Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Bernard NordlingerHalfdan SorbyeBengt GlimeliusGraeme-J. PostonPeter-M. SchlagPhilippe RougierWolf-O. BechsteinJohn-N. PrimroseEuan-T. WalpoleMeg Finch-JonesDaniel JaeckDarius MirzaRowan-W. ParksLaurence ColletteMichel PraetUllrich BetheEric van CutsemWerner ScheithauerThomas GruenbergerJean-Pierre Arnaud
• Organismes : Haukeland University Hospital Uppsala Universitet [Uppsala] Hôpital Européen Georges Pompidou [APHP] Centre de Chirurgie Viscérale, Hépatique et de Transplantation Multiorganes European Organisation for Research and Treatment of Cancer [Bruxelles] Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Centre Énergétique et Procédés Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques
• Publié dans The Lancet le 02/11/2020

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Résumé :

SummaryBackgroundSurgical resection alone is regarded as the standard of care for patients with liver metastases from colorectal cancer, but relapse is common. We assessed the combination of perioperative chemotherapy and surgery compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Methods This parallel-group study reports the trial's final data for progression-free survival for a protocol unspecified interim time-point, while overall survival is still being monitored. 364 patients with histologically proven colorectal cancer and up to four liver metastases were randomly assigned to either six cycles of FOLFOX4 before and six cycles after surgery or to surgery alone (182 in perioperative chemotherapy group vs 182 in surgery group). Patients were centrally randomised by minimisation, adjusting for centre and risk score. The primary objective was to detect a hazard ratio (HR) of 0·71 or less for progression-free survival. Primary analysis was by intention to treat. Analyses were repeated for all eligible (171 vs 171) and resected patients (151 vs 152). This trial is registered with ClinicalTrials.gov, number NCT00006479. Findings In the perioperative chemotherapy group, 151 (83%) patients were resected after a median of six (range 1–6) preoperative cycles and 115 (63%) patients received a median six (1–8) postoperative cycles. 152 (84%) patients were resected in the surgery group. The absolute increase in rate of progression-free survival at 3 years was 7·3% (from 28·1% [95·66% CI 21·3–35·5] to 35·4% [28·1–42·7]; HR 0·79 [0·62–1·02]; p=0·058) in randomised patients; 8·1% (from 28·1% [21·2–36·6] to 36·2% [28·7–43·8]; HR 0·77 [0·60–1·00]; p=0·041) in eligible patients; and 9·2% (from 33·2% [25·3–41·2] to 42·4% [34·0–50·5]; HR 0·73 [0·55–0·97]; p=0·025) in patients undergoing resection. 139 patients died (64 in perioperative chemotherapy group vs 75 in surgery group). Reversible postoperative complications occurred more often after chemotherapy than after surgery (40/159 [25%] vs 27/170 [16%]; p=0·04). After surgery we recorded two deaths in the surgery alone group and one in the perioperative chemotherapy group. Interpretation Perioperative chemotherapy with FOLFOX4 is compatible with major liver surgery and reduces the risk of events of progression-free survival in eligible and resected patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Nicolas MangoldAline GendrinBrigitte GondetStéphane Le MouélicCathy Quantin-NatafV. AnsanJean-Pierre BibringYves LangevinPhilippe MassonGerhard Neukum
• Organismes : Interactions et dynamique des environnements de surface Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Interactions et dynamique des environnements de surface Interactions et dynamique des environnements de surface Institut d'astrophysique spatiale Institut d'astrophysique spatiale Interactions et dynamique des environnements de surface
• Publié dans Icarus le 30/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Matt GriffinBruce SwinyardLaurent VigrouxAlain AbergelPeter AdePhilippe AndreJean-Paul BaluteauJames BockAlberto FranceschiniWalter GearJason GlennMaohai HuangDouglas GriffinKen KingEmmanuel LellouchDavid NaylorSeb OliverGöran OlofssonIsmael Perez-FournonMat PageMichael Rowan-RobinsonPaolo SaracenoEric SawyerGillian WrightAnnie ZavagnoAsier AbreuGeorge BendoAlan DowellDarren DowellMarc FerletTrevor FultonPeter HargraveGlenn LaurentSarah LeeksTanya LimNanyao LuHien NguyenAlan PearceEdward PolehamptonDavide RizzoBernhard SchulzSunil SidherDave SmithLocke SpencerIvan ValtchanovAdam WoodcraftKevin XuLijun Zhang
• Organismes : Service d'Astrophysique Institut d'astrophysique spatiale Recherche en épidémiologie et biostatistique Observatoire Astronomique de Marseille Provence Laboratoire d'Astrophysique de Marseille Laboratoire d'études spatiales et d'instrumentation en astrophysique Astronomy Centre, University of Sussex Imperial College London Observatoire Astronomique de Marseille Provence Laboratoire d'Astrophysique de Marseille CEA Cadarache Ton Duc Thang University [Hô-Chi-Minh-City] University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] NASA Herschel Science Center Herschel Science Centre Department of Informatics and Mathematical Modelling [Lyngby]

