Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jonathan PolCatherine Le PendevenAgnès Beby-DefauxElodie RabutJean Philippe JaisMarilyse PillouxCatherine OsadaFadila ZatlaHichem AssamiJean Didier GrangeDina KremsdorfJean Claude NicolasPatrick Soussan
• Organismes : Pathogenèse des Virus de l'Hépatite B Département de Virologie - Department of Virology UFR Médecine [Santé] - Université Paris Cité CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 UFR Médecine [Santé] - Université Paris Cité CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Tenon [AP-HP] Pathogenèse des Virus de l'Hépatite B Université Paris Descartes - Paris 5 Département de Virologie - Department of Virology CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 Pathogenèse des Virus de l'Hépatite B Université Paris Descartes - Paris 5 CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 Département de Virologie - Department of Virology
• Publié dans Journal of Virological Methods le 27/10/2020

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Résumé : The quantitation of human hepatitis B virus (HBV) in the serum of infected patients is recommended to characterize the course of chronic HBV infection. The aim of this prospective study was to evaluate the performance of the Abbott RealTime PCR assay for HBV DNA quantitation by comparison with the standard Versant HBV DNA 3.0 assay. The better sensitivity and broader dynamic range of HBV DNA quantitation using the Abbott RealTime PCR assay was confirmed by the study of 362 serum samples from 311 patients. In addition, data analysis revealed the concordance of HBV DNA quantitations between the two assays. When this evaluation was assessed as a function of HBV genotype, there was discordance for HBV genotype C samples. Thus, we performed an in-house PCR to confirm the discrepancy observed regarding the HBV genotypes. The in-house PCR results agreed better with the Abbott RealTime PCR method when compared with the standard hybridization assay. In conclusion, the wide dynamic range of HBV DNA quantitation achieved with the Abbott RealTime PCR assay makes it appropriate for the clinical monitoring of HBV infected patients. However, a change of HBV DNA quantitation method could influence results on the follow-up of HBV genotype C infected patients.

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Fichiers liés : 2008-12 - JVM - Pol J & al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre-Loïc CornutChristophe ChiquetAlain BronJean-Paul RomanetGérard LinaPierre-Olivier LafontaineYvonne BenitoAndré PechinotCarole BurillonFrancois VandeneschPhilippe DenisNon Renseigné
• Organismes : Department of Ophtalmology Department of Ophtalmology Service d'Ophtalmologie (CHU de Dijon) Department of Ophtalmology Immunité infection vaccination Laboratoire de Bactériologie Service d'Ophtalmologie (CHU de Dijon) Immunité infection vaccination Laboratoire de Bactériologie Laboratoire de Microbiologie Médicale et Moléculaire Biomatériaux et remodelages matriciels Immunité infection vaccination Laboratoire de Bactériologie Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice [CHU Rouen]
• Publié dans Journal of Glaucoma le 01/11/2020

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Résumé : PURPOSE: To report the clinical presentation and outcome of delayed-onset endophthalmitis caused by Moraxella species and to evaluate the eubacterial polymerase chain reaction (PCR) in aqueous humor samples for the microbiologic diagnosis. PATIENTS AND METHODS: Seven patients with bleb-related delayed onset-endophthalmitis caused by Moraxella were included in a prospective multicenter study (FRIENDS group, 2004 to 2005). Eubacterial PCR followed by direct sequencing and conventional cultures were carried out on aqueous humor samples taken before the first intravitreal antibiotic injection and on vitreous samples taken during pars plana vitrectomy. RESULTS: All cases were postoperative (5 after filtering surgery and 2 inadvertent filtering blebs). The mean delay of onset of endophthalmitis was 41.3 months+/-30.4 (SD) (range, 2.4 to 84.8) after surgery. Initial visual acuity was limited to light perception for 3 patients, hand motions for 2 patients, count fingers for 1 patient, and 20/125 for 1 patient. Functional recovery was variable with final visual acuity ranging from no light perception to 20/25. The eubacterial PCR carried out on aqueous humor provided microbiologic identification in all cases, whereas the cultures were negative in 6 of 7 cases. The eubacterial PCR performed on vitreous samples of 3 vitrectomized patients, after 2 intravitreal injections of antibiotics, identified Moraxella in 2 patients, whereas cultures were negative in all cases. CONCLUSIONS: Delayed-onset endophthalmitis caused by Moraxella occurs predominantly after a bleb-related infection. PCR is a more sensitive technique for the microbiologic diagnosis in this context than conventional culture.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : L. EliasFrançoise FenouillotJean-Charles MajestéPierre AlcouffePhilippe Cassagnau
• Organismes : Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Macromoléculaires Laboratoire de Rhéologie des Matières Plastiques Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux
• Publié dans Polymer le 27/10/2020

