Philippe JEAN-PIERRE

ARES VI. Viability of one-dimensional retrieval models for transmission spectroscopy characterization of exo-atmospheres in the era of JWST and Ariel

Type de publi. : Article dans une revue
Date de publi. : 09/01/2024
Auteurs : Yassin JaziriWilliam PlurielAndrea BocchieriPanek EmilieLucas TeinturierAnastasia IvanovaNatalia E RektsiniPierre DrossartJean-Philippe BeaulieuAurélien FalcoJérémy LeconteLorenzo V MugnaiOlivia Venot

ARES VI. Viability of one-dimensional retrieval models for transmission spectroscopy characterization of exo-atmospheres in the era of JWST and Ariel

Type de publi. : Article dans une revue
Date de publi. : 09/01/2024
Auteurs : Yassin JaziriWilliam PlurielAndrea BocchieriPanek EmilieLucas TeinturierAnastasia IvanovaNatalia E RektsiniPierre DrossartJean-Philippe BeaulieuAurélien FalcoJérémy LeconteLorenzo V MugnaiOlivia Venot
Organismes : PLANETO - LATMOS Observatoire Astronomique de l'Université de Genève Laboratoire d'Astrophysique de Bordeaux [Pessac] Observatoire Astronomique de l'Université de Genève Dipartimento di Fisica [Roma La Sapienza] Institut d'Astrophysique de Paris Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire de Météorologie Dynamique (UMR 8539) PLANETO - LATMOS Institut d'Astrophysique de Paris School of Natural Sciences [Hobart] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris School of Natural Sciences [Hobart] Institut de Physique du Globe de Paris Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Bordeaux [Pessac] School of Physics and Astronomy [Cardiff] Dipartimento di Fisica [Roma La Sapienza] Department of Physics and Astronomy [UCL London] INAF - Osservatorio Astronomico di Palermo Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire Interuniversitaire des Systèmes Atmosphériques
Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

Résumé : Observed exoplanet transit spectra are usually retrieved using 1D models to determine atmospheric composition. However, planetary atmospheres are 3D. With the new state-of-the-art James Webb Space Telescope (JWST) and future space telescopes such as Ariel (Atmospheric Remote-sensing Infrared Exoplanet Large-survey), we will be able to obtain increasingly accurate transit spectra. The 3D effects on the spectra will be visible, and we can expect biases in the 1D extractions. In order to elucidate these biases, we have built theoretical observations of transit spectra, from 3D atmospheric modeling through transit modeling to instrument modeling. For this purpose, we used a global climate model (GCM) to simulate the atmosphere, a 3D radiative transfer model to calculate theoretical transmission spectra, and adapted instrument software from JWST and Ariel to reproduce telescope noise. Next, we used a 1D radiative transfer inversion model to retrieve the known input atmosphere and disentangle any biases that might be observed. The study was done from warm planets to ultra-hot planets to assess biases as a function of average planet temperature. Three-dimensional effects are observed to be strongly nonlinear from the coldest to the hottest planets. These effects also depend on the planet’s metallicity and gravity. Considering equilibrium chemistry, 3D effects are observed through very strong variations in certain features of the molecule or very small variations over the whole spectrum. We conclude that we cannot rely on the uncertainty of retrievals at all pressures, and that we must be cautious about the results of retrievals at the top of the atmosphere. However the results are still fairly close to the truth at mid-altitudes (those probed). We also need to be careful with the chemical models used for planetary atmosphere. If the chemistry of one molecule is not correctly described, this will bias all the others, and the retrieved temperature as well. Finally, although tting a wider wavelength range and higher resolution has been shown to increase retrieval accuracy, we show that this could depend on the wavelength range chosen, due to the accuracy on modeling the different features. In any case, 1D retrievals are still correct for the detection of molecules, even in the event of an erroneous abundance retrieval.

