Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Loic BrancheriauPhilippe LasayguesEric DebieuJean-Pierre Lefebvre
• Organismes : Production et valorisation des bois tropicaux Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille]
• Publié dans Annals of Forest Science le 26/10/2020

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Résumé : • Ultrasonic computed tomography in reflection was used to assess the integrity of green wood. Qualitative reflectivity images were obtained from back-scattered measurements by reflection tomography, like ultrasound in medical applications. • The reconstruction algorithm was designed using, in particular, a linear approximation of the forward problem (Born approximation) and based on the assumption that a transversal cross section of wood is isotropic. The experimental device was composed of only one rotating emitter–receiver transducer to record and compute the projections. In this specific case, a tomographic projection was directly associated with a recorded signal. The qualitative aspect of this imaging technique was validated by performing a numerical simulation and tested on a small diameter green wood (Picea abies) log. • The images obtained were geometrically accurate considering the internal inclusions. It was, however, not possible in the simulation to differentiate the object shape from the background (coupling medium) because the reflectivity value associated with the object was too low. The image obtained with the spruce sample mainly showed the position of the bark as indicated by a very high contrast area. The proportion of transmitted energy was, however, sufficient to reconstruct the artificial inclusion within the sample.

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Fichiers liés : Tomographies_des_arbres.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre GibotMontse Casas-CabanasLydia LaffontStéphane LevasseurPhilippe CarlachStéphane HameletJean‐marie TarasconChristian Masquelier
• Organismes : Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV UMICORE Research UMICORE Research Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV
• Publié dans Nature Materials le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Philippe BlanchardDaniel GandolfoJean RuizMarc Wouts
• Organismes : Theoretische Physik und BiBoS [Bielefeld] Centre de Physique Théorique - UMR 6207 Centre de Physique Théorique - UMR 7332 Centre de Physique Théorique - UMR 6207 Centre de Physique Théorique - UMR 7332 Laboratoire de Probabilités et Modèles Aléatoires Modélisation aléatoire de Paris X
• Publié dans EPL - Europhysics Letters le 23/10/2020

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Résumé : We present a study of phase transitions of the Curie--Weiss Potts model at (inverse) temperature $\beta$, in presence of an external field $h$. Both thermodynamic and topological aspects of these transitions are considered. For the first aspect we complement previous results and give an explicit equation of the thermodynamic transition line in the $\beta$--$h$ plane as well as the magnitude of the jump of the magnetization (for $q \geqslant 3)$. The signature of the latter aspect is characterized here by the presence or not of a giant component in the clusters of a Fortuin--Kasteleyn type representation of the model. We give the equation of the Kertész line separating (in the $\beta$--$h$ plane) the two behaviours. As a result, we get that this line exhibits, as soon as $q \geqslant 3$, a very interesting cusp where it separates from the thermodynamic transition line.

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Fichiers liés : BGRW-EPL-rev2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Sandra Charreire-PetitEmmanuel GarcionJean-Pierre BenoîtPhilippe Menei
• Organismes : Centre de Recherche en Gestion Micro et Nanomédecines Biomimétiques Micro et Nanomédecines Biomimétiques Micro et Nanomédecines Biomimétiques
• Publié dans Revue Neurologique le 31/10/2020

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Résumé :

Many arguments support the development of local therapies for malignant gliomas. Simple injections of antimitotic agents into the surgical cavity has been replaced by more sophisticated systems. Tissues can be infused with complex prolonged-release polymeric or lipidic systems with macroscopic, microscopic and now even nanometric particles. But, as for any drug, the developments of these new agents has been long and only very few reach the stage of the clinic trials.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Nathalie SabaaLucia De FranceschiPhilippe BonninYves CastierGiorgio MalpeliHaythem DebbabiAriane GalaupMicheline Maier-RedelspergerSophie VandermeerschAldo ScarpaAnne JaninBernard LevyRobert GirotYves BeuzardChristophe LeboeufAnnie HenriStéphane GermainJean-Claude DussaulePierre-Louis Tharaux
• Organismes : Angiogénèse embryonnaire et pathologique Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Centre interdisciplinaire de recherche en biologie
• Publié dans Journal of Clinical Investigation le 24/10/2020

