Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2007
• Auteurs : Cendra AgulhonJean-Claude PlatelBogdan KolomietsValérie ForsterSerge PicaudJacques S. BrocardPhilippe FaurePhilippe Brulet
• Organismes : Embryologie Moléculaire Dynamique des Reseaux Neuronaux Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Organisation Fonctionnelle du Cytosquelette Neurobiologie Intégrative des Systèmes Cholinergiques Embryologie Moléculaire
• Publié dans The Journal of Physiology le 29/10/2020

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Résumé : Glial Ca(2+) excitability plays a key role in reciprocal neuron-glia communication. In the retina, neuron-glia signalling is expected to be maximal in the dark, but the glial Ca(2+) signal characteristics under such conditions have not been evaluated. To address this question, we used bioluminescence imaging to monitor spontaneous Ca(2+) changes under dark conditions selectively in M?r cells, the principal retinal glial cells. By combining this imaging approach with network analysis, we demonstrate that activity in M?r cells is organized in networks of coactive cells, involving 2-16 cells located distantly and/or in clusters. We also report that spontaneous activity of small networks (2-6 M?r cells) repeat over time, sometimes in the same sequential order, revealing specific temporal dynamics. In addition, we show that networks of coactive glial cells are inhibited by TTX, indicating that ganglion and/or amacrine neuronal cells probably regulate M?r cell network properties. These results represent the first demonstration that spontaneous activity in adult M?r cells is patterned into correlated networks that display repeated sequences of coactivations over time. Furthermore, our bioluminescence technique provides a novel tool to study the dynamic characteristics of glial Ca(2+) events in the retina under dark conditions, which should greatly facilitate future investigations of retinal dark-adaptive processes.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/09/2007
• Auteurs : Arnaud JaccardPhilippe MoreauVéronique LeblondXavier LeleuLofti BenboubkerOlivier HermineChristian RécherBouchra AsliBruno LioureBruno RoyerFabrice JardinFranck BridouxBernard GrosboisJérôme JaubertJean-Charles PiettePierre RoncoFabrice QuetMichel CognéJean-Paul Fermand
• Organismes : Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service d'Hématologie biologique [CHU Limoges] Service d'hématologie clinique Service Hématologie thérapie cellulaire Service d'immuno-hématologie pédiatrique [CHU Necker] Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Remodelage et Reparation du Tissu Renal Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Université de Limoges
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a randomized study. METHODS: We conducted a randomized trial comparing high-dose intravenous melphalan followed by autologous hematopoietic stem-cell rescue with standard-dose melphalan plus high-dose dexamethasone in patients with AL amyloidosis. Patients (age range, 18 to 70 years) with newly diagnosed AL amyloidosis were randomly assigned to receive intravenous high-dose melphalan plus autologous stem cells or oral melphalan plus oral high-dose dexamethasone. RESULTS: Fifty patients were enrolled in each group. The results were analyzed on an intention-to-treat basis, with overall survival as the primary end point. After a median follow-up of 3 years, the estimated median overall survival was 22.2 months in the group assigned to receive high-dose melphalan and 56.9 months in the group assigned to receive melphalan plus high-dose dexamethasone (P=0.04). Among patients with high-risk disease, overall survival was similar in the two groups. Among patients with low-risk disease, there was a nonsignificant difference between the two groups in overall survival at 3 years (58% in the group assigned to receive high-dose melphalan vs. 80% in the group assigned to receive melphalan plus high-dose dexamethasone; P=0.13). CONCLUSIONS: The outcome of treatment of AL amyloidosis with high-dose melphalan plus autologous stem-cell rescue was not superior to the outcome with standard-dose melphalan plus dexamethasone. (ClinicalTrials.gov number, NCT00344526 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2007
• Auteurs : Nicolas BellegardePhilippe DessantePierre VidalJean-Claude Vannier
• Organismes : SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif

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Résumé : This paper describes the design of a drive consisting of a DC motor, a speed reducer, a lead screw transformation system, a power converter and its associated DC source. The objective is to reduce the mass of the system. Indeed, the volume and weight optimisation of an electrical drive is an important issue for embedded applications. Here, we present an analytical model of the system in a specific application and afterwards an optimisation of the motor and speed reducer main dimensions and the battery voltage in order to reduce the weight.