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Résumé : The effect of inorganic silica nanoparticles on the morphology and viscoelastic properties of polypropylene/poly(ethylene-co-vinyl acetate) (PP/EVA) immiscible blends has been investigated. Different EVA with different molar masses were used in this study. Virgin and filled blends were prepared by using a twin-screw mini-extruder. Microscopy studies revealed a significant change in morphology of PP/EVA blend in the presence of silica nanoparticles. Also, the images proved the migration of silica nanoparticles toward EVA phase, and to the interface. The quantitative analysis of the rheological experimental data was based on the framework of the Palierne model, extended to filled immiscible blends. Based on this model, a method of determination of the interfacial tension from rheological measurement has been addressed with an improved accuracy. Even if silica mainly plays a thermodynamic role in the stabilization mechanism by decreasing the effective interfacial tension, the influence of particular rheological conditions and the structure of the phases must be taken into account for a complete understanding of the final morphology of such systems.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Anne Lacheret-DujourNicolas ObinJean-Philippe GoldmanMathieu Avanzi
• Organismes : Modèles, Dynamiques, Corpus Sciences et Technologies de la Musique et du Son Université Catholique de Louvain = Catholic University of Louvain Université de Neuchâtel = University of Neuchatel Modèles, Dynamiques, Corpus Chaire de Linguistique du Français Moderne

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Résumé : This paper presents the inner details of three different algorithms for prominence detection. On the basis of a 50- minute corpus made of five speaking styles and manually annotated for prominence, a quantitative evaluation compares the three approaches.

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Fichiers liés : 13.JEP2008_PROM.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Marielle SaunoisCéline MariV. ThouretJ.-P. CammasPhilippe PeyrilléJean-Philippe LaforeB. SauvageA. Volz-ThomasP. NédélecJean-Pierre Pinty
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Laboratoire d'aérologie Laboratoire d'aérologie Centre national de recherches météorologiques Centre national de recherches météorologiques Laboratoire d'aérologie Institut für Chemie und Dynamik der Geosphäre - Troposphäre Laboratoire d'aérologie Laboratoire d'aérologie
• Publié dans Journal of Geophysical Research: Atmospheres le 24/10/2020

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Résumé : An idealized vertical-meridional zonally symmetrical version of the Méso-NH model is used to study the response of tropospheric ozone to the dynamics of the West African monsoon, as well as surface emissions and NOx-production by lightning (LNOx). An O3-NOx-VOC chemical scheme has been added to the dynamical model, including surface emissions and a parameterization of the LNOx production. The model shows that the ozone precursors emitted at the surface are uplifted by deep convection and then advected in the upper branches of the Hadley cells on both sides of the Inter Tropical Convergence Zone (ITCZ). The NOx produced by lightning promotes chemical ozone production in the middle and upper troposphere from the oxidation of CO and VOCs. The analysis of the convective and chemical tendencies shows that the ozone minimum at the ITCZ is induced by venting of ozone-poor air masses into the upper troposphere. The bi-dimensional model suffers from limitations due to the absence of exchange with the higher latitudes and ventilation in the zonal direction. Despite of these restrictions, sensitivity simulations show that the LNOx source and biogenic VOCs are necessary to create the meridional gradient of ozone observed by the Measurements of OZone and water vapor by in-service AIrbus airCraft (MOZAIC) aircrafts in the southern Hadley cell. The LNOx source is also required to maintain the meridional ozone gradient up to 24°N in the northern Hadley cell. The modeled meridional gradient of O3 in the upper troposphere ranges from 0.22 to 0.52 ppbv/deg without the LNOx source and from 0.60 to 1.08 ppbv/deg with the LNOx source, in the southern and the northern cells respectively.