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Résumé : Patients with sickle-cell disease (SCD) suffer from tissue damage and life-threatening complications caused by vasoocclusive crisis (VOC). Endothelin receptors (ETRs) are mediators of one of the most potent vasoconstrictor pathways in mammals, but the relationship between vasoconstriction and VOC is not well understood. We report here that pharmacological inhibition of ETRs prevented hypoxia-induced acute VOC and organ damage in a mouse model of SCD. An in vivo ultrasonographic study of renal hemodynamics showed a substantial increase in endothelin-mediated vascular resistance during hypoxia/reoxygenation-induced VOC. This increase was reversed by administration of the dual ETR antagonist (ETRA) bosentan, which had pleiotropic beneficial effects in vivo. It prevented renal and pulmonary microvascular congestion, systemic inflammation, dense rbc formation, and infiltration of activated neutrophils into tissues with subsequent nitrative stress. Bosentan also prevented death of sickle-cell mice exposed to a severe hypoxic challenge. These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : K. AamodtA. Abrahantes QuintanaR. AchenbachS. AcounisD. AdamováC. AdlerM. AggarwalFranck AgneseG. Aglieri RinellaZ. AhammedA. AhmadN. AhmadS. AhmadA. AkindinovP. AkishinD. AleksandrovB. AlessandroR. AlfaroG. AlfaroneA. AliciJ. AlmeT. AltS. AltinpinarW. AmendC. AndreiYves AndresA. AndronicG. AnelliM. AnfrevilleV. AngelovA. AnzoC. AnsonT. AnticicV. AntonenkoD. AntonczykF. AntinoriS. AntinoriP. AntonioliL AphecetcheH. AppelshäuserV. AproduM. ArbaS. ArcelliA. ArgentieriN. ArmestoR. ArnaldiA. ArefievI. ArseneA. AsryanA. AugustinusT.C. AwesJ. ÄystoM. Danish AzmiS. BablockA. BadalàS.K. BadyalJ. BaechlerS. BagnascoR. BailhacheR. BalaA. BaldisseriA. BalditJ. BánR. BarberaP.-L. BarberisJean-Michel BarbetG. BarnäfoldiV. BarretJ. BartkeD. BartosM. BasileV. BasmanovN. BastidGuillaume BatigneB. BatyunyaJérôme BaudotCédric BaumannI. BeardenB. BeckerJ. BelikovR. BellwiedE. Belmont-MorenoA. BelogianniS. BelyaevA. BenatoJ.L. BeneyL. BenhabibF. BenottoS. BeoléI. BerceanuA. BercuciE. BerdermannY. BerdnikovC. BernardR. BernyJ.D. BerstH. BertelsenL. BetevA. BhasinP. BaskarA. BhatiN. BianchiJ. BielcikJ. BielcikováL. BimbotG. BlanchardF. BlancoD. BlauC. BlumeS. BlythM. BoccioliA. BogdanovH. BøggildM. BogolyubskyL. BoldizsárM. BombaraC. BombonatiM. BondilaD. BonnetV. BonviciniH. BorelF. BorottoV. BorshchovY. BortoliO. BorysovS. BoseL. BosisioM. BotjeS. BöttgerG. BourdaudO. BourrionS. BouvierA. BraemM. BraunP. Braun-MunzingerL. BravinaM. BregantG. BrucknerR. BrunE. BrunaO. BrunassoG.E. BrunoD. BucherV. BudilovD. BudnikovH. BueschingP. BuncicM. BurnsS. BurachasO. BuschJ. BushopX. CaiH. CainesF. CalaonM. CaldognoI. CaliP. CameriniR. CampagnoloM. CampbellX. CaoG.P. CapitaniG. Cara RomeoM. Cardenas-MontesH. CardunerF. CarenaW. CarenaP. CariolaF. CarminatiJ. CasadoA. Casanova DiazM. CaselleJ. Castillo CastellanosJ. CastorV. CatanescuE. CattaruzzaD. CavazzaP. CerelloS. CeresaV. ČernýV. ChambertS. ChapelandA. CharpyDidier CharrierM. ChartoireJ.L. CharvetS. ChattopadhyayV. ChepurnovS. ChernenkoM. CherneyC. CheshkovB. CheynisP. ChochulaE. ChiavassaV. Chibante BarrosoJ. ChoiP. ChristakoglouP. ChristiansenC. ChristensenO.A. ChykalovC. CicaloL. Cifarelli-StrolinM. CiobanuF. CindoloC. CirstoiuO. ClausseJ. CleymansO. CobanogluJ.