Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 19/02/2008
• Auteurs : Alexis Le FaucheurPierre AbrahamVincent JaquinandiPhilippe BouyéJean Louis SaumetBénédicte Noury-Desvaux
• Organismes : Biologie Neurovasculaire Intégrée Biologie Neurovasculaire Intégrée Cabinet de médecine vasculaire Biologie Neurovasculaire Intégrée Activité Physique, Corps, Sport et Santé
• Publié dans Circulation le 29/10/2020

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Résumé : Background— The maximal walking distance (MWD) performed on a treadmill test remains the “gold standard” in estimating the walking capacity of patients who have peripheral arterial disease with intermittent claudication, although treadmills are not accessible to most physicians. We hypothesized that global positioning system (GPS) recordings could monitor community-based outdoor walking and provide valid information on walking capacity in patients with peripheral arterial disease. Methods and Results— We studied 24 patients (6 women) with arterial claudication (median [25th to 75th percentile] values: 57 years old [48 to 67 years], 169 cm tall [164 to 172 cm], weight 81 kg [71 to 86 kg], and ankle-brachial index 0.64 [0.56 to 0.74]). MWD on the treadmill was 184 m (144 to 246 m), which was compared with the results of self-reported MWD, the distance score from the Walking Impairment Questionnaire, MWD observed during a 6-minute walking test, and MWD measured over a GPS-recorded unconstrained outdoor walk in a public park. Self-reported MWD, Walking Impairment Questionnaire distance score, 6-minute walking test score, and GPS-measured MWD were 300 m (163 to 500 m), 28% (15% to 47%), 405 m (338 to 441 m), and 609 m (283 to 1287 m), respectively. The best correlation with MWD on the treadmill test was obtained with the MWD measured by the GPS (Spearman r =0.81, P <0.001). Conclusions— Outdoor walking capacity measured by a low-cost GPS is a potentially innovative way to study the walking capacity of patients with peripheral arterial disease. It opens new perspectives in the study of walking capacity for vascular patients with claudication under free-living conditions or for physicians who do not have a treadmill.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 12/02/2008
• Auteurs : David ChavalariasJean-Philippe Cointet
• Organismes : Centre de Recherche en Epistémologie Appliquée Institut des Systèmes Complexes - Paris Ile-de-France Centre de Recherche en Epistémologie Appliquée

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Résumé : We propose a series of methods to represent the evolution of a field of science at different levels: namely micro, meso and macro levels. We use a previously introduced asymmetric measure of paradigmatic proximity between terms that enable us to extract structure from a large publications database. We apply our set of methods on a case study from the Complex Systems Community through the mapping of more than 400 Complex Systems Science concepts indexed from a database as large as several millions of journal papers. We will first recapitulate the main properties of our asymmetric proximity measure. Then we show how salient paradigmatic fields can be embedded into a 2-dimensional visualization into which the terms are plotted according to their relative specificity and generality index. This meso-level helps us producing macroscopic maps of the field of science studied featuring the former paradigmatic fields.

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Fichiers liés : CointetChavalariasNHMV1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/02/2008
• Auteurs : Suzana P SalcedoMaría Ines MarchesiniHugues LelouardEmilie FugierGilles JollyStéphanie BalorAlexandre MullerNicolas N. LapaqueOlivier DemariaLena AlexopoulouDiego J ComerciRodolfo A UgaldePhilippe PierreJean-Pierre Gorvel
• Organismes : Centre d'Immunologie de Marseille - Luminy Instituto de Investigaciones Biotecnológicas [San Martín] Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Instituto de Investigaciones Biotecnológicas [San Martín] Instituto Nacional de Tecnología Industrial Instituto de Investigaciones Biotecnológicas [San Martín] Instituto Nacional de Tecnología Industrial Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy
• Publié dans PLoS Pathogens le 27/10/2020

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Résumé : Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops, dendritic cells from ileal Peyer's patches become infected and constitute a cell target for this pathogen. In vitro, we found that Brucella replicates within dendritic cells and hinders their functional activation. In addition, we identified a new Brucella protein Btp1, which down-modulates maturation of infected dendritic cells by interfering with the TLR2 signaling pathway. These results show that intracellular Brucella is able to control dendritic cell function, which may have important consequences in the development of chronic brucellosis.

