Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Marianne ZellerDavid MassonMichel FarnierLuc LorgisValérie DeckertJean-Paul Pais de BarrosCatherine DesrumauxPierre SicardJacques GroberDenis BlachePhilippe P. GambertLuc RochetteYves CottinLaurent Lagrost
• Organismes : Santé - STIC Lipides - Nutrition - Cancer (U866) Point médical (Dijon) Observatoire RICO (ObseRvatoire des Infarctus de Côte d’Or) [Dijon] Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Santé - STIC Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Santé - STIC Service de Cardiologie [CHU de Dijon] Lipides - Nutrition - Cancer (U866)
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Our aim was to characterize cholesteryl ester transfer protein (CETP) activity in the early phase of acute myocardial infarction (MI). Cholesteryl ester transfer protein catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) donors to apolipoprotein B-containing lipoprotein acceptors. The CETP concentration, lipid profiles, and the rate of cholesteryl ester transfer (CET) from a tracer dose of radiolabeled HDL toward endogenous lipoproteins were determined within 24 h after symptom onset. Among 347 patients with first MI, CETP concentration, triglycerides, and non-HDL-cholesterol increased across tertiles of the CET rate, whereas HDL-cholesterol, HDL, and LDL sizes decreased gradually. Among lipoprotein donors and acceptors, the best predictors of the CET rate were HDL2b and non-HDL-cholesterol, respectively. Mean age at first MI was 8.5 years lower in the patients from the highest CET tertile than in those in the lowest CET tertile. Diagonal stratification according to both non-HDL-cholesterol and HDL2b tertiles revealed that patients in the highest CET group were 18 years younger than patients in the lowest CET group. Parameters of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad were independently associated with the CET rate. In patients with acute MI, high CET rates are characterized by the presence of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad. The association of high CET rates with young age at first MI lends support to a significant contribution of CETP to the accelerated progression of disease among asymptomatic patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Philippe Jean-Pierre
• Organismes : Centre d'Économie et de Management de l'Océan Indien
• Publié dans AFD Research Paper Series le 05/02/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Magdalini KypriotouGallic BeauchefChristos E ChadjichristosRussell WidomEmmanuelle RenardSergio JimenezJoseph KornFrançois-Xavier MaquartThierry OddosOtto von StettenJean-Pierre PujolPhilippe Galéra
• Organismes : Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie IFR146 CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de Biochimie du tissu conjonctif IFR146 CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée IFR146 Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Boston University School of Medicine IFR146 Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Jefferson (Philadelphia University + Thomas Jefferson University) Boston University School of Medicine Laboratoire de Biochimie Médicale et Biologie Moléculaire Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 Johnson & Johnson Santé Beauté Johnson & Johnson Santé Beauté CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de Biochimie du tissu conjonctif IFR146 Johnson & Johnson Santé Beauté
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known. We have investigated the role of hc-Krox transcription factor on type I collagen expression by human dermal fibroblasts. hc-Krox exerted a stimulating effect on type I collagen protein synthesis and enhanced the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in foreskin fibroblasts (FF), adult normal fibroblasts (ANF), and scleroderma fibroblasts (SF). Forced hc-Krox expression was found to up-regulate COL1A1 transcription through a –112/–61-bp sequence in FF, ANF, and SF. Knockdown of hc-Krox by short interfering RNA and decoy strategies confirmed the transactivating effect of hc-Krox and decreased substantially COL1A1 transcription levels in all fibro-blast types. The –112/–61-bp sequence bound specifically hc-Krox but also Sp1 and CBF. Attempts to elucidate the potential interactions between hc-Krox, Sp1, and Sp3 revealed that all of them co-immunoprecipitate from FF cellular extracts when a c-Krox antibody was used and bind to the COL1A1 promoter in chromatin immunoprecipitation assays. Moreover, hc-Krox DNA binding activity to its COL1A1-responsive element is increased in SF, cells producing higher amounts of type I collagen compared with ANF and FF. These data suggest that the regulation of COL1A1 gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1, and Sp3, which could act in concert to up-regulate COL1A1 transcriptional activity and provide evidence for a pro-fibrotic role of hc-Krox.