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Fichiers liés : 2007JD008707.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Stéphane ThoboisBénédicte BallangerJing Xie-BrustolinPhilippe DamierFranck DurifJean-Philippe AzulayPhilippe DerostTatiana WitjasSylvie RaoulDidier Le BarsEmmanuel Broussolle
• Organismes : Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Clinique neurologique Service Neurologie [CHU Clermont-Ferrand] Hôpital de la Timone [CHU - APHM] Service Neurologie [CHU Clermont-Ferrand] Laboratoire de Neurosciences Cognitives [Marseille] Service de physiologie Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
• Publié dans Journal of Cerebral Blood Flow and Metabolism le 01/11/2020

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Résumé : Tardive dystonia (TD) is a disabling disorder induced by neuroleptics. Internal globus pallidus (GPi) stimulation can dramatically improve TD. The present positron emission tomography and H215O study aimed to characterize the abnormalities of brain activation of TD and the impact of GPi stimulation on these abnormalities in five TD patients treated with GPi stimulation and eight controls. Changes of regional cerebral blood flow (rCBF) were determined: (i) at rest; (ii) when moving a joystick with the right hand in three freely chosen directions in on and off bilateral GPi stimulation. A significant increase of rCBF was found in TD patients in off-stimulation condition compared to controls: (1) during motor execution in the prefrontal, premotor lateral, and anterior cingulate cortex; (2) at rest, in the prefrontal and anterior cingulate cortex and the cerebellum. Internal globus pallidus stimulation led to a reduction of rCBF (1) during motor execution, in the primary motor and prefrontal cortex and the cerebellum; (2) at rest, in the primary motor and anterior cingulate cortex and supplementary motor area. The results are as follows: (1) TD is related to an excess of brain activity notably in the prefrontal and premotor areas; (2) GPi stimulation reduces the activation of motor, premotor, and prefrontal cortex as well as cerebellum.

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Fichiers liés : Thobois et al. - 2008 - Globus Pallidus Stimulation Reduces Frontal Hypera.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Serge JanicotChris D. ThorncroftAbdou AliNicole AsencioGareth J. BerryOlivier BockBernard BourlèsGuy CaniauxFabrice ChauvinAbdoulaye DèmeLaurent KergoatJean-Philippe LaforeChristophe LavaysseThierry LebelBeatrice MarticorenaFlore MounierPhilippe NédélecJean-Luc RedelspergerFabrizio RavegnaniClaire E. ReevesRémy RocaPatricia de RosnayHans SchlagerBenjamin SultanMireille TomasiniAlexey Ulanovsky
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Department of Earth and Atmospheric Sciences [Albany] Laboratoire d'étude des transferts en hydrologie et environnement Centre national de recherches météorologiques Department of Earth and Atmospheric Sciences [Albany] Service d'aéronomie Laboratoire d'études en Géophysique et océanographie spatiales Centre national de recherches météorologiques Centre national de recherches météorologiques Laboratoire de Météorologie Dynamique (UMR 8539) Centre d'études spatiales de la biosphère Centre national de recherches météorologiques Service d'aéronomie Laboratoire d'étude des transferts en hydrologie et environnement Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'aérologie Centre national de recherches météorologiques Istituto di Scienze dell'Atmosfera e del Clima School of Environmental Sciences [Norwich] Laboratoire de Météorologie Dynamique (UMR 8539) Centre d'études spatiales de la biosphère DLR Institut für Physik der Atmosphäre = DLR Institute of Atmospheric Physics Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Centre national de recherches météorologiques Central Aerological Observatory
• Publié dans Annales Geophysicae le 26/10/2020

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Résumé : The AMMA (African Monsoon Multidisciplinary Analysis) program is dedicated to providing a better understanding of the West African monsoon and its influence on the physical, chemical and biological environment regionally and globally, as well as relating variability of this monsoon system to issues of health, water resources, food security and demography for West African nations. Within this framework, an intensive field campaign took place during the summer of 2006 to better document specific processes and weather systems at various key stages of this monsoon season. This campaign was embedded within a longer observation period that documented the annual cycle of surface and atmospheric conditions between 2005 and 2007. The present paper provides a large and regional scale overview of the 2006 summer monsoon season, that includes consideration of of the convective activity, mean atmospheric circulation and synoptic/intraseasonal weather systems, oceanic and land surface conditions, continental hydrology, dust concentration and ozone distribution. The 2006 African summer monsoon was a near-normal rainy season except for a large-scale rainfall excess north of 15° N. This monsoon season was also characterized by a 10-day delayed onset compared to climatology, with convection becoming developed only after 10 July. This onset delay impacted the continental hydrology, soil moisture and vegetation dynamics as well as dust emission. More details of some less-well-known atmospheric features in the African monsoon at intraseasonal and synoptic scales are provided in order to promote future research in these areas.