-P. CoffinS. ColiA. CollaC. ColledaniC. CombaretM. CombetM. CometsG. Conesa BalbastreZaida Conesa del ValleG. ContinJ. ContrerasT. CormierF. CorsiP. CorteseF. CostaE. CrescioP. CrochetE. CuautleJean-Pierre CussonneauM. DahlingerA. DaineseH.H. DalsgaardL. DanielI. DasT. DasA. DashR. da SilvaM. DavenportH. DauesA. de CaroG. de CataldoJ. de CuvelandA. de FalcoM. de GaspariP. de GirolamoJ. de GrootD. de GruttolaA. de HaasN. de MarcoS. de PasqualeP. de RemigisD. de VauxG. DecockH. DelagrangeM. del FrancoG. DellacasaC. Dell'OlioD. Dell'OlioA. DeloffV. DemanovEric DenesG. d'ErasmoD. DerkachA. DevauxD. Di BariA. Di BartelomenC. Di GiglioS. Di LibertoA. Di MauroP. Di NezzaM. DialinasL. DiazR. Díaz ValdesT. DietelR. DimaH. DingC. DincaR. DiviàV. DobretsovA. DobrinB. DoenigusT. DobrowolskiI. DomínguezM. DornSébastien DrouetA.E. DubeyL. DucrouxF. DumitracheE. DumonteilP. DupieuxV. DutaA. Dutta MajumdarM. Dutta MajumdarTh. DyhreL. EfimovA. EfremovD. EliaD. EmschermannC. EngsterA. EnokizonoB. EspagnonMagali EstienneA. EvangelistaD. EvansS. EvrardC.W. FabjanD. FabrisJ. FaivreD. FalchieriA. FantoniR. FaranoR. FearickO. FedorovV. FeketeD. FeleaG. FeofilovA. Férnandez TéllezA. FerrettiF. FicheraS. FilchaginE. FiloniChristian FinckR. FiniE.M. FioreD. FlierlM. FlorisZ. FodorY. FokaS. FokinP. ForceF. FormentiE. FragiacomoM. FragkiadakisD. FraissardAlejandro FrancoMaximilien FrancoU. FrankenfeldU. FratinoS. FresneauA. FrolovU. FuchsJ. FujitaChristophe FurgetM. FuriniM. Fusco GirardJ.-J. GaardhøjeA. GabrielliS. GadratM. GagliardiA. GagoL. GaidoA. Gallas TorreiraM. GallioE. GandolfiP. GanotiM. GantiJ. GarabatosA. Garcia LopezL. GarizzoL. GaudichetR. GemmeMarie GermainA. GheataM. GheataB. GhidiniP. GhoshG. GioluG. GiraudoP. GiubellinoR. GlasowP. GlässelE.G. FerreiroC. Gonzalez GutierrezL.H. Gonzales-TruebaS. GorbunovY. GorbunovH. GosJ. GossetS. GotovacH. GottschlagD. GottschalkV. GrabskiT. GrassiH. GrayO. GrebenyukK. GrebieszkowC. GregoryC. GrigorasN. GrionV. GrigorievA. GrigoryanC. GrigoryanS. GrigoryanY. GrishukP. GrosJ. Grosse-OetringhausJ.-Y. GrossiordR. GrossoB. GrynyovC. GuarnacciaF. GuberFabien GuérinR. GuernaneM. GuerzoniA. GuichardM. GuidaG. GuillouxH. GulkanyanK. GulbrandsenT. GunjiA. GuptaV. GuptaH.-A. GustafssonH. GutbrodC. HadjidakisM. HaiducG. HamarH. HamagakiJ. HamblenJ.C. HansenP. HardyD. HatzifotiadouJ.W. HarrisM. HartigA. HarutyunyanA. HayrapetyanD. HaschD. HaseganJ. HehnerN. HeineM. HeinzH. HelstrupA. HerghelegiuS. HerlantG. Herrera CorralN. HerrmannK. HetlandP. HilleH. HinkeB. HippolyteM. HochH. HoebbelH. HoedlmoserT. HoraguchiM. HornerP. HristovI. HrivnácováS. HuC. Hu GuoT. HumanicA. HurtadoD.S. HwangJ.-C. IanigroM. IdzikS. IgolkinR. IlkaevI. IlkivM. ImhoffP.G. InnocentiE. IonescuM. IppolitovM. IrfanC. InsaM. InuzukaC. IvanA. IvanovM. IvanovV. IvanovP. JacobsA. JacholkowskiL. JancurováR. JanikM. JasperC. JenaL. JirdenD.P. JohnsonG.T. JonesC. JorgensenFrançois JouveP. JovanovicA. JuniqueA. JuskoH. JungW. JungK. KadijaA. KamalR. KamermansS. KapustaA. KaidalovV. KakoyanS. KalcherE. KangJ. KapitanV. KaplinK. KaradzhevO. KaravichevT. KaravichevaE. KarpechevK. KarpioA. KazantsevU. KebschullR. KeidelM. Mohsin KhanA. KhanzadeevY. KharlovD. KikolaB. KilengD. KimD.S. KimD.W. KimH.N. KimJ.S. KimS. KimJ.B. KinsonS.K. KiprichI. KiselS. KiselevA. KisielTamás KissV. KiworraJ. KlayC. Klein BösingM. KliemantA. KlimovA. KlovningA. KlugeR. KluitS. KniegeR. KolevatovT. KolleggerA. KolojvariV. KondratievE. KornasE. KoshurnikovI. KotovR. KourM. KowalskiS. KoxK. KozlovI. KrálikF. KramerI. KrausA. KravcákováT. KrawutschkeM. KrivdaE. KryshenY. KucheriaevA. KuglerC. KuhnP. KuijerL. KumarN. KumarP. KumpumaekiA. KurepinA.N. KurepinS. KushpilV. KushpilM. KutovskyH. KvaernoM. KweonJ.-C. LabbéF. LacknerP. Ladron de GuevaraV. LafageP. La RoccaM. LamontC. LaraD.T. LarsenG. LaurentiC. LazzeroniY. Le BornecN. Le BrisC. Le GailliardV. LebedevJ. LecoqK.S. LeeS.C. LeeF. LefévreI. LegrandT. LehmannL. LeistamP. LenoirV. LentiH. LeonI. Leon MonzonP. LévaiQ. LiX. LiF. LibrizziR. LietavaN. LindegaardV. LindenstruthC. LippmannM. LisaO.M. ListratenkoF. LittelY. LiuJ. LoV. LobanovV. LoginovM. López NoriegaR. López-RamírezE. López TorresP.M. LorenzoG. LøvhøidenS. LuW. LudolphsM. LunardonL. LuquinS. LussoJ.