Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/03/2008
• Auteurs : Rabie Ben AtitallahPhilippe MarquetÉric PielSamy MeftaliSmail NiarAnne EtienJean-Luc DekeyserPierre Boulet
• Organismes : Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time Laboratoire d'Informatique Fondamentale de Lille Contributions of the Data parallelism to real time

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• Type de publi. : Article dans une revue
• Date de publi. : 06/03/2008
• Auteurs : Philippe PoncetRoland HildebrandGeorges-Henri CottetPetros Koumoutsakos
• Organismes : Mathématiques pour l'Industrie et la Physique Calculs Algébriques et Systèmes Dynamiques Equations aux Dérivées Partielles Computational Science and Engineering Laboratory
• Publié dans Journal of Fluid Mechanics le 26/10/2020

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Résumé : We report high drag reduction in Direct Numerical Simulations of controled flows past circular cylinders at Reynolds numbers of 300 and 1000. The flow is controlled by the azimuthal component of the tangential velocity of the cylinder surface. Starting from a spanwise uniform velocity profile that leads to high drag reduction, the optimization procedure identifies, for the same energy input, spanwise varying velocity profiles that lead to higher drag reduction. The three dimensional variations of the velocity field, corresponding to the modes A and B of three dimensional wake instabilities, are largely responsible for this drag reduction. The spanwise, wall velocity variations introduce streamwise vortex braids in the wake that are responsible for reducing the drag induced by the primary spanwise vortices shed by the cylinder. The results demonstrate that extending two dimensional controllers to three-dimensional flows is not optimal as three dimensional control strategies can lead efficiently to higher drag reduction.

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Fichiers liés : JFM-07-FT-0401.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/03/2008
• Auteurs : Philippe MenaschéOttavio AlfieriStefan JanssensWilliam MckennaHermann ReichenspurnerLudovic TrinquartJean-Thomas VilquinJean-Pierre MarolleauBarbara SeymourJérôme LargheroStephen LakeGilles ChatellierScott SolomonMichel DesnosAlbert Hagège
• Organismes : Centre de recherche en Myologie – U974 SU-INSERM
• Publié dans Circulation le 29/10/2020

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Résumé : Background— Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to determine whether this procedure was functionally effective and arrhythmogenic. Methods and Results— This multicenter, randomized, placebo-controlled, double-blind study included patients with left ventricular (LV) dysfunction (ejection fraction ≤35%), myocardial infarction, and indication for coronary surgery. Each patient received either cells grown from a skeletal muscle biopsy or a placebo solution injected in and around the scar. All patients received an implantable cardioverter-defibrillator. The primary efficacy end points were the 6-month changes in global and regional LV function assessed by echocardiography. The safety end points comprised a composite index of major cardiac adverse events and ventricular arrhythmias. Ninety-seven patients received myoblasts (400 or 800 million; n=33 and n=34, respectively) or the placebo (n=30). Myoblast transfer did not improve regional or global LV function beyond that seen in control patients. The absolute change in ejection fraction (median [interquartile range]) between 6 months and baseline was 4.4% (0.2; 7.3), 3.4% (−0.3; 12.4), and 5.2% (−4.4; 11.0) in the placebo, low-dose, and high-dose groups, respectively ( P =0.95). However, the high-dose cell group demonstrated a significant decrease in LV volumes compared with the placebo group. Despite a higher number of arrhythmic events in the myoblast-treated patients, the 6-month rates of major cardiac adverse events and of ventricular arrhythmias did not differ significantly between the pooled treatment and placebo groups. Conclusions— Myoblast injections combined with coronary surgery in patients with depressed LV function failed to improve echocardiographic heart function. The increased number of early postoperative arrhythmic events after myoblast transplantation, as well as the capability of high-dose injections to revert LV remodeling, warrants further investigation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Dinah ParkerVincent DupuisFrançois LadieuJean-Philippe BouchaudDubois EmmanuelleRégine PerzynskiEric Vincent
• Organismes : Service de physique de l'état condensé University of Oxford Liquides Ioniques et Interfaces Chargées Service de physique de l'état condensé Service de physique de l'état condensé Liquides Ioniques et Interfaces Chargées Liquides Ioniques et Interfaces Chargées Service de physique de l'état condensé
• Publié dans Physical Review B: Condensed Matter and Materials Physics (1998-2015) le 02/11/2020

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Résumé : In this paper we investigate the superspin glass behavior of a concentrated assembly of interacting maghemite nanoparticles and compare it to that of canonical atomic spin glass systems. ac versus temperature and frequency measurements show evidence of a superspin glass transition taking place at low temperature. In order to fully characterize the superspin glass phase, the aging behavior of both the thermo-remanent magnetization (TRM) and ac susceptibility has been investigated. It is shown that the scaling laws obeyed by superspin glasses and atomic spin glasses are essentially the same, after subtraction of a superparamagnetic contribution from the superspin glass response functions. Finally, we discuss a possible origin of this superparamagnetic contribution in terms of dilute spin glass models.

