Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2007
• Auteurs : Thibault de La Motte RougeLorenzo GalluzziKen OlaussenYael ZermatiEzgi TasdemirThomas RobertHugues RipocheVladimir LazarPhilippe DessenFrancis HarperGerard PierronGuillaume PinnaNatalia AraujoAnnick Harel-BelanJean-Pierre ArmandTai Wai WongJean Charles SoriaGuido Kroemer
• Organismes : Institut Gustave Roussy Apoptose, cancer et immunité Institut Gustave Roussy Apoptose, cancer et immunité Institut Gustave Roussy Apoptose, cancer et immunité Apoptose, cancer et immunité Institut Gustave Roussy Institut Gustave Roussy Apoptose, cancer et immunité Institut Gustave Roussy Bases fondamentales et stratégies nouvelles en cancérologie Institut Gustave Roussy Génomes et cancer Institut Gustave Roussy Institut Gustave Roussy Génomes et cancer Génétique moléculaire et intégration des fonctions cellulaires Génétique moléculaire et intégration des fonctions cellulaires Laboratoire Epigenetique et Cancer Laboratoire Epigenetique et Cancer Laboratoire Epigenetique et Cancer Institut Gustave Roussy Bristol-Myers Squibb [Princeton] Institut Gustave Roussy Institut Gustave Roussy Apoptose, cancer et immunité
• Publié dans Cancer Research le 29/10/2020

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Résumé : Abstract Non–small cell lung cancer (NSCLC) with activating mutations in the epidermal growth factor receptor (EGFR) responds to EGFR tyrosine kinase inhibitors such as erlotinib. However, secondary somatic EGFR mutations (e.g., T790M) confer resistance to erlotinib. BMS-690514, a novel panHER/vascular endothelial growth factor receptor (VEGFR) inhibitor described here, exerted antiproliferative and proapoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation. In this model, BMS-690514 induced a G1 cell cycle arrest, as well as ultrastructural hallmarks of apoptosis, mitochondrial release of cytochrome c, and activation of caspases involved in the intrinsic (e.g., caspase-2, caspase-3, caspase-7, and caspase-9), but not in the extrinsic (e.g., caspase-8), pathway. Caspase inhibition conferred partial protection against BMS-690514 cytotoxicity, pointing to the involvement of both caspase-dependent and caspase-independent effector mechanisms. Transcriptome analyses revealed the up-regulation of proapoptotic (e.g., Bim, Puma) and cell cycle inhibitory (e.g., p27Kip1, p57Kip2) factors, as well as the down-regulation of antiapoptotic (e.g., Mcl1), heat shock (e.g., HSP40, HSP70, HSP90), and cell cycle promoting [e.g., cyclins B1, D1, and D3; cyclin-dependent kinase 1 (CDK1); MCM family proteins; proliferating cell nuclear antigen (PCNA)] proteins. BMS-690514–induced death of H1975 cells was modified in a unique fashion by a panel of small interfering RNAs targeting apoptosis modulators. Down-regulation of components of the nuclear factor-κB survival pathway (e.g., p65, Nemo/IKKγ, TAB2) sensitized cells to BMS-690514, whereas knockdown of proapoptotic factors (e.g., Puma, Bax, Bak, caspase-2, etc.) and DNA damage–related proteins (e.g., ERCC1, hTERT) exerted cytoprotective effects. BMS-690514 is a new pan-HER/VEGFR inhibitor that may become an alternative to erlotinib for the treatment of NSCLC. [Cancer Res 2007;67(13):6253–62]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2007
• Auteurs : Bénédicte StengelCorinne AntignacGabriel BaverelGabriel ChoukrounOlivier CussenotJean-Claude DussauleGérard FriedlanderPhilippe LangMartine Lelièvre-PégorierZiad MassyRenato C. MonteiroAngelo PariniJean Paul SoulillouLaurent BaudPierre Ronco
• Organismes : Recherche en épidémiologie et biostatistique Neuropathies héréditaires et rein en développement Hôpital Necker - Enfants Malades [AP-HP] Métabolomique et maladies métaboliques Hôpital Guillaume-et-René-Laennec [CHU Nantes] Université de Picardie Jules Verne CHU Tenon [AP-HP] Centre de Recherche Saint-Antoine Hôpital Necker - Enfants Malades [AP-HP] Centre de recherche Croissance et signalisation Hôpital Henri Mondor Centre de Recherche des Cordeliers Université de Picardie Jules Verne Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques Immunopathologie rénale, récepteurs et inflammation Institut de médecine moléculaire de Rangueil Institut de transplantation et de recherche en transplantation Université de Nantes - UFR de Médecine et des Techniques Médicales Immunointervention dans les allo et xénotransplantations CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal CHU Tenon [AP-HP] Remodelage et Reparation du Tissu Renal
• Publié dans Néphrologie & Thérapeutique le 01/11/2020