Fichiers liés : aa47379-23.pdf

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Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Type de publi. : Article dans une revue
Date de publi. : 06/01/2024
Auteurs : Kanika Inamdar DharmayatAntonio J Vallejo-VazChristophe a T StevensJulia M BrandtsAlexander R M LyonsUrh GroseljMarianne AbifadelCarlos A Aguilar-SalinasKhalid AlhabibMutaz AlkhnifsawiWael AlmahmeedFahad AlnouriRodrigo AlonsoKhalid Al-RasadiTester F AshavaidMaciej BanachSophie BéliardChristoph BinderMafalda BourbonKrzysztof ChlebusPablo CorralDiogo CruzOlivier S DescampsEuridiki DrogariRonen DurstMarat V EzhovJacques GenestMariko Harada-ShibaKirsten B HolvenSteve E HumphriesWeerapan KhovidhunkitKatarina LalicUlrich LaufsEvangelos LiberopoulosJeanine Roeters van LennepMarcos Miguel Lima-MartinezJie LinVincent MaherWinfried MärzAndré R MiserezOlena MitchenkoHapizah NawawiAndrie G PanayiotouGyörgy ParaghArman PostadzhiyanAshraf RedaŽeljko ReinerXimena ReyesFouzia SadiqAmirhossein SahebkarHeribert SchunkertAleksandr B ShekEric StroesTa-Chen SuTavintharan SubramaniamAndrey SusekovAlejandra Vázquez CárdenasThanh Huong TruongAlexandros D TselepisBranislav VohnoutLuya WangShizuya YamashitaAhmad Al-SarrafNasreen Al-SayedKairat DavletovBambang DwiputraDan GaitaMeral KayikciogluGustavs LatkovskisA. David MaraisAnne Thushara MatthiasErkin MirrakhimovBørge G NordestgaardZaneta PetrulionieneBelma PojskicWilson SadohMyra TilneyBrian TomlinsonAnne Tybjærg-HansenMargus ViigimaaAlberico L CatapanoTomas FreibergerG. Kees HovinghPedro MataHandrean SoranFrederick RaalGerald F WattsLaura SchreierVirginia BañaresSusanne Greber-PlatzerMargot Baumgartner-KautCharlotte de GierHans DieplingerFlorian HöllerlReinhold InnerhoferDaniela KarallJulia LischkaBernhard LudvikMartin MäserSabine Scholl-BürgiAlexandra ThajerHermann ToplakFabian DemeureAnn MertensJean-Luc BalligandXavier StephenneEtienne SokalIvo PetrovAssen GoudevFedya NikolovSnejana TishevaYoto YotovIvajlo TzvetkovRobert A HegeleDaniel GaudetLiam BrunhamIsabelle RuelBrian MccrindleAda CuevasDražen PericaPhivos SymeonidesEfstratios TrogkanisAndreas KostisAndreas IoannouAngeliki MouzarouAnthoula GeorgiouAndreas StylianouGeorge MiltiadousParis IacovidesConstantinos DeltasMichal VrablikZuzana UrbanovaPavel JesinaLukas TichyJosef HyanekJana DvorakovaJana CepovaJosef SykoraKristyna BuresovaMichal PipekEva PistkovaIvana BartkovaLenka ToukalkovaMichaela SpenerovaJan MalyMarianne BennAhmed BendaryAtef ElbahryJean FerrièresDorota FerrieresNoel PerettiÉric BruckertAntonio GalloRené ValéroFlorian MourreKarine AouchicheRachel ReynaudPatrick TounianJulie LemaleFranck BoccaraPhilippe MoulinSybil CharrièresMathilde Di FilippoBertrand CariouFrançois PaillardCaroline DourmapAlain PradignacBruno VergesIsabelle SimoneauMichel FarnierYves CottinCecile YelnikRegis HankardFrançois SchieleVincent DurlachAriane SultanAlain CarriéJean-Pierre RabèsVeronika SaninRaphael S SchmiederSara AtesChristos V RizosIoannis SkoumasKonstantinos TziomalosLoukianos RallidisVasileios KotsisMichalis DoumasEmmanouil SkalidisGenovefa KolovouVana KolovouAnastasia GaroufiIosif KoutagiarGeorgios PolychronopoulosEstela KiouriChristina AntzaEvangelos ZacharisAchilleas AttilakosGeorge SfikasCharalambos KoumarasPanagiotis AnagnostisGeorgia AnastasiouGeorge LiamisPetros-Spyridon AdamidisHaralambos MilionisVaia LambadiariStella StabouliTheodosios FilippatosVicky MollakiAnastasia TsaroumiFrida LamariPavlos ProyiasMariann HarangiLakshmi Lavanya ReddySwarup a V ShahChandrashekhar K PondeJamshed J DalalJitendra P S SawhneyIshwar C VermaSusan HosseiniTannaz JamialahmadiMohammed AlareedhFoaad ShagheeSabah Hasan RhadiMaryam AbduljalalSarmad AlfilHuda KareemHofit CohenEran LeitersdorfDaniel SchurrShoshi ShpitzenMarcello ArcaMaurizio AvernaStefano BertoliniSebastiano CalandraPatrizia TarugiManuela CasulaFederica GalimbertiMarta GazzottiElena OlmastroniRiccardo SarzaniClaudio FerriElena RepettiFrancesco GiorginoPatrizia SuppressaAntonio Carlo BossiClaudio BorghiSandro MuntoniFrancesco CipolloneRoberto ScicaliArturo PujiaAngelina PassaroMartina BerteottiValerio PecchioliLivia PisciottaGiuseppe MandraffinoFabio PellegattaGiuliana MombelliAdriana BranchiAnna Maria FiorenzaCristina PederivaJosé Pablo WerbaGianfranco ParatiFabio NascimbeniLorenzo IughettiGiuliana FortunatoRaimondo CavallaroGabriella IannuzzoPaolo CalabròAngelo Baldassare CefalùMaria Elena CapraAlberto ZambonMatteo PirroFrancesco SbranaChiara TrentiIlenia MinicocciMassimo FedericiMaria del BenPaola Sabrina BuonuomoSimona MoffaAntonio PipoloNadia CitroniOrnella GuardamagnaSalvatore LiaAndrea BensoGianni Biolo BioloLorenzo MaroniAlessandro LupiLuca BonanniElisabetta RinaldiMaria Grazia ZentiDaisaku MasudaLinda MahfouzSelim JambartCarine AyoubYoumna GhalebNoor Alicezah Mohd KasimNoor Shafina Mohd NorAlyaa Al-KhateebSiti Hamimah Sheikh Abdul KadirYung-An ChuaAimi Zafira RazmanSukma Azureen NazliNorashikin Mohd RanaiAhmad Zubaidi Abd LatifMaría Teresa Magaña TorresRoopa MehtaAlexandro J MartagonGabriela a Galan RamirezNeftali Eduardo Antonio-VillaArsenio Vargas-VazquezDaniel Elias-LopezGustavo Gonzalez RetanaBethsabel Rodrıguez EncinasJose J Ceballos MacıasAlejandro Romero ZazuetaRocio Martinez AlvaradoJulieta D Morales PortanoHumberto Alvares LopezLeobardo Sauque-ReynaLaura G Gomez HerreraLuis E Simental MendiaHumberto Garcia AguilarElizabeth Ramirez CooremansVictoria Mendoza ZubietaPerla a Carrillo GonzalezAldo Ferreira-HermosilloNacu Caracas PortillaGuadalupe Jimenez DominguezAlinna y Ruiz GarciaHector E Arriaga CazaresJesus R Gonzalez GonzalezCarla V Mendez ValenciaFrancisco G Padilla PadillaRamon Madriz PradoManuel O de los Rios IbarraKarina J Acevedo RiveraRicardo Allende CarreraJose A AlvarezJose C Amezcua MartinezManuel de los Reyes Barrera BustilloGonzalo Carazo VargasRoberto Contreras ChaconMario H Figueroa AndradeAshanty Flores OrtegaHector Garcia AlcalaLaura E Garcia de LeonBerenice Garcia GuzmanJuan C Garnica CuellarJose R Gomez CruzAnell Hernandez GarciaJesus R Holguin AlmadaUrsulo Juarez HerreraFabiola Lugo SobrevillaEduardo Marquez RodriguezCristina Martinez SibajaAlma B Medrano RodriguezJose C Morales OyervidesDaniel I Perez VazquezEduardo A Reyes RodriguezMa Ludivina Robles OsorioJuan Rosas SaucedoMargarita Torres TamayoLuis A Valdez TalaveraLuis E Vera ArroyoEloy A Zepeda CarrilloAnnette Galema-BoersAlbert WeigmanMartin P BogsrudMunir MalikSaeedullah ShahSabeen Abid KhanMuhammad Asim RanaHijab BatoolEwa StarosteckaAgnieszka KonopkaJoanna LewekAgata Bielecka-DąbrowaAgnieszka GachJacek JóźwiakMarcin PajkowskiMarzena Romanowska-KocejkoMarta Żarczyńska-BuchowieckaMarcin HellmannMagdalena ChmaraBartosz WasągAleksandra ParczewskaNatasza Gilis-MalinowskaJustyna Borowiec-WolnaAneta StróżykAleksandra Michalska-GrzonkowskaIzabela ChlebusMariola KleinschmidtAgnieszka WojteckaTomasz ZdrojewskiMałgorzata MyśliwiecMatylda HennigAna Margarida MedeirosAna Catarina AlvesAna Filipa AlmeidaAndreia LopesAntónio GuerraCarla BilhotoFernando SimõesFrancisco SilvaGoreti LobarinhasGuida GamaIsabel PalmaJosé Miguel SalgadoLuísa Diogo MatosMárcio De MouraMaria João VirtuosoMónica TavaresPatrícia FerreiraPatrícia PaisPaula GarciaRaquel CoelhoRaquel RibeiroSusana CorreiaDinara SadykovaEvgenia SlastnikovaDalal AlammariHoria Ahmed MawlawiAtif AlsahariAlia Abdullah KhudaryNawal Lafi AlrowailyNatasa RajkovicLjiljana PopovicSandra SinghIva RasulicAna PetakovNebojsa M LalicFabian Kok PengRashida Farhan VasanwalaSreedharan Aravind VenkateshKatarina RaslovaLubomira FabryovaJan NociarJana ŠaligovaLudmila PotočňákováMiriam KozárováTibor VargaMichaela KadurovaMarianna DebreovaPeter NovodvorskyKatarina GonovaAlexander KlabnikIngrid BuganovaTadej BattelinoBarbara Jenko BizjanMarusa DebeljakJernej KovacMatej MlinaricNeza MolkJaka SikonjaUrsa SustarKatarina Trebusak PodkrajsekOvidio Muñiz-GrijalvoJose Luis Díaz-DíazRaimundo de AndrésFrancisco Fuentes-JiménezDirk BlomEleonore B MiserezJanine L ShiptonPoranee GanokrojMarta FutemaUma RamaswamiRano B AlievaKhurshid G FozilovShavkat U KhoshimovUlugbek I NizamovGuzal J AbdullaevaLiliya E KanAlisher A AbdullaevDaria V ZakirovaDoan-Loi DoMai-Ngoc-Thi NguyenNgoc-Thanh KimThanh-Tung LeHong-An LeRaul SantosKausik K Ray

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Type de publi. : Article dans une revue
Date de publi. : 06/01/2024
Auteurs : Kanika Inamdar DharmayatAntonio J Vallejo-VazChristophe a T StevensJulia M BrandtsAlexander R M LyonsUrh GroseljMarianne AbifadelCarlos A Aguilar-SalinasKhalid AlhabibMutaz AlkhnifsawiWael AlmahmeedFahad AlnouriRodrigo AlonsoKhalid Al-RasadiTester F AshavaidMaciej BanachSophie BéliardChristoph BinderMafalda BourbonKrzysztof ChlebusPablo CorralDiogo CruzOlivier S DescampsEuridiki DrogariRonen DurstMarat V EzhovJacques GenestMariko Harada-ShibaKirsten B HolvenSteve E HumphriesWeerapan KhovidhunkitKatarina LalicUlrich LaufsEvangelos LiberopoulosJeanine Roeters van LennepMarcos Miguel Lima-MartinezJie LinVincent MaherWinfried MärzAndré R MiserezOlena MitchenkoHapizah NawawiAndrie G PanayiotouGyörgy ParaghArman PostadzhiyanAshraf RedaŽeljko ReinerXimena ReyesFouzia SadiqAmirhossein SahebkarHeribert SchunkertAleksandr B ShekEric StroesTa-Chen SuTavintharan SubramaniamAndrey SusekovAlejandra Vázquez CárdenasThanh Huong TruongAlexandros D TselepisBranislav VohnoutLuya WangShizuya YamashitaAhmad Al-SarrafNasreen Al-SayedKairat DavletovBambang DwiputraDan GaitaMeral KayikciogluGustavs LatkovskisA. David MaraisAnne Thushara MatthiasErkin MirrakhimovBørge G NordestgaardZaneta PetrulionieneBelma PojskicWilson SadohMyra TilneyBrian TomlinsonAnne Tybjærg-HansenMargus ViigimaaAlberico L CatapanoTomas FreibergerG. Kees HovinghPedro MataHandrean SoranFrederick RaalGerald F WattsLaura SchreierVirginia BañaresSusanne Greber-PlatzerMargot Baumgartner-KautCharlotte de GierHans DieplingerFlorian HöllerlReinhold InnerhoferDaniela KarallJulia LischkaBernhard LudvikMartin MäserSabine Scholl-BürgiAlexandra ThajerHermann ToplakFabian DemeureAnn MertensJean-Luc BalligandXavier StephenneEtienne SokalIvo PetrovAssen GoudevFedya NikolovSnejana TishevaYoto YotovIvajlo TzvetkovRobert A HegeleDaniel GaudetLiam BrunhamIsabelle RuelBrian MccrindleAda CuevasDražen PericaPhivos SymeonidesEfstratios TrogkanisAndreas KostisAndreas IoannouAngeliki MouzarouAnthoula GeorgiouAndreas StylianouGeorge MiltiadousParis IacovidesConstantinos DeltasMichal VrablikZuzana UrbanovaPavel JesinaLukas TichyJosef HyanekJana DvorakovaJana CepovaJosef SykoraKristyna BuresovaMichal PipekEva PistkovaIvana BartkovaLenka ToukalkovaMichaela SpenerovaJan MalyMarianne BennAhmed BendaryAtef ElbahryJean FerrièresDorota FerrieresNoel PerettiÉric BruckertAntonio GalloRené ValéroFlorian MourreKarine AouchicheRachel ReynaudPatrick TounianJulie LemaleFranck BoccaraPhilippe MoulinSybil CharrièresMathilde Di FilippoBertrand CariouFrançois PaillardCaroline DourmapAlain PradignacBruno VergesIsabelle SimoneauMichel FarnierYves CottinCecile YelnikRegis HankardFrançois SchieleVincent DurlachAriane SultanAlain CarriéJean-Pierre RabèsVeronika SaninRaphael S SchmiederSara AtesChristos V RizosIoannis SkoumasKonstantinos TziomalosLoukianos RallidisVasileios KotsisMichalis DoumasEmmanouil SkalidisGenovefa KolovouVana KolovouAnastasia GaroufiIosif KoutagiarGeorgios PolychronopoulosEstela KiouriChristina AntzaEvangelos ZacharisAchilleas AttilakosGeorge SfikasCharalambos KoumarasPanagiotis AnagnostisGeorgia AnastasiouGeorge LiamisPetros-Spyridon AdamidisHaralambos MilionisVaia LambadiariStella StabouliTheodosios FilippatosVicky MollakiAnastasia TsaroumiFrida LamariPavlos ProyiasMariann HarangiLakshmi Lavanya ReddySwarup a V ShahChandrashekhar K PondeJamshed J DalalJitendra P S SawhneyIshwar C VermaSusan HosseiniTannaz JamialahmadiMohammed AlareedhFoaad ShagheeSabah Hasan RhadiMaryam AbduljalalSarmad AlfilHuda KareemHofit CohenEran LeitersdorfDaniel SchurrShoshi ShpitzenMarcello ArcaMaurizio AvernaStefano BertoliniSebastiano CalandraPatrizia TarugiManuela CasulaFederica GalimbertiMarta GazzottiElena OlmastroniRiccardo SarzaniClaudio FerriElena RepettiFrancesco GiorginoPatrizia SuppressaAntonio Carlo BossiClaudio BorghiSandro MuntoniFrancesco CipolloneRoberto ScicaliArturo PujiaAngelina PassaroMartina BerteottiValerio PecchioliLivia PisciottaGiuseppe MandraffinoFabio PellegattaGiuliana MombelliAdriana BranchiAnna Maria FiorenzaCristina PederivaJosé Pablo WerbaGianfranco ParatiFabio NascimbeniLorenzo IughettiGiuliana FortunatoRaimondo CavallaroGabriella IannuzzoPaolo CalabròAngelo Baldassare CefalùMaria Elena CapraAlberto ZambonMatteo PirroFrancesco SbranaChiara TrentiIlenia MinicocciMassimo FedericiMaria del BenPaola Sabrina BuonuomoSimona MoffaAntonio PipoloNadia CitroniOrnella GuardamagnaSalvatore LiaAndrea BensoGianni Biolo BioloLorenzo MaroniAlessandro LupiLuca BonanniElisabetta RinaldiMaria Grazia ZentiDaisaku MasudaLinda MahfouzSelim JambartCarine AyoubYoumna GhalebNoor Alicezah Mohd KasimNoor Shafina Mohd NorAlyaa Al-KhateebSiti Hamimah Sheikh Abdul KadirYung-An ChuaAimi Zafira RazmanSukma Azureen NazliNorashikin Mohd RanaiAhmad Zubaidi Abd LatifMaría Teresa Magaña TorresRoopa MehtaAlexandro J MartagonGabriela a Galan RamirezNeftali Eduardo Antonio-VillaArsenio Vargas-VazquezDaniel Elias-LopezGustavo Gonzalez RetanaBethsabel Rodrıguez EncinasJose J Ceballos MacıasAlejandro Romero ZazuetaRocio Martinez AlvaradoJulieta D Morales PortanoHumberto Alvares LopezLeobardo Sauque-ReynaLaura G Gomez HerreraLuis E Simental MendiaHumberto Garcia AguilarElizabeth Ramirez CooremansVictoria Mendoza ZubietaPerla a Carrillo GonzalezAldo Ferreira-HermosilloNacu Caracas PortillaGuadalupe Jimenez DominguezAlinna y Ruiz GarciaHector E Arriaga CazaresJesus R Gonzalez GonzalezCarla V Mendez ValenciaFrancisco G Padilla PadillaRamon Madriz PradoManuel O de los Rios IbarraKarina J Acevedo RiveraRicardo Allende CarreraJose A AlvarezJose C Amezcua MartinezManuel de los Reyes Barrera BustilloGonzalo Carazo VargasRoberto Contreras ChaconMario H Figueroa AndradeAshanty Flores OrtegaHector Garcia AlcalaLaura E Garcia de LeonBerenice Garcia GuzmanJuan C Garnica CuellarJose R Gomez CruzAnell Hernandez GarciaJesus R Holguin AlmadaUrsulo Juarez HerreraFabiola Lugo SobrevillaEduardo Marquez RodriguezCristina Martinez SibajaAlma B Medrano RodriguezJose C Morales OyervidesDaniel I Perez VazquezEduardo A Reyes RodriguezMa Ludivina Robles OsorioJuan Rosas SaucedoMargarita Torres TamayoLuis A Valdez TalaveraLuis E Vera ArroyoEloy A Zepeda CarrilloAnnette Galema-BoersAlbert WeigmanMartin P BogsrudMunir MalikSaeedullah ShahSabeen Abid KhanMuhammad Asim RanaHijab BatoolEwa StarosteckaAgnieszka KonopkaJoanna LewekAgata Bielecka-DąbrowaAgnieszka GachJacek JóźwiakMarcin PajkowskiMarzena Romanowska-KocejkoMarta Żarczyńska-BuchowieckaMarcin HellmannMagdalena ChmaraBartosz WasągAleksandra ParczewskaNatasza Gilis-MalinowskaJustyna Borowiec-WolnaAneta StróżykAleksandra Michalska-GrzonkowskaIzabela ChlebusMariola KleinschmidtAgnieszka WojteckaTomasz ZdrojewskiMałgorzata MyśliwiecMatylda HennigAna Margarida MedeirosAna Catarina AlvesAna Filipa AlmeidaAndreia LopesAntónio GuerraCarla BilhotoFernando SimõesFrancisco SilvaGoreti LobarinhasGuida GamaIsabel PalmaJosé Miguel SalgadoLuísa Diogo MatosMárcio De MouraMaria João VirtuosoMónica TavaresPatrícia FerreiraPatrícia PaisPaula GarciaRaquel CoelhoRaquel RibeiroSusana CorreiaDinara SadykovaEvgenia SlastnikovaDalal AlammariHoria Ahmed MawlawiAtif AlsahariAlia Abdullah KhudaryNawal Lafi AlrowailyNatasa RajkovicLjiljana PopovicSandra SinghIva RasulicAna PetakovNebojsa M LalicFabian Kok PengRashida Farhan VasanwalaSreedharan Aravind VenkateshKatarina RaslovaLubomira FabryovaJan NociarJana ŠaligovaLudmila PotočňákováMiriam KozárováTibor VargaMichaela KadurovaMarianna DebreovaPeter NovodvorskyKatarina GonovaAlexander KlabnikIngrid BuganovaTadej BattelinoBarbara Jenko BizjanMarusa DebeljakJernej KovacMatej MlinaricNeza MolkJaka SikonjaUrsa SustarKatarina Trebusak PodkrajsekOvidio Muñiz-GrijalvoJose Luis Díaz-DíazRaimundo de AndrésFrancisco Fuentes-JiménezDirk BlomEleonore B MiserezJanine L ShiptonPoranee GanokrojMarta FutemaUma RamaswamiRano B AlievaKhurshid G FozilovShavkat U KhoshimovUlugbek I NizamovGuzal J AbdullaevaLiliya E KanAlisher A AbdullaevDaria V ZakirovaDoan-Loi DoMai-Ngoc-Thi NguyenNgoc-Thanh KimThanh-Tung LeHong-An LeRaul SantosKausik K Ray
Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
Publié dans The Lancet le 02/11/2020

Résumé : Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2•1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies.

Methods

For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13•0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings Of 63 093 individuals in the FHSC registry, 11 848 (18•8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50•2%) of 11 476 included individuals were female and 5720 (49•8%) were male. Sex data were missing for 372 (3•1%) of 11 848 individuals. Median age at registry entry was 9•6 years (IQR 5•8-13•2). 10 099 (89•9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10•1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5•2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92•4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48•0%] of 415). 3414 (31•6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72•4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5•00 mmol/L (IQR 4•05-6•08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life.

Fichiers liés : 205 Familial hypercholesterolaemia in children and adolescents from 48 countries.pdf

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Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Type de publi. : Article dans une revue
Date de publi. : 06/01/2024
Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El BaghdadiSara Espinosa-PadillaJosé Luis FrancoAntoine FroidureDavid HaginSarah HenricksonElena HsiehEystein HusebyeKohsuke ImaiYuval ItanErich JarvisTimokratis KaramitrosKai KisandCheng-Lung KuYun LingCarrie LucasLászló MaródiIsabelle MeytsJoshua MilnerKristina MironskaTomohiro MorioLisa NgLuigi NotarangeloCliona O’FarrellySatoshi OkadaAnna PlanasLluis Quintana-MurciLaurent ReniaIgor ResnickCarlos Rodríguez-GallegoVanessa Sancho-ShimizuAnna SedivaMikko SeppänenAnna ShcherbinaOndrej SlabyAndrew SnowPere Soler-PalacínAndrás SpaanIvan TancevskiStuart TangyeSathishkumar RamaswamyStuart TurveyFurkan UddinMohammed UddinDiederik van de BeekDonald VinhMayana ZatzHelen SuJean-Laurent CasanovaSerge BureauYannick VacherAnne Gysembergh-HoualLauren DemervilleAbla ChachouaSébastien AbadRadhiya AbassiAbdelrafie AbdellaouiAbdelkrim AbdelmalekHendy AbdoulHelene AbergelFariza AbeudSophie AbgrallNoemie AbisrorMarylise AdechianNordine AderdourHakeem Farid AdmaneFrederic AdnetSara AfrittHelene 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BenkheloufJihene BenlaghaChahinez BenmostafaSkander BenothmaneMiassa BentifraouineLaurence BerardQuentin BernierEnora BertiAstrid BertierLaure BertonSimon BessisAlexandra BeurtonCeline BiancoClara BianquisFrank BidarPhilippe BlancheClarisse BlayauAlexandre BleibtreuEmmanuelle BlinCoralie Bloch-QueyratMarie-Christophe BoissierDiane BollensMarion BolzoniRudy Pierre BompardNicolas BonnetJustine BonnouvrierShirmonecrystal BothaWissam BoucennaFatiha BouchamaOlivier BouchaudHanane BouchghoulTaoueslylia BoudjeblaNoel BoudjemaCatherine BouffardAdrien BougleMeriem BouguerraLeila BourasAgnes BourcierAnne Bourgarit DurandAnne BourrierFabrice BouscaratDiane BouvryNesrine BouziriOns BouzraraSarah BribierDelphine BrugierMelanie BrunelEida BuiAnne BuissonIryna BukreyevaCôme BureauJacques CadranelJohann CailholRuxandra CalinClara Campos VegaPauline CanavaggioMarta CancellaDelphine CantinAlbert CaoLionel CarbillonNicolas CarlierClementine CassardGuylaine CastorMarion CauchyOlivier ChaBenjamin 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DerradjiNawal DerridjVincent DescampsLydia DeschampsCeline DesconcloisCyrielle DesnosKarine DesonginsRobin DhoteBenjamin DialloMorgane DidierMyriam DiemerStephane DiezJuliette Djadi-PratFatima-Zohra Djamouri MonnorySiham DjebaraNaoual DjebraMinette DjietcheuHadjer DjillaliNouara DjouadiSeverine DonnegerCatarina dos SantosNathalie DournonMartin DresLaura DroctoveMarie DrogreyMargot DropyElodie DrouetValérie DubosqEvelyne DubreucqEstelle DubusBoris DuchemannThibault DuchenoyEmmanuel DudoignonRomain DufauFlorence DumasClara DuranEmmanuelle DuronAntoine DurrbachClaudine DuvivierNathan EbsteinJihane El KhalifaAlexandre ElabbadiCaroline ElieGabriel ErnotteAnne EslingMartin EtienneXavier EyerMuriel Sarah FartoukhTakoua FayaliMarion FermautArianna FiorentinoSouha FlissMarie-Céline FournierBenjamin FournierHélène FrancoisOlivia FreynetYvann FrigoutIsaure FromontAxelle FuentesThomas FuretJoris GalandMarc GarnierAgnes GaubertStéphane GaudrySamuel GaugainDamien GauthierMaxime GautierSophie Georgin-LavialleDaniela GerominMohamed GhalayiniBijan GhalehMyriam GhezalAude GibelinLinda GimenoBenoit GirardBénédicte Giroux LeprieurDoryan GomesElisabete Gomes-PiresAnne GougeAmel GoujaHelene GouletSylvain GoupilJeanne Goupil de BouilleJulien GrasSegolene GreffeLamiae GrimaldiPaul GuedeneyBertrand GuidetMatthias GuilloMariechristelle GulczynskiTassadit HadjamDidier HaguenauerSoumeya HammalNadjib HammoudiOlivier HanonAnarole HarroisCoraline HautemGuillaume HékimianNicholas HemingOlivier HermineSylvie HoMarie HoullierBenjamin HuotTessa HuscenotWafa Ibn SaiedGhilas IkherbaneMeriem ImarazenePatrick IngilizLina IratniStephane JaureguiberryJean-Francois Jean-MarcDeleena JeyarajasinghamPauline JouanyVeronique JouisClement JourdaineOuifiya KafifRim KallalaSandrine KatsahianLilit KelesyanVixra KeoFlora KetzWarda KhamisEnfel KheliliMehdi KhellafChristy Gaëlla Kotokpo YoukouIlias KounisGaelle KpalmaJessica KrauseVincent LabbeKarine LacombeJean-Marc LacorteAnne Gaelle LafontEmmanuel LafontLynda LaghaLionel LamhautAymeric LancelotCecilia LandmanFanny LanternierCecile LarchevequeCaroline Lascoux CombeLudovic LasselBenjamin LaverdantChristophe LavergneJean-Rémi LavillegrandPompilia LazureanuLoïc Le GuennecLamia LeberreClaire LeblancMarion LeboyerFrancois LecomteMarine LecorreRomain LeenhardtMarylou LefebvreBénédicte LefebvrePaul LegendreAnne LegerLaurence LegrosJustyna LegrosseSébastien LehuunghiaJulien LemarecJeremie Leporrier-ExtManon LeseinHubert LesurVincent LevyAlbert LevyEdwige LopesAmanda LopesVanessa LopezJulien LopintoOlivier LortholaryBadr LouadahBénédicte LozeMarie-Laure LucasAxelle LucasamichiLiem Binh LuongArouna Magazimama-ExtDavid MaingretLakhdar MameriPhilippe ManivetCylia MansouriEstelle MarcaultJonathan MareyNathalie MarinClémence MaroisOlivier MartinLou MartineauCannelle Martinez-LopezPierre MartyniuckPauline Mary de FarcyNessrine MarzoukRafik MasmoudiAlexandre MebazaaFrédéric MechaiFabio MecozziChamseddine MediouniBruno MegarbaneMohamed MeghadechaÉlodie MejeanArsène MékinianNour Mekki AbdelhadiRania MekniThinhinan Sabrina MelitiBreno Melo LimaParis MengSoraya MerbahFadhila MessaniYasmine MessaoudiBaboo-Irwinsingh MewasingLydia MezianeCarole Michelot-BurgerFrançoise MignotFadi Hillary MinkaMakoto MiyaraPierre MoineJean-Michel MolinaAnaïs Montegnies-BouletAlexandra MontiClaire MontlahucAnne-Lise MontoutAlexandre MooresCaroline MorbieuHelene MorteletteStéphane MoulyRosita MuzaffarCherifa Iness NacerddineMarine NadalHajer NadifKladoum NassarmadjiPierre NatellaSandrine NdingamondzeStefan NeraalCaroline NguyenBao N’guyenIsabelle Nion LarmurierLuc NlomenyengueNicolas NoelHilario NunesEdris OmarZineb OuazeneElise OuedraogoWassila OuelaaAnissa OukhedoumaYasmina Ould AmaraHerve OyaJohanna OzielThomas PadillaElena PaillaudSolenne PaivaBeatrice ParfaitPerrine ParizeChristophe ParizotAntoine ParrotArthur PavotLaetitia PeaudecerfFrédéric PeneMarion PepinJulie PernetClaire PerninMylène PetitOlivier PeyronyMarie-Pierre PietriOlivia PietriMarc Pineton 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SemeranoMarie-Victoire SenatDamien SèneAlexandra SerrisLucile SeseNaima SghiouarJohanna SigauxMartin SiguierJohanne SilvainNoémie Simon-TillauxTabassome SimonLina Innes SkandriMiassa SlimaniAurélie SnauwaertHarry SokolHeithem SolimanNisrine SoltaniBenjamin SoyerPhilippe Gabriel StegLydia SuarezTali-Anne SzwebelKossi TaffameClaire TantetMariagrazia TateoIgor TheodosePierre Clement ThiebaudCaroline ThomasKelly TierceletJulie TisserandCarole TomczakKrystel TorelinoFatima Touam-ExtLilia ToumiGustave TouryMireille Toy-MiouOlivia Tran Dinh Thanh LienAlexy TrandinhJean-Marc TreluyerBaptiste TrinqueJennifer TruchotSimone TunesiMatthieu TurpinAgathe TurpinTomas UrbinaRafael Usubillaga NarvaezYurdagul UzunhanPrabakar VaittinadaayarArnaud ValentMaelle ValentianNadia ValinHélène ValletMarina VazMiguel-Alejandro VazquezibarraBenoit VedieLaetitia VellyCeline VerstuyftCedric VialletteEric VicautDorothee VignesDamien VimpereMyriam VirlouvetGuillaume VoiriotLena VoisotEmmanuel WeissNicolas WeissAnaïs WinchenneYouri YordanovLara ZafraniMohamad ZaidanWissem ZaidiCathia ZakAida Zarhrate-GhoulOuassila ZatoutSuzanne ZeinoMichel ZeitouniNaïma ZemirliLorene ZerahOunsa ZiaMarianne ZiolOceane ZolarioJulien ZuberLaurent AbelClaire AndréjakFrançois AngoulvantDelphine BacheletMarie BartoliRomain BasmaciSylvie BehilillMarine BeluzeDehbia BenkerrouKrishna BhavsarLila BouadmaSabelline BouchezMaude BouscambertMinerva Cervantes-GonzalezAnissa ChairCatherine ChirouzeAlexandra CoelhoCamille CouffignalSandrine Couffin-CadierguesEric D’ortenzioMarie-Pierre DebrayLauren DeconinckDominique DeplanqueDiane DescampsMathilde DesvalléeAlpha DialloAlphonsine DioufCéline DorivalFrançois DubosXavier DuvalBrigitte ElharrarPhilippine EloyVincent EnoufHélène EsperouMarina Esposito-FareseManuel EtienneEglantine Ferrand DevougeNathalie GaultAlexandre GaymardJade GhosnTristan GiganteMorgane GilgJérémie GuedjAlexandre HoctinIsabelle HoffmannIkram HouasJean-Sébastien HulotSalma JaafouraOuifiya KafifFlorentia KaguelidouSabrina KaliAntoine KhalilCoralie KhanCédric LaouénanSamira LaribiMinh LeQuentin Le HingratSoizic Le MestreHervé Le NagardFrançois-Xavier LescureSophie LetrouYves LevyBruno LinaGuillaume LingasJean Christophe LucetDenis MalvyMarina MambertFrance MentréAmina MezianeHugo MouquetJimmy MullaertNadège NeantDuc NguyenMarion NoretSaad NseirAurélie PapadopoulosChristelle PaulNathan Peiffer-SmadjaThomas PerpointVentzislava Petrov-SanchezGilles PeytavinHuong PhamOlivier PiconeValentine PiquardOriane PuéchalChristian RabaudManuel Rosa-CalatravaBénédicte RossignolPatrick RossignolCarine RoyMarion SchneiderRicha SuCoralie TardivonMarie-Capucine TellierFrançois TéouléOlivier TerrierJean-François TimsitChristelle TualSylvie van der WerfNoémie VanelAurélie VeislingerBenoit VisseauxAurélie WiedemannYazdan YazdanpanahLoubna AlavoineSylvie BehillilCharles BurdetCharlotte CharpentierAline DechanetDiane DescampsXavier DuvalJean-Luc EcobichonVincent EnoufWahiba FrezoulsNadhira HouhouOuifiya KafifJonathan LehacautSophie LetrouBruno LinaJean-Christophe LucetPauline ManchonMariama NouroudineValentine PiquardCaroline QuintinMichael ThySylvie van der WerfValérie VignaliBenoit VisseauxYazdan YazdanpanahAbir ChahineNawal WaucquierMaria-Claire MigaudDominique DeplanqueFélix DjossouMayka Mergeay-FabreAude LucarelliMagalie DemarLéa BruneauPatrick GérardinAdrien MaillotChristine PayetBruno LaviolleFabrice LaineChristophe ParisMireille Desille-DugastJulie FouchardDenis MalvyDuc NguyenThierry PistonePauline PerreauValérie GissotCarole GoasSamatha MontagneLucie RichardCatherine ChirouzeKevin BouillerMaxime DesmaretsAlexandre MeunierMarilou BourgeonBenjamin LefévreHélène JeulinKarine LegrandSandra LomazziBernard TardyAmandine Gagneux-BrunonFrédérique BertholonElisabeth Botelho-NeversChristelle KouakamLeturque NicolasLayidé RoufaiKarine AmatSandrine Couffin-CadierguesHélène EspérouSamia HendouGiuseppe FotiGiacomo BellaniGiuseppe CiterioErnesto ControAlberto PesciMaria Grazia ValsecchiMarina CazzanigaJorge AbadGiulia AccordinoCristian AchilleSergio Aguilera-AlbesaAina Aguiló-CucurullEsra Akyüz ÖzkanJonathan Antonio Roblero AlbisuresJuan AldaveMiquel Alfonso RamosTaj Ali KhanAnna AlibertiSeyed Alireza NadjiGulsum AlkanSuzan AlkhaterJerome Allardet-ServentMohammed AlshahraniLaia AlsinaMarie-Alexandra AlyanakianBlanca Amador BorreroZahir AmouraArnau AntolíRomain ArrestierMélodie AubartTeresa AuguetIryna AvramenkoGökhan AytekinAxelle AzotSeiamak BahramFanny BajolleFausto BaldantiAurélie BaldolliMaite BallesterHagit Baris FeldmanBenoît BarrouSabrina BassoGulsum Iclal BayhanAlexandre BelotLiliana BezrodnikAgurtzane BilbaoGeraldine Blanchard-RohnerIgnacio BlancoAdeline BlandinièresDaniel Blázquez-GameroAlexandre BleibtreuMarketa BloomfieldMireia Bolivar-PradosAnastasiia BondarenkoAlessandro BorghesiRaphael BorieElisabeth Botdhlo-NeversAhmed BousfihaAurore BousquetDavid BoutolleauClaire BouvattierOksana BoyarchukJuliette BravaisM. Luisa BrionesMarie-Eve BrunnerRaffaele BrunoMaria Rita P. BuenoHuda BukhariJacinta BustamanteJuan José Cáceres AgraRuggero CapraRaphaël CarapitoMaria CarrabbaCarlos CasasnovasMarion CaserisIrene CassanitiMartin CastelleFrancesco CastelliMartín Castillo de VeraMateus CastroEmilie CatherinotJale Bengi CelikAlessandro CeschiMartin ChalumeauBruno CharbitMatthew ChengPère ClavéBonaventura ClotetAnna CodinaYves CohenCloé ComarmondAlain CombesPatrizia ComoliAngelo CorsicoBetul SozeriTaner CoşkunerAleksandar CvetkovskiCyril CyrusDavid DalmauFrançois DanionDavid Ross DarleyVincent DasNicolas DaubyStéphane DaugerPaul de MunterLoic de PontualAmin DehbanGeoffroy DelplancqAlexandre DemouleIsabelle DesguerreAntonio Di SabatinoJean-Luc DiehlStephanie DobbelaereElena Domínguez-GarridoClément DubostOlov EkwallŞefika Elmas BozdemirMarwa ElnagdyMelike EmirogluAkifumi EndoEmine Hafize ErdenizSelma Erol AytekinMaria Pilar Etxart LasaRomain EuvrardGiovanna FabioLaurence FaivreAntonin FalckMuriel FartoukhMorgane FaureMiguel Fernandez ArqueroRicard FerrerJose FerreresBruno FrancoisVictoria FumadóKitty FungFrancesca FuscoAlenka GagroBlanca Garcia SolisPierre GarçonPascale GaussemZeynep GayretliJuana Gil-HerreraLaurent GilardinAudrey Giraud GatineauMònica Girona-AlarcónKaren Alejandra Cifuentes GodínezJean-Christophe GoffardNacho GonzalesLuis Gonzalez-GranadoRafaela González-MontelongoAntoine GuerderBelgin GülhanVictor Daniel GumucioLeif Gunnar HanitschJan GunstJérôme HadjadjTetyana HariyanNevin HatipogluDeniz HeppekcanElisa Hernandez-BritoPo-Ki HoMaría Soledad Holanda-PeñaJuan HorcajadaSami HraiechLinda HumbertIvan HungAlejandro IglesiasAntonio Íñigo-CamposMatthieu JammeMaría Jesús ArranzMarie-Thérèse JimenoIolanda JordanSaliha Kanik-YüksekYalcin Burak KaraAydın KarahanKadriye Kart YasarOzgur KasapcopurKenichi KashimadaYasemin Kendir DemirkolYasutoshi KidoCan KizilAhmet Osman KılıçAdam KlocperkAntonia KoutsoukouZbigniew KrólHatem KsouriPaul KuentzArthur KwanYat Wah M. KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnes LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalSébastien VielCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessia FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie Cobat

