Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/09/2007
• Auteurs : Aldo AmodeoIna MattisChristine BöckmannGiuseppe d'AmicoDetlef MüllerLukas OsterlohAnatoly ChaikovskyGelsomina PappalardoAlbert AnsmannArnoud ApituleyLucas Alados-ArboledasDimitris BalisAdolfo ComerónVolker FreudenthalerValentin MitevDoina NicolaeAlexandros PapayannisMaria Rita PerroneAleksander PietruczukManuel PujadasJean-Philippe PutaudFrançois RavettaVincenzo RiziValentin SimeonovNicola SpinelliKerstin StebelDimitar StoyanovThomas TricklMatthias Wiegner
• Organismes : Istituto di Metodologie per l'Analisi Ambientale Leibniz Institute for Tropospheric Research Institut für Mathematik [Potsdam] Istituto di Metodologie per l'Analisi Ambientale Leibniz Institute for Tropospheric Research Institut für Mathematik [Potsdam] B. I. Stepanov Institute of Physics [Minsk] Istituto di Metodologie per l'Analisi Ambientale Leibniz Institute for Tropospheric Research National Institute for Public Health and the Environment [Bilthoven] Departamento de Fisica Aplicada [Granada] Laboratory of Atmospheric Physics [Thessaloniki] Remote Sensing Laboratory [Barcelona] Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München Observatoire Cantonal de Neuchâtel National Institute of Research and Development for Optoelectronics National Technical University of Athens Università del Salento = University of Salento [Lecce] Institute of Geophysics [Warsaw] Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas JRC Institute for Environment and Sustainability Service d'aéronomie Università degli Studi dell'Aquila = University of L'Aquila = Université de L'Aquila Ecole Polytechnique Fédérale de Lausanne Consorzio Nazionale Interuniversitario per le Scienze FIsiche della Materia Norwegian Institute for Air Research Institute of Electronics [Sofia] Institute for Meteorology and Climate Research Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München

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Résumé : EARLINET-ASOS (European Aerosol Research Lidar Network - Advanced Sustainable Observation System) is a 5-year EC Project started in 2006. Based on the EARLINET infrastructure, it will provide appropriate tools to improve the quality and availability of the continuous observations. The EARLINET multi-year continental scale data set is an excellent instrument to assess the impact of aerosols on the European and global environment and to support future satellite missions. The project is addressed in optimizing instruments and algorithms existing within EARLINET-ASOS, exchanging expertise, with the main goal to build a database with high quality aerosol data. In particular, the optimization of the algorithms for the retrieval of the aerosol optical and microphysical properties is a crucial activity. The main objective is to provide all partners with the possibility to use a common processing chain for the evaluation of their data, from raw signals to final products. Raw signals may come from different types of systems, and final products are profiles of optical properties, like backscatter and extinction, and, if the instrument properties permit, of microphysical properties. This will have a strong impact on the scientific community because data with homogeneous well characterized quality will be made available in nearly real time.

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• Type de publi. :
• Date de publi. : 17/09/2007
• Auteurs : Jean-Yves SalpinRiccardo SpeziaMarie-Pierre GaigeotJeanine TortajadaD. ScuderiJoël LemairePhilippe Maıtre
• Organismes : Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/09/2007
• Auteurs : Hongzhi WangPierre LerayJacques PalicotJean-Philippe Delahaye
• Organismes : Institut d'Electronique et de Télécommunications de Rennes Institut d'Électronique et des Technologies du numéRique

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2007
• Auteurs : Cendra AgulhonJean-Claude PlatelBogdan KolomietsValérie ForsterSerge PicaudJacques S. BrocardPhilippe FaurePhilippe Brulet
• Organismes : Embryologie Moléculaire Dynamique des Reseaux Neuronaux Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Organisation Fonctionnelle du Cytosquelette Neurobiologie Intégrative des Systèmes Cholinergiques Embryologie Moléculaire
• Publié dans The Journal of Physiology le 29/10/2020