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Résumé : The National Institute of Health and Medical Research (Inserm), the Society of Nephrology, and the French Kidney Foundation recognized the need to create a National Research Program for kidney and urinary tract diseases. They organized a conference gathering 80 researchers to discuss the state-of-the art and evaluate the strengths and weaknesses of kidney and urinary tract disease research in France, and to identify research priorities. From these priorities emerged 11 of common interest: 1) conducting epidemiologic studies; 2) conducting large multicenter cohorts of well-phenotyped patients with blood, urine and biopsy biobanks; 3) developing large scale approach: transcriptomics, proteomics, metabolomics; 4) developing human and animal functional imaging techniques; 5) strengthening the expertise in renal pathology and electrophysiology; 6) developing animal models of kidney injury; 7) identifying nontraumatic diagnostic and prognostic biomarkers; 8) increasing research on the fetal programming of adult kidney diseases; 9) encouraging translational research from bench to bedside and to population; 10) creating centers grouping basic and clinical research workforces with critical mass and adequate logistic support; 11) integrating and developing european research programs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2007
• Auteurs : Charles LeyderMarco RomanelliJean-Philippe KarrElisabeth GiacobinoTim C.H. LiewMikhail M. GlazovAlexey KavokinGuillaume MalpuechAlberto Bramati
• Organismes : Laboratoire Kastler Brossel Institut de Physique de Rennes Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Nanyang Technological University [Singapour] A.F. Ioffe Physical-Technical Institute University of Southampton Laboratoire des sciences et matériaux pour l'électronique et d'automatique Laboratoire Kastler Brossel
• Publié dans Nature Physics le 01/11/2020

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Résumé : The spin Hall effect consists of the generation of a spin current perpendicular to the charge current flow. Thirty-five years after its prediction by Dyakonov and Perel'1, it is the focus of experimental and theoretical investigations and constitutes one of the most remarkable effects of spintronics. Owing to scattering and dephasing in electronic gases, it is difficult to observe and has only been demonstrated for the first time a few years ago2, 3, 4, 5. Recently, three of us have predicted the optical spin Hall effect6, which consists of a separation in real space and momentum space of spin-polarized exciton-polaritons generated by a laser in a semiconductor microcavity7. The separation takes place owing to a combination of elastic scattering of exciton-polaritons by structural disorder and an effective magnetic field coming from polarization splitting of the polariton states. The excitonic spin current is controlled by the linear polarization of the laser pump. Here, we report the first experimental evidence for this effect and demonstrate propagation of polariton spin currents over 100 mum in a high-quality GaAs/AlGaAs quantum microcavity. By rotating the polarization plane of the exciting light, we were able to switch the directions of the spin currents.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2007
• Auteurs : Istvan S. VariBeverley BalkauAdrien KettanehPhilippe AndréJean TichetFrédéric FumeronEmile CacesMichel MarreBernard GranchampPierre Ducimetière
• Organismes : Recherche en épidémiologie et biostatistique École des hautes études en sciences sociales Recherche en épidémiologie et biostatistique Recherche en épidémiologie et biostatistique Recherche en épidémiologie et biostatistique Institut inter-Régional pour la SAnté Déterminants génétiques du diabète de type 2 et de ses complications vasculaires Institut inter-Régional pour la SAnté Déterminants génétiques du diabète de type 2 et de ses complications vasculaires Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Centre de recherche biomédicale Bichat-Beaujon Service de biochimie hormonale, métabolique et génétique Recherche en épidémiologie et biostatistique
• Publié dans Diabetes Care le 01/11/2020

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Résumé : OBJECTIVE—To study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities. METHODS—469 men, 278 pre- and 197 post-menopausal women from the French D.E.S.I.R. cohort, aged 30-65 years, were followed over six years. RESULTS—Higher concentrations of both ferritin and transferrin were associated with the IDF, and NCEP-ATP III original and revised metabolic syndromes at baseline: for the IDF metabolic syndrome the standardized, age-adjusted odds ratios (95% CI) for log(ferritin) were: 1.49 (1.14-1.94) for men, 2.10 (1.27-3.48) for pre-menopausal women, 1.80 (1.21-2.68) for post-menopausal women; for transferrin they were respectively: 1.94 (1.53-2.47), 2.22 (1.32-3.75), 2.14 (1.47-3.10). After 6-years of follow-up, the change in the presence of the metabolic syndrome was associated with higher baseline log(ferritin) in all three groups: 1.46 (1.13 1.89), 1.28 (0.85-1.94), 1.62 (1.10-2.38), and transferrin: 1.41 (1.10-1.81), 1.63 (1.05-2.52), 1.51 (1.02-2.22). Among syndrome components, hypertriglyceridemia at 6 years was the component most strongly associated with baseline ferritin and transferrin. The odds of an incident IDF-defined metabolic syndrome after 6 years, was more than four-fold higher when ferritin and transferrin were both above the group-specific top tertile, in comparison with participants with both parameters below these thresholds. CONCLUSIONS—This is the first prospective study associating ferritin and transferrin with the metabolic syndrome and its components. When both markers of the iron metabolism are elevated, the incidence of the metabolic syndrome is increased in men and both pre- and post-menopausal women.

