Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/05/2007
• Auteurs : Nathalie DestouchesPierre ChavelPhilippe LalanneI. MustonenH. OttevaereNicolas PassillyS. PereiraStéphanie ReynaudJean-Claude RodierL. SteinbockJ. van ErpsC. Ziebert
• Organismes : Laboratoire Hubert Curien Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Naphel Laboratoire Hubert Curien Laboratoire Charles Fabry de l'Institut d'Optique / Naphel

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/05/2007
• Auteurs : Alessandra GianoncelliJacques CastaingLuc OrtegaEric DooryheeM. EvenoJoseph SalomonPierre BordetJean-Louis HodeauPhilippe Walter
• Organismes : Centre de recherche et de restauration des musées de France Centre de recherche et de restauration des musées de France X'Press : diffraction et hautes pressions Matériaux, Rayonnements, Structure Centre de recherche et de restauration des musées de France Centre de recherche et de restauration des musées de France Matériaux, Rayonnements, Structure Matériaux, Rayonnements, Structure Centre de recherche et de restauration des musées de France

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Résumé : X-ray fluorescence (XRF) and X-ray diffraction (XRD) are necessary for complete identification of materials. Works of art and samples have to be carried to specialised laboratories for XRD analyses. In certain cases, this is uneasy or even infeasible. Fresco paintings or other artefacts with elevated security concerns cannot be moved, hence the interest of portable XRD. In the framework of the project EuArtech a portable XRF and XRD instrumentation has been developed. The instrument combines both XRF and XRD techniques in order to perform simultaneously elemental analysis and crystal structure identification. The system has a reasonable weight and requires low electrical power supply. In the present paper, the system design is shown and the first experimental results are discussed. They have been performed on paintings, glazes on ceramics and oxidized bronze. No damages have been detected on the analysed objects, even on paintings covered by varnish.

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• Type de publi. : Article dans une revue
• Date de publi. : 08/05/2007
• Auteurs : Morgane BessonSylvie GranonMonica Mameli-EngvallIsabelle Cloëz-TayaraniNicolas MaubourguetAnne CormierPierre CazalaV. DavidJean-Pierre ChangeuxPhilippe Faure
• Organismes : Récepteurs et Cognition Récepteurs et Cognition Department of Physiology and Pharmacology Récepteurs et Cognition Récepteurs et Cognition Récepteurs et Cognition Neurosciences cognitives Neurosciences cognitives Collège de France Récepteurs et Cognition
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta2*- vs. alpha7*nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta2*- or alpha7*nAChRs.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/05/2007
• Auteurs : Pierre-Yves BardPhilippe GuéguenJean-Louis ChazelasM. KhamJean-François Semblat
• Organismes : Laboratoire de Géophysique Interne et Tectonophysique Laboratoire de Géophysique Interne et Tectonophysique Division Reconnaissance et Mécanique des Sols EDF R&D Division Mécanique des Sols des Roches et de la Géologie de l'Ingénieur

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Résumé : It is most generally admitted that seimic ground motion is the convolution of source, path and site effects. The question addressed here is whether a fourth term, called "Site-City Interaction" (SCI), should be added for densely urbanized areas, corresponding to feedback effects from the shaken buildings in the soil. After a short overview of various, consistent observations, several specific experimental and numerical results are briefly summarized, that clearly evidence the wave radiation from isolated buildings and the possibilty of interactions between close buildings as well. The seismic response of a simple "city model" represented by a group of buildings is then addressed through a series of numerical simulations, which allow to determine under which conditions such SCI effects may be significant. These findings are consistent with a very simple "rule of thumb" approach based on the comparison between kinematic energies in soils and buildings, pointing to the significance of SCI effects for dense cities where building and soil periods coincide. The last section thus discusses the practical consequences of such SCI effects, and some possible directions to get unambiguous experimental evidence in real cities.

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• Type de publi. : Article dans une revue
• Date de publi. : 07/05/2007
• Auteurs : Alice BourdonLimor MinaiValérie SerreJean-Philippe JaisEmmanuelle SarziSophie AubertDominique ChrétienPascale de LonlayVéronique Paquis-FlucklingerHirofumi ArakawaYusuke NakamuraArnold MunnichAgnès Rötig
• Organismes : Physiologie membranaire et moléculaire du chloroplaste Institut National de la Santé et de la Recherche Médicale Université Paris Diderot - Paris 7 Service d'informatique médicale et biostatistiques [CHU Necker] Institut des Neurosciences de Montpellier Université Paris-Sorbonne Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement Service de génétique médicale Instabilité génétique : maladies rares et cancers Human Genome Center, Institute of Medical Science Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement Université Paris Descartes - Paris 5
• Publié dans Nature Genetics le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 07/05/2007
• Auteurs : Frederic DeschaseauxZohair SelmaniPierre-Emmanuel FalcozNursen MersinNicolas MeneveauAlfred PenfornisColette KleinclaussSidney ChocronJoseph-Philippe EtieventPierre TiberghienJean-Pierre KantelipSiamak Davani
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Service de Diabétologie - Endocrinologie [CHRU Besançon] Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920)
• Publié dans European Journal of Pharmacology le 30/11/2018

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Résumé : 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used to decrease cholesterol synthesis and are well established to reduce vascular diseases. Recently, it has been proposed that statins mobilize endothelial progenitor cells from bone marrow during the first four weeks, which could help to prevent vascular diseases. However, in humans there are few data concerning the long term effects of statin treatment on these endothelial progenitor cells. We investigated whether endothelial progenitor cells can be detected and characterized in patients receiving long term statin therapy. Mononuclear cells from patients receiving or not receiving statin therapy were assessed for progenitor cell content by flow cytometry and were cultured in specific conditions to determine the number and the type of progenitors. Our results showed there were significantly more CD34(+), CD34(+)/CD144(+) circulating progenitor cells in the statin(pos) group than in the statin(neg) group. In culture two types of endothelial progenitor cells were detected. Early endothelial progenitor cells gave colonies at day 5 comprising elongated cells whereas late endothelial progenitor cells generated cobblestone-like colonies with strong proliferation capacities. The number of circulating early endothelial progenitor cells was significantly higher in the statin(neg) group, while only late endothelial progenitor cells were detected in the statin(pos) group. Moreover, cells from cobblestones clearly had an endothelial phenotype CD31(+), VEGF-R2(+), CD34(+), CD146(+) in contrast to cells from colonies from early endothelial progenitor cells, which were VEGF-R2(low), CD34(-). These results strongly suggest that long term statin treatment specifically maintains late endothelial progenitor cells in circulation with a CD34(+)/CD144(+) phenotype.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2007
• Auteurs : Anne Sophie Hatzfeld-CharbonnierAudrey LasekLaurent CasteraPhilippe GossetThierry VeluPierre FormstecherLaurent MortierPhilippe Marchetti
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Biomolécules et inflammation pulmonaire Department d'oncologie médicale [Bruxelles, Belgique] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Journal of Leukocyte Biology le 26/10/2020

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Résumé : Mild heat stress can modulate the activities of immune cells, including dendritic cells (DC) and theoretically, would constitute an innovative approach capable of enhancing the antitumor functions of DC. Therefore, we tested the effects of mild heat stress on the physiology and viability of human monocyte-derived DC, the major type of DC used in tumor immunotherapy trials. We first designed a heat-stress protocol consisting of repetitive, sublethal heat shocks throughout the generation of DC. Using this protocol, we observed that heat stress did not perturb the morphology and the phenotype of immature or mature DC or the capacities of immature DC to uptake antigens efficiently. It is noteworthy that in response to heat stress, mature DC produced higher levels of IL-12p70 and TNF-alpha, which are two cytokines involved in the stimulation of inflammatory reaction, whereas IL-10 production remained low. After heat-stress exposure, mature DC have the full ability to stimulate naive T cells with Th1 response polarization (high IFN-gamma and low IL-4 production) in an allogeneic MLR. It is interesting that heat stress enhanced the migratory capacities of DC in response to MIP-3beta/CCL19. Finally, heat stress partly protected DC from apoptosis induced by cytokine withdrawal. Overall, these findings validate the feasibility of improving immune response by heating human monocyte-derived DC and provide a strong rationale for using mild heat stress in combination with DC vaccination to increase antitumor response.

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Fichiers liés : Fig2.pdf Fig1vjanv07.pdf Fig3.pdf Fig4.pdf Fig5.pdf Fig6.pdf Hatzfeld_et_al_01_07.pdf

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• Type de publi. :
• Date de publi. : 01/05/2007
• Auteurs : Philippe ArtillanBruno EstibalsAlain SallesJean AbboudPierre AloisiCorinne Alonso
• Organismes : Centre National de la Recherche Scientifique Équipe Intégration de Systèmes de Gestion de l'Énergie Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation Équipe Intégration de Systèmes de Gestion de l'Énergie Équipe Intégration de Systèmes de Gestion de l'Énergie Équipe Intégration de Systèmes de Gestion de l'Énergie Équipe Intégration de Systèmes de Gestion de l'Énergie Université Toulouse III - Paul Sabatier Équipe Intégration de Systèmes de Gestion de l'Énergie

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Résumé : The electrical behavior of circular spiral inductive components in a homogeneous environment is analyzed by using the concentric ring approximation. This work is based on the partial element equivalent circuit (PEEC) modeling method which is extended to rotational symmetry case. Analytic approximations of all integral formulas are used in order to enable fast computation of the partial inductance and capacitance coefficients, to provide an efficient tool for design. The result is a full modeling method allowing the plotting of complex impedance frequency response and also the drawing of charge and current densities distribution inside of the conductors.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2007
• Auteurs : M.-L. MathéJean-Philippe LavigneMarie-Claire Oliva-LauraireGuiraud IPierre MarèsRenaud de Tayrac
• Organismes : Service de gynécologie-obstétrique Laboratoire universitaire d'antibiologie Systèmes de sécrétion de type IV et virulence bactérienne Laboratoire de physiologie cardiovasculaire Laboratoire d'histologie–embryologie–cytogénétique Service de gynécologie-obstétrique Service de gynécologie-obstétrique
• Publié dans Gynécologie Obstétrique & Fertilité le 30/10/2020

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Résumé : OBJECTIVES: The purpose of this study was to develop an animal model of prosthetic infection and compare in vivo bacterial infectiosity of different biomaterials used in vaginal surgery. MATERIALS AND METHODS: We implanted 36 prostheses of poly(lactic acid) with 94% L forms (PLA94), in a model of incisional abdominal hernia in Wistar rats. Bacterial inoculation was done just after implantation with three strains of Escherichia coli of variable virulence, two different concentrations and two different times of inoculation (during surgery or 48 hours after). All meshes were explanted and animals sacrificed on day 30 after intervention. Bacteriology and histology were then performed. In the same way, three materials used in vaginal surgery (knitted light-weight polypropylene [PP], thermoformed PP [Uratape] and polyurethane coated poly[ethylene terephtalate] [PTFE]) were tested and compared to the PLA94 using the same protocol. RESULTS: All inoculated prostheses were still infected at day 30 after implantation with the same E. coli strain. There was a significant difference in bacterial infectiosity linked to virulence of the inoculated strain (p=.005) and the amount injected (P<0.001). Infectiosity was significantly lower for PLA94 when compared to the three other prostheses (P=0.008). The most important infectiosity was seen with PTFE and thermoformed PP. For histologists, PLA94 also gave the weakest inflammatory reaction. DISCUSSION AND CONCLUSION: An original animal model of prosthetic infection allowed us to compare in vivo bacterial infectiosity of different biomaterials used in vaginal surgery and to demonstrate that the PLA94 mesh induces a milder risk of infection than polypropylene.

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Fichiers liés : GOF2007.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2007
• Auteurs : Jean-Philippe KarrFranck BielsaTristan ValenzuelaAlbane DouilletLaurent HilicoVladimir Korobov
• Organismes : Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Bogoliubov Laboratory of Theoretical Physics [Dubna]
• Publié dans Canadian Journal of Physics le 27/10/2020

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