-R. LutzM. LuvisettoV. LyapinA. MaevskayaC. MagureanuA. MahajanS. MajahanT. MahmoudA. MairaniD. MahapatraA. MakarovI. MakhlyuevaM. MalekT. MalkiewiczD. Mal'KevichP. MalzacherA. MamonovC. ManeaL.K. MangotraD. ManieroV. MankoF. MansoV. ManzariY. MaoA. MarcelS. MarchiniJ. MarešG.V. MargagliottiA. MargottiA. MarinJ.-C. MarinD. MarrasP. MartinengoM.I. MartínezA. Martinez-DavalosGines Martinez GarciaS. MartiniA. Marzari ChiesaC. MarzoccaS. MasciocchiM. MaseraM. MasettiN.I. MaslovA. MasoniF. MasseraM. MastA. MastroserioZ.L. MatthewsB. MayerG. MazzaM.D. MazzaroA. MazzoniF. MeddiE. MeleshkoA. Menchaca-RochaS. MeneghiniM. MeoniJ. Mercado PerezP. MereuO. MeunierY. MiakeA. MichalonR. MichinelliN. MiftakhovM. MignoneK. MikhailovJ. MilosevicY. MinaevF. MinafraA. MischkeD. MiskowiecV. MitsynC. MituB. MohantyD. MoisaL. MolnarM. MondalN. MondalL. Montaño ZetinaM. MontenoM. MorandoM. MorelS. MorettoTh. MorhardtA. MorschT. MoukhanovaM. MucchiV. MucciforaE. MudnicH. MüllerW. MüllerJ. MunozD. MuraL. MusaJean-François MurazA. MussoR. NaniaB. NandiE. NappiF. NavachS. NavinT. NayakS. NazarenkoG. NazarovL. NellenF. NendazA. NianineM. NicassioB.S. NielsenS. NikolaevV. NikolicS. NikulinV. NikulinB. NilsenM. NittiF. NoferiniP. NomokonovG. NoorenF. NotoD. NouaisA. NyiriJ. NystrandG. OdyniecH. OeschlerM. OinonenM. OldenburgI. OleksE.K. OlsenV. OnuchinC. OppedisanoF. OrsiniA. Ortiz-VelázquezC. OskampA. OskarssonF. OsmicL. ÖstermanI. OtterlundG. OvrebekkK. OyamaM. PachrP. PaganoG. PaicC. PajaresS. PalG. PállaA. PalmeriG. PancaldiR. PanseA. PantaleoG.S. PappalardoB. PastircákC. PastoreO. PatarakinV. PaticchioG. PatimoA. PavlinovT. PawlakT. PeitzmannY. PénichotA. PepatoH. PereiraD. PeresunkoC. PerezJ. Perez GriffoD. PeriniD. PerrinoW. PerytA. PesciV. PeskovY. PestovA.J. PetersV. PetrácekA. PetridisM. PetrisV. PetrovM. PetroviciJ. PeyréS. PianoA. PiccottiP. PichotC. PiemonteM. PiknaR. PilastriniPhilippe PillotO. PinazzaB. PiniL. PinskyV. Pinto MoraisV. PismennayaF. PiuzR. PlattM. PloskonS. PlumeriJ. PlutaT. PocheptsovP. PodestaF. PoggioM. PoghosyanT. PoghosyanK. PolákB. PolichtchoukP. PolozovV. PolyakovB. PommereschF. PompeiA. PopS. PopescuF. PosaV. PospíšilB. PotukuchiJ. PouthasS. PrasadR. PreghenellaF. PrinoL. ProdanG. PronoM.A. ProtsenkoC.A. PruneauA. PrzybylaI. PshenichnovG. PudduP. PujahariA. PulvirentiA. PuninV. PuninJ. PutschkeJ. QuartieriE. QuercighI. RachevskayaA. RachevskiA. RademakersS. RadomskiA. RaduJ. RakL. RamelloR. RaniwalaS. RaniwalaO.B. RasmussenJ. RassonV. RazinK. ReadJ.S. RealK. RedlichC. ReichlingC. RenardG. RenaultR. RenfordtA.R. ReolonA. ReshetinJ.-P. RevolK. ReygersH. RicaudL. RiccatiR.A. RicciM. RichterP. RiedlerL.M. RigalleauF. RiggiW. RieglerE. RindelJ. RisoA. RivettiM. RizziV. RizziM. Rodriguez CahuantziK. RøedD. RöhrichS. Román-LópezM. RomanatoR. RomitaF. RonchettiP. RosinskyP. RosnetS. RosseggerA. RossiV. RostchinF. RotondoF. RoukoutakisS. RousseauChristelle RoyDaniel RoyPascal RoyL. RoyerG. RubinA. RubioR. RuiI. RusanovG. RussoV. RuuskanenE. RyabinkinA. RybickiS. SadovskyK. ŠafaríkR. SahooJ. SainiP. SaizS. SalurS. SambyalV. SamsonovL. ŠándorA. SandovalH. SannJ.-C. SantiardR. SantoR. SantoroG. SargsyanP. SaturniniE. ScapparoneF. ScarlassaraB. SchackertC. SchiauaR. SchickerT. SchiolerJ.D. SchippersC. SchmidtH. SchmidtR. SchneiderK. SchossmaierJ. SchukraftY. SchutzK. SchwarzK. SchwedaE. SchynsG. ScioliE. ScomparinH. SnowS. SedykhG. SegatoS. SellittoF. SemeriaS. SenyukovH. SeppänenS. SerciL. SerkinS. SerraT. SesselmannA. SevcencoI. SguraG. ShabratovaR. ShahoyanE. SharkovS. SharmaK. ShigakiK. ShileevP. ShuklaA. ShuryginM. ShuryginaY. SibiriakE. SiddiT. SiemiarczukM.H. SigwardA. SilenziD. SilvermyrR. SilvestriE. SimiliV. SimionR. SimonL. SimonettiR. SingarajuV. SinghalB. SinhaT. SinhaM. SiskaB. SitárM. SittaB. SkaaliP. SkowronskiM. SlodkowskiN. SmirnovL. SmykovR. SnellingsW. SnoeysC. SoegaardJ. SoerensenO. SokolovA. SoldatovA. SolovievH. SoltveitR. SoltzW. SommerC. SoosF. SoramelS. SorensenD. SoykM. Spyropoulou-StassinakiJ. StachelF. StaleyI. StanA. StavinskiyJ. SteckertG. StefaniniG. StefanekT. SteinbeckH. StelzerE. StenlundDiego StoccoM. StockmeierG. StoiceaP. StolpovskyP. StrmenJ.S. StutzmannG. SuT. SugitateM. ŠumberaC. SuireT. SusaK. Sushil KumarD. SwobodaJ. SymonsI. SzarkaA. SzostakM. SzubaP. SzymanskiM. TadelC. TagridisL. TanD. Tapia TakakiH. TauregA. TauroM. TavletG. Tejeda MunozJ. ThäderR. TieulentP. TimmerT. TolyhyN. TopilskayaC. Torcato de MatosH. ToriiL. ToscanoF. ToselloA. TournaireT. TraczykG. TrögerW. TromeurD. TruesdaleW. TrzaskaG. TsiledakisE. TsilisA. TsvetkovM. TurcatoR. TurrisiM. TuveriT. TveterH. TydesjoL. TykarskiK. TywoniukE. UgoliniK. UllalandJ. UrbanG.M. UrciuoliG.L. UsaiM. UsseglioA. VacchiM. ValaF. ValievP. Vande VyvreA. van den BrinkN. van EijndhovenN. van Der KolkMarco van LeeuwenL. VannucciS. VanzettoJ.-P. VanuxemM.A. VargasR. VarmaA. VascottoA. VasilievM. VassiliouP. VastaV. VecherninM. VenaruzzoE. VercellinS. VergaraW. VerhoevenF. VeroneseI. VetlitskiyR. VernetV. VictorovL. VidakG. ViestiO. VikhlyantsevZ. VilakaziO. Villalobos BaillieA. VinogradovL. VinogradovY. VinogradovT. VirgiliY. ViyogiA. VodopianovG. VolpeD. VranicJ. VrlákováB. VulpescuC. WabnitzV. WagnerL. WalletR. WanY. WangR. WheadonR. WeisQ. WenJ. WesselsJ. WestergaardJ. WiechulaA. WiesenaeckerJ. WikneA. WilkG. WilkC. WilliamsN. WillisB. WindelbandR. WittH. WoehriK. WyllieC. XuChun YangH. YangF. YermiaZ. YinB. Yun KyI. YushmanovB. YutingE. ZabrodinS. ZagatoB. ZagreevP. ZahariaA. ZaliteG. ZampaC. ZampolliY. ZanevskiyA. ZarochentsevO. ZaudtkeP. ZávadaH. ZbroszczykA. ZepedaV. ZeterI. ZguraM. ZhalovD. ZhouS. ZhouG. ZhuA. ZichichiA. ZinchenkoG. ZinovjevY. ZoccaratoA. ZubarevA. ZucchiniM. Zuffa
• Organismes : Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut de Physique Nucléaire d'Orsay Institut de Physique Nucléaire d'Orsay Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique Nucléaire de Lyon Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique Nucléaire d'Orsay Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire d'Orsay Institut de Physique Nucléaire de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut de Physique Nucléaire d'Orsay Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Corpusculaire - Clermont-Ferrand ALICE Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Institut de Physique Nucléaire d'Orsay Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire d'Orsay Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique Subatomique et de Cosmologie Institut de Physique Nucléaire de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique Nucléaire d'Orsay Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire d'Orsay Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut de Physique Nucléaire d'Orsay Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Corpusculaire - Clermont-Ferrand Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire d'Orsay Institut de Physique Nucléaire de Lyon Laboratoire de physique subatomique et des technologies associées Institut de Physique Nucléaire de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique Nucléaire de Lyon Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire d'Orsay Institut de Physique Nucléaire d'Orsay Institut Pluridisciplinaire Hubert Curien Institut de Physique Nucléaire de Lyon
• Publié dans Journal of Instrumentation le 30/10/2020