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Fichiers liés : vari_DC-06-2312._22_03_07.pdf

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• Type de publi. :
• Date de publi. : 24/06/2007
• Auteurs : Jean-Sébastien GuezAnne-Sophie DrucbertPierre Marie DanzéPhilippe Jacques
• Organismes : Institut Pascal

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/06/2007
• Auteurs : Benjamin BoisPhilippe PieriLoïc CommagnacPhilippe ChéryCornelis van LeeuwenJean-Pierre J.-P. GaudillereEtienne SaurLucien Wald
• Organismes : Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux Ecophysiologie et Génomique Fonctionnelle de la Vigne Transfert Sol-Plante et Cycle des Eléments Minéraux dans les Ecosystèmes Cultivés Centre Énergétique et Procédés

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Résumé : Solar radiation has a major impact on grapevine development and berry ripening. It has a large influence on photosynthetic activity, as well as on anthocyanin and aromatic compound synthesis in grape berries. Incoming and intercepted solar radiations are also key-variables in soil water balance, water fluxes and plant water stress. However, irradiation data is seldom available in weather station records. In this paper, the use of a digital elevation model coupled with remotely sensed solar radiation is investigated in order to characterize the agroclimatic potential of a viticultural production area. First solar radiation data retrieved from the Helioclim-1 database is used to estimate direct and diffuse solar radiation proportions. Then, using r.sun algorithm, 50 meters resolution daily maps of global irradiation are produced, based upon a Digital Elevation Model (DEM). This method was applied to the winegrowing area Côtes-de-Bourg, Bordeaux, France. This region exhibits moderated orography (mean slope = 3°, with a standard deviation of 2.4°). However, cumulated incoming solar radiation from veraison to berry maturity (SVM index) varied from -13% to +9% of the horizontal surface values. A zoning was realized based on SVM index values, dividing Côtes-de-Bourg area according to the SVM index (low, medium and high) of 2003 to 2005. This zoning was compared to Vitis vinifera cv Merlot berries characteristics of 6 sites located in areas of high and medium SVM index. Sites located in high SVM index area produced berries with lower titrable acidity, higher pH and higher mean weight than sites located in areas characterized by medium SVM index. No significant difference was found with berry sugar concentration. The solar radiation mapping methodology presented here is applicable for European and African vineyards, as satellite sensed solar irradiation data is compiled in the Helioclim-1 database, available at http://www.sodais.org.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/06/2007
• Auteurs : Julien AussibalPierre BorgnatYann LabitGuillaume DewaeleNicolas LarrieuLaurent GallonPhilippe OwezarskiPatrice AbryK. Boudaoud
• Organismes : Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour Laboratoire de Physique de l'ENS Lyon Équipe Services et Architectures pour Réseaux Avancés Laboratoire de Physique de l'ENS Lyon Interpretation and Modelling of Images and Videos Ecole Nationale de l'Aviation Civile Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour Équipe Services et Architectures pour Réseaux Avancés Laboratoire de Physique de l'ENS Lyon Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis

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Résumé : L'objectif de ce papier consiste à décrire la base d'anomalies créée dans le cadre du projet METROSEC. Cette base contient des traces d'anomalies, légitimes (foules subites,...) et illégitimes (DDoS). Elle permet de calibrer les outils de détection d'anomalies développés dans le projet, et de mesurer leurs performances en termes de faux positifs et faux négatifs.

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Fichiers liés : SAR07-final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Bruno GomesMarilena Djata CabralAlexandra GallardMagali SavignacPierre PauletPhilippe DruetBernard MariaméMarc M. MoreauCatherine LeclercJean-Charles GuéryLucette Pelletier
• Organismes : Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Centre de biologie du développement Centre de biologie du développement Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan
• Publié dans American Journal of Respiratory and Critical Care Medicine le 26/10/2020

