Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/11/2006
• Auteurs : Lin WuFrançois-Xavier Le DimetPhilippe de ReffyeBao-Gang Hu
• Organismes : State Key Laboratory of Lithospheric Evolution Modelling, Observations, Identification for Environmental Sciences Botanique et Modélisation de l'Architecture des Plantes et des Végétations Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées

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Résumé : In this paper a new mathematical formulation for plant structure dynamics is presented. We enhance the formulation of dual scale automaton by introducing botanic growth rules for an explicit description of chronological-age based structure dynamics. The merits of different plant architectural models are combined. The botanic concepts are introduced for not only the efficient simulations, but also the better integration of topological growth patterns and physiological laws, such that a complete functional-structural description of plant growth could be readily achieved.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 02/11/2006
• Auteurs : Sylvain HuonBoris BellangerPhilippe BontéStéphane SogonPascal PodwojewskiCyril GirardinChristian ValentinHendrina de RouwFernando VelasquezJean-Pierre BricquetAndré A. Mariotti
• Organismes : Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Géochimie Des Impacts Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Géochimie Des Impacts Sols, usages des terres, dégradation, réhabilitation Biogéochimie et écologie des milieux continentaux Sols, usages des terres, dégradation, réhabilitation Sols, usages des terres, dégradation, réhabilitation Sols, usages des terres, dégradation, réhabilitation Biogéochimie et écologie des milieux continentaux

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Résumé : Soils of tropical regions account for ca. 30 % of the terrestrial organic carbon pool. Present-day fires, deforestation and land use changes enhance soil erosion and soil organic matter mineralization, increasing as much the CO2 flux to the atmosphere and reducing the efficiency of organic carbon storage in soils. This chapter presents the results of several isotopic studies carried out on two cultivated watersheds with steep slopes located in tropical regions (Venezuela, Laos) in order to better: 1) link the erosion status and the organic carbon content of cultivated soils by coupling 137Cs and total organic carbon measurements; 2) constraint the source of suspended organic matter during flood events by monitoring the composition of suspended loads in runoff and stream flows with d15N and d13C measurements and; 3) evaluate the impact of a water reservoir set up at the outlet of a watershed on suspended organic carbon fluxes generated by erosion. The redistribution pattern of fallout 137Cs and the soil organic carbon content in the first 30 - cm layer of cultivated soils of the Houay Pano catchment (Laos) are significantly linked. A common process apparently relates the soil erosion status with the amount of organic matter contained in the topsoil horizons. However, the budgets based on soil organic carbon depletion trends are higher than those derived from 137Cs soil erosion rate models. This difference provides evidence for additional organic carbon losses, most likely controlled by mineralization of soil organic matter and dissolved organic carbon release by runoff. The d15N composition of fine-sized suspended organic matter transported by runoff and stream flows during flood events on the Rio Boconó watershed (Venezuela) highlights the contribution of particulate organic carbon derived from incisive erosion of organic matter bearing rocks (“fossil” organic carbon) of the geological basement (i.e.: shales and argillaceous rocks of the river banks). The extent of “fossil” organic carbon release depends on the intensity of the flood event. During an intense event with a return period of 10 years, the contribution of “fossil” organic carbon to suspended sediments was approximately equivalent to that of soils sensu stricto Monitoring the composition of fine (<50 µm or <200 µm) size suspended organic matter with d13C and d15N measurements during flood events also indicates that the transport of particulate organic matter is conservative at different scales for most of the stream flow, providing soil organic carbon specific erosions in the same order of magnitude. The extent of organic carbon transport in the hydrographic network can be thoroughly reduced by water reservoirs set up at the outlet of the watersheds. For the Peña Larga water reservoir, sedimentary accumulation and in-situ mineralization processes reduced by ca. 94 % the organic carbon outflow generated by erosion on the watershed.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2006
• Auteurs : Michel MoncuquetNicole MeyerJean-Louis BougeretSang HoangKarine IssautierAlain LecacheuxMilan MaksimovicFilippo PantelliniPhilippe ZarkaIoannis Zouganelis
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Jean-Philippe VerhoyeBertrand de LatourJean-François HeautotMarco VolaThierry LanganayHervé CorbineauAlain LeguerrierXavier BarralJean-Pierre Favre
• Organismes : Laboratoire Traitement du Signal et de l'Image Laboratoire Traitement du Signal et de l'Image Institut de médecine moléculaire de Rangueil
• Publié dans Annals of Vascular Surgery le 26/10/2020

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Résumé : We report the initial experience of two cardiovascular surgery centers in the treatment of descending thoracic aorta lesions with covered stent grafts in high-surgical risk patients. From April 1999 to November 2004, 54 patients, mean age 64 years (range 16-83), were treated by stent graft for a lesion of the descending aorta (degenerative aneurysms n = 22, aortic dissections n = 12, chronic post traumatic aneurysms n = 5, anastomotic false aneurysms n = 2, penetrating ulcers n = 4, intramural hematomas n = 5, traumatic rupture n = 4), with 42.6% treated on an emergency basis. Three devices were used: Talent (n = 49), Excluder (n = 4), and Zenith (n = 1). In three patients, combined surgery of the proximal aorta was performed. Prior bypass of the left supra-aortic arteries was performed in four patients. The follow-up was clinical and radiological (plain chest film and computed tomographic scan) at 1, 3, 6, 12, 18, and 24 months and yearly thereafter. The stent graft was successfully deployed in all cases. Two early deaths related to the stent graft (one migration and aortic rupture and one stroke) and one related to adult respiratory distress syndrome occurred. Morbidity was 16.6% (iliac access damage n = 4, groin reintervention n = 3, transient ischemic attack n = 1, tamponade n = 1). The follow-up was 100% complete (mean 22.8 months, range 3-51). Fifteen primary endoleaks (type I n = 6, type II n = 8, type III n = 1) and one secondary endoleak were reported. They were treated by additional stent graft (n = 7) and elective surgical conversion (n = 1). Six endoleaks resolved spontaneously at 6 months, and two are being monitored. Twelve endoleaks (75%) occurred in patients treated for degenerative aneurysms. Freedom from secondary reintervention was 81.3% at 3 years. Two transient paraparesias were observed at 3 and 18 months. Of the 13 deaths observed during the follow-up, only one was related to the stent graft. Actuarial survival at 12 and 24 months was 90.0% and 75.4%, respectively. Mortality results are encouraging in this specific cohort of high-surgical risk patients. A new kind of morbidity is observed, related to endoleaks, whose necessary management could hinder the durability of the technique.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2006
• Auteurs : Pierre-Jean BarreAlain BouscayrolPhilippe DelarueEric DumetzFrederic GiraudJean-Paul HautierXavier KestelynBetty Lemaire-SemailEric Semail
• Organismes : Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697

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Résumé : Causal Ordering Graph and Energetic Macroscopic Representation are graphical descriptions to model electromechanical systems using integral causality. Inversion rules have been defined in order to deduce control structure step-bystep from these graphical descriptions. These two modeling tools can be used together to develop a two-layer control of system with complex parts. A double-drive paper system is taken as an example. The deduced control yields good performances of tension regulation and velocity tracking.

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Fichiers liés : L2EP_IECON_2006_SEMAIL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Jean-Bernard PouvreauMichèle MorançaisFabrice FleuryPhilippe RosaLaurent ThionBlanche CahingtFranck ZalJoël FleurencePierre Pondaven
• Organismes : Unité de Biotechnologie, Biocatalyse et Biorégulation
• Publié dans Journal of Applied Phycology le 31/10/2020

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Résumé : Haslea ostrearia is a common marine tychopelagic diatom which has the particularity of synthesizing a blue-green hydrosoluble pigment called “marennine”. This pigment, when released into the external medium, is known to be responsible for the colour of oyster gills. Here we present results for main biophysical and biochemical characteristics of pure intra- and extracellular marennine. Tests for chemical determination show that the nature of the two forms of marennine cannot be distinguished and could be related to a polyphenolic compound. Nevertheless, based on spectral properties and the molecular weight, which is about 10751 ± 1 and 9893 ± 1 Da, for the intracellular and extracellular forms respectively, we assess that the pigment accumulated in the apex of the cell and the one released in the external medium have probably distinct molecular structures.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Elodie Blanc-DelmasNicolas LebegueValérie WallezVéronique LeclercSaïd YousPascal CaratoAmaury FarceCaroline BennejeanPierre RenardDaniel-Henri CaignardValérie Audinot-BouchezPascale ChomaratJean BoutinNathalie HennuyerKatie LoucheMaria Carmen CarmonaBart StaelsLuc PénicaudLouis CasteillaMichel LonchamptCatherine DacquetPhilippe ChavattePascal BerthelotDaniel Lesieur
• Organismes : Université de Lille Université de Lille Université de Lille Université de Lille Université de Lille Université de Lille Université de Lille Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Université de Lille Laboratoire Servier Laboratoire Servier Laboratoire Servier Laboratoire Servier Université de Lille Université de Lille Université de Lille
• Publié dans Bioorganic and Medicinal Chemistry le 28/10/2020

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/11/2006
• Auteurs : Sébastien RogerPierre BessonPhilippe BougnouxJean-Yves Le Guennec
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif