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Résumé : Glial Ca(2+) excitability plays a key role in reciprocal neuron-glia communication. In the retina, neuron-glia signalling is expected to be maximal in the dark, but the glial Ca(2+) signal characteristics under such conditions have not been evaluated. To address this question, we used bioluminescence imaging to monitor spontaneous Ca(2+) changes under dark conditions selectively in M?r cells, the principal retinal glial cells. By combining this imaging approach with network analysis, we demonstrate that activity in M?r cells is organized in networks of coactive cells, involving 2-16 cells located distantly and/or in clusters. We also report that spontaneous activity of small networks (2-6 M?r cells) repeat over time, sometimes in the same sequential order, revealing specific temporal dynamics. In addition, we show that networks of coactive glial cells are inhibited by TTX, indicating that ganglion and/or amacrine neuronal cells probably regulate M?r cell network properties. These results represent the first demonstration that spontaneous activity in adult M?r cells is patterned into correlated networks that display repeated sequences of coactivations over time. Furthermore, our bioluminescence technique provides a novel tool to study the dynamic characteristics of glial Ca(2+) events in the retina under dark conditions, which should greatly facilitate future investigations of retinal dark-adaptive processes.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/09/2007
• Auteurs : Arnaud JaccardPhilippe MoreauVéronique LeblondXavier LeleuLofti BenboubkerOlivier HermineChristian RécherBouchra AsliBruno LioureBruno RoyerFabrice JardinFranck BridouxBernard GrosboisJérôme JaubertJean-Charles PiettePierre RoncoFabrice QuetMichel CognéJean-Paul Fermand
• Organismes : Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service d'Hématologie biologique [CHU Limoges] Service d'hématologie clinique Centre Hospitalier Régional Universitaire de Tours Service d'immuno-hématologie pédiatrique [CHU Necker] Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Remodelage et Reparation du Tissu Renal Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Université de Limoges
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a randomized study. METHODS: We conducted a randomized trial comparing high-dose intravenous melphalan followed by autologous hematopoietic stem-cell rescue with standard-dose melphalan plus high-dose dexamethasone in patients with AL amyloidosis. Patients (age range, 18 to 70 years) with newly diagnosed AL amyloidosis were randomly assigned to receive intravenous high-dose melphalan plus autologous stem cells or oral melphalan plus oral high-dose dexamethasone. RESULTS: Fifty patients were enrolled in each group. The results were analyzed on an intention-to-treat basis, with overall survival as the primary end point. After a median follow-up of 3 years, the estimated median overall survival was 22.2 months in the group assigned to receive high-dose melphalan and 56.9 months in the group assigned to receive melphalan plus high-dose dexamethasone (P=0.04). Among patients with high-risk disease, overall survival was similar in the two groups. Among patients with low-risk disease, there was a nonsignificant difference between the two groups in overall survival at 3 years (58% in the group assigned to receive high-dose melphalan vs. 80% in the group assigned to receive melphalan plus high-dose dexamethasone; P=0.13). CONCLUSIONS: The outcome of treatment of AL amyloidosis with high-dose melphalan plus autologous stem-cell rescue was not superior to the outcome with standard-dose melphalan plus dexamethasone. (ClinicalTrials.gov number, NCT00344526 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2007
• Auteurs : Nicolas BellegardePhilippe DessantePierre VidalJean-Claude Vannier
• Organismes : SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif SUPELEC-Campus Gif

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Résumé : This paper describes the design of a drive consisting of a DC motor, a speed reducer, a lead screw transformation system, a power converter and its associated DC source. The objective is to reduce the mass of the system. Indeed, the volume and weight optimisation of an electrical drive is an important issue for embedded applications. Here, we present an analytical model of the system in a specific application and afterwards an optimisation of the motor and speed reducer main dimensions and the battery voltage in order to reduce the weight.

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Fichiers liés : Full_Version.pdf

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• Type de publi. : Rapport
• Date de publi. : 12/09/2007
• Auteurs : Anne-Marie KermarrecErwan FaouJean-Pierre MerletPhilippe RobertLuc Segoufin
• Organismes : As Scalable As Possible: foundations of large scale dynamic distributed systems Invariant Preserving SOlvers Constraints solving, optimization and robust interval analysis Networks, Algorithms and Probabilities Integration of data and knowledge distributed over the web

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Résumé : La Commissiond 'Évaluation(CE) de l'INRIA a souhaité mener une réflexion sur les indicateurs bibliométriques de façon à mieux comprendre ce qu'ils mesurent, leur pertinence et leur fiabilité,en particulier dans le contexte de la recherche menée à l'INRIA. Le présent document est le résultat du travail d'un groupe de réflexion animé par Jean-Pierre Merlet et composé également de A-M.Kermarrec, E.Faou, P. Robert et L. Segoufin. Ce document a fait l'objet de discussions lors de deux séances de la Commission d'Evaluation en janvier et septembre 2007 et prend en compte les remarques des membres de la Commission.

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Fichiers liés : indicateurv08.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2007
• Auteurs : Claude C. ChevaletJean-François HocquettePierre P. SellierPhilippe Monget
• Organismes : Laboratoire de Génétique Cellulaire Unité de Recherches sur les Herbivores Station de Génétique Quantitative et Appliquée Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/09/2007
• Auteurs : Arturo Gil-PintoPhilippe FraisseRené ZapataPierre Dauchez
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Robotique mobile pour l'exploration de l'environnement Laboratoire Toulousain de Technologie et d'Ingénierie des Systèmes

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