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Type de publi. : Article dans une revue
Date de publi. : 06/01/2024
Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El 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ValsecchiMarina CazzanigaJorge AbadGiulia AccordinoCristian AchilleSergio Aguilera-AlbesaAina Aguiló-CucurullEsra Akyüz ÖzkanJonathan Antonio Roblero AlbisuresJuan AldaveMiquel Alfonso RamosTaj Ali KhanAnna AlibertiSeyed Alireza NadjiGulsum AlkanSuzan AlkhaterJerome Allardet-ServentMohammed AlshahraniLaia AlsinaMarie-Alexandra AlyanakianBlanca Amador BorreroZahir AmouraArnau AntolíRomain ArrestierMélodie AubartTeresa AuguetIryna AvramenkoGökhan AytekinAxelle AzotSeiamak BahramFanny BajolleFausto BaldantiAurélie BaldolliMaite BallesterHagit Baris FeldmanBenoît BarrouSabrina BassoGulsum Iclal BayhanAlexandre BelotLiliana BezrodnikAgurtzane BilbaoGeraldine Blanchard-RohnerIgnacio BlancoAdeline BlandinièresDaniel Blázquez-GameroAlexandre BleibtreuMarketa BloomfieldMireia Bolivar-PradosAnastasiia BondarenkoAlessandro BorghesiRaphael BorieElisabeth Botdhlo-NeversAhmed BousfihaAurore BousquetDavid BoutolleauClaire BouvattierOksana BoyarchukJuliette BravaisM. Luisa BrionesMarie-Eve BrunnerRaffaele BrunoMaria Rita P. BuenoHuda BukhariJacinta BustamanteJuan José Cáceres AgraRuggero CapraRaphaël CarapitoMaria CarrabbaCarlos CasasnovasMarion CaserisIrene CassanitiMartin CastelleFrancesco CastelliMartín Castillo de VeraMateus CastroEmilie CatherinotJale Bengi CelikAlessandro CeschiMartin ChalumeauBruno CharbitMatthew ChengPère ClavéBonaventura ClotetAnna CodinaYves CohenCloé ComarmondAlain CombesPatrizia ComoliAngelo CorsicoBetul SozeriTaner CoşkunerAleksandar CvetkovskiCyril CyrusDavid DalmauFrançois DanionDavid Ross DarleyVincent DasNicolas DaubyStéphane DaugerPaul de MunterLoic de PontualAmin DehbanGeoffroy DelplancqAlexandre DemouleIsabelle DesguerreAntonio Di SabatinoJean-Luc DiehlStephanie DobbelaereElena Domínguez-GarridoClément DubostOlov EkwallŞefika Elmas BozdemirMarwa ElnagdyMelike EmirogluAkifumi EndoEmine Hafize ErdenizSelma Erol AytekinMaria Pilar Etxart LasaRomain EuvrardGiovanna FabioLaurence FaivreAntonin FalckMuriel FartoukhMorgane FaureMiguel Fernandez ArqueroRicard FerrerJose FerreresBruno FrancoisVictoria FumadóKitty FungFrancesca FuscoAlenka GagroBlanca Garcia SolisPierre GarçonPascale GaussemZeynep GayretliJuana Gil-HerreraLaurent GilardinAudrey Giraud GatineauMònica Girona-AlarcónKaren Alejandra Cifuentes GodínezJean-Christophe GoffardNacho GonzalesLuis Gonzalez-GranadoRafaela González-MontelongoAntoine GuerderBelgin GülhanVictor Daniel GumucioLeif Gunnar HanitschJan GunstJérôme HadjadjTetyana HariyanNevin HatipogluDeniz HeppekcanElisa Hernandez-BritoPo-Ki HoMaría Soledad Holanda-PeñaJuan HorcajadaSami HraiechLinda HumbertIvan HungAlejandro IglesiasAntonio Íñigo-CamposMatthieu JammeMaría Jesús ArranzMarie-Thérèse JimenoIolanda JordanSaliha Kanik-YüksekYalcin Burak KaraAydın KarahanKadriye Kart YasarOzgur KasapcopurKenichi KashimadaYasemin Kendir DemirkolYasutoshi KidoCan KizilAhmet Osman KılıçAdam KlocperkAntonia KoutsoukouZbigniew KrólHatem KsouriPaul KuentzArthur KwanYat Wah M. KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnes LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalSébastien VielCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessia FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie Cobat
Organismes : Human genetics of infectious diseases : Mendelian predisposition Génétique Physiologie et Systèmes d'Elevage Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Institut Necker Enfants-Malades Rockefeller University [New York] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Département de Pédiatrie et maladies infectieuses [CHU Necker] Huazhong Agricultural University [Wuhan] Helix [San Mateo, CA] Rockefeller University [New York] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] St. Giles Laboratory of Human Genetics of Infectious Diseases St. Giles Laboratory of Human Genetics of Infectious Diseases Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] IRCCS San Raffaele Scientific Institute [Milan, Italie] San Raffaele Telethon Institute for Gene Therapy [Milan, Italy] Karolinska University Hospital [Stockholm] Children’s Medical Center [Tehran, Liban] IRCCS San Raffaele Scientific Institute [Milan, Italie] San Raffaele Telethon Institute for Gene Therapy [Milan, Italy] Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] Shahid Beheshti University of Medical Sciences [Tehran] Collège de France - Chaire Génomique humaine et évolution Immunologie intégrative des tumeurs et immunothérapie des cancers Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Hospices Civils de Lyon
Publié dans Genome Medicine le 24/10/2020

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Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT)

Type de publi. : Article dans une revue
Date de publi. : 05/01/2024
Auteurs : François RoubilleNadia BouabdallaouiSimon KouzDavid WatersRafael DiazAldo MaggioniFausto PintoJean GrégoireHabib GamraGhassan KiwanColin BerryJosé López-SendónWolfgang KoenigLaurent DelormeMeyer ElbazPierre CosteMylène ProvencherZohar BassevitchLucie BlondeauPhilippe L’allierMarie-Claude GuertinJean-Claude Tardif

Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT)

Type de publi. : Article dans une revue
Date de publi. : 05/01/2024
Auteurs : François RoubilleNadia BouabdallaouiSimon KouzDavid WatersRafael DiazAldo MaggioniFausto PintoJean GrégoireHabib GamraGhassan KiwanColin BerryJosé López-SendónWolfgang KoenigLaurent DelormeMeyer ElbazPierre CosteMylène ProvencherZohar BassevitchLucie BlondeauPhilippe L’allierMarie-Claude GuertinJean-Claude Tardif
Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
Publié dans Diabetes Care le 01/11/2020

Résumé : OBJECTIVE The cardiovascular benefits of low-dose colchicine have been demonstrated in patients with coronary disease. Its effects were evaluated in this prespecified analysis in patients with type 2 diabetes (T2D) from the COLchicine Cardiovascular Outcomes Trial (COLCOT). RESEARCH DESIGN AND METHODS COLCOT was a randomized, double-blinded trial of colchicine, 0.5 mg daily, versus placebo initiated within 30 days after a myocardial infarction. RESULTS There were 959 patients with T2D enrolled and monitored for a median of 22.6 months. A primary end point event occurred in 8.7% of patients in the colchicine group and in 13.1% in the placebo group (hazard ratio 0.65; 95% CI 0.44–0.96; P = 0.03). Nausea was reported in 2.7% and 0.8% in the study groups (P = 0.03), and pneumonia occurred in 2.4% and 0.4% (P = 0.008). CONCLUSIONS Among patients with T2D and a recent myocardial infarction, colchicine, 0.5 mg daily, leads to a large reduction of cardiovascular events. These results support the conduct of the COLCOT-T2D trial in primary prevention.

