Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 17/04/2007
• Auteurs : Carole AurouetFrançois Amy de la BretèqueZernik CléliaSchmidt NicolasDominique MemmiPagliano Jean-PierreGuillaume BridetLemonnier AnneVienne MaïtéGénot PhilippeMontagne AlbertGudin ChristineSchneider RolandLivolsi FlorenceSaleh ZeenatBourget GilberteJohnson ClarisseMeflah NadiaThierry NatachaCompère DanielVéronique Dominguez-GuillaumeSébastien DenisSmadja IsabelleGiraud CécileVarda AgnèsAngel HélèneMichel Ocelot
• Organismes : IRCAV - Institut de Recherche sur le Cinéma et l'Audiovisuel - EA 185 Université Paul-Valéry - Montpellier 3 Cultures et sociétés urbaines - UMR7112 EA 452
• Publié dans CinémAction le 28/10/2020

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Résumé : Les contes populaires ont très tôt servi de sources d'inspiration aux campagnes publicitaires. En effet, dès le XIXème siècle, la publicité y puise allégrement son inspiration. Comme l'a très bien retracé tout un pan de l'exposition « Il était une fois… les contes de fées », organisée par la Bibliothèque nationale de France avec la collaboration scientifique de La Joie des livres et du Centre national du livre pour enfants, présentée à Paris, du 20 mars au 17 juin 2001 1 , la publicité s'approprie ce genre pour vanter les mérites des produits qu'elle désire vendre. Certaines marques utilisent les personnages éponymes de Grimm ou de Perrault. Le Chat botté se retrouve alors placardé sur des affiches publicitaires au service de laines ou de cirage comme Blanche-Neige et les sept nains le sont pour le chocolat Menier en 1939 (celui qu'ils préfèrent nous dit-on…). Outre les personnages, dans les brochures publicitaires de cette période, les contes originels sont l'objet d'adaptation, de recomposition en vue de mettre en avant le produit à promouvoir. Ils sont alors remodelés dans un but commercial. La célèbre marque Nicolas (le spécialiste du vin depuis 1822 affirment les réclames) reprend par exemple le conte de La Belle au bois dormant : sur l'affiche, la marque insère une bouteille de verre qui fait figure de cercueil dans lequel est allongée la Belle pour mettre en parallèle le vin centenaire (1829) avec le sommeil de la jeune femme. Outre ces détournements-usurpations des contes par les publicitaires-certains grands magasins comme le Bon Marché-mais aussi certains commerçants de taille plus modeste-respectent le support de base et l'illustrent pour fidéliser le client. C'est le cas des images polychromes, les chromos, qui sont éditées par ces derniers et qui reproduisent des contes de fées sous la forme de plusieurs vignettes qui sont données au client avec chaque achat effectué. Ils sont souvent extrêmement fidèles aux illustrations faites par le maître en la matière qu'est Gustave Doré. Pour se procurer la série dans son intégralité, le consommateur est par conséquent invité et incité à effectuer plusieurs achats en ce lieu dans un temps limité. Force est de constater que, de nos jours, la publicité se sert toujours des contes pour vanter les mérites des produits qu'elles souhaitent nous faire acheter. Si nous envisageons les spots publicitaires qui abreuvent la télévision et les cinémas, nous sommes tous rapidement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/04/2007
• Auteurs : Olivier BourT. JacobFrédéric BoudinFrédérique MoreauR. BayerMarcia MaiaJean-Pierre CaudalPhilippe DavyOlivier DauteuilPierre GavrilenkoStéphane Durand
• Organismes : Géosciences Rennes Laboratoire Dynamique de la Lithosphère Institut de Physique du Globe de Paris Géosciences Rennes Laboratoire Dynamique de la Lithosphère Domaines Océaniques Géosciences Rennes Géosciences Rennes Géosciences Rennes Géosciences Rennes Laboratoire de géodésie et de géomatique

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2007
• Auteurs : Agnes DechartresIsabelle BoutronRemy NizardSerge PoiraudeauCarine RoyPhilippe RavaudJean-François Ravaud
• Organismes : Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques Département d'épidémiologie, biostatistique et recherche clinique Service d'Orthopédie Service d'Orthopédie Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap Université Paris Descartes - Faculté de Médecine Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques Département d'épidémiologie, biostatistique et recherche clinique Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques Département d'épidémiologie, biostatistique et recherche clinique Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap CERMES - Centre de recherche Médecine, Science, Santé Société Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques
• Publié dans Arthritis and Rheumatism le 27/10/2020

