Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Julie PannequinNathalie DelaunayCharbel DaridoTangui MauricePhilippe CrespyMichael FrohmanMaria BaldaKarl MatterDominique JoubertJean-François BourgauxJean-Pierre BaliFrédéric Hollande
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Mécanismes moléculaires dans les démences neurodégénératives Institut de Génomique Fonctionnelle Stony Brook University [SUNY] University College London [UCL] University College London [UCL] Institut de Génomique Fonctionnelle Hôpital Universitaire Carémeau [Nîmes] Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans Molecular Cancer Research le 29/10/2020

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Résumé : Chronic alcohol consumption is associated with increased risk of gastrointestinal cancer. High concentrations of ethanol trigger mucosal hyperregeneration, disrupt cell adhesion, and increase the sensitivity to carcinogens. Most of these effects are thought to be mediated by acetaldehyde, a genotoxic metabolite produced from ethanol by alcohol dehydrogenases. Here, we studied the role of low ethanol concentrations, more likely to mimic those found in the intestine in vivo, and used intestinal cells lacking alcohol dehydrogenase to identify the acetaldehyde-independent biological effects of ethanol. Under these conditions, ethanol did not stimulate the proliferation of nonconfluent cells, but significantly increased maximal cell density. Incorporation of phosphatidylethanol, produced from ethanol by phospholipase D, was instrumental to this effect. Phosphatidylethanol accumulation induced claudin-1 endocytosis and disrupted the claudin-1/ZO-1 association. The resulting nuclear translocation of ZONAB was shown to mediate the cell density increase in ethanol-treated cells. In vivo, incorporation of phosphatidylethanol and nuclear translocation of ZONAB correlated with increased proliferation in the colonic epithelium of ethanol-fed mice and in adenomas of chronic alcoholics. Our results show that phosphatidylethanol accumulation after chronic ethanol exposure disrupts signals that normally restrict proliferation in highly confluent intestinal cells, thus facilitating abnormal intestinal cell proliferation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Marianne ZellerDavid MassonMichel FarnierLuc LorgisValérie DeckertJean-Paul Pais de BarrosCatherine DesrumauxPierre SicardJacques GroberDenis BlachePhilippe P. GambertLuc RochetteYves CottinLaurent Lagrost
• Organismes : Santé - STIC Lipides - Nutrition - Cancer (U866) Point médical (Dijon) Observatoire RICO (ObseRvatoire des Infarctus de Côte d’Or) [Dijon] Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Santé - STIC Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Lipides - Nutrition - Cancer (U866) Santé - STIC Service de Cardiologie [CHU de Dijon] Lipides - Nutrition - Cancer (U866)
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Our aim was to characterize cholesteryl ester transfer protein (CETP) activity in the early phase of acute myocardial infarction (MI). Cholesteryl ester transfer protein catalyzes the transfer of cholesteryl esters from high-density lipoprotein (HDL) donors to apolipoprotein B-containing lipoprotein acceptors. The CETP concentration, lipid profiles, and the rate of cholesteryl ester transfer (CET) from a tracer dose of radiolabeled HDL toward endogenous lipoproteins were determined within 24 h after symptom onset. Among 347 patients with first MI, CETP concentration, triglycerides, and non-HDL-cholesterol increased across tertiles of the CET rate, whereas HDL-cholesterol, HDL, and LDL sizes decreased gradually. Among lipoprotein donors and acceptors, the best predictors of the CET rate were HDL2b and non-HDL-cholesterol, respectively. Mean age at first MI was 8.5 years lower in the patients from the highest CET tertile than in those in the lowest CET tertile. Diagonal stratification according to both non-HDL-cholesterol and HDL2b tertiles revealed that patients in the highest CET group were 18 years younger than patients in the lowest CET group. Parameters of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad were independently associated with the CET rate. In patients with acute MI, high CET rates are characterized by the presence of the high CETP mass/high non-HDL-cholesterol/low HDL2b triad. The association of high CET rates with young age at first MI lends support to a significant contribution of CETP to the accelerated progression of disease among asymptomatic patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Charles LeyderTim C.H. LiewAlexey KavokinIvan A. ShelykhMarco RomanelliJean-Philippe KarrElisabeth GiacobinoAlberto Bramati
• Organismes : Laboratoire Kastler Brossel Nanyang Technological University [Singapour] University of Southampton Science Institute Institut de Physique de Rennes Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Laboratoire Kastler Brossel
• Publié dans Physical Review Letters le 02/11/2020