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Fichiers liés : SGNanoparticles_ParkerDupuis_Feb08.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/03/2008
• Auteurs : Philippe SabouraultJean-François SidanerHormoz ModaressiJean-Louis DurvilleMarc WecksteinJean-Luc BerenguerMartine AufeuvreJean VirieuxJean-Pierre TouretPascal BernardPierre-Yves Bard
• Organismes : Direction Générale de la Prévention des Risques Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Géoazur Département de sismologie Laboratoire de Géophysique Interne et Tectonophysique

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Emilie DubuissonSabine SzuneritsJean-Pierre CairePhilippe LavieSarah Cordier
• Organismes : Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces PSA Peugeot-Citroen PSA Peugeot-Citroen
• Publié dans Journal of Applied Electrochemistry le 02/11/2020

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Résumé : Electrochemical impedance spectroscopy in 500-1100 μu m large liquid droplets containing chloride and sulphate ions has been used to investigate the local corrosion rate of galvanised steel. The objective was the empirical modelling of the corrosion rate as a function of temperature, electrolyte thickness, and chloride and sulphate concentrations. The first experiments showed that the corrosion time was one of the critical parameters; it was then included in the investigation. An empirical numerical model was obtained for steel and galvanised steel. The statistical model highlighted the respective importance of the five parameters on atmospheric corrosion and gave qualitative results in accordance with the literature. The statistical study also suggested that the corrosion potential was easier to model than corrosion currents.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Mathilde Body-MalapelSébastien DharancyDominique BerrebiAlexandre LouvetJean-Pierre HugotDana J PhilpottMarco GiovanniniFabrice ChareyreGilles PagesEmilie GantierStephen E GirardinIrène GarciaSylvie HudaultFiloména ContiPhilippe J SansonettiMathias ChamaillardPierre DesreumauxLaurent DubuquoyPhilippe Mathurin
• Organismes : Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Service d'Anatomie et de Cytologie Pathologiques Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Inflammation intestinale pathologique de l'enfant Department of Immunology Génomique Fonctionnelle des Tumeurs Solides Génomique Fonctionnelle des Tumeurs Solides Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Department of Laboratory Medicine and Pathobiology Université de Genève = University of Geneva Pathogenes et Fonctions des Cellules Epitheliales Polarisees Laboratoire de Biologie Cellulaire Pathogénie Microbienne Moléculaire Collège de France - Chaire Microbiologie et Maladies infectieuses Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition Physiopathologie des Maladies Inflammatoires de l'Intestin Université de Lille, Droit et Santé Hôpital Duriez, Service des Maladies de l'Appareil digestif et de la Nutrition
• Publié dans Laboratory Investigation le 27/10/2020

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Résumé : The recent discovery of bacterial receptors such as NOD2 that contribute to crosstalk between innate and adaptive immune systems in the digestive tract constitutes an important challenge in our understanding of liver injury mechanisms. The present study focuses on NOD2 functions during liver injury. NOD2, TNF-alpha and IFN-gamma mRNA were quantified using real-time PCR in liver samples from patients and mice with liver injury. We evaluated the susceptibility of concanavalin A (ConA) challenge in NOD2-deficient mice (Nod2-/-) compared to wild-type littermates. We tested the effect of muramyl dipeptide (MDP), the specific activator of NOD2, on ConA-induced liver injury in C57BL/6 mice. We studied the cellular distribution and the role of NOD2 in immune cells and hepatocytes. We demonstrated that NOD2, TNF-alpha and IFN-gamma were upregulated during liver injury in mice and humans. Nod2-/- mice were resistant to ConA-induced hepatitis compared to their wild-type littermates, through reduced IFN-gamma production by immune cells. Conversely, administration of MDP exacerbated ConA-induced liver injury. MDP was a strong inducer of IFN-gamma in freshly isolated human PBMC, splenocytes and hepatocytes. Our study supports the hypothesis that NOD2 contributes to liver injury via a regulatory mechanism affecting immune cells infiltrating the liver and hepatocytes. Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Benjamin TerrierArnaud JaccardJean-Luc HarousseauRichard DelarueOlivier TournilhacMathilde Hunault-BergerMohamed A. HamidouJacques DantalMarc BernardBernard GrosboisPierre MorelValérie CoiteuxOlivier GisserotPhilippe RodonArnaud HotCaroline ElieVéronique LeblondJean-Paul FermandFadi Fakhouri
• Organismes : Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service d'Hématologie biologique [CHU Limoges] Service d'immuno-hématologie pédiatrique [CHU Necker] Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] Immunointervention dans les allo et xénotransplantations Institut de transplantation et de recherche en transplantation Laboratoire Hubert Curien Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes] Laboratoire de physique des milieux ionisés et applications Service d'immunologie Service de néphrologie pédiatrique [CHU Necker]
• Publié dans Medicine le 28/10/2020

