Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/01/2008
• Auteurs : Bruno PaganoOlivier AndrieuBenjamin CanouEmmanuel ChaillouxJean-Louis ColaçoThomas MoniotPhilippe Wang
• Organismes : Preuves, Programmes et Systèmes Systèmes Polynomiaux, Implantation, Résolution Algébrique Systèmes Polynomiaux, Implantation, Résolution Algébrique Systèmes Polynomiaux, Implantation, Résolution Algébrique

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/01/2008
• Auteurs : Yann H. KerrPhilippe WaldteufelPhilippe RichaumeArnaud MialonFrançois CabotMaria Jose EscorihuelaWigneron J.-P.Paolo FerrazzoliSteven DelwardAli Mahmoodi
• Organismes : Centre d'études spatiales de la biosphère Service d'aéronomie Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] European Space Research and Technology Centre Array Systems Computing

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Fichiers liés : 20984_20080425012937162_1.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 04/01/2008
• Auteurs : Pierre BomelGogniat GuyJean-Philippe Diguet
• Organismes : Lab-STICC_UBS_CACS_MOCS Laboratoire d'Electronique des Systèmes TEmps Réel Lab-STICC_UBS_CACS_MOCS

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Résumé : Nous présentons une architecture matérielle et logicielle ainsi qu'une implémentation de protocole réseau destinées à la reconfiguration dynamique partielle de FPGA dans le but d'obtenir des systèmes "ultra-légers reconfigurables à distance". Ces systèmes sont destinés aux applications embarquées ayant très peu de ressources matérielles et tirant profit d'architectures dédiées. Ils sont fondés sur un simple FPGA associé à son contrôleur réseau, et ne requièrent pas demémoires externes pour stocker le code de l'exécutif temps réel, ni les tamponsmémoires des protocoles de communication. Nosmesures prouvent que nos systèmes ultra-légers atteignent des débits de reconfiguration aumoins dix fois plus rapides que les meilleurs actuels.

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Fichiers liés : sympa2008.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/01/2008
• Auteurs : Marc BolletNicolas ServantPierre NeuvialCharles DecraeneIngrid LebigotJean-Philippe MeynielYann de RyckeAlexia SavignoniGuillem RigaillPhilippe HupéAlain FourquetBrigitte Sigal-ZafraniEmmanuel BarillotJean-Paul Thiery
• Organismes : Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Laboratoire de Probabilités et Modèles Aléatoires Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Régulations cellulaires et oncogenèse ISoft [Saint-Aubin] Institut Curie [Paris] Régulations cellulaires et oncogenèse Institut Curie [Paris] Unité de recherche Mathématiques et Informatique Appliquées Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Biologie Cellulaire et Cancer Institut Curie [Paris] Institut Curie [Paris] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Institut Curie [Paris] Institute of Molecular and Cell Biology [Singapore]
• Publié dans JNCI: Journal of the National Cancer Institute le 31/10/2020