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Résumé : ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries. Its overall dimensions are 161626 m3 with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre RousseauJean-Philippe SteyerEveline VolckeNicolas BernetFabrice Beline
• Organismes : Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture
• Publié dans Water Science and Technology le 26/10/2020

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Résumé : In order to deal with the environmental problems associated with animal production industrialization and at the same time considering energy costs increasing, a piggery wastewater treatment process consisting of combined anaerobic digestion and biological nitrogen removal by activated sludge was developed. This contribution presents a modelling framework in order to optimize this process. Modified versions of the well established ASM1 and ADM1 models have been used. The ADM1 was extended with biological denitrification. pH calculation and liquid gastransfer were modified to take into account the effect of associated components. Finally, two interfaces (ADMtoASM and ASMtoADM) were built in order to combine both models. These interfaces set up the COD, nitrogen, alkalinity and charge fractionation between both models. However, for the mass balances between both models, some hypotheses were considered and might be evaluated.

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• Type de publi. : Autre publication
• Date de publi. : 01/01/2008
• Auteurs : Lionel PerrierNicola CautelaMagali MorelleNathalie HavetFrançoise DucimetièreAntoine LurkinJean-Yves BlayPierre BironDominique Ranchère-VinceAnne-Valérie DecouvelaerePhilippe ThiesseChristophe BergeronFrançois GillyGuy de LarocheDominic CellierMathieu LaramasThierry PhilipIsabelle Ray-Coquard
• Organismes : Université de Lyon Centre Léon Bérard [Lyon] Groupe d'analyse et de théorie économique Université de Lyon Laboratoire d'Economie de la Firme et des Institutions Université de Lyon Centre Léon Bérard [Lyon] Groupe d'analyse et de théorie économique Université de Lyon Groupe d'analyse et de théorie économique Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Santé Individu Société Université de Lyon Oncogénèse et progression tumorale Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Institut de Cancérologie de la Loire Lucien Neuwirth Merck Santé - Lyon Centre hospitalier universitaire de Grenoble Université de Lyon Centre Léon Bérard [Lyon] Université de Lyon Santé Individu Société

