Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre BleuetÉléonore WelcommeEric DooryheeJean SusiniJean-Louis HodeauPhilippe Walter
• Organismes : European Synchrotron Radiation Facility Centre de recherche et de restauration des musées de France Matériaux, Rayonnements, Structure European Synchrotron Radiation Facility Matériaux, Rayonnements, Structure Centre de recherche et de restauration des musées de France
• Publié dans Nature Materials le 31/10/2020

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Résumé : The advent of nanosciences calls for the development of local structural probes, in particular to characterize ill-ordered or heterogeneous material. Furthermore, because materials properties are often related to their heterogeneity and the hierarchical arrangement of their structure, different structural probes covering a wide range of scales are required. X-ray diffraction is one of the prime structural methods but suffers from a relatively low detection limit, whereas transmission electron analysis involves destructive sample preparation. Here we show the potential of coupling pencil-beam tomography with X-ray diffraction to examine unidentified phases in nanomaterials and polycrystalline materials. The demonstration is carried out on a high-pressure pellet containing several carbon phases and on a heterogeneous powder containing chalcedony and iron pigments. The present method enables a non-invasive structural refinement with a weight sensitivity of one part per thousand. It enables the extraction of the scattering patterns of amorphous and crystalline compounds with similar atomic densities and compositions. Furthermore, such a diffraction tomography experiment can be carried out simultaneously with X-ray fluorescence, Compton and absorption tomographies, enabling amultimodal analysis of prime importance in materials science, chemistry, geology, environmental science, medical science, palaeontology and cultural heritage.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Philippe BertusJan SzymoniakErwann JeanneauTibor DocsaPal GergelyJean-Pierre PralySébastien Vidal
• Organismes : Unité de chimie organique moléculaire et macromoléculaire Institut de Chimie Moléculaire de Reims Institut de Chimie Moléculaire de Reims Université Claude Bernard Lyon 1 University of Debrecen University of Debrecen Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
• Publié dans Bioorganic and Medicinal Chemistry Letters le 28/10/2020

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Résumé : The synthesis of carbohydrate-based glycogen phosphorylase inhibitors is attractive for potential applications in the treatment of type 2 diabetes. A titanium-mediated synthesis led to a benzoylated C-glucosylated cyclopropylamine intermediate, which underwent a benzoyl migration to afford the corresponding 2-hydroxy-C-glycoside. X-ray crystallographic studies revealed a unit cell composed of four molecules as pairs of dimers connected through two hydrogen bonds. The deprotection of the benzoate esters under Zemplén conditions afforded a glycogen phosphorylase inhibitor candidate displaying weak inhibition toward glycogen phosphorylase (16% at 2.5 mM).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Philippe BlanchardDaniel GandolfoJean RuizMarc Wouts
• Organismes : Theoretische Physik und BiBoS [Bielefeld] Centre de Physique Théorique - UMR 6207 Centre de Physique Théorique - UMR 7332 Centre de Physique Théorique - UMR 6207 Centre de Physique Théorique - UMR 7332 Laboratoire de Probabilités et Modèles Aléatoires Modélisation aléatoire de Paris X
• Publié dans EPL - Europhysics Letters le 23/10/2020

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Résumé : We present a study of phase transitions of the Curie--Weiss Potts model at (inverse) temperature $\beta$, in presence of an external field $h$. Both thermodynamic and topological aspects of these transitions are considered. For the first aspect we complement previous results and give an explicit equation of the thermodynamic transition line in the $\beta$--$h$ plane as well as the magnitude of the jump of the magnetization (for $q \geqslant 3)$. The signature of the latter aspect is characterized here by the presence or not of a giant component in the clusters of a Fortuin--Kasteleyn type representation of the model. We give the equation of the Kertész line separating (in the $\beta$--$h$ plane) the two behaviours. As a result, we get that this line exhibits, as soon as $q \geqslant 3$, a very interesting cusp where it separates from the thermodynamic transition line.

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Fichiers liés : BGRW-EPL-rev2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Boris AleilLaurent JacqueminFabien de PoliMichel ZaehringerJean-Philippe ColletGilles MontalescotJean-Pierre CazenaveMarie-Claude DickeleJean-Pierre MonassierChristian Gachet
• Organismes :
• Publié dans JACC: Cardiovascular Interventions le 23/10/2020

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Résumé : OBJECTIVES: We investigated whether maintenance therapy with clopidogrel 150 mg/day produces greater platelet inhibition than the standard 75-mg/day dose and whether the higher maintenance dose increases platelet inhibition in low responders to clopidogrel 75 mg/day. BACKGROUND: Patients show interindividual variability in their platelet response to clopidogrel. Low responders could potentially obtain greater clinical benefit from greater doses of clopidogrel. METHODS: One hundred fifty-three elective percutaneous coronary intervention patients were randomized to clopidogrel 150 mg/day (n = 58) or 75 mg/day (n = 95) for 4 weeks, with vasodilator-stimulated phosphoprotein assay-guided switching to clopidogrel 150 mg/day after 2 weeks in low responders (platelet reactivity index >or=69%). All patients received aspirin 75 mg/day. RESULTS: After 2 weeks, clopidogrel 150 mg/day produced a significantly lower platelet reactivity index than clopidogrel 75 mg/day (43.9 +/- 17.3% vs. 58.6 +/- 17.7%; p < 0.0001). The proportion of low responders was significantly lower in patients randomized to clopidogrel 150 mg/day than in those randomized to clopidogrel 75 mg/day (8.6% vs. 33.7%; p = 0.0004). In the clopidogrel 75 mg/day group, 64.5% (20 of 31) of low responders became responders after switching to clopidogrel 150 mg/day for 2 weeks. No major bleeds occurred during the study; the incidence of minor bleeds was similar in each treatment group. CONCLUSIONS: In elective percutaneous coronary intervention patients, a 150-mg/day clopidogrel maintenance dose produces greater inhibition of platelet function than clopidogrel 75 mg/day. In low responders to clopidogrel 75 mg/day, switching to clopidogrel 150 mg/day overcomes low responsiveness in a majority of patients. These findings warrant further clinical evaluation. (VASP-02; EudraCT number: 2004-005230-40).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : J.-P. CammasGilles AthierDamien BoulangerFrançoise ChérouxJean-Marc CousinFrançoise GirodFernand KarcherKathy S. LawPhilippe NédélecVincent-Henri PeuchHerman SmitMagali StollDelphine TexierValérie ThouretAndreas Volz-ThomasRégina Zbinden
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Laboratoire d'aérologie Centre national de recherches météorologiques Laboratoire d'aérologie Centre National d'Études Spatiales [Toulouse] Centre national de recherches météorologiques Service d'aéronomie Laboratoire d'aérologie Centre national de recherches météorologiques Institut für Chemie und Dynamik der Geosphäre - Troposphäre Centre national de recherches météorologiques Services communs OMP Laboratoire d'aérologie Institut für Chemie und Dynamik der Geosphäre - Troposphäre Laboratoire d'aérologie
• Publié dans La Météorologie le 02/11/2020

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Résumé : Mozaic est un programme initié en 1993 par des scientifiques européens, Airbus et des compagnies aériennes, pour mesurer les concentrations d'ozone, de vapeur d'eau, de monoxyde de carbone et des oxydes d'azote, en utilisant cinq avions long-courrier en service commercial. La base de donnée de Mozaic, unique en son genre, permet d'étudier les processus physiques et chimiques atmosphériques, pour mieux comprendre les problèmes qui se posent à l'échelle globale sur le climat et la qualité de l'air. Iagos prépare les bases d'une infrastructure distribuée pour l'observation globale de la composition chimique, des aérosols, des nuages et des traînées de condensation à partir d'avions commerciaux en service. Pour cet objectif, de nouveaux instruments sont développés sur la base des instruments Mozaic.