Fichiers liés : 2024 Roubille et al., Low.pdf

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How local reference panels improve imputation in French populations

Type de publi. : Article dans une revue
Date de publi. : 03/01/2024
Auteurs : Anthony Francis HerzigLourdes Velo‐suárezDominique CampionJean-François DartiguesJean-Charles LambertThomas E LudwigBenjamin Grenier-BoleySébastien LetortPierre LindenbaumVincent MeyerOlivier QuenezCéline BellenguezCamille Charbonnier-Le ClézioJoanna GiemzaStéphanie ChatelClaude FerecHervé Le MarecLuc LetenneurGaël NicolasKaren RouaultDelphine BacqAnne BolandDoris LechnerChantal AdjouStéphanie ChatelMarcel GoldbergPhilippe-Antoine HalboutHervé Le MarecDavid L’helgouachKaren RouaultJean-Jacques SchottAnne VogelspergerMarie ZinsDelphine BacqHélène BlanchéAnne BolandRobert OlasoPierre LindenbaumThomas LudwigVincent MeyerFlorian SandronDamien DelafoyLourdes Velo-SuárezIsabel AlvesOzvan BocherAnthony F HerzigMatilde KarakachoffGaëlle MarenneAude Saint PierreVéronique GeoffroyChristian DinaRichard RedonJean-François DeleuzeEmmanuelle Génin

How local reference panels improve imputation in French populations

Type de publi. : Article dans une revue
Date de publi. : 03/01/2024
Auteurs : Anthony Francis HerzigLourdes Velo‐suárezDominique CampionJean-François DartiguesJean-Charles LambertThomas E LudwigBenjamin Grenier-BoleySébastien LetortPierre LindenbaumVincent MeyerOlivier QuenezCéline BellenguezCamille Charbonnier-Le ClézioJoanna GiemzaStéphanie ChatelClaude FerecHervé Le MarecLuc LetenneurGaël NicolasKaren RouaultDelphine BacqAnne BolandDoris LechnerChantal AdjouStéphanie ChatelMarcel GoldbergPhilippe-Antoine HalboutHervé Le MarecDavid L’helgouachKaren RouaultJean-Jacques SchottAnne VogelspergerMarie ZinsDelphine BacqHélène BlanchéAnne BolandRobert OlasoPierre LindenbaumThomas LudwigVincent MeyerFlorian SandronDamien DelafoyLourdes Velo-SuárezIsabel AlvesOzvan BocherAnthony F HerzigMatilde KarakachoffGaëlle MarenneAude Saint PierreVéronique GeoffroyChristian DinaRichard RedonJean-François DeleuzeEmmanuelle Génin
Organismes : Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) EFS Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre national de référence pour les malades Alzheimer jeunes Institut für Geowissenschaften [Heidelberg] Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) EFS Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre national de référence pour les malades Alzheimer jeunes Institut für Geowissenschaften [Heidelberg] Bordeaux population health Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) EFS Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre national de référence pour les malades Alzheimer jeunes Institut für Geowissenschaften [Heidelberg] Institut de Recherche en Informatique et Systèmes Aléatoires Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) EFS Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre national de référence pour les malades Alzheimer jeunes Institut für Geowissenschaften [Heidelberg] Institut de Recherche en Informatique et Systèmes Aléatoires ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre National de Recherche en Génomique Humaine Service de Génétique [CHU Rouen] Cancer and Brain Genomics Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Bordeaux population health Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge Institut National de la Santé et de la Recherche Médicale Centre de recherche sur l'Inflammation Centre Hospitalier Régional Universitaire de Brest Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Cohortes épidémiologiques en population ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Régional Universitaire de Brest Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Institut du Thorax [CHU Nantes] Cohortes épidémiologiques en population Centre National de Recherche en Génomique Humaine Fondation Jean Dausset CEPH Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
Publié dans Scientific Reports le 26/10/2020

Résumé : Imputation servers offer the exclusive possibility to harness the largest public reference panels which have been shown to deliver very high precision in the imputation of European genomes. Many studies have nonetheless stressed the importance of ‘study specific panels’ (SSPs) as an alternative and have shown the benefits of combining public reference panels with SSPs. But such combined approaches are not attainable when using external imputation servers. To investigate how to confront this challenge, we imputed 550 French individuals using either the University of Michigan imputation server with the Haplotype Reference Consortium (HRC) panel or an in‑house SSP of 850 whole‑genome sequenced French individuals. With approximate geo‑localization of both our target and SSP individuals we are able to pinpoint different scenarios where SSP‑based imputation would be preferred over server‑based imputation or vice‑versa. This is achieved by showing to a high degree of resolution the importance of the proximity of the reference panel to target individuals; with a focus on the clear added value of SSPs for estimating haplotype phase and for the imputation of rare variants (minor allele‑frequency below 0.01). Such benefits were most evident for individuals from the same geographical regions in France as the SSP individuals. Overall, only 42.3% of all 125,442 variants evaluated were better imputed with an SSP from France compared to an external reference panel, however this rises to 58.1% for individuals from geographic regions well covered by the SSP. By investigating haplotype sharing and population fine‑structure in France, we show the importance of including SSP haplotypes for imputation but also that they should ideally be combined with large public panels. In the absence of the unattainable results from a combined panel of the HRC and our French SSP, we put forward a pragmatic solution where server‑based and SSP‑based imputation outcomes can be combined based on comparing posterior genotype probabilities. We show that such an approach can give a level of imputation accuracy in excess of what could be achieved with either strategy alone. The results presented provide detailed insights into the accuracy of imputation that should be expected from different strategies for European populations.

Fichiers liés : How local reference panels.pdf

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Control of disease activity with large extended-interval dosing of rituximab/ocrelizumab in highly active pediatric multiple sclerosis

Type de publi. : Article dans une revue
Date de publi. : 02/01/2024
Auteurs : Melany VenetAnne LepineAdil MaaroufDamien BiottiClémence BoutiereOlivier CasezMikael CohenPierre DurozardSarah DemortièreLaetitia GiorgiElisabeth MaillartGuillaume MatheyLaure MazzolaAudrey RicoJean-Philippe CamdessancheKumaran DeivaJean PelletierBertrand Audoin

Control of disease activity with large extended-interval dosing of rituximab/ocrelizumab in highly active pediatric multiple sclerosis

Type de publi. : Article dans une revue
Date de publi. : 02/01/2024
Auteurs : Melany VenetAnne LepineAdil MaaroufDamien BiottiClémence BoutiereOlivier CasezMikael CohenPierre DurozardSarah DemortièreLaetitia GiorgiElisabeth MaillartGuillaume MatheyLaure MazzolaAudrey RicoJean-Philippe CamdessancheKumaran DeivaJean PelletierBertrand Audoin
Organismes : Centre de résonance magnétique biologique et médicale Service de Neurologie [CHU de Saint-Étienne] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Centre de résonance magnétique biologique et médicale Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Assistance Publique - Hôpitaux de Marseille Centre Hospitalier Universitaire [CHU Grenoble] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Centre hospitalier d'Ajaccio Centre de résonance magnétique biologique et médicale Service de neurologie [Le Kremlin Bicêtre] Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de résonance magnétique biologique et médicale Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Assistance publique - Hôpitaux de Paris (AP-HP) Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Hôpital de la Timone [CHU - APHM] Centre de résonance magnétique biologique et médicale
Publié dans Multiple Sclerosis Journal le 31/10/2020

Résumé : Recent studies in adults suggested that extended-interval dosing of rituximab/ocrelizumab (RTX/OCR) larger than 12 months was safe and could improve safety. This was an observational cohort study of very active pediatric-onset multiple sclerosis (PoMS) (median (range) age, 16 (12–17) years) treated with RTX/OCR with 6 month standard-interval dosing ( n = 9) or early extended-interval dosing ( n = 12, median (range) interval 18 months (12–25)). Within a median (range) follow-up of 31 (12–63) months after RTX/OCR onset, one patient (standard-interval) experienced relapse and no patient showed disability worsening or new T2-weighted lesions. This study suggests that the effectiveness of RTX/OCR is maintained with a median extended-interval dosing of 18 months in patients with very active PoMS.

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Structures and energies of twist grain boundaries in Mg2SiO4 forsterite

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Jean FurstossPierre HirelPhilippe CarrezKarine GourietVictoire Meko-FotsoPatrick Cordier

Structures and energies of twist grain boundaries in Mg2SiO4 forsterite

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Jean FurstossPierre HirelPhilippe CarrezKarine GourietVictoire Meko-FotsoPatrick Cordier
Organismes : Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207
Publié dans Computational Materials Science le 30/10/2020

Résumé : In this work, we investigate twist grain boundary (GB) energies and structures in Mg2SiO4 forsterite using atomistic simulations. We first present a new bond orientational order parameter allowing to highlight disordered regions in this low-symmetry crystal for which classical visualization tools are ineffective. Then we examine three GB planes, (010), (120) and (001), corresponding to the most favorable free surfaces of this crystal. We show that twist GB follow the same energy ordering as corresponding free surfaces. In addition, except for some misorientation angles and for the (120) GB plane, GB energies and structures are quite insensitive to microscopic translational degrees of freedom. The dislocation composition of low-angle twist GB can be related to ?-surfaces in the corresponding planes, and are in good agreement with first-principle calculations. It is also shown that the dislocation core structures in low angle twist GB can strongly differ from the ones of intracrystalline dislocations.

Fichiers liés : Furstoss-et-al(2024)TwistGrainBoundariesForsterite.pdf

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Adapting agricultural production systems to changes in the environmental, agricultural and social context, and the role of legumes in the agro-ecological transition

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Marjorie UbertosiGilles BrunschwigThierry CastelDenis ChapuisJean-Philippe GoronMaé GuinetAnne JarousseAnnabelle LarmureChristophe LecomteJean- Pierre ManteauxAymeric MondiereClaire MosnierBernard NicolardotMarie- Sophie PetitWilfried QueyrelCorinne TanguyEglantine ThieryMarie-Hélène VergotePatrick VeyssetAnne-Sophie VoisinCandice Laroche

Adapting agricultural production systems to changes in the environmental, agricultural and social context, and the role of legumes in the agro-ecological transition

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Marjorie UbertosiGilles BrunschwigThierry CastelDenis ChapuisJean-Philippe GoronMaé GuinetAnne JarousseAnnabelle LarmureChristophe LecomteJean- Pierre ManteauxAymeric MondiereClaire MosnierBernard NicolardotMarie- Sophie PetitWilfried QueyrelCorinne TanguyEglantine ThieryMarie-Hélène VergotePatrick VeyssetAnne-Sophie VoisinCandice Laroche
Organismes : Agroécologie [Dijon] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Centre de Recherches de Climatologie [UMR Biogéosciences] Chambre d'Agriculture de Saône-et-Loire PEP bovins lait chambre agriculture Chambre d'Agriculture de l'Isère Agroécologie [Dijon] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Agroécologie [Dijon] Chambre d’Agriculture de la Drôme Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Chambre Régionale d’Agriculture de Bourgogne Franche-Comté Agroécologie [Dijon] Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Unité Mixte de Recherche sur les Herbivores - UMR 1213 Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Institut Agro Dijon
Publié dans Innovations Agronomiques le 24/10/2020

Résumé : In the Burgundy Franche-Comté and Auvergne-Rhône-Alpes French regions, the regional projects POEETE and ProSys dealt with the adaptation of agricultural production systems to changes in the environmental, agricultural and social context, focusing on different scales and taking into account the context of reduced inputs and the search for autonomy by introducing legume crops. The processed data come from various approaches: surveys, experimental monitoring, modelling approach... The impact of climate change on the ecophysiology of legume crops was addressed through a model plant, the pea, and two criteria: flowering date and frost stress. To ensure the sustainability of mixed farming operations, new forage mixtures have been tested. Then the ecosystemic services provided by legume crops were studied: precedent effect, nitrogen content and interest in improving the protein autonomy of farms. The prioritization of ecosystem services in the adoption of these crops was studied via surveys of pioneer farmers in the region. Finally, the agroecological transition was studied via questions about the complementarity of mixed farming and livestock production, the performance of cropping systems including legume crops, farmers' motivations to develop more agro-ecological practices and the study of model farm trajectories.

Fichiers liés : 2024_Ubertosi_Innovations Agronomiques_Vol 86_GB.pdf

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DOP23 The role of histology for the prediction of clinical relapse in Crohn’s Disease: A substudy of the STORI cohort

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Catherine ReenaersD. EneaMaria NachuryDavid LaharieYoram BouhnikMathurin FumeryJean-Marc GornetAurélien AmiotRomain AltweggMartine de VosPhilippe MarteauArnaud BourreilleStéphane NanceyStéphanie ViennotE LouisMagali Svrcek

DOP23 The role of histology for the prediction of clinical relapse in Crohn’s Disease: A substudy of the STORI cohort

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Catherine ReenaersD. EneaMaria NachuryDavid LaharieYoram BouhnikMathurin FumeryJean-Marc GornetAurélien AmiotRomain AltweggMartine de VosPhilippe MarteauArnaud BourreilleStéphane NanceyStéphanie ViennotE LouisMagali Svrcek
Organismes : Centre Hospitalier Universitaire Sart Tilman CHU Saint-Antoine [AP-HP] Hôpital Claude Huriez [Lille] Service d'Hépato-Gastro-Entérologie Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Service d'hépato-gastro-entérologie Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre] CHU Montpellier = Montpellier University Hospital UZ-Gent CHU Saint-Antoine [AP-HP] Service d'hépato-gastro-entérologie, cancérologie digestive et assistance nutritionnelle [CHU de Nantes] Centre Hospitalier Lyon Sud [CHU - HCL] Clinique de l'Alma, Paris, France. CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire Sart Tilman CHU Saint-Antoine [AP-HP]
Publié dans Journal of Crohn's and Colitis le 31/10/2020

Résumé : Abstract Background Deep remission has become the target in the management of Crohn’s disease (CD). The role of histology in the management of CD has not yet been established. The aim of this work was to study the impact of histological inflammation on the risk of clinical relapse in patients with CD in clinical and endoscopic remission and to study the correlation between histology and endoscopic scores and biomarkers. Methods All patients included in STORI (1) were eligible for inclusion. Fecal calproptectin and colonoscopy with CDEIS calculation were performed at inclusion. Two biopsies, taken either from the most inflammed macroscopic area or from an area with previous inflammation in case of mucosal healing (MH) were prospectively performed. MH was defined by the absence of ulcers. Different histological scores were calculated by 2 independent pathologists: Robart, Geboes, modified Geboes, Nancy, and DCA-IBD scores. Histological remission was defined by Nancy=0 ; Geboes ≤2 ; modified Geboes of grade 0 ; Robarts ≤3, IBD-DCA of C≤1 and A=0. Clinical relapse was prospectively evaluated in the STORI trial as CDAI>250 or CDAI between 150 and 250 with an increase of 70 points during 2 successive weeks compared to the inclusion visit. (1) Louis E et al .Gastroenterology 2012 Results Eighty biopsies (22 ileal and 58 colonic) were available from 76/115 patients included in STORI. Among the 45 patients with MH, 30 had colonic biopsies, 11 had ileal biopsies and 4 had biopsies in both locations. Among colonic biopsies 68% had histological remission according to Nancy and modified Geboes scores, 65% according to DCA-IBD and Geboes scores and 71% according to Robarts score. Among ileal biopsies 53% had histological remission according to Nancy score, 47% according to Modified Geboes, Geboes and DCA-IBD scores, and 67% according to the Robarts score. Thirty-five patients (46%) experienced a clinical relapse during the follow-up including 16/45 (36%) and 19/31 (61%) in the group with MH and without MH respectively. Histological characteristics and histological scores were not predictive of clinical relapse. In the total cohort (n=76), the CDEIS score was correlated to Nancy (p<0,001, r=0,43), Geboes (p<0,001, r=0,47) and Robarts (p<0,001, r=0,45) scores. Fecal calprotectin was correlated to Nancy (p<0,001, r=0,48), Geboes (p<0,001, r=0,45) and Robarts (p<0,001, r=0,46) scores. The histological scores of Nancy, Robarts and Geboes were highly correlated (p<0,0001 ; r > 0,9). Conclusion Although correlated with endoscopy and biomarkers, histology was not predictive of clinical relapse in CD patients in clinical and endoscopic remission. These findings do not support the use of histology to predict clinical relapse in CD in clinical practice.

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Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Laetitia LengeléYves RollandLaurent MartinezSophie Gillette-GuyonnetAngelo PariniAlexandre LucasBruno VellasPhilipe Barreto de SoutoIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley

Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study

Type de publi. : Article dans une revue
Date de publi. : 01/01/2024
Auteurs : Laetitia LengeléYves RollandLaurent MartinezSophie Gillette-GuyonnetAngelo PariniAlexandre LucasBruno VellasPhilipe Barreto de SoutoIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
Organismes : Gérontopôle Gérontopôle Equipe AGING (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Gérontopôle Equipe AGING (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Gérontopôle Gérontopôle Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Laboratoire Eau Environnement et Systèmes Urbains IUT Sénart-Fontainebleau Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health Equipe AGING (CERPOP) Equipe EQUITY (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP)
Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

Résumé : Background: Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods: IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results: Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions: GDF-15 plasma levels were related to key malnutrition criteria.

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Philippe JEAN-PIERRE

Professeur des universités en sciences de gestion

ARES VI. Viability of one-dimensional retrieval models for transmission spectroscopy characterization of exo-atmospheres in the era of JWST and Ariel

ARES VI. Viability of one-dimensional retrieval models for transmission spectroscopy characterization of exo-atmospheres in the era of JWST and Ariel

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT)

Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the COLchicine Cardiovascular Outcomes Trial (COLCOT)

How local reference panels improve imputation in French populations

How local reference panels improve imputation in French populations

Control of disease activity with large extended-interval dosing of rituximab/ocrelizumab in highly active pediatric multiple sclerosis

Control of disease activity with large extended-interval dosing of rituximab/ocrelizumab in highly active pediatric multiple sclerosis

Structures and energies of twist grain boundaries in Mg2SiO4 forsterite

Structures and energies of twist grain boundaries in Mg2SiO4 forsterite

Adapting agricultural production systems to changes in the environmental, agricultural and social context, and the role of legumes in the agro-ecological transition

Adapting agricultural production systems to changes in the environmental, agricultural and social context, and the role of legumes in the agro-ecological transition

DOP23 The role of histology for the prediction of clinical relapse in Crohn’s Disease: A substudy of the STORI cohort

DOP23 The role of histology for the prediction of clinical relapse in Crohn’s Disease: A substudy of the STORI cohort

Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study

Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study