Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/08/2006
• Auteurs : Sylvestre LacourGuy PerrinXavier HauboisSerge MeimonJohn D. MonnierJean-Philippe BergerWesley A. TraubPeter A. Schuller
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA

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• Type de publi. : Article dans une revue
• Date de publi. : 16/08/2006
• Auteurs : Robert NymanGaël VaroquauxFabien LienhartDamien ChambonSalah BoussenJean-François ClémentT. MullerGiorgio SantarelliFranck Pereira dos SantosAndré ClaironAlexandre BressonArnaud LandraginPhilippe Bouyer
• Organismes : laboratoire Charles Fabry de l'Institut d'Optique / Optique atomique laboratoire Charles Fabry de l'Institut d'Optique / Optique atomique ONERA - The French Aerospace Lab [Châtillon] Systèmes de Référence Temps Espace ONERA - The French Aerospace Lab [Châtillon] laboratoire Charles Fabry de l'Institut d'Optique / Optique atomique Systèmes de Référence Temps Espace Institute for Quantum Optics Systèmes de Référence Temps Espace Systèmes de Référence Temps Espace Systèmes de Référence Temps Espace ONERA - The French Aerospace Lab [Châtillon] Systèmes de Référence Temps Espace laboