Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 13/09/2007
• Auteurs : Arnaud JaccardPhilippe MoreauVéronique LeblondXavier LeleuLofti BenboubkerOlivier HermineChristian RécherBouchra AsliBruno LioureBruno RoyerFabrice JardinFranck BridouxBernard GrosboisJérôme JaubertJean-Charles PiettePierre RoncoFabrice QuetMichel CognéJean-Paul Fermand
• Organismes : Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service d'Hématologie biologique [CHU Limoges] Service d'hématologie clinique Centre Hospitalier Régional Universitaire de Tours Service d'immuno-hématologie pédiatrique [CHU Necker] Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Remodelage et Reparation du Tissu Renal Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Université de Limoges
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a randomized study. METHODS: We conducted a randomized trial comparing high-dose intravenous melphalan followed by autologous hematopoietic stem-cell rescue with standard-dose melphalan plus high-dose dexamethasone in patients with AL amyloidosis. Patients (age range, 18 to 70 years) with newly diagnosed AL amyloidosis were randomly assigned to receive intravenous high-dose melphalan plus autologous stem cells or oral melphalan plus oral high-dose dexamethasone. RESULTS: Fifty patients were enrolled in each group. The results were analyzed on an intention-to-treat basis, with overall survival as the primary end point. After a median follow-up of 3 years, the estimated median overall survival was 22.2 months in the group assigned to receive high-dose melphalan and 56.9 months in the group assigned to receive melphalan plus high-dose dexamethasone (P=0.04). Among patients with high-risk disease, overall survival was similar in the two groups. Among patients with low-risk disease, there was a nonsignificant difference between the two groups in overall survival at 3 years (58% in the group assigned to receive high-dose melphalan vs. 80% in the group assigned to receive melphalan plus high-dose dexamethasone; P=0.13). CONCLUSIONS: The outcome of treatment of AL amyloidosis with high-dose melphalan plus autologous stem-cell rescue was not superior to the outcome with standard-dose melphalan plus dexamethasone. (ClinicalTrials.gov number, NCT00344526 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2007
• Auteurs : Nicolas BellegardePhilippe DessantePierre VidalJean-Claude Vannier
• Organismes : SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif

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Résumé : This paper describes the design of a drive consisting of a DC motor, a speed reducer, a lead screw transformation system, a power converter and its associated DC source. The objective is to reduce the mass of the system. Indeed, the volume and weight optimisation of an electrical drive is an important issue for embedded applications. Here, we present an analytical model of the system in a specific application and afterwards an optimisation of the motor and speed reducer main dimensions and the battery voltage in order to reduce the weight.

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Fichiers liés : Full_Version.pdf

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• Type de publi. : Rapport
• Date de publi. : 12/09/2007
• Auteurs : Anne-Marie KermarrecErwan FaouJean-Pierre MerletPhilippe RobertLuc Segoufin
• Organismes : As Scalable As Possible: foundations of large scale dynamic distributed systems Invariant Preserving SOlvers Constraints solving, optimization and robust interval analysis Networks, Algorithms and Probabilities Integration of data and knowledge distributed over the web

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Résumé : La Commissiond 'Évaluation(CE) de l'INRIA a souhaité mener une réflexion sur les indicateurs bibliométriques de façon à mieux comprendre ce qu'ils mesurent, leur pertinence et leur fiabilité,en particulier dans le contexte de la recherche menée à l'INRIA. Le présent document est le résultat du travail d'un groupe de réflexion animé par Jean-Pierre Merlet et composé également de A-M.Kermarrec, E.Faou, P. Robert et L. Segoufin. Ce document a fait l'objet de discussions lors de deux séances de la Commission d'Evaluation en janvier et septembre 2007 et prend en compte les remarques des membres de la Commission.