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Résumé : Ionic channels are proteins embedded into the plasma membrane allowing ions to flow into or out of the cells, depending on the electrochemical gradient (see figure 1). Voltage-gated sodium channels (NaV1) are classically found in excitable cells since they are responsible for the depolarisation phase and propagation of action potentials. Tetrodotoxin (TTX), a toxin isolated from tetradontidae puffer fishes, is the reference inhibitor of NaV1 (figure 2). The involvement of ionic channels in oncogenic properties such as proliferation has been known since the 1980s but it took nearly a decade before they were explored functionally (see [1]). In 1997, the expression of functional NaV1 was observed in a human prostatic metastatic cell line [2]. Recently, the presence of the channel protein was correlated with the grade of the disease [3]. In 2003 we described for the first time the presence of a NaV1 in a human breast metastatic cancer cell line, MDA-MB-231 [4]. Later on it was shown that the channel expressed in these cells is the cardiac isoform NaV1.5 [11]. Inhibiting the channel with TTX or conversely increasing its activity with veratridine allowed the demonstration of a high correlation between the activity of the channel and the capacity of the cells to invade a Matrigel® which mimics the extracellular matrix (see figure 3). The membrane potential of breast cancer cells is located within the range -30 to -40mV. At this potential, NaV1.5 are partially open. Thus they let sodium ions enter into the cells continuously. Such a perturbation of the homeostasis of sodium could disturb intracellular pH and calcium homeostasis which in turn could modulate some proteolytic activities. Indeed, we observed that some cysteine proteases, also known as cathepsins, are regulated by functional NaV1.5 (see figure 4). Later on, it was found that NaV1.5 (foetal variant) can be observed in biopsies and this expression is correlated to the grade of the disease [9]. We also worked with the non-small lung cancer cell (NSCLC) lines A549, H23, H460 and Calu-1 and the immortalized non cancerous cell lines NL-20 and BEAS-2B [10]. We did not find any sodium current in these cells (NL-20 and BEAS-2B) nor in the weakly metastatic cell line A549. Conversely, the strongly metastatic cell lines H23, H460 and Calu-1 expressed functional NaV1. The common feature between all the cancer cells expressing functional channels is that the activity of the channels almost doubles the capacity of the cells to invade Matrigel® whatever the isoform of the functional channels.

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Fichiers liés : Roger_et_al_Toxines.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Marie Potier-CartereauVirginie JoulinSébastien RogerPierre BessonMarie-Lise JourdanJean-Yves LeguennecPhilippe BougnouxChristophe Vandier
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif
• Publié dans Mol Cancer Ther le 01/01/2003

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Résumé : Potassium channels have been involved in epithelial tumorigenesis but the role of small-conductance Ca(2+)-activated K(+) channels is unknown. We report here that small-conductance Ca(2+)-activated K(+) channels are expressed in a highly metastasizing mammary cancer cell line, MDA-MB-435s. Patch-clamp recordings showed typical small-conductance Ca(2+)-activated K(+) channel-mediated currents sensitive to apamin, 4-aminopyridine, and tetraethylammonium. Moreover, the cells displayed a high intracellular calcium concentration, which was decreased after 24 hours of apamin treatment. By regulating membrane potential and intracellular calcium concentration, these channels were involved in MDA-MB-435s cell migration, but not in proliferation. Only SK3 protein expression was observed in these cells in contrast to SK2, which was expressed both in cancer and noncancer cell lines. Whereas small interfering RNA directed against SK3 almost totally abolished MDA-MB-435s cell migration, transient expression of SK3 increased migration of the SK3-deficient cell lines, MCF-7 and 184A1. SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues. Thus, SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a potential target for a new class of anticancer agents. [Mol Cancer Ther 2006;5(11):2946-53].

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2006
• Auteurs : Pierre-François MorlatPhilippe MaryGuillaume VillemaudJean-Marie GorceMarylin Arndt
• Organismes : Architectures of networks of services France Télécom Recherche & Développement Architectures of networks of services Architectures of networks of services France Télécom Recherche & Développement

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Résumé : This paper assesses the efficiency of a multi standard and multi antenna receiver using simulation and test measurements in a real propagation environment. A multi-standard and multi-antenna receiver is firstly designed with the ADS© software. Secondly, the performance of this system is evaluated with several multi-antenna algorithms, under real radio propagation conditions depending on the standard we choose to deal with. At this time the receiver can run with 802.11b and 802.11g standards in a 36 MHz bandwidth. Some first results are presented using multi antenna algorithm in a receiver dealing with two 802.11g or 802.11b transmission on overlapped communication channels.

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