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Fichiers liés : journal.ppat.0040021.PDF

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/02/2008
• Auteurs : Andrzej RybakGisèle BoiteuxPierre AlcouffePhilippe CassagnauGérard SeytreYevgen MamunyaMaksym Iurzhenko
• Organismes : Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Institute of Macromolecular Chemistry of NAS of Ukraine Institute of Macromolecular Chemistry of NAS of Ukraine

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2008
• Auteurs : Hélène MauryKarine Le GuenJean-Michel AndréZ. WangJia DongFrançoise BridouFranck DelmottePhilippe Jonnard
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Institute of Precision Optical Engineering, Department of Physics Institute of Precision Optical Engineering [Shangai] Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire de Chimie Physique - Matière et Rayonnement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/02/2008
• Auteurs : Hélène MauryPhilippe JonnardKarine Le GuenJean-Michel AndréFranck DelmotteFrançoise BridouMarie-Françoise Ravet-KrillStephano NanaronneNicola Mahne
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratorio Nazionale TASC Laboratorio Nazionale TASC

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Philippe BonninHaythem DebbabiJean MarianiChristiane Charriaut-MarlangueSylvain Renolleau
• Organismes : Neurobiologie des processus adaptatifs CHU Charles Foix [AP-HP] Service d'explorations fonctionnelles GIS Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs CHU Trousseau [APHP]
• Publié dans Ultrasound in Medicine & Biology le 12/12/2019

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Résumé : A model of ischemic brain injury in 7-day-old rat pups has been developed to study perinatal ischemia. It combines permanent occlusion of the distal left middle cerebral artery (LMCA) and transient occlusion of homolateral common carotid artery (LCCA). At removal of the clip on LCCA, reflow allowed brain reperfusion through cortical anastomoses. In 10 rat pups, we measured blood flow velocities (BFV) in main cerebral arteries with 12-MHz ultrasound imaging. At basal states, peak systolic BFV in proximal LMCA was 16.0 +/- 3.0 cm.s(-1). Occlusion of LMCA did not yield significant modifications. Occlusion of LCCA involved only a decrease in BFV to 9.5 +/- 2.6 cm.s(-1) (p < 0.001). Indeed, LMCA was then supply by the right internal carotid and the vertebral arteries through the circle of Willis. In three rat pups, release of occlusion of LCCA was followed by restoration of BFV in the left internal carotid artery and in LMCA, in seven pups, by a reversed flow in the LICA and lower BFV in LMCA (11.9 +/- 2.3, p < 0.05). BFV returned to basal values from h5 to h48 in all animals. In addition, ultrasound imaging is a useful, reproducible, non invasive, easy-to-repeat, method to assess and monitor arterial cerebral blood flow supply in small animals. It helps to characterize changes occurring during cerebral ischemia and reperfusion, particularly the depth of the hypoperfusion, as well as the variability of reflow. In preclinical studies, this method could help to identify what can be assigned to a neuroprotective treatment and what depends on changes in cerebral blood flow supply. (E-mail: philippe.bonnin@lrb.aphp.fr).