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Résumé : Background To distinguish new primary breast cancers from true recurrences, pangenomic analyses of DNA copy number alterations (CNAs) using single-nucleotide polymorphism arrays have proven useful. Methods The pangenomic profiles of 22 pairs of primary breast carcinoma (ductal or lobular) and ipsilateral breast cancers from the same patients were analyzed. Hierarchical clustering was performed using CNAs and DNA breakpoint information. A partial identity score developed using DNA breakpoint information was used to quantify partial identities between two tumors. The nature of ipsilateral breast cancers (true recurrence vs new primary tumor) as defined using the clustering methods and the partial identity score was compared with that based on clinical characteristics. Metastasis-free survival was compared among patients with primary tumors and true recurrences as defined using the partial identity score and by clinical characteristics. All statistical tests were two-sided. Results All methods agreed on the nature of ipsilateral breast cancers for 14 pairs of samples. For five pairs, the clinical definition disagreed with both clustering methods. For three pairs, the two clustering methods were discordant and the one using DNA breakpoints agreed with the clinical definition. The partial identity score confirmed the nature of ipsilateral breast cancers as defined by clustering of DNA breakpoints in 21 of 22 pairs. The difference in metastasis-free survival of patients with new primary tumors and those with true recurrences was not statistically significant when tumors were defined based on clinical and histologic characteristics (5-year metastasis-free survival: 76%, 95% confidence interval [CI] = 52% to 100% for new primary tumors and 38%, 95% CI = 17% to 83% for true recurrences; P = .18; new primary tumor vs true recurrence, hazard ratio = 2.8, 95% CI = 0.6 to 13.7), but the difference was statistically significant when tumors were defined using the partial identity score (5-year metastasis-free survival: 100% for new primary tumors and 29%, 95% CI = 11% to 78% for true recurrences; P = .01). Conclusions DNA breakpoint information more often agreed with the clinical determination than CNAs in this population. The partial identity score, which was calculated based on DNA breakpoints, allows statistical discrimination between new primary tumors and true recurrences that could outperform the clinical determination in terms of prognosis.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Tarik Ait Si SelmiPeter C. M. VerdonkPierre ChambatFrédéric DubranaJean-François PotelLaurence BarnouinPhilippe Neyret
• Organismes : Centre Livet [Hôpital de la Croix Rousse, Hospices Civils de Lyon] Centre Livet [Hôpital de la Croix Rousse, Hospices Civils de Lyon] Clinique Sainte Anne Lumière Service de chirurgie orthopédique, traumatologique et réparatrice [Brest] Clinique Cours Dillon Tbf - Tissue Bank of France Laboratoire de Biomécanique et Mécanique des Chocs
• Publié dans Journal of Bone and Joint Surgery, British Volume le 01/11/2020

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Résumé : Autologous chondrocyte implantation is an established method of treatment for symptomatic articular defects of cartilage. CARTIPATCH is a monolayer-expanded cartilage cell product which is combined with a novel hydrogel to improve cell phenotypic stability and ease of surgical handling. Our aim in this prospective, multicentre study on 17 patients was to investigate the clinical, radiological, arthroscopic and histological outcome at a minimum follow-up of two years after the implantation of autologous chondrocytes embedded in a three-dimensional alginate-agarose hydrogel for the treatment of chondral and osteochondral defects. Clinically, all the patients improved significantly. Patients with lesions larger than 3 cm(2) improved significantly more than those with smaller lesions. There was no correlation between the clinical outcome and the body mass index, age, duration of symptoms and location of the defects. The mean arthroscopic International Cartilage Repair Society score was 10 (5 to 12) of a maximum of 12. Predominantly hyaline cartilage was seen in eight of the 13 patients (62%) who had follow-up biopsies. Our findings suggest that autologous chondrocyte implantation in combination with a novel hydrogel results in a significant clinical improvement at follow-up at two years, more so for larger and deeper lesions. The surgical procedure is uncomplicated, and predominantly hyaline cartilage-like repair tissue was observed in eight patients.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/01/2008
• Auteurs : Vincent CalvezNatacha LenuzzaDietmar OelzJean-Philippe DeslysPascal Laurent-GengouxFranck MouthonBenoît Perthame
• Organismes : Département de Mathématiques et Applications - ENS-PSL (UMR8553) Groupe d'Innovation Diagnostique et Thérapeutique sur les Infections à Prions Institute for Analysis and Scientific Computing [Wien] Groupe d'Innovation Diagnostique et Thérapeutique sur les Infections à Prions Mathématiques Appliquées aux Systèmes - EA 4037 Groupe d'Innovation Diagnostique et Thérapeutique sur les Infections à Prions Laboratoire Jacques-Louis Lions

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Résumé : We consider a model for the polymerization (fragmentation) process involved in infectious prion self-replication and study both its dynamics and non-zero steady state. We address several issues. Firstly, we give conditions leading to size repartitions of PrPsc aggregates that exhibit bimodal distributions, as indicated by recent experimental studies of prion aggregates distribution. Secondly, we show stability results for this steady state for general coefficients where reduction to a system of differential equations is not possible. We use a duality method based on recent ideas developed for population models. These results underline the potential influence of the amyloid precursor production rate in promoting amyloidogenic diseases. Finally, we numerically investigate the influence of different parameters of the model on PrPsc accumulation kinetics, in the aim to study specific features of prion strains.