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Fichiers liés : PIIS0021925820430248.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/10/2007
• Auteurs : Xing MeiPhilippe DecaudinBao-Gang Hu
• Organismes : Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées Virtual environments for animation and image synthesis of natural objects Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées

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Résumé : Natural mountains and valleys are gradually eroded by rainfall and river flows. Physically-based modeling of this complex phenomenon is a major concern in producing realistic synthesized terrains. However, despite some recent improvements, existing algorithms are still computationally expensive, leading to a time-consuming process fairly impractical for terrain designers and 3D artists. In this paper, we present a new method to model the hydraulic erosion phenomenon which runs at interactive rates on today's computers. The method is based on the velocity field of the running water, which is created with an efficient shallow-water fluid model. The velocity field is used to calculate the erosion and deposition process, and the sediment transportation process. The method has been carefully designed to be implemented totally on GPU, and thus takes full advantage of the parallelism of current graphics hardware. Results from experiments demonstrate that our method is effective and efficient. It can create realistic erosion effects by rainfall and river flows, and produce fast simulation results for terrains with large sizes.

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Fichiers liés : FastErosion_PG07.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/10/2007
• Auteurs : Yann H. KerrPhilippe WaldteufelPhilippe RichaumeFrançois CabotArnaud MialonWigneron J.-P.Paolo FerrazzoliAli MahmoodiMaria Jose EscorihuelaKauzar Saleh ContellSteven Delwart
• Organismes : Centre d'études spatiales de la biosphère Institut Pierre-Simon-Laplace Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] Array Systems Computing Centre d'études spatiales de la biosphère University of Cambridge [Cambridge, UK] European Space Research and Technology Centre

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/10/2007
• Auteurs : Kauzar Saleh ContellYann H. KerrGilles BouletMaria Jose EscorihuelaPhilippe MaisongrandePhilippe RichaumePatricia de RosnayWigneron J.-P.Aurelio CanoErnesto Lopez-BaezaJennifer P. GrantNiels SkouRocco PancieraJeffrey P. WalkerMichael Berger
• Organismes : Department of geography Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère European Centre for Medium-Range Weather Forecasts Écologie fonctionnelle et physique de l'environnement Universitat de València = University of Valencia = Universidade de Valencia Universitat de València = University of Valencia = Universidade de Valencia Vrije Universiteit Amsterdam [Amsterdam] Danmarks Tekniske Universitet = Technical University of Denmark University of Melbourne University of Melbourne European Space Research and Technology Centre

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2007
• Auteurs : Jean-Philippe AntoniPierre FrankhauserCécile TannierSamy Youssoufi
• Organismes : Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049)

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Résumé : In France, managing urban growth and sprawl depends on the housing policies made by municipalities (or groups of municipalities), by the Department, the Region or the State (i.e. by public actors) through specific statutory documents like PLU (Plan locaux d'urbanisme) or SCOT (Schémas de cohérence territoriaux). Currently, the policies leading to such documents appear very crucial. Indeed, sustainability in urban development has become a crucial issue. To manage it, urban planners use a variety of prescriptive tools such as Geographic information systems (SIG) or Computer aided drafting (CAD) softwares. Nevertheless, these "traditional" tools have a reduced predictive capability and since about 20 years, researchers try to develop modeling approaches allowing to improve describing and forecasting urban growth and its consequences. The aim of this paper is to present and compare three of these modeling tools, relaying on different theories. The heterogeneity of the produced results is discussed in the conclusion and envisaged as a interesting contribution to feed debates about urban growth management in the current framework of territorial intelligence.