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Résumé : OBJECTIVE: To describe disability in individuals with hip arthroplasty and its evolution over 2 years compared with that in the general population, and to compare the degree of disability between subjects with recent and older hip arthroplasty. METHODS: We selected a national representative sample of 16,945 subjects from the 1999 French population census. This sample, interviewed in 1999 and 2001 about their level of disability, included 527 subjects with hip arthroplasty (i.e., representing 424,000 individuals in the French noninstitutionalized population): 145 who underwent the procedure between 1999 and 2001 (recent hip arthroplasty) and 382 with an older hip arthroplasty. RESULTS: Subjects with hip arthroplasty reported more difficulty in bending forward (odds ratio [OR] 4.5, 95% confidence interval [95% CI] 3.1-6.6), climbing stairs (OR 2.2, 95% CI 1.5-3.1), walking >300 meters (OR 1.6, 95% CI 1.03-2.6), dressing (OR 2.9, 95% CI 2.1-4.2), and getting in and out of a chair (OR 2.5, 95% CI 1.7-3.6) than the general population. However, the evolution in disability was similar to that of the general population. Compared with subjects with older hip arthroplasty, those with recent hip arthroplasty reported more difficulty walking >300 meters (OR 2.7, 95% CI 1.3-5.6), washing (OR 2.9, 95% CI 1.6-5.4), dressing (OR 2.2, 95% CI 1.2-4.2), and getting in and out of a chair (OR 2.1, 95% CI 1.1-3.9). CONCLUSION: This study describes the potential future disability in the more elderly population, with implications for health-related planning.

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Fichiers liés : HID2finalmodif61.pdf figure1modif.pdf figure2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2007
• Auteurs : Pascal JouquetNicolas BottinelliJean-Christophe LataPhilippe MoraSandrine Caquineau
• Organismes : Biodiversité et fonctionnement du sol Biodiversité et fonctionnement du sol Biogéochimie et écologie des milieux continentaux Biodiversité et fonctionnement du sol Institut de Recherche pour le Développement
• Publié dans Geoderma le 25/10/2020

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Résumé : This work focuses on the interactions between fungus-growing termites (Isoptera, Macrotermitinae), clay particles and soil organic matter (SOM). As major bioturbators in tropical ecosystems, termites create biogenic structures (galleries, sheetings, nests, mounds, fungus-comb chambers) that strongly influence the physical and chemical properties of soils. Different kinds of substrates were given to Pseudacanthotermes spiniger, one of the main famous Macrotermitinae termite species in West Africa: (i) clay (mainly illite), (ii) a mix of sand and clay, or (iii) sand. When we proposed both clay and sand, we observed a high selection of clay by termites. Observation of the properties of biogenic structures by Xray analysis showed that illite contained in the sheetings was strongly modified when compared to the bulk soil. We argue that the termite's saliva and/or the action of stimulated associate microorganisms have extracted un-exchangeable potassium, then leading to the creation of smectite layers. Thus, the termites P. spiniger, thanks to their building activity, can be seen as weathering agents of clay minerals. SOM content of the biogenic structures was found to be highly variable depending on the type of soil used (clay vs. sand) with enriched or impoverished C and N contents. Finally, we discuss how the auto-ecological requirements of termites (the balance between the cost of organic matter incorporation and the stability of the rehandled substrates) can affect soil and ecosystem functioning.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2007
• Auteurs : Pierre KrystkowiakSophie Tezenas Du MontcelLaurent VercueilJean-Luc HouetoChristelle LagrangePhilippe CornuSerge BlondAlim-Louis BenabidPierre PollakMarie Vidailhet
• Organismes : Noyaux gris centraux CHU Pitié-Salpêtrière [AP-HP] Département de neurologie Biologie de la communication cellulaire Service de neurologie [CHU de Poitiers] Département de neurologie Biologie de la communication cellulaire CHU Pitié-Salpêtrière [AP-HP] Service de neuro-chirurgie Biologie de la communication cellulaire Département de neurochirurgie Département de neurologie Biologie de la communication cellulaire CHU Saint-Antoine [AP-HP] Neurologie et thérapeutique expérimentale
• Publié dans Movement Disorders le 31/10/2020

