on a single population, revealed more alleles and gave a more precise position of the QTLs that were common to several populations and/or seasons. Identification of candidate genes was a result of integration of QTL analysis and genomics in M. truncatula.

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