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Fichiers liés : meteo_2008_62_18.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Roi AlonsoMichel AuvergneAnnie BaglinMarc OllivierClaire MoutouDaniel RouanHans J. DeegSuzanne AigrainJose Manuel Almenara VillaMauro BarbieriPierre BargeWilly BenzP. BordéFrançois BouchyR. de la RezaMagali DeleuilRudolf DvorakAnders EriksonMalcolm C. FridlundMichel GillonPhilippe GondoinTristan GuillotArtie P. HatzesGuillaume HébrardP. KabathLaurent JordaHelmut LammerAlain LégerAntoine LlebariaB. LoeilletPierre MagainMichel MayorTsevi MazehM. PätzoldFrancesco PepeFrédéric PontDidier QuelozHeike RauerA. ShporerJean SchneiderBringfried StecklumStéphane UdryGünther Wuchterl
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Institut d'astrophysique spatiale Laboratoire d'Astrophysique de Marseille Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Instituto de Astrofisica de Canarias University of Exeter Instituto de Astrofisica de Canarias Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Physikalisches Institut, Universität Bern Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Observatório Nacional/MCTI Laboratoire d'Astrophysique de Marseille Institut für Astronomie, Universität Wien DLR Institute of Planetary Research Research and Scientific Support Department, ESA-ESTEC Observatoire Astronomique de l'Université de Genève Research and Scientific Support Department, ESA-ESTEC Observatoire de la Côte d'Azur Thüringer Landessternwarte Tautenburg Institut d'Astrophysique de Paris DLR Institute of Planetary Research Laboratoire d'Astrophysique de Marseille Osterreichische Akademie der Wissenschaften = Académie autrichienne des sciences Institut d'astrophysique spatiale Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Observatoire Astronomique de l'Université de Genève Tel Aviv University Rheinisches Institut für Umweltforschung Observatoire Astronomique de l'Université de Genève Observatoire Astronomique de l'Université de Genève Observatoire Astronomique de l'Université de Genève DLR Institute of Planetary Research Tel Aviv University Laboratoire Univers et Théories Thüringer Landessternwarte Tautenburg Observatoire Astronomique de l'Université de Genève Thüringer Landessternwarte Tautenburg
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context: The CoRoT mission, a pioneer in exoplanet searches from space, has completed its first 150 days of continuous observations of ~12 000 stars in the galactic plane. An analysis of the raw data identifies the most promising candidates and triggers the ground-based follow-up. Aims: We report on the discovery of the transiting planet CoRoT-Exo-2b, with a period of 1.743 days, and characterize its main parameters. Methods: We filter the CoRoT raw light curve of cosmic impacts, orbital residuals, and low frequency signals from the star. The folded light curve of 78 transits is fitted to a model to obtain the main parameters. Radial velocity data obtained with the SOPHIE, CORALIE and HARPS spectrographs are combined to characterize the system. The 2.5 min binned phase-folded light curve is affected by the effect of sucessive occultations of stellar active regions by the planet, and the dispersion in the out of transit part reaches a level of 1.09×10^-4 in flux units. Results: We derive a radius for the planet of 1.465 ± 0.029 R_Jup and a mass of 3.31 ± 0.16 M_Jup, corresponding to a density of 1.31 ± 0.04 g/cm^3. The large radius of CoRoT-Exo-2b cannot be explained by current models of evolution of irradiated planets.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2008
• Auteurs : Jean‐sébastien LauretGurvan MagadurValérie AlainPhilippe RoussignolChristophe VoisinEmmanuelle DeleporteJacques A. Delaire
• Organismes : Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires

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Résumé : Tailoring the properties of carbon nanotubes by functionalizing their side-wall is an important point towards the realization of carbon nanotube-based optoelectronic or electronic devices. Interactions between nanotubes and porphyrin molecules have attracted much attention for about five years [1-8]. We report here on "p-stacking" functionalization of CoMoCaT nanotubes with hydrosoluble porphyrins (TPPS). The mutual influence on electronic properties of both porphyrins molecules and nanotubes is studied by optical absorption, photoluminescence and excitation of photoluminescence spectroscopy in both species optical transitions energy range. The optical absorption spectrum of porphyrins adsorbed on nanotubes exhibits a 120 meV red shift of the Soret band. The porphyrin-nanotube complex shows a 99% quenching of the TPPS emission. In contrast with previous studies photoluminescence intensity of the nanotubes is enhanced in presence of porphyrins. Moreover this enhancement is much better when the excitation energy is in resonance with the “p-stacked" porphyrin absorption band. This reveals the existence of an excitation transfer from the porphyrin molecules to the nanotube.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Benjamin BoisLucien WaldPhilippe PieriCornelis van LeeuwenLoïc CommagnacPhilippe ChéryMaxime ChristenJean-Pierre GaudillèreEtienne Saur
• Organismes : Ecophysiologie et Génomique Fonctionnelle de la Vigne CEP/Sophia Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Transfert Sol-Plante et Cycle des Eléments Minéraux dans les Ecosystèmes Cultivés Transfert Sol-Plante et Cycle des Eléments Minéraux dans les Ecosystèmes Cultivés École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux Ecophysiologie et Génomique Fonctionnelle de la Vigne Transfert Sol-Plante et Cycle des Eléments Minéraux dans les Ecosystèmes Cultivés
• Publié dans Journal International des Sciences de la Vigne et du Vin le 01/01/2003