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Résumé : BACKGROUND: The multicenter SPIDY trial (pallidal stimulation for generalized, idiopathic dystonia) recently reported a marked improvement in dystonia which was assessed by the Burke-Fahn-Marsden (BFM) scale. However, the reliability of this tool has rarely been evaluated and its use in a multicenter study has never been assessed prospectively. PURPOSE: To evaluate the concordance between three unblinded clinical raters and one single-blinded rater for 10 prospective series of ratings on the BFM scale in 22 dystonic patients of the SPIDY study. METHODS: Ten assessments on the BFM scale were performed under various stimulation conditions at different time points (before surgery and 1, 3, 6, and 12 months afterwards). Patients were first evaluated by three unblinded clinical raters (one per center). All assessments were videotaped and sent to a blinded rater. Intra- and inter-rater reliability was assessed using intraclass correlation coefficients. RESULTS: The intra-rater reliability at inclusion was better for the blinded rater than for the clinical raters. The inter-rater reliability (comparing the blinded rater with each clinical rater) was "very good" at inclusion, "fair" at month 1 and was "good" at month 3, month 6, and month 12. CONCLUSION: Blinding (rather than video) is probably the key factor in better intra-rater reliability and can produce more accurate rating than clinical rating. Consequently, a blind procedure should be performed systematically in multicenter studies. As inter-rater reliability is good in trained unblinded raters, the BFM scale may also be used in the follow up of dystonic patients in movement disorders centers, in clinical practice.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2007
• Auteurs : Jean-Pierre LevraudPierre BoudinotIngrid ColinAbdenour BenmansourNadine PeyriérasPhilippe HerbomelGeorges Lutfalla
• Organismes : Macrophages et Développement de l'Immunité Unité de recherche Virologie et Immunologie Moléculaires Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard Unité de recherche Virologie et Immunologie Moléculaires Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard Macrophages et Développement de l'Immunité Dynamique des interactions membranaires normales et pathologiques
• Publié dans Journal of Immunology le 27/10/2020

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Résumé : The recent description of virus-induced fish IFNs has raised questions about the evolution of this complex antiviral system. Identification of the receptor of the zebrafish virus-induced IFN (zIFN) was sought to help resolve these questions. We set up an experimental system to study the zIFN system in the course of a viral infection of zebrafish embryos. In this setting, zIFN was induced by viral infection, and we identified zIFN-dependent induced transcripts. Embryos quickly died from the infection, but zIFN overexpression increased their survival. We took advantage of this experimental system to perform in vivo loss and gain of function analysis of candidate receptors of the class II helical receptor family and identified zCRFB1 and zCRFB5 as the two subunits of the zebrafish IFN receptor. Based on the organization of the zIFN gene and the protein structure of the identified receptor components, the virus-induced fish IFNs appear as orthologs of mammalian IFN-lambda, specifying type III IFN as the ancestral antiviral system of vertebrates.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2007
• Auteurs : Michel MeybeckLaurence LestelPhilippe BontéR. MoilleronJean Louis ColinOlivier RousselotHervé DanielClaire de PontevèsCécile GrosboisDaniel R. Thevenot
• Organismes : Structure et fonctionnement des systèmes hydriques continentaux Centre d'histoire des techniques et de l'environnement Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Géochimie Des Impacts Centre d'Enseignement et de Recherche Eau Ville Environnement Laboratoire Interuniversitaire des Systèmes Atmosphériques Direction de la Recherche et du Développement Arrondissement des Boucles de la Seine Structure et fonctionnement des systèmes hydriques continentaux Hydrogéologie, Argiles, Sols et Altérations - UMR 6532 Centre d'Enseignement et de Recherche Eau Ville Environnement
• Publié dans Science of the Total Environment le 29/10/2020

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Résumé : The Driver-Pressures-State-Impact-Response approach is applied to heavy metals in the Seine River catchment (65,000 km(2); 14 million people of which 10 million are aggregated within Paris megacity; 30% of French industrial and agricultural production). The contamination pattern at river mouth is established on the particulate material at different time scales: 1930-2000 for floodplain cores, 1980-2003 for suspended particulate matter (SPM) and bed-sediments, 1994-2003 for atmospheric fallout and annual flood deposits. The Seine has been among the most contaminated catchments with maximum contents recorded at 130 mg kg(-1) for Cd, 24 for Hg, 558 for Pb, 1620 for Zn, 347 for Cu, 275 for Cr and 150 for Ni. Today, the average levels for Cd (1.8 mg kg(-1)), Hg (1.08), Pb (108), Zn (370), Cu (99), Cr (123) and Ni (31) are much lower but still in the upper 90% of the global scale distribution (Cr and Ni excepted) and well above the natural background values determined on pre-historical deposits. All metal contents have decreased at least since 1955/65, well before metal emission regulations that started in the mid 1970's and the metal monitoring in the catchment that started in the early 1980's. In the last 20 y, major criteria changes for the management of contaminated particulates (treated urban sludge, agricultural soils, dredged sediments) have occurred. In the mid 1990's, there was a complete shift in the contamination assessment scales, from sediment management and water usage criteria to the good ecological state, now required by the 2000 European Directive. When comparing excess metal outputs, associated to river SPM, to the average metal demand within the catchment from 1950 to 2000, the leakage ratios decrease exponentially from 1950 to 2000 for Cd, Cr, Cu, Pb and Zn, meanwhile, a general increase of the demand is observed: the rate of recycling and/or treatment of metals within the anthroposphere has been improved ten-fold. Hg environmental trajectory is very specific: there is a marked decontamination from 1970 to 2000, but the leakage ratio remains very high (10 to 20%) during this period. Drivers and Pressures are poorly known prior to 1985; State evolution since 1935 has been reconstructed from flood plain cores analysis; Impacts were maximum between 1950 and 1970 but remained unknown due to analytical limitation and lack of awareness. Some Responses are lagging 10 y behind monitoring and have much evolved in the past 10 y.