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Fichiers liés : indicateurv08.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/09/2007
• Auteurs : Arturo Gil-PintoPhilippe FraisseRené ZapataPierre Dauchez
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Robotique mobile pour l'exploration de l'environnement Laboratoire Toulousain de Technologie et d'Ingénierie des Systèmes

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/09/2007
• Auteurs : Philippe AmatWilliam PuechSébastien DruonJean-Pierre Pedeboy
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Image & Interaction Interactive Digital Humans Stratégies S.A. [Rungis]

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Résumé : In this paper we present a new method of data hiding in 3D objects. This method is based on a 3D model represented by a cloud of vertices and a list of edges corresponding to the triangular mesh of the surface. The main idea of this method is to find and to synchronize particular areas that can be used to embed the message. The data hiding relies on the modification of the topology of edges in chosen areas. These modifications, as a consequence, have to change the structure of triangles constructed in these areas. This method has the advantage of not changing the position of the vertices of the 3D model. This invariant on the vertex positions allows us to carry out an embedding that is robust to the affine transformations of type rotation, translation or zoom.

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Fichiers liés : D5P-K02.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/09/2007
• Auteurs : Jean-Louis BoizardMichel DevyPhilippe FillatreauJean-Yves FourniolsPierre LacroixNadim NasreddinneF.X. BernardThierry Sentenac
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Équipe Robotique, Action et Perception Laboratoire Génie de Production Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Équipe Robotique, Action et Perception

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Résumé : This paper concerns the integration of a complex vision algorithm on a dedicated architecture. Perception is required on a vehicle (robot or car), especially in order to detect obstacles along a trajectory for a robot or on the road for a car. This function must satisfy very hard real-time constraints so that an avoidance strategy could be executed by the onboard system on a robot or by a driver on a car: it is required to detect obstacles at 100Hz. Several sensors have been used to acquire perceptual data from which obstacles are detected: we propose to use a stereovision sensor. This algorithm is so complex that it must be integrated on a dedicated architecture to provide a high resolution 3D reconstruction of the environment at 100Hz. At first, this paper describes a correlation-based stereovision algorithm, and a generic architecture including several FPGA-based boards, designed to execute visual functions at very high frequency. Then we propose a strategy to implement our stereovision algorithm on this computing unit, with four FPGA-based boards.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/09/2007
• Auteurs : Nacim RamdaniChristine Azevedo CosteDavid GuiraudPhilippe FraisseRodolphe HéliotGaël Pages
• Organismes : Artificial movement and gait restoration Artificial movement and gait restoration Artificial movement and gait restoration Artificial movement and gait restoration Département Microtechnologies pour la Biologie et la Santé Artificial movement and gait restoration Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier MXM-Laboratoires de Techologies Médicales

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2007
• Auteurs : Philippe LainéVincent MocquetMarion BonfantiCathy BraunJean-Marc EglyPierre Brousset
• Organismes : Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire
• Publié dans DNA Repair le 01/11/2020

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Résumé : The xeroderma pigmentosum group D (XPD/ERCC2), a subunit of TFIIH, plays a critical role in nucleotide excision repair (NER) and basal transcription. There are hot spots of single nucleotide polymorphism (SNP) within the XPD gene sequence that have been incriminated in the pathophysiology of human cancers, possibly by altering the capacity of the cells for removing DNA damage induced by chemical adducts and UV radiation. A controversy persists on the role of these SNPs and this question has not been approached with appropriate biochemical tests. Thus, we sought to quantify in vitro, the effect of codon variants 201 (p.H201Y), 312 (p.D312N), 751 (p.K751Q) of XPD as well as the double XPD variant (p.D312N/p.K751Q) on NER and basal transcription. We used the baculovirus expression system to reconstitute recombinant TFIIH complexes in which the XPD variants were introduced and we analyzed their specific transcription and NER activities. Experimentally, variations in NER capacity and basal transcription activation of the four variants were not detectable in vitro. Structural analyses of XPD revealed that these single nucleotide polymorphisms sites were located outside the main catalytic domains. Altogether, evolutionary data, structural analyses and biochemical investigations strongly suggest that all XPD variants are comparable regarding the main properties of XPD and TFIIH.

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