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• Type de publi. :
• Date de publi. : 01/02/2008
• Auteurs : Pierre BomelJean-Philippe DiguetGogniat Guy
• Organismes : Lab-STICC_UBS_CACS_MOCS Lab-STICC_UBS_CACS_MOCS Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192)

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Résumé : Ce procédé de reconfiguration d'un ensemble de composants d'un circuit électronique muni de ressources mémoires internes, ledit circuit étant connecté à un réseau, est caractérisé en ce qu'il comporte une étape de téléchargement de données de configuration dudit ensemble vers les ressources mémoires du circuit électronique à partir d'un serveur connecté audit réseau.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Nathalie ChantretJérôme SalseFrancois SabotArnaud BellecBastien LaubinIvan I. DuboisCarole DossatPierre SourdillePhilippe JoudrierMarie Francoise GautierL. CattolicoMichel BeckertSébastien AubourgJean WeissenbachMichel M. CabochePhilippe LeroyMichel BernardPaul Chalhoub
• Organismes : Diversité et adaptation des plantes cultivées Génétique Diversité et Ecophysiologie des Céréales Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale Génétique Diversité et Ecophysiologie des Céréales Genoscope - Centre national de séquençage [Evry] Genoscope - Centre national de séquençage [Evry] Génétique Diversité et Ecophysiologie des Céréales Développement et amélioration des plantes Développement et amélioration des plantes Genoscope - Centre national de séquençage [Evry] Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale Genoscope - Centre national de séquençage [Evry] Unité de recherche en génomique végétale Génétique Diversité et Ecophysiologie des Céréales Génétique Diversité et Ecophysiologie des Céréales Unité de recherche en génomique végétale
• Publié dans Journal of Molecular Evolution le 28/10/2020

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Résumé : We study here the evolution of genes located in the same physical locus using the recently sequenced Ha locus in seven wheat genomes in diploid, tetraploid, and hexaploid species and compared them with barley and rice orthologous regions. We investigated both the conservation of microcolinearity and the molecular evolution of genes, including coding and noncoding sequences. Microcolinearity is restricted to two groups of genes (Unknown gene-2, VAMP, BGGP, Gsp-1, and Unknown gene-8 surrounded by several copies of ATPase), almost conserved in rice and barley, but in a different relative position. Highly conserved genes between wheat and rice run along with genes harboring different copy numbers and highly variable sequences between close wheat genomes. The coding sequence evolution appeared to be submitted to heterogeneous selective pressure and intronic sequences analysis revealed that the molecular clock hypothesis is violated in most cases

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2008
• Auteurs : Jean-Philippe LachauxJulien JungNelly MainyJ. C. DreherOlivier BertrandMonica BaciuLorella MinottiDominique M. HoffmannPhilippe Kahane
• Organismes : IFR des neurosciences de Lyon Processus mentaux et activation cérébrale IFR des neurosciences de Lyon Processus mentaux et activation cérébrale IFR des neurosciences de Lyon Processus mentaux et activation cérébrale Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Processus mentaux et activation cérébrale Équipe Dynamique Cérébrale et Cognition - Brain Dynamics and Cognition Team Laboratoire de Psychologie et NeuroCognition Dynamique des Reseaux Neuronaux Département de neurologie Département de neurochirurgie Dynamique des Reseaux Neuronaux
• Publié dans Cerebral Cortex le 29/10/2020

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Résumé : It is becoming increasingly clear that attention-demanding tasks engage not only activation of specific cortical regions but also deactivation of other regions that could interfere with the task at hand. At the same time, electrophysiological studies in animals and humans have found that the participation of cortical regions to cognitive processes translates into local synchronization of rhythmic neural activity at frequencies above 40 Hz (so-called gamma-band synchronization). Such synchronization is seen as a potential facilitator of neural communication and synaptic plasticity. We found evidence that cognitive processes can also involve the disruption of gamma-band activity in high-order brain regions. Intracerebral electroencephalograms were recorded in 3 epileptic patients during 2 reading tasks. Visual presentation of words induced a strong deactivation in a broad (20-150 Hz) frequency range in the left ventral lateral prefrontal cortex, in parallel with gamma-band activations within the reading network, including Broca's area. The observed energy decrease in neural signals was reproducible across patients. It peaked around 500 ms after stimulus onset and appeared subject to attention-modulated amplification. Our results suggest that cognition might be mediated by a coordinated interaction between regional gamma-band synchronizations and desynchronizations, possibly reflecting enhanced versus reduced local neural communication.

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