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Résumé : Immunoglobulin M (IgM)-related amyloidosis remains a rare and little-known complication of monoclonal IgM-associated disorders. We sought to determine the clinical and laboratory presentation, response to treatment, and outcome of patients with IgM-related amyloidosis in the era of new therapeutic approaches. We conducted a retrospective study in 29 French centers to identify patients with monoclonal IgM and biopsy-proven amyloidosis; we reviewed patients' records and collected relevant clinical and laboratory data. We identified 72 patients with IgM-related amyloidosis. Systemic primary amyloidosis (AL) was present in 64, peritumoral AL in 5, and systemic secondary amyloidosis (AA) in 3 patients. A peculiar pattern of relatively frequent lymph node (31%) and lung (17%) involvement was noted in patients with systemic AL amyloidosis. Response to alkylating agents was poor, with a hematologic response in 37%, a complete remission in 0%, and an organ response in 21%. Response to hematopoietic stem cell transplantation showed a hematologic response in 100% with complete remission in 75% and an organ response in 75%. Purine analogs and rituximab induced a hematologic response in 73% and 60%, respectively, with complete remission in 9% and 0% and an organ response in 55% and 0%, respectively. In multivariate analysis, prognostic factors for survival were serum albumin level < or =3.5 g/dL (p = 0.018) and heart involvement (p = 0.0034). Further prospective studies are needed in patients with IgM-related amyloidosis, with special emphasis on treatment options: hematopoietic stem cell transplantation and purine analogs could represent the most effective therapies. The identification of adverse prognostic factors of survival could be useful for those managing and making treatment decisions for these patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Loretxu BergouignanCédric LemogneAurélie FoucherEstelle LonginDamien VistoliJean-François AllilairePhilippe Fossati
• Organismes : Vulnérabilité Adaptation et Psychopathologie Centre de Psychiatrie et Neurosciences Centre Hospitalier Universitaire de La Réunion Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
• Publié dans Behaviour Research and Therapy le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2008
• Auteurs : Tristan CenierCorine AmatPhilippe LitaudonSamuel GarciaPierre Lafaye de MicheauxBenoit LiquetStéphane G. RouxNathalie Buonviso
• Organismes : Neurosciences Sensorielles Comportement Cognition Neurosciences Sensorielles Comportement Cognition Laboratoire d'analyse et d'architecture des systèmes Neurosciences Sensorielles Comportement Cognition Neurosciences Sensorielles Comportement Cognition Stress Cellulaire Croissance cellulaire, réparation et régénération tissulaires Statistique Appliquée et de Géométrie Aléatoire de Grenoble Grenoble Institut des Neurosciences Institut de Santé Publique, d'Epidémiologie et de Développement Laboratoire de Statistiques et Analyse des Données Biostatistique Epidémiologie et Biostatistique [Bordeaux] Laboratoire de Physique de l'ENS Lyon Neurosciences Sensorielles Comportement Cognition
• Publié dans European Journal of Neuroscience le 22/10/2020

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Résumé : A central question in chemical senses is the way that odorant molecules are represented in the brain. To date, many studies, when taken together, suggest that structural features of the molecules are represented through a spatio-temporal pattern of activation in the olfactory bulb (OB), in both glomerular and mitral cell layers. Mitral/tufted cells interact with a large population of inhibitory interneurons resulting in a temporal patterning of bulbar local field potential (LFP) activity. We investigated the possibility that molecular features could determine the temporal pattern of LFP oscillatory activity in the OB. For this purpose, we recorded the LFPs in the OB of urethane-anesthetized, freely breathing rats in response to series of aliphatic odorants varying subtly in carbon-chain length or functional group. In concordance with our previous reports, we found that odors evoked oscillatory activity in the LFP signal in both the beta and gamma frequency bands. Analysis of LFP oscillations revealed that, although molecular features have almost no influence on the intrinsic characteristics of LFP oscillations, they influence the temporal patterning of bulbar oscillations. Alcohol family odors rarely evoke gamma oscillations, whereas ester family odors rather induce oscillatory patterns showing beta/gamma alternation. Moreover, for molecules with the same functional group, the probability of gamma occurrence is correlated to the vapor pressure of the odor. The significance of the relation between odorant features and oscillatory regimes along with their functional relevance are discussed.

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