Philippe JEAN-PIERRE

---

• Type de publi. :
• Date de publi. : 24/06/2007
• Auteurs : Jean-Sébastien GuezAnne-Sophie DrucbertPierre Marie DanzéPhilippe Jacques
• Organismes : Institut Pascal

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 20/06/2007
• Auteurs : Benjamin BoisPhilippe PieriLoïc CommagnacPhilippe ChéryCornelis van LeeuwenJean-Pierre J.-P. GaudillereEtienne SaurLucien Wald
• Organismes : Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux Ecophysiologie et Génomique Fonctionnelle de la Vigne Transfert Sol-Plante et Cycle des Eléments Minéraux dans les Ecosystèmes Cultivés Centre Énergétique et Procédés

---

Résumé : Solar radiation has a major impact on grapevine development and berry ripening. It has a large influence on photosynthetic activity, as well as on anthocyanin and aromatic compound synthesis in grape berries. Incoming and intercepted solar radiations are also key-variables in soil water balance, water fluxes and plant water stress. However, irradiation data is seldom available in weather station records. In this paper, the use of a digital elevation model coupled with remotely sensed solar radiation is investigated in order to characterize the agroclimatic potential of a viticultural production area. First solar radiation data retrieved from the Helioclim-1 database is used to estimate direct and diffuse solar radiation proportions. Then, using r.sun algorithm, 50 meters resolution daily maps of global irradiation are produced, based upon a Digital Elevation Model (DEM). This method was applied to the winegrowing area Côtes-de-Bourg, Bordeaux, France. This region exhibits moderated orography (mean slope = 3°, with a standard deviation of 2.4°). However, cumulated incoming solar radiation from veraison to berry maturity (SVM index) varied from -13% to +9% of the horizontal surface values. A zoning was realized based on SVM index values, dividing Côtes-de-Bourg area according to the SVM index (low, medium and high) of 2003 to 2005. This zoning was compared to Vitis vinifera cv Merlot berries characteristics of 6 sites located in areas of high and medium SVM index. Sites located in high SVM index area produced berries with lower titrable acidity, higher pH and higher mean weight than sites located in areas characterized by medium SVM index. No significant difference was found with berry sugar concentration. The solar radiation mapping methodology presented here is applicable for European and African vineyards, as satellite sensed solar irradiation data is compiled in the Helioclim-1 database, available at http://www.sodais.org.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 12/06/2007
• Auteurs : Julien AussibalPierre BorgnatYann LabitGuillaume DewaeleNicolas LarrieuLaurent GallonPhilippe OwezarskiPatrice AbryK. Boudaoud
• Organismes : Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour Laboratoire de Physique de l'ENS Lyon Équipe Services et Architectures pour Réseaux Avancés Laboratoire de Physique de l'ENS Lyon Interpretation and Modelling of Images and Videos Ecole Nationale de l'Aviation Civile Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour Équipe Services et Architectures pour Réseaux Avancés Laboratoire de Physique de l'ENS Lyon Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis

---

Résumé : L'objectif de ce papier consiste à décrire la base d'anomalies créée dans le cadre du projet METROSEC. Cette base contient des traces d'anomalies, légitimes (foules subites,...) et illégitimes (DDoS). Elle permet de calibrer les outils de détection d'anomalies développés dans le projet, et de mesurer leurs performances en termes de faux positifs et faux négatifs.

---

Fichiers liés : SAR07-final.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Bruno GomesMarilena Djata CabralAlexandra GallardMagali SavignacPierre PauletPhilippe DruetBernard MariaméMarc M. MoreauCatherine LeclercJean-Charles GuéryLucette Pelletier
• Organismes : Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de biologie du développement Centre de biologie du développement Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan
• Publié dans American Journal of Respiratory and Critical Care Medicine le 26/10/2020