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Résumé : We demonstrate, theoretically and experimentally, a polarization-controlled optical gate based on a degenerate polariton-polariton scattering process occurring in semiconductor microcavities. Because of the interference between coherent polaritons, this process is observed in the case of polaritons generated from two collinearly polarized coherent pump beams. On the contrary, if the beams are cross polarized, the scattering is suppressed.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Laurent VercueilJean-Luc HouetoPierre KrystkowiakChristelle LagrangeFrançois CassimAbdelhamid BenazzouzBernard PidouxAlain DestéeYves AgidPhilippe CornuSerge BlondAlim-Louis BenabidPierre PollakMarie VidailhetSpidy Group
• Organismes : Département de neurologie CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Amiens] Département de neurologie Service de neurologie [Amiens] Département de neurologie CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Amiens] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Amiens] Département de neurologie Département de neurologie CHU Saint-Antoine [AP-HP] Neurologie et thérapeutique expérimentale
• Publié dans Deutsche Zeitschrift für Nervenheilkunde / Deutsche Zeitschrift f ur Nervenheilkunde le 09/12/2014

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Résumé : BACKGROUND: Various pulse widths (from 60-450 mus) have been used for bilateral pallidal stimulation in generalized dystonia but, to date, no comparison of this parameter's effects is available. OBJECTIVE: To provide an analysis of the differential effects of bilateral short, medium and long stimulus pulse width (PW) on clinical improvement in primary generalized dystonia. METHODS: The most effective therapeutic stimulation parameters were recorded in 22 patients using bilateral pallidal stimulation. Six months after surgery, the effects of bilateral pallidal short (60-90 micros), medium (120-150 micros) and long (450 micros) PWs were studied in 20 of those patients. The effect of the stimulation was assessed by reviewing videotaped sessions by an observer blinded to treatment status (Burke-Fahn-Marsden movement score). Patients were tested on separate days, in random order, for the stimulation conditions (acute effect with the stimulation condition lasting 10 hours). The same contact was used for each stimulation condition. All the electrodes were set at 130 Hz (monopolar stimulation) and the intensity was set individually 10% below the side effect threshold. RESULTS: Median PWs of 60 (short), 120 (medium) and 450 micros (long) were compared,with a mean intensity of 4.46, 3.45 and 2.47 V, respectively. This study failed to demonstrate any significant difference in the movement scale dystonia mean scores depending on PW. CONCLUSION: According to our findings, short duration stimulus PWs are as effective as longer ones during a 10 hour period of observation. Confirmation of this finding for chronic use could be of importance in saving stimulator energy. Moreover, the use of smaller stimulus pulse widths are said to reduce charge injection and increase the therapeutic window between therapeutic effects and side effects.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Sylvie BaudinoJean-Claude CaissardVéronique BergougnouxFrédéric JullienJean-Louis MagnardGabriel ScallietJ. Mark CockPhilippe Hugueney
• Organismes : Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales BioSciences Lyon-Gerland Reproduction et développement des plantes Végétaux marins et biomolécules BioSciences Lyon-Gerland Reproduction et développement des plantes
• Publié dans Plant Signaling and Behavior le 02/11/2020

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Résumé : We localized the tissues and cells that contribute to scent biosynthesis in scented and nonscented Rosa x hybrida cultivars as part of a detailed cytological analysis of the rose petal. Adaxial petal epidermal cells have a typical conical, papillate shape whereas abaxial petal epidermal cells are flat. Using two different techniques, solid/liquid phase extraction and headspace collection of volatiles, we showed that, in roses, both epidermal layers are capable of producing and emitting scent volatiles, despite the different morphologies of the cells of these two tissues. Moreover, OOMT, an enzyme involved in scent molecule biosynthesis, was localized in both epidermal layers. These results are discussed in view of results found in others species such as Antirrhinum majus, where it has been shown that the adaxial epidermis is the preferential site of scent production and emission.

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Fichiers liés : BaudinoPSB2007.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Jérémie BottonB. HeudePh. AndréJean-Louis BressonPierre DucimetièreMarie‐aline CharlesFlvs Study Group
• Organismes : Recherche en épidémiologie et biostatistique Recherche en épidémiologie et biostatistique Recherche en épidémiologie et biostatistique CIC Necker Enfants Malades Recherche en épidémiologie et biostatistique Recherche en épidémiologie et biostatistique Association Fleurbaix Laventie Ville Santé
• Publié dans Diabetes & Metabolism le 31/10/2020

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Résumé : AIM: Elevated gamma-glutamyltransferase (GGT) is positively associated with severity of obesity in obese children and with increased BMI and waist circumference in general populations of adults. We aimed to study the relationships between GGT and anthropometric parameters in a general population of children. METHODS: This cross-sectional study was conducted in 219 boys and 214 girls included in the Fleurbaix Laventie Ville Sant?I study. Weight, height, four skinfolds and waist circumference were measured. We compared the means of GGT activity according to gender and Tanner stage, and according to overweight status (IOTF definition) and quartiles of anthropometric parameters. We then calculated partial Pearson correlations by gender between GGT and anthropometric parameters taking age and Tanner stage into account. RESULTS: GGT activity was higher in boys than in girls as soon as puberty started (P<0.001). The higher difference was observed for Tanner stage III (GGT=10.2 UI/L, CI95% of mean (9.5, 11.1) vs. 7.8 UI/L (7.2, 8.4)). Anthropometric parameters were significantly associated with GGT, particularly waist circumference (r=0.28 in boys; r=0.24 in girls). After an additional adjustment for sum of skinfolds, this correlation disappeared in boys (r=0.06), and was still significant in girls (r=0.19). CONCLUSION: In a general population of children, overweight and abdominal fat distribution were associated with increased GGT. As some studies have shown that GGT could predict the metabolic syndrome in children and type 2 diabetes in adults, the modest elevation of GGT observed in overweight children may be of pathophysiological importance in the long term.