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Fichiers liés : PrionBimodalHAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-Philippe BorgesAnnick BarreRaphael CulerrierClaude GranierAlain DidierPierre Rougé
• Organismes : Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis
• Publié dans Biochemical and Biophysical Research Communications le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Joël ConstansLouis-Rachid SalmiMarie-Antoinette Pietri-SevestreSophie PerusatMonika NguonMaryse DegeilhJ. LabarèreOlivier GattolliatCarine BoulonJean-Pierre LarochePhilippe Le RouxOlivier PichotIsabelle QuereClaude ConriJean-Luc Bosson
• Organismes : Imagerie Fonctionnelle et Métabolique en Oncologie Départment de Neuroradiologie [CHU Caen] Epidémiologie, santé publique et développement Institut de Santé Publique, d'Epidémiologie et de Développement Service d'information médicale Epidémiologie, santé publique et développement Epidémiologie et Biostatistique [Bordeaux] Techniques pour l'Evaluation et la Modélisation des Actions de la Santé Unite de recherche en résonance magnétique médicale Arènes: politique, santé publique, environnement, médias Techniques pour l'Evaluation et la Modélisation des Actions de la Santé
• Publié dans Thrombosis and Haemostasis le 22/10/2020

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Résumé : It was the objective of this study to design a clinical prediction score for the diagnosis of upper extremity deep venous thrombosis (UEDVT). A score was built by multivariate logistic regression in a sample of patients hospitalized for suspicion of UEDVT (derivation sample). It was validated in a second sample in the same university hospital, then in a sample from the multicenter OPTIMEV study that included both outpatients and inpatients. In these three samples, UEDVT diagnosis was objectively confirmed by ultrasound. The derivation sample included 140 patients among whom 50 had confirmed UEDVT, the validation sample included 103 patients among whom 46 had UEDVT, and the OPTIMEV sample included 214 patients among whom 65 had UEDVT. The clinical score identified a combination of four items (venous material, localized pain, unilateral pitting edema and other diagnosis as plausible). One point was attributed to each item (positive for the first 3 and negative for the other diagnosis). A score of -1 or 0 characterized low probability patients, a score of 1 identified intermediate probability patients, and a score of 2 or 3 identified patients with high probability. Low probability score identified a prevalence of UEDVT of 12, 9 and 13%, respectively, in the derivation, validation and OPTIMEV samples. High probability score identified a prevalence of UEDVT of 70, 64 and 69% respectively. In conclusion we propose a simple score to calculate clinical probability of UEDVT. This score might be a useful test in clinical trials as well as in clinical practice.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-Paul ChabannesNadine BazinDenis LeguayPhilippe NussCharles-Siegfried PerettiPatrick TatuAhcene HamegRicardo P GarayMaurice Ferreri
• Organismes : Cesame Hospital, Université Pierre et Marie Curie - Paris 6 Centre de Recherche Saint-Antoine Department of Psychiatry, Psychiatric Department,
• Publié dans European Psychiatry le 23/10/2020