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Fichiers liés : Full_Version.pdf

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• Type de publi. : Rapport
• Date de publi. : 12/09/2007
• Auteurs : Anne-Marie KermarrecErwan FaouJean-Pierre MerletPhilippe RobertLuc Segoufin
• Organismes : As Scalable As Possible: foundations of large scale dynamic distributed systems Invariant Preserving SOlvers Constraints solving, optimization and robust interval analysis Networks, Algorithms and Probabilities Integration of data and knowledge distributed over the web

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Résumé : La Commissiond 'Évaluation(CE) de l'INRIA a souhaité mener une réflexion sur les indicateurs bibliométriques de façon à mieux comprendre ce qu'ils mesurent, leur pertinence et leur fiabilité,en particulier dans le contexte de la recherche menée à l'INRIA. Le présent document est le résultat du travail d'un groupe de réflexion animé par Jean-Pierre Merlet et composé également de A-M.Kermarrec, E.Faou, P. Robert et L. Segoufin. Ce document a fait l'objet de discussions lors de deux séances de la Commission d'Evaluation en janvier et septembre 2007 et prend en compte les remarques des membres de la Commission.

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Fichiers liés : indicateurv08.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/09/2007
• Auteurs : Arturo Gil-PintoPhilippe FraisseRené ZapataPierre Dauchez
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Robotique mobile pour l'exploration de l'environnement Laboratoire Toulousain de Technologie et d'Ingénierie des Systèmes

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/09/2007
• Auteurs : Jean-Louis BoizardMichel DevyPhilippe FillatreauJean-Yves FourniolsPierre LacroixNadim NasreddinneF.X. BernardThierry Sentenac
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Équipe Robotique, Action et Perception Laboratoire Génie de Production Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Équipe Robotique, Action et Perception

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Résumé : This paper concerns the integration of a complex vision algorithm on a dedicated architecture. Perception is required on a vehicle (robot or car), especially in order to detect obstacles along a trajectory for a robot or on the road for a car. This function must satisfy very hard real-time constraints so that an avoidance strategy could be executed by the onboard system on a robot or by a driver on a car: it is required to detect obstacles at 100Hz. Several sensors have been used to acquire perceptual data from which obstacles are detected: we propose to use a stereovision sensor. This algorithm is so complex that it must be integrated on a dedicated architecture to provide a high resolution 3D reconstruction of the environment at 100Hz. At first, this paper describes a correlation-based stereovision algorithm, and a generic architecture including several FPGA-based boards, designed to execute visual functions at very high frequency. Then we propose a strategy to implement our stereovision algorithm on this computing unit, with four FPGA-based boards.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/09/2007
• Auteurs : Philippe AmatWilliam PuechSébastien DruonJean-Pierre Pedeboy
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Image & Interaction Interactive Digital Humans Stratégies S.A. [Rungis]

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Résumé : In this paper we present a new method of data hiding in 3D objects. This method is based on a 3D model represented by a cloud of vertices and a list of edges corresponding to the triangular mesh of the surface. The main idea of this method is to find and to synchronize particular areas that can be used to embed the message. The data hiding relies on the modification of the topology of edges in chosen areas. These modifications, as a consequence, have to change the structure of triangles constructed in these areas. This method has the advantage of not changing the position of the vertices of the 3D model. This invariant on the vertex positions allows us to carry out an embedding that is robust to the affine transformations of type rotation, translation or zoom.

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Fichiers liés : D5P-K02.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2007
• Auteurs : Mustapha RachdiPhilippe Vieu
• Organismes : Statistique Fonctionnelle & Sondages Institut de Mathématiques de Toulouse UMR5219 Laboratoire de Statistique et Probabilités
• Publié dans Journal of Statistical Planning and Inference le 26/10/2020

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Résumé : We study regression estimation when the explanatory variable is functional. Nonparametric estimates of the regression operator have been recently introduced. They depend on a smoothing factor which controls its behavior, and the aim of our work is to construct some data-driven criterion for choosing this smoothing parameter. The criterion can be formulated in terms of a functional version of cross-validation ideas. Under mild assumptions on the unknown regression operator, it is seen that this rule is asymptotically optimal. As by-products of this result, we state some asymptotic equivalences for several measures of accuracy for nonparametric estimate of the regression operator. We also present general inequalities for bounding moments of random sums involving functional variables. Finally, a short simulation study is carried out to illustrate the behavior of our method for finite samples.

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