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Résumé : SPIRE, the Spectral and Photometric Imaging Receiver, is a submillimetre camera and spectrometer for Herschel. It comprises a three-band camera operating at 250, 350 and 500 Â\textmum, and an imaging Fourier Transform Spectrometer covering 194-672 \ensuremathμm. The photometer field of view is 4x8 arcmin., viewed simultaneously in the three bands. The FTS has an approximately circular field of view of 2.6 arcmin. diameter and spectral resolution adjustable between 0.04 and 2 cm^-1 ( \ensuremathλ/▵\ensuremathλ=20-1000 at 250 \ensuremathμm). Following successful testing in a dedicated facility designed to simulate the in-flight operational conditions, SPIRE has been integrated in the Herschel spacecraft and is now undergoing system-level testing prior to launch. The main design features of SPIRE are reviewed, the key results of instrument testing are outlined, and a summary of the predicted in-flight performance is given.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Jean-Louis PradelDaniel BurenJean NouvelLuc GwiazdzinskiPierre AuboironErik OrsennaPhilippe Dagen
• Organismes : Pacte, Laboratoire de sciences sociales

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Résumé : Mettre des mots sur ce que l'on ressent et parler de son travail est toujours difficile pour un artiste. Un livre est, par essence, fait de mots... j'ai donc cherché des regards qui soient pertinents en m'entourant de camarades, rencontrés au gré de mon exploration sensible de la nuit, amorcée il y a une trentaine d'années. Cet " ouvrage à secrets ", qui se livre peu à peu, donne non pas une explication analytique de mon travail- y en a-t-il seulement une ? - mais des clefs ouvrant des pistes d'exploration de mon terrain de jeu favori : la nuit

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Elodie Françoise VerhaegheAurélien FraysseJean-Luc Guerquin-KernTing‐di WuGuillaume DevèsCharles MioskowskiCatherine LeblancOrtega RYves AmbroisePhilippe Potin
• Organismes : Institut de Biologie et de Technologies de Saclay Chimie Nucléaire Analytique et Bio-environnementale laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff] Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff]
• Publié dans Journal of Biological Inorganic Chemistry le 31/10/2020

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Résumé : Brown algal kelp species are the most efficient iodine accumulators among all living systems, with an average content of 1.0% of dry weight in Laminaria digitata. The iodine distributions in stipe and blade sections from L. digitata were investigated at tissue and subcellular levels. The quantitative tissue mapping of iodine and other trace elements (Cl, K, Ca, Fe, Zn, As and Br) was provided by the proton microprobe with spatial resolutions down to 2 mum. Chemical imaging at a subcellular resolution (below 100 nm) was performed using the secondary ion mass spectrometry microprobe. Sets of samples were prepared by both chemical fixation and cryofixation procedures. The latter prevented the diffusion and the leaching of labile inorganic iodine species, which were estimated at around 95% of the total content by neutron activation analysis. The distribution of iodine clearly shows a huge, decreasing gradient from the meristoderm to the medulla. The contents of iodine reach very high levels in the more external cell layers, up to 191 +/- 5 mg g(-1) of dry weight in stipe sections. The peripheral tissue is consequently the main storage compartment of iodine. At the subcellular level, iodine is mainly stored in the apoplasm and not in an intracellular compartment as previously proposed. This unexpected distribution may provide an abundant and accessible source of labile iodine species which can be easily remobilized for potential chemical defense and antioxidative activities. According to these imaging data, we proposed new hypotheses for the mechanism of iodine storage in L. digitata tissues.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-Baptiste PierreThierry HuguetPhilippe BarreChristian HuygheBernadette Julier
• Organismes : Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité mixte de recherche interactions plantes-microorganismes École nationale supérieure agronomique de Toulouse Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères
• Publié dans TAG Theoretical and Applied Genetics le 01/11/2020

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Résumé : Adaptation to the environment and reproduction are dependent on the date of flowering in the season. The objectives of this paper were to evaluate the effect of photoperiod on flowering date of the model species for legume crops, Medicago truncatula and to describe genetic architecture of this trait in multiple mapping populations. The effect of photoperiod (12 and 18 h) was analysed on eight lines. Quantitative variation in three recombinant inbred lines (RILs) populations involving four parental lines was evaluated, and QTL detection was carried out. Flowering occurred earlier in long than in short photoperiods. Modelling the rate of progression to flowering with temperature and photoperiod gave high R-2, with line-specific parameters that indicated differential responses of the lines to both photoperiod and temperature. QTL detection showed a QTL on chromosome 7 that was common to all populations and seasons. Taking advantage of the multiple mapping populations, it was condensed into a single QTL with a support interval of only 0.9 cM. In a bioanalysis, six candidate genes were identified in this interval. This design also indicated other genomic regions that were involved in flowering date variation more specifically in one population or one season. The analysis on three different mapping populations detected more QTLs than on a single population, revealed more alleles and gave a more precise position of the QTLs that were common to several populations and/or seasons. Identification of candidate genes was a result of integration of QTL analysis and genomics in M. truncatula.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Pierre-Yves LéoMarie-Christine MonnoyerJean Philippe
• Organismes : Centre d'Études et de Recherche en Gestion d'Aix-Marseille management

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2008
• Auteurs : Philippe Martin
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Marie KempfRegine BaraducHenri BonnabauMichel BrunH. CharbonJacques CroizéMarie-Claude DemachyPierre-Yves DonnioPhilippe DupontThierry FosseLaurent GibelAlain GravetTahar HadouFarida HamdadJean-Louis KoeckG. LauransJeanne MaugeinAndre PéchinotMarie-Cécile PloyJosette RaymondAlain RosMicheline Roussel-DelvallezChristine SegondsMichel VergnaudVeronique Vernet-GarnierM. WeberLaurent GutmannEmmanuelle VaronAgnes LepoutrePhilippe Lanotte
• Organismes : Groupe d'Étude des Interactions Hôte-Pathogène

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• Type de publi. : Autre publication
• Date de publi. : 01/01/2008
• Auteurs : Philippe Martin
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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