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Fichiers liés : botton_fig1.pdf botton_fig2.pdf botton_fig3.pdf botton_fig4.pdf botton_fig5.pdf Diab_Metab-botton-V2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Philippe Jean-Pierre
• Organismes : Centre d'Économie et de Management de l'Océan Indien
• Publié dans AFD Research Paper Series le 05/02/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2007
• Auteurs : Magdalini KypriotouGallic BeauchefChristos E ChadjichristosRussell WidomEmmanuelle RenardSergio JimenezJoseph KornFrançois-Xavier MaquartThierry OddosOtto von StettenJean-Pierre PujolPhilippe Galéra
• Organismes : Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie IFR146 CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de Biochimie du tissu conjonctif IFR146 CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée IFR146 Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Boston University School of Medicine IFR146 Laboratoire de Biochimie du tissu conjonctif CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Jefferson (Philadelphia University + Thomas Jefferson University) Boston University School of Medicine Laboratoire de Biochimie Médicale et Biologie Moléculaire Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 Johnson & Johnson Santé Beauté Johnson & Johnson Santé Beauté CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de Biochimie du tissu conjonctif IFR146 Johnson & Johnson Santé Beauté
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known. We have investigated the role of hc-Krox transcription factor on type I collagen expression by human dermal fibroblasts. hc-Krox exerted a stimulating effect on type I collagen protein synthesis and enhanced the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in foreskin fibroblasts (FF), adult normal fibroblasts (ANF), and scleroderma fibroblasts (SF). Forced hc-Krox expression was found to up-regulate COL1A1 transcription through a –112/–61-bp sequence in FF, ANF, and SF. Knockdown of hc-Krox by short interfering RNA and decoy strategies confirmed the transactivating effect of hc-Krox and decreased substantially COL1A1 transcription levels in all fibro-blast types. The –112/–61-bp sequence bound specifically hc-Krox but also Sp1 and CBF. Attempts to elucidate the potential interactions between hc-Krox, Sp1, and Sp3 revealed that all of them co-immunoprecipitate from FF cellular extracts when a c-Krox antibody was used and bind to the COL1A1 promoter in chromatin immunoprecipitation assays. Moreover, hc-Krox DNA binding activity to its COL1A1-responsive element is increased in SF, cells producing higher amounts of type I collagen compared with ANF and FF. These data suggest that the regulation of COL1A1 gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1, and Sp3, which could act in concert to up-regulate COL1A1 transcriptional activity and provide evidence for a pro-fibrotic role of hc-Krox.

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Fichiers liés : PIIS0021925820430248.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/10/2007
• Auteurs : Xing MeiPhilippe DecaudinBao-Gang Hu
• Organismes : Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées Virtual environments for animation and image synthesis of natural objects Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées

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Résumé : Natural mountains and valleys are gradually eroded by rainfall and river flows. Physically-based modeling of this complex phenomenon is a major concern in producing realistic synthesized terrains. However, despite some recent improvements, existing algorithms are still computationally expensive, leading to a time-consuming process fairly impractical for terrain designers and 3D artists. In this paper, we present a new method to model the hydraulic erosion phenomenon which runs at interactive rates on today's computers. The method is based on the velocity field of the running water, which is created with an efficient shallow-water fluid model. The velocity field is used to calculate the erosion and deposition process, and the sediment transportation process. The method has been carefully designed to be implemented totally on GPU, and thus takes full advantage of the parallelism of current graphics hardware. Results from experiments demonstrate that our method is effective and efficient. It can create realistic erosion effects by rainfall and river flows, and produce fast simulation results for terrains with large sizes.

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Fichiers liés : FastErosion_PG07.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/10/2007
• Auteurs : Yann H. KerrPhilippe WaldteufelPhilippe RichaumeFrançois CabotArnaud MialonWigneron J.-P.Paolo FerrazzoliAli MahmoodiMaria Jose EscorihuelaKauzar Saleh ContellSteven Delwart
• Organismes : Centre d'études spatiales de la biosphère Institut Pierre-Simon-Laplace Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] Array Systems Computing Centre d'études spatiales de la biosphère University of Cambridge [Cambridge, UK] European Space Research and Technology Centre

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