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Résumé : RATIONALE: Ca(2+) signaling controls the production of T helper (Th) type 2 cytokines known to be deleterious in asthma. Recently, we showed that Ca(2+) signaling was dihydropyridine (DHP)-sensitive in Th2 lymphocytes and that the DHP derivate, nicardipine, used in the treatment of cardiovascular pathologies, prevents Th2-dependent B cell polyclonal activation. OBJECTIVES: We tested the effect of nicardipine in experimental allergic asthma. METHODS: BALB/c mice immunized with ovalbumin (OVA) in alum and challenged with intranasal OVA were treated with nicardipine once the Th2 response, or even airway inflammation, was induced. We also tested the effect of nicardipine in asthma induced by transferring OVA-specific Th2 cells in BALB/c mice exposed to intranasal OVA. We checked the impact of nicardipine on T-cell responses and airway inflammation. MEASUREMENTS AND MAIN RESULTS: Nicardipine inhibited in vitro Ca(2+) response in Th2 cells. In vivo, it impeded the development of Th2-mediated airway inflammation and reduced the capacity of lymphocytes from lung-draining lymph nodes to secrete Th2, but not Th1, cytokines. Nicardipine did not affect antigen presentation to CD4(+) T lymphocytes, nor the initial localization of Th2 cells into the lungs of mice exposed to intranasal OVA; however, it reduced the production of type 2 cytokines and the amplification of the Th2 response in mice with asthma. Conversely, nicardipine had no effect on Th1-mediated airway inflammation. CONCLUSIONS: Nicardipine improves experimental asthma by impairing Th2-dependent inflammation. This study could provide a rationale for developing drugs selectively targeting DHP receptors of Th2 lymphocytes, potentially beneficial in the treatment of asthma.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Marion SourisseauClémentine SchilteNicoletta CasartelliCéline TrouilletFlorence Guivel-BenhassineDominika RudnickaNathalie Sol-FoulonKarin Le RouxMarie-Christine PrevostHafida FsihiMarie-Pascale FrenkielFabien P. BlanchetPhilippe V AfonsoPierre-Emmanuel CeccaldiSimona OzdenAntoine GessainIsabelle SchuffeneckerBruno VerhasseltAlessia ZamborliniAli SaïbFélix A. ReyFernando Arenzana-SeisdedosPhilippe DesprèsAlain MichaultMatthew L AlbertOlivier Schwartz
• Organismes : Virus et Immunité Immunobiologie des Cellules Dendritiques Virus et Immunité Virus et Immunité Virus et Immunité Virus et Immunité Virus et Immunité Laboratoire de Microbiologie Microscopie électronique (Plate-forme) Département Infection et Epidémiologie - Department of Infection and Epidemiology Interactions Moléculaires Flavivirus-Hôtes Virus et Immunité Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections [CIRI] Universiteit Gent = Ghent University = Université de Gand Hôpital Saint-Louis Hôpital Saint-Louis Virologie Structurale Pathogénie Virale Moléculaire Interactions Moléculaires Flavivirus-Hôtes Laboratoire de Microbiologie Immunobiologie des Cellules Dendritiques Virus et Immunité
• Publié dans PLoS Pathogens le 27/10/2020

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Résumé : An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of encephalitis. The basis for chikungunya disease and the tropism of CHIKV remain unknown. Here, we describe the replication characteristics of recent clinical CHIKV strains. Human epithelial and endothelial cells, primary fibroblasts and, to a lesser extent, monocyte-derived macrophages, were susceptible to infection and allowed viral production. In contrast, CHIKV did not replicate in lymphoid and monocytoid cell lines, primary lymphocytes and monocytes, or monocyte-derived dendritic cells. CHIKV replication was cytopathic and associated with an induction of apoptosis in infected cells. Chloroquine, bafilomycin-A1, and short hairpin RNAs against dynamin-2 inhibited viral production, indicating that viral entry occurs through pH-dependent endocytosis. CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host.

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Fichiers liés : journal.ppat.0030089.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2007
• Auteurs : Smail HamlatFerhat HammoumPierre-Yves HicherChristian StefaniJean-Philippe Terrier
• Organismes : Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées Institut de Recherche en Génie Civil et Mécanique Laboratoire Central des Ponts et Chaussées Division Matériaux et Structures de Chaussées Laboratoire Central des Ponts et Chaussées - Nantes Division Matériaux et Structures de Chaussées
• Publié dans Bulletin des Laboratoires des Ponts et Chaussees le 19/09/2018

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Résumé : A new method for performing laboratory evaluations of the resistance to tangential forces of bituminous mixes used on wearing courses will be presented herein. Tire-pavement surface contact mechanics have been taken into account for the purpose of reproducing, as accurately as possible, the effect of tangential forces generated at specific area throughout the road network. Phenomena associated with the indentation between tire rubber and to consists of aggregate asperities have also been incorporated. The new testing protocol calls for loading the surface of an bitumen mix with an inclined force. The cyclic action of this force causes sliding of the tread rubber on the surface of the specimen and generates a loss of aggregates that varies depending characteristics of bituminous mix. An assessment of the resistance to tangential forces based on specimen mass loss will be proposed. Using this test, it becomes possible to determine the effect of binder type on this resistance to tangential forces. Lastly, the change in specimen mass loss will be correlated with the properties of bitumen used here.

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Fichiers liés : Hamlat2007.pdf

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