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Fichiers liés : angeo-26-2569-2008.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Alexandre FinkePhilippe PoizotClaude GuéryLoïc DupontPierre-Louis TabernaPatrice SimonJean‐marie Tarascon
• Organismes : Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Centre interuniversitaire de recherche et d'ingénierie des matériaux Centre interuniversitaire de recherche et d'ingénierie des matériaux Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV
• Publié dans Electrochemical and Solid-State Letters le 02/11/2020

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Résumé : We report that nanometric bismuth can directly be electrodeposited at room temperature without the use of a nanoporous template. The morphology, microstructure, and purity of the as-prepared electrodeposits were characterized by scanning electron microscopy, transmission electron microscopy, and infrared spectroscopy. Typically, well-crystallized nanometer-sized particles of Bi ranging from 10 to 20 nm are obtained. The key to success of such a process lies in the electrochemical coreduction of pyrocatechol violet during the bismuth deposition, which disturbs the electrocrystallization process. As a first possible application, we show that Bi/Cu nanoarchitectured electrodes exhibit interesting rate capabilities when used as electrode material vs Li.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Laetitia Le DeitStéphane Le MouélicOlivier BourgeoisJean-Philippe CombeDaniel MègeChristophe SotinAline GendrinE. HauberNicolas MangoldJean-Pierre Bibring
• Organismes : Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Bear Fight Institute Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Institut d'astrophysique spatiale DLR Institut für Planetenforschung Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Institut d'astrophysique spatiale
• Publié dans Journal of Geophysical Research. Planets le 26/10/2020

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Résumé : The mineralogical composition of the Martian surface is constrained by analyzing the data of the OMEGA visible and near infrared imaging spectrometer onboard Mars Express. Ferric signatures had previously been reported in Valles Marineris, Margaritifer Terra, and Terra Meridiani. Here we use three independent data reduction methods (Spectral Angle Mapper, a modified Spectral Mixture Analysis and Modified Gaussian Model) to detect and map ferric oxides in East Candor Chasma, a part of Valles Marineris. Ferric oxides in East Candor Chasma are concentrated in scattered formations. MOLA altimetry indicates that the ferric oxides are preferentially located in topographic lows. THEMIS, HRSC and MOC images show that the ferric oxide spectral signatures are systematically correlated with superficial deposits of low albedo, located at the foot of, or resting on Interior Layered Deposits (ILDs). This spatial distribution suggests that ferric oxides are genetically linked to ILDs. Gravity and wind‐driven remobilization of ferric oxides previously formed in the ILDs can explain their accumulation around the ILDs.

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Fichiers liés : Le Deit_JGR 2008.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Laurent MiseryLuc ThomasDenis JullienFrédéric CambazardPhilippe HumbertLouis DubertretLaure DehenGuy MacySami BoussettaCharles Taieb
• Organismes : Service de dermatologie Service de dermatologie Service de dermatologie Service de dermatologie Département de dermatologie Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service de dermatologie [Paris] Service de dermatologie [Paris] Laboratoires dermatologiques Ducray Laboratoires dermatologiques Ducray Pierre Fabre S.A
• Publié dans European Journal of Dermatology le 30/10/2020

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Résumé : In this study, perceived stress and quality of life were measured with PCV-Metra and SF-12 scales in outpatients consulting for different dermatoses in 5 academic dermatology departments for 5 consecutive days. 658 patients were enrolled in the study. Perceived stress was higher in women and the mental component of their quality of life was more altered. Perceived stress was higher in Paris than in other areas and was respectively 11.4, 10.4, 9.2 and 8.9 for psoriasis, acne, atopic dermatitis and pigmented tumours. Perceived stress was correlated to mental quality of life. Stress was more elevated in people with inflammatory dermatoses than in those with tumours. To our knowledge, this is the first comparative study of both stress and quality of life levels in different dermatoses. Stress levels were lower in people with pigmented tumours, suggesting that they can be used as controls in comparative studies because they can be considered as healthy subjects. On the contrary, patients with psoriasis had a very high level of perceived stress and a deeply altered quality of life.

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