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Fichiers liés : STOTEN Metal-Trends-Meybecketal-2006-07-20.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/04/2007
• Auteurs : Benjamin PohlJean-Philippe DuvelPierre Camberlin
• Organismes : Centre de Recherches de Climatologie Laboratoire de Météorologie Dynamique (UMR 8539) Centre de Recherches de Climatologie

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Résumé : The Intraseasonal Oscillation (ISO; 20-120 day) is an important component of the variability of the Tropical convection that strongly perturbs the Asian and the Aus- tralian monsoons. Our knowledge of the physical origin of the ISO however remains largely incomplete, partially because of the large variability of its characteristics from one event to another. The aim is to determine how the patterns of the different ISO events may be objectively regrouped in a few types, related for example to season, ENSO or other large scale forcing. Patterns of the different ISO events are extracted using a Local Mode Analysis (LMA, Goulet and Duvel 2000). The LMA is based on complex empirical orthogonal functions computed for successive positions of a moving temporal window. When a maximum of variance percentage is detected, the pattern of the corresponding ISO event is extracted. For the present study, the ISO events are detected by an LMA applied on the 20-120-day band pass filtered OLR field for a large tropical region (0˚-200˚E; 30˚N-30˚S) and for the 1979-2005 period. The 144 events extracted are then objectively clustered into homogeneous types us- ing a Hierarchical Ascending Classification. Our classification in 8 types synthetically describes 50% of the overall diversity of the ISO events. The 8 types depict primarily the seasonality in the ISO modes, with the known north- ward (eastward) propagations over the Indian and Western Pacific basins during the northern summer (winter) seasons. While some similarities are noted from one type to another, important differences confirm however that the ISO may be classified in more than two types (i.e. the summer and winter types). In particular, some modes are very specific to particular months (bogus onset in May over the Bay of Bengal, for example). Also, different types are obtained for each season in relation to interannual variability of the sea surface temperature field related primarily to ENSO. This study also shows different equatorial propagation characteristics (i.e. Madden Julian Oscil- lation) for each type confirming that the MJO is not a phenomenon distinct from the ISO.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2007
• Auteurs : Fabrice LorchelKarine PeignauxGilles CréhangeMathieu BossetMarc PuyraveauMariette MercierJean-François BossetPhilippe Maingon
• Organismes : Service de Radiothérapie [CHRU Besançon] Service d'hématologie [Hôpital Edouard Herriot - HCL] Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) Laboratoire Pierre Süe Interactions et dynamique des environnements de surface Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181)
• Publié dans Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology le 30/10/2020

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Résumé : PURPOSE: We performed a retrospective analysis in order to evaluate the compliance with preoperative radiotherapy in patients aged>or=70 with locally advanced resectable rectal cancer, and to evaluate the influence of comorbidities on treatment tolerance and oncological results. METHODS: From March 1984 to December 2000, 95 patients with T3-T4 N0 M0 rectal cancer received a preoperative radiotherapy in 2 radiotherapy departments. Nineteen patients received concomitant chemotherapy. RESULTS: All patients completed the radiation schedule. Six patients suffered grade 3 acute WHO toxicity. Surgical resection was performed in 87 patients. There were 3 post-operative deaths. Analysis of peri-operative complications showed thromboembolism (4.9%), ileus (9.8%) and diarrhoea (6.1%). After a median follow-up of 29 months, the 3- and 5-year overall survival rates were 65% and 49% respectively. In univariate analysis, a tumour located in the mid part of the rectum, a radiation dose less than 40 Gy, the absence of chemotherapy were significantly associated with a poor prognosis. There was a trend to a better survival for patients with a Charlson score of 0 (P=0.0584). In multivariate analysis, only initial WHO performance status was significant. CONCLUSIONS: Compliance with preoperative radiotherapy is good in elderly patients. Toxicity rates are similar to those described in randomised trials in which only younger patients were included. Initial WHO performance status

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2007
• Auteurs : Sophie Le Ricousse-RoussanneJérôme LargheroJean-Marc ZiniVeronique BarateauPhilippe FoubertGeorges UzanXuhui LiuMarie-Noëlle LacassagneBrigitte TernauxIsabelle RobertMarc BenbunanJean-Thomas VilquinKarine VauchezGerard TobelemJean-Pierre Marolleau
• Organismes : Centre de recherche en Myologie – U974 SU-INSERM Centre de recherche en Myologie – U974 SU-INSERM
• Publié dans Experimental Cell Research le 25/10/2020

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