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Résumé : Background: The impact of compliance to clinical practice guidelines (CPG) on outcomes and/or costs of care has not been completely clarified. Objective: To estimate relationships between medical expenditures and compliance to CPG for initial sarcoma treatment. Research design: Selected cohorts of patients diagnosed with sarcoma in 2005 and 2006, and treated at the University hospital and/or the cancer centre of the Rhône-Alpes region, France (n=90). Main outcome measurements were: patient characteristics, compliance with CPG, health outcomes, and costs. Data were mainly extracted from patient records. The logarithm of treatment costs was modelled using linear and Tobit regressions. Results: Rates of compliance with CPG were 86%, 66%, 88%, 89%, and 95% for initial diagnosis, primary surgical excision, wide surgical excision, chemotherapy, and radiotherapy, respectively. Total average costs reached €24,439, with €1,784, €11,225, €10,360, and €1,016 for diagnosis, surgery (primary and wide surgical excisions), chemotherapy, and radiotherapy, respectively. Compliance of diagnosis with CPG decreased the cost of diagnosis, whereas compliance of primary surgical excision increased the cost of chemotherapy. Compliance of chemotherapy with CPG decreased the cost of radiotherapy. Conclusion: Since chemotherapy is one of the major cost drivers, these results support that compliance with guidelines increases medical care expenditures in short term.