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Fichiers liés : Antoni_JP._Modeling_urbanization_to_simulate_prospective_scenarios.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 21/10/2007
• Auteurs : Anne-Sophie WalkerVéronique DecognetMarc FermaudAlexandre BoutJohann ConfaisPierre LerouxAngelique GautierFabián MartínezJean RoudetPhilippe C. NicotMarc BardinPhilippe RobinMélody PotronElisabeth Fournier
• Organismes : BIOlogie et GEstion des Risques en agriculture Unité de Pathologie Végétale Santé et agroécologie du vignoble Institut Sophia Agrobiotech BIOlogie et GEstion des Risques en agriculture BIOlogie et GEstion des Risques en agriculture BIOlogie et GEstion des Risques en agriculture Santé et agroécologie du vignoble Santé et agroécologie du vignoble Unité de Pathologie Végétale Unité de Pathologie Végétale BIOlogie et GEstion des Risques en agriculture BIOlogie et GEstion des Risques en agriculture BIOlogie et GEstion des Risques en agriculture

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Fichiers liés : 2007-Walker-Cape Town-pop genet_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 18/10/2007
• Auteurs : Gert SclepJoke AllemeerschRobin LiechtiBjörn de MeyerJim BeynonRishikesh BhaleraoYves MoreauWilfried NietfeldJean-Pierre RenouPhilippe ReymondMartin KuiperPierre Hilson
• Organismes : Universiteit Gent = Ghent University = Université de Gand
• Publié dans BMC Bioinformatics le 01/11/2020

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Résumé : Abstract Background The Complete Arabidopsis Transcript MicroArray (CATMA) initiative combines the efforts of laboratories in eight European countries [1] to deliver gene-specific sequence tags (GSTs) for the Arabidopsis research community. The CATMA initiative offers the power and flexibility to regularly update the GST collection according to evolving knowledge about the gene repertoire. These GST amplicons can easily be reamplified and shared, subsets can be picked at will to print dedicated arrays, and the GSTs can be cloned and used for other functional studies. This ongoing initiative has already produced approximately 24,000 GSTs that have been made publicly available for spotted microarray printing and RNA interference. Results GSTs from the CATMA version 2 repertoire (CATMAv2, created in 2002) were mapped onto the gene models from two independent Arabidopsis nuclear genome annotation efforts, TIGR5 and PSB-EuGène, to consolidate a list of genes that were targeted by previously designed CATMA tags. A total of 9,027 gene models were not tagged by any amplified CATMAv2 GST, and 2,533 amplified GSTs were no longer predicted to tag an updated gene model. To validate the efficacy of GST mapping criteria and design rules, the predicted and experimentally observed hybridization characteristics associated to GST features were correlated in transcript profiling datasets obtained with the CATMAv2 microarray, confirming the reliability of this platform. To complete the CATMA repertoire, all 9,027 gene models for which no GST had yet been designed were processed with an adjusted version of the Specific Primer and Amplicon Design Software (SPADS). A total of 5,756 novel GSTs were designed and amplified by PCR from genomic DNA. Together with the pre-existing GST collection, this new addition constitutes the CATMAv3 repertoire. It comprises 30,343 unique amplified sequences that tag 24,202 and 23,009 protein-encoding nuclear gene models in the TAIR6 and EuGène genome annotations, respectively. To cover the remaining untagged genes, we identified 543 additional GSTs using less stringent design criteria and designed 990 sequence tags matching multiple members of gene families (Gene Family Tags or GFTs) to cover any remaining untagged genes. These latter 1,533 features constitute the CATMAv4 addition. Conclusion To update the CATMA GST repertoire, we designed 7,289 additional sequence tags, bringing the total number of tagged TAIR6-annotated Arabidopsis nuclear protein-coding genes to 26,173. This resource is used both for the production of spotted microarrays and the large-scale cloning of hairpin RNA silencing vectors. All information about the resulting updated CATMA repertoire is available through the CATMA database http://www.catma.org.

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Fichiers liés : 2007_Sclep_BMC_Bioinformatics.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/10/2007
• Auteurs : Ibrahim CheddadiPierre SaramitoGraner FrançoisPhilippe MarmottantChristophe Raufaste
• Organismes : Modelling, Observations, Identification for Environmental Sciences Modelling, Observations, Identification for Environmental Sciences Laboratoire de Spectrométrie Physique Laboratoire de Spectrométrie Physique Institut de Recherche sur les Phénomènes Hors Equilibre Laboratoire de Spectrométrie Physique Physique et mécanique des milieux hétérogènes

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