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Résumé : Aims: This paper presents a study solar radiation spatial and temporal variations in Bordeaux winegrowing area, for a 20 year period (1986-2005). Methods and results: Solar radiation data was retrieved from the HelioClim-1 database, elaborated from Meteosat satellite images, using the Heliosat-2 algorithm. Daily data was interpolated using ordinary kriging to produce horizontal solar radiation maps at a 500 m resolution. Using a digital elevation model, high resolution daily solar radiation maps with terrain integration were then produced for the period 2001-2005, at a 50 m resolution. The long term (20 years) analysis of solar radiation at low spatial resolution (500 m) showed a west to east decreasing gradient within Bordeaux vineyards. Mean August-to-September daily irradiation values, on horizontal surface, were used to classify Bordeaux winegrowing areas in three zones: low, medium, and high solar radiation areas. This initial zoning was upscaled at 50 m resolution, applying a local correction ratio, based on 2001-2005 solar radiation on inclined surface analysis. Grapevine development and maturation potential of the different zones of appellation of origin of Bordeaux winegrowing area are discussed in relation with this zoning. 2 Conclusions: Solar radiation variability within Bordeaux winegrowing area is mainly governed by terrain slopes and orientations, which induce considerable variations within the eastern part of Bordeaux vineyards. Significance and impact of the study: Solar radiation has a major impact on vineyard water balance, grapevine development and berry ripening. However, irradiation data is seldom available in weather stations records. This paper underline the interest of high resolution cartography of solar radiation, using satellite sensing and terrain effect integration, for agroclimatic studies in viticulture.

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Fichiers liés : 2008_journalDuVin_bois.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Sandra Charreire-PetitEmmanuel GarcionJean-Pierre BenoîtPhilippe Menei
• Organismes : Centre de Recherche en Gestion Micro et Nanomédecines Biomimétiques Micro et Nanomédecines Biomimétiques Micro et Nanomédecines Biomimétiques
• Publié dans Revue Neurologique le 31/10/2020

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Résumé :

Many arguments support the development of local therapies for malignant gliomas. Simple injections of antimitotic agents into the surgical cavity has been replaced by more sophisticated systems. Tissues can be infused with complex prolonged-release polymeric or lipidic systems with macroscopic, microscopic and now even nanometric particles. But, as for any drug, the developments of these new agents has been long and only very few reach the stage of the clinic trials.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre RousseauJean-Philippe SteyerEveline VolckeNicolas BernetFabrice Beline
• Organismes : Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture
• Publié dans Water Science and Technology le 26/10/2020

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Résumé : In order to deal with the environmental problems associated with animal production industrialization and at the same time considering energy costs increasing, a piggery wastewater treatment process consisting of combined anaerobic digestion and biological nitrogen removal by activated sludge was developed. This contribution presents a modelling framework in order to optimize this process. Modified versions of the well established ASM1 and ADM1 models have been used. The ADM1 was extended with biological denitrification. pH calculation and liquid gastransfer were modified to take into account the effect of associated components. Finally, two interfaces (ADMtoASM and ASMtoADM) were built in order to combine both models. These interfaces set up the COD, nitrogen, alkalinity and charge fractionation between both models. However, for the mass balances between both models, some hypotheses were considered and might be evaluated.

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