---

Résumé : RATIONALE: Ca(2+) signaling controls the production of T helper (Th) type 2 cytokines known to be deleterious in asthma. Recently, we showed that Ca(2+) signaling was dihydropyridine (DHP)-sensitive in Th2 lymphocytes and that the DHP derivate, nicardipine, used in the treatment of cardiovascular pathologies, prevents Th2-dependent B cell polyclonal activation. OBJECTIVES: We tested the effect of nicardipine in experimental allergic asthma. METHODS: BALB/c mice immunized with ovalbumin (OVA) in alum and challenged with intranasal OVA were treated with nicardipine once the Th2 response, or even airway inflammation, was induced. We also tested the effect of nicardipine in asthma induced by transferring OVA-specific Th2 cells in BALB/c mice exposed to intranasal OVA. We checked the impact of nicardipine on T-cell responses and airway inflammation. MEASUREMENTS AND MAIN RESULTS: Nicardipine inhibited in vitro Ca(2+) response in Th2 cells. In vivo, it impeded the development of Th2-mediated airway inflammation and reduced the capacity of lymphocytes from lung-draining lymph nodes to secrete Th2, but not Th1, cytokines. Nicardipine did not affect antigen presentation to CD4(+) T lymphocytes, nor the initial localization of Th2 cells into the lungs of mice exposed to intranasal OVA; however, it reduced the production of type 2 cytokines and the amplification of the Th2 response in mice with asthma. Conversely, nicardipine had no effect on Th1-mediated airway inflammation. CONCLUSIONS: Nicardipine improves experimental asthma by impairing Th2-dependent inflammation. This study could provide a rationale for developing drugs selectively targeting DHP receptors of Th2 lymphocytes, potentially beneficial in the treatment of asthma.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Marion SourisseauClémentine SchilteNicoletta CasartelliCéline TrouilletFlorence Guivel-BenhassineDominika RudnickaNathalie Sol-FoulonKarin Le RouxMarie-Christine PrevostHafida FsihiMarie-Pascale FrenkielFabien P. BlanchetPhilippe V AfonsoPierre-Emmanuel CeccaldiSimona OzdenAntoine GessainIsabelle SchuffeneckerBruno VerhasseltAlessia ZamborliniAli SaïbFélix A. ReyFernando Arenzana-SeisdedosPhilippe DesprèsAlain MichaultMatthew L AlbertOlivier Schwartz
• Organismes : Virus et Immunité Immunobiologie des Cellules Dendritiques Virus et Immunité Virus et Immunité Virus et Immunité Virus et Immunité Virus et Immunité Laboratoire de Microbiologie Microscopie électronique (Plate-forme) Département Infection et Epidémiologie - Department of Infection and Epidemiology Interactions Moléculaires Flavivirus-Hôtes Virus et Immunité Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections [CIRI] Universiteit Gent = Ghent University = Université de Gand Hôpital Saint-Louis Hôpital Saint-Louis Virologie Structurale Pathogénie Virale Moléculaire Interactions Moléculaires Flavivirus-Hôtes Laboratoire de Microbiologie Immunobiologie des Cellules Dendritiques Virus et Immunité
• Publié dans PLoS Pathogens le 27/10/2020

---

Résumé : An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of encephalitis. The basis for chikungunya disease and the tropism of CHIKV remain unknown. Here, we describe the replication characteristics of recent clinical CHIKV strains. Human epithelial and endothelial cells, primary fibroblasts and, to a lesser extent, monocyte-derived macrophages, were susceptible to infection and allowed viral production. In contrast, CHIKV did not replicate in lymphoid and monocytoid cell lines, primary lymphocytes and monocytes, or monocyte-derived dendritic cells. CHIKV replication was cytopathic and associated with an induction of apoptosis in infected cells. Chloroquine, bafilomycin-A1, and short hairpin RNAs against dynamin-2 inhibited viral production, indicating that viral entry occurs through pH-dependent endocytosis. CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host.

---

Fichiers liés : journal.ppat.0030089.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Smail HamlatFerhat HammoumPierre-Yves HicherChristian StefaniJean-Philippe Terrier
• Organismes : Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées Institut de Recherche en Génie Civil et Mécanique Laboratoire Central des Ponts et Chaussées Division Matériaux et Structures de Chaussées Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées
• Publié dans Bulletin des Laboratoires des Ponts et Chaussees le 19/09/2018

---

Résumé : A new method for performing laboratory evaluations of the resistance to tangential forces of bituminous mixes used on wearing courses will be presented herein. Tire-pavement surface contact mechanics have been taken into account for the purpose of reproducing, as accurately as possible, the effect of tangential forces generated at specific area throughout the road network. Phenomena associated with the indentation between tire rubber and to consists of aggregate asperities have also been incorporated. The new testing protocol calls for loading the surface of an bitumen mix with an inclined force. The cyclic action of this force causes sliding of the tread rubber on the surface of the specimen and generates a loss of aggregates that varies depending characteristics of bituminous mix. An assessment of the resistance to tangential forces based on specimen mass loss will be proposed. Using this test, it becomes possible to determine the effect of binder type on this resistance to tangential forces. Lastly, the change in specimen mass loss will be correlated with the properties of bitumen used here.

---

Fichiers liés : Hamlat2007.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Agnès JanoshaziMaud DeraetJacques CallebertVincent SetolaSilke GuentherBruno SaubaméaPhilippe ManivetJean-Marie LaunayLuc Maroteaux
• Organismes : Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Service de Biochimie Institut de génétique et biologie moléculaire et cellulaire Institut du Fer à Moulin Institut de génétique et biologie moléculaire et cellulaire Service de Biochimie Service de Biochimie Service de Biochimie Institut de génétique et biologie moléculaire et cellulaire Institut du Fer à Moulin
• Publié dans Molecular Pharmacology le 31/10/2020

---

Résumé : Serotonin 5-HT2B receptors are often co-expressed with 5-HT1B receptors, and crosstalk between the two receptors has been reported in various cell types. However, many mechanistic details underlying 5-HT1B and 5-HT2B receptors crosstalk have not been elucidated. We hypothesized that 5-HT2B and 5-HT1B receptors affect each other's signaling by modulating each other's trafficking. We thus examined the agonist stimulated internalization kinetics of fluorescent protein-tagged 5-HT2B and 5-HT1B receptors when expressed alone and upon co-expression in LMTK(-) murine fibroblasts. Time-lapse confocal microscopy and whole-cell radioligand binding analyses revealed that 5-HT2B and 5-HT1B receptors when expressed alone displayed distinct half-lives. Upon co-expression, serotonin-induced internalization of 5-HT2B receptors was accelerated five-fold, and insensitive to a 5-HT2B receptor antagonist. In this context, 5-HT2B receptors did internalize in response to a 5-HT1B receptor agonist. In contrast, co-expression did not render 5-HT1B receptor internalization sensitive to a 5-HT2B receptor agonist. The altered internalization kinetics of both receptors upon co-expression was likely not due to direct interaction as only low levels of co-localization were observed. Antibody knock-down experiments revealed that internalization of 5-HT1B receptors (expressed alone) was entirely clathrin-independent and Caveolin1-dependent, while that of 5-HT2B receptors (expressed alone) was Caveolin1-independent and clathrin-dependent. Upon co-expression, serotonin-induced 5-HT2B receptor internalization became partially Caveolin1-dependent, and serotonin-induced 5-HT1B receptor internalization became entirely Caveolin1-independent in a protein kinase Cepsilon-dependent fashion. In conclusion, these data demonstrate that co-expression of 5-HT1B and 5-HT2B receptors influences the internalization pathways and kinetics of both receptors.

---

Fichiers liés : mol.106.032656v1.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Christian DinaDavid MeyreSophie GallinaEmmanuelle DurandAntje KörnerPeter JacobsonLena M S CarlssonWieland KiessVincent VatinCecile LecoeurJérome DelplanqueEmmanuel VaillantFrançois PattouJuan A. C. RuizJacques WeillClaire Levy-MarchalFritz F. HorberNatascha PotocznaSerge HercbergCatherine Le StunffPierre BougnèresPeter KovacsMichel MarreBeverley BalkauStephane CauchiJean-Claude ChèvrePhillippe Froguel
• Organismes : Génétique des maladies multifactorielles Génétique des maladies multifactorielles Génétique des maladies multifactorielles Institut de biologie de Lille - UMS 3702 Génétique des maladies multifactorielles Institut de Chimie de la Matière Condensée de Bordeaux Développement artériel Mercator Océan Génétique des maladies multifactorielles Génétique des maladies multifactorielles Centre de Physique Théorique - UMR 6207 Universidad Politécnica de Madrid Laboratoire d'Ingénierie des Projets Industriels, Ecole Nationale Supérieure de Synthèses, de Procédés et d'Ingénierie Chimiques d'Aix-Marseille Centro de Estudios en Semiconductores (C.E.S.), Dpto. Física, Fac. Ciencias Instituto de Quimica Laboratoire de chimie organique et organométallique Centre de Physique Théorique - UMR 7332 Service d'endocrinologie pédiatrique [CHU Lille] Liquides Ioniques et Interfaces Chargées Dr. Horber Adipositas Stiftung Dr. Horber Adipositas Stiftung Unité de Recherche en Epidémiologie Nutritionnelle Déterminants génétiques du diabète de type 2 et de ses complications vasculaires Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Recherche en épidémiologie et biostatistique Epidémiologie cardiovasculaire et métabolique Génétique des maladies multifactorielles Génétique des maladies multifactorielles Section of Genomic Medicine Genome Centre
• Publié dans Nature Genetics le 29/10/2020

---

Résumé : We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2007
• Auteurs : Philippe DessusJean-Philippe PerninAnne Lejeune
• Organismes : Laboratoire des Sciences de l'Éducation (Grenoble) Technologies nouvelles et éducation Communication Langagière et Interaction Personne-Système Communication Langagière et Interaction Personne-Système

---

Résumé : Cet article met en perspective deux champs de recherche indépendants, celui de l'étude de la cognition des enseignants et celui de la scénarisation pédagogique, autour d'un objet central : le schéma. Nous passons tout d'abord en revue les différents types de schémas (routines, scripts, recettes), pour montrer ensuite comment ils sont mis en oeuvre dans l'activité d'enseignement, et plus particulièrement à quatre fins : agir en situation, planifier l' enseignement, comprendre une situation et aider la collaboration. Pour chacune de ces activités, nous montrons que des travaux dans le domaine de la scénarisation pédagogique réfèrent, souvent implicitement, aux différents types de schémas et qu'ils gagneraient à les incorporer de manière plus systématique.

---

Fichiers liés : 10.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2007
• Auteurs : Anne-Marie Costa FerreiraChristian GermainSaeid HomayouniJean-Pierre da CostaGilbert GrenierElisa MargueritJean-Philippe RobyCornelis van Leeuwen
• Organismes : Laboratoire de l'intégration, du matériau au système Laboratoire de l'intégration, du matériau au système Laboratoire de l'intégration, du matériau au système Laboratoire de l'intégration, du matériau au système

---

Résumé : Vigour is an essential parameter in vineyard management. Highest grape quality potential is obtained when vine vigour is moderate. Excessive vigour induces high yield and shaded canopy, resulting in quality losses. Excessively low vigour reduces crop yield. Vine vigour is highly variable among vineyard blocks as well as inside vineyard blocks. The reasons for this variability are mainly soil type, soil depth and topography. Spatial representation of vine vigour (vigour maps) can provide a useful tool for vineyard management. Traditionally, vine vigour is estimated either by the measurement of pruning weight or by the measurement of leaf area, and particularly of secondary leaf area. These techniques are labour intensive and they cannot be implemented to map vine vigour at a reasonable cost. Vine vigour can be mapped by remote sensing, using vegetation indexes like NDVI (Normalized Differential Vegetation Index). In low density vineyards, row width varies with vine vigour. In these conditions vine vigour can be mapped by means of remote sensing without differentiating pixels from the canopy and the soil, given that no vegetation is present on the soil. In high density vineyards, vine canopy is severely trimmed and row width does not vary with vine vigour, making vigour mapping by remote sensing much more complex. It is only possible, when very high resolution images contain pixels largely inferior in size to the row with, i.e. inferior to 10 cm, in order to separate pixels from canopy and pixel from soil. We developed a semi-automatic method to transform high resolution images in vine vigour maps, by using only pixels from the canopy. Images are spatially referenced. Red and Near Infra Red images are combined to construct a NDVI image. An algorithm based on deformable templates was developed to find automatically the centres of the rows. NDVI is calculated on the pixels of the centres of the rows and on the two adjacent pixels on each side. All other pixels (soil pixels, mixed soil-vegetation pixels) are excluded. Anisotropic NDVI data is transformed in a NDVI map by means of a Geographic Information System (G.I.S.). The NDVI vigour maps can be used in a precision viticulture approach, to implement an intra-block modulation of the use of fertilizers or pesticide sprayings depending on the density of vine vegetation.

---

Source