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Fichiers liés : 0822.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre-Francois BoulinRafaël Angulo-JaramilloJean-Francois DaianJean TalandierPhilippe Berne
• Organismes : Laboratoire d'étude des transferts en hydrologie et environnement Agence nationale pour le gestion des déchets radioactifs Laboratoire des Technologies des Traceurs Laboratoire d'étude des transferts en hydrologie et environnement Laboratoire des Sciences de l'Environnement Laboratoire d'étude des transferts en hydrologie et environnement Agence nationale pour le gestion des déchets radioactifs Laboratoire des Technologies des Traceurs
• Publié dans Applied Clay Science le 27/10/2020

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Résumé : Deep geological barriers, such as Callovo-Oxfordian argillites, display suitable characteristics for a high level radioactive waste repository. Their low permeability is a key parameter to retain radionuclides locally. However, once the system is closed, gases produced by corrosion of the waste canisters can represent a risk to the installation safety. Gas pressure will build up with time, partially and locally desaturating Callovo-Oxfordian argillites. The pressure rise may fracture the argillites locally if the gas released through the host barrier is not evacuated fast enough. The present work focuses on porous-network identification with regard to gas transfer process. Mercury intrusion experiments were performed to evaluate how argillite reacts to gas intrusion. A sharp threshold is observed for pore diameters of 20 nm. Measured mercury porosity is 14% and is mainly made of mesopores (diameter < 100 nm). These experiments were complemented by water adsorption isotherms. Due to the evapo-condensation phenomenon, the results were different from the mercury intrusion curves. The method reveals that a larger trapped porosity exists (diameters between 20 nm and 1 μm). Pores of 20 nm diameter represent the capillary barrier to gas breakthrough. A network model, based on percolation, namely XDQ was built based on the connectivity and pore size distribution obtained previously. It predicts gas permeability of 10− 18 m2 at atmospheric pressure. The Klinkenberg effect greatly increases the gas permeability compared to water one. Gas permeability measurements confirm XDQ results. According to the XDQ model, permeability depends mainly on the percolation threshold and saturation. The model shows that partially desaturated network have no connected pathways for gas migration. In any case, pore connectivity is the key factor in gas transfer issues.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Bérengère MartyVirginie MaireEleonore GravierGuillem RigaillAnne Vincent-SalomonMarion KapplerIngrid LebigotFathia DjeltiAudrey TourdesPierre GestraudPhilippe HupéEmmanuel BarillotFrancisco CruzaleguiGordon C TuckerMarc-Henri SternJean-Paul ThieryJohn A HickmanThierry Dubois
• Organismes : Département de Transfert Département de Transfert Département de Transfert Département de biostatistiques Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Mathématiques et Informatique Appliquées Département de Transfert Service de Pathologie Département de Transfert Service de Pathologie Département de Transfert Département de Transfert Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) Compartimentation et dynamique cellulaires Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Mines Paris - PSL (École nationale supérieure des mines de Paris) SERVIER SERVIER Unité de génétique et biologie des cancers Département de Transfert SERVIER Département de Transfert
• Publié dans Breast Cancer Research le 29/10/2020

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Résumé : Introduction Basal-like carcinomas (BLCs) and human epidermal growth factor receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that have the most aggressive clinical behaviour. In contrast to HER2+ carcinomas, no targeted therapy is currently available for the treatment of patients with BLCs. In order to discover potential therapeutic targets, we aimed to discover deregulated signalling pathways in human BLCs. Methods In this study, we focused on the oncogenic phosphatidylinositol 3-kinase (PI3K) pathway in 13 BLCs, and compared it with a control series of 11 hormonal receptor negative- and grade III-matched HER2+ carcinomas. The two tumour populations were first characterised by immunohistochemistry and gene expression. The PI3K pathway was then investigated by gene copy-number analysis, gene expression profiling and at a proteomic level using reverse-phase protein array technology and tissue microarray. The effects of the PI3K inhibition pathway on proliferation and apoptosis was further analysed in three human basal-like cell lines. Results The PI3K pathway was found to be activated in BLCs and up-regulated compared with HER2+ tumours as shown by a significantly increased activation of the downstream targets Akt and mTOR (mammalian target of rapamycin). BLCs expressed significantly lower levels of the tumour suppressor PTEN and PTEN levels were significantly negatively correlated with Akt activity within that population. PTEN protein expression correlated significantly with PTEN DNA copy number and more importantly, reduced PTEN DNA copy numbers were observed specifically in BLCs. Similar to human samples, basal-like cell lines exhibited an activation of PI3K/Akt pathway and low/lack PTEN expression. Both PI3K and mTOR inhibitors led to basal-like cell growth arrest. However, apoptosis was specifically observed after PI3K inhibition. Conclusions These data provide insight into the molecular pathogenesis of BLCs and implicate the PTEN-dependent activated Akt signalling pathway as a potential therapeutic target for the management of patients with poor prognosis BLCs.

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Fichiers liés : 2008_Marty_Breast Cancer Research _1.pdf

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