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Résumé : It is not clear whether patient's psycho-education enhances compliance to antipsychotic treatments and reduces the number of relapses. Here we investigated the impact of a new psycho-educational program (SOLEDUC) on the one- and two-years rate of relapse (primary outcome measure) and a number of clinical assessments (secondary outcome measures). This was a multicentric French clinical trial (51 centers) of Phase IV, open, controlled, randomized, consisting in two parallel groups: the Soleduc group (N=111) and the control group (N=109). All subjects received a variable dose over the 2-year period of the same antipsychotic drug (amisulpride). Soleduc consisted of a 7-session program (1h per session), presented three times (at baseline, 6-months and 12-months). Patients in the control group received a non-specific psychosocial training for an equivalent period of time. The models of Andersen-Gill (AG) and Prentice, Williams and Peterson (PWP) were used to analyze relapses. Patients in the Soleduc group attended 14.8+/-6.1 sessions (mean+/-SD), including 17 patients who never attended a session. Intent to treat analysis showed less patients relapsing in the Soleduc group as compared to the control group (21.6% versus 28.4% after 1 year and 84.4% versus 90.8% after 2years), but the differences were not statistically significant. Relapse risk was significantly reduced for patients who followed at least 7 modules (p=0.015 AG-test; p<0.001 PWP-test). In conclusion, no significant differences in relapse rates were found between patients attending the Soleduc program and the control group. Attendance of at least 7 out of 21 program sessions was required to see a modest, but significant two-year relapse prevention in schizophrenia. Other well designed studies are required to evaluate the medical impact of patient's education programs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre NahonAngela SuttonPierre RufatMarianne ZiolGabriel ThabutPierre-Olivier SchischmanoffDominique VidaudNathalie CharnauxPhilippe CouvertNathalie Ganne-CarriéJean-Claude TrinchetLiliane GattegnoMichel Beaugrand
• Organismes : Service d'hépato-gastroentérologie UPRES EA 3410 UPRES EA 3410 Service de Biochimie CHU Pitié-Salpêtrière [AP-HP] Service d'anatomie pathologique UPRES EA3406 Département d'Epidemiologie, Biostatistique et Recherche Clinique UPRES EA3406 Service de biochimie et biologie moléculaire Service de Biochimie et Génétique Moléculaire UPRES EA 3410 Service de Biochimie Service d'hépato-gastroentérologie Service d'hépato-gastroentérologie UPRES EA3409 Service d'hépato-gastroentérologie UPRES EA3409 UPRES EA 3410 Service de Biochimie Service d'hépato-gastroentérologie UPRES EA 3410
• Publié dans Gastroenterology le 25/10/2020

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Résumé : BACKGROUND & AIMS: The influence of HFE gene mutations and liver iron overload on hepatocellular carcinoma (HCC) occurrence in patients with cirrhosis is subjected to controversial results. The aim of this work was to clarify this influence in a large cohort of prospectively followed-up cirrhotic patients classified according to the cause of their liver disease. METHODS: Three hundred one consecutive cirrhotic patients (162 alcoholics and 139 HCV-infected patients) were included at time of diagnosis of cirrhosis and followed-up. Liver iron overload on initial biopsy according to modified Deugnier's score and C282Y/H63D HFE gene mutations were assessed. RESULTS: In patients with alcoholic cirrhosis (mean iron score, 2.0 +/- 3.0; mean time of follow-up, 66.1 +/- 45.1 months), 40 (24.6%) developed HCC. Thirteen (8.02%) were heterozygotes for C282Y HFE gene mutation and had higher hepatic iron scores (3.6 +/- 3.8 vs 1.9 +/- 2.8, respectively, P = .05). In univariate analysis, liver iron overload as a continuous variable (HR, 1.23 [1.13-1.34], P < .001) or in binary coding with an optimal threshold of iron score >/=2.0 (HR, 4.1 [2.1-7.3], P < .0001) and C282Y mutation carriage (HR, 2.7 [1.2-6.3], P = .01) were risk factors for HCC. In multivariate analysis, liver iron and C282Y mutation carriage remained independent risk factors for HCC. In patients with HCV-related cirrhosis (C282Y mutation carriage, 17 [12.23%]; mean liver iron score, 0.9 +/- 1.9; mean time of follow-up, 85.5 +/- 42.1 months; HCC, 63 [45.32%] patients), C282Y mutation carriage and liver iron were not associated with HCC occurrence. CONCLUSIONS: Liver iron overload and C282Y mutation are associated with a higher risk of HCC in patients with alcoholic but not HCV-related cirrhosis.

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Fichiers liés : Nahon_et_al_final._Gastroenterology_Ms._No._GASTRO-D-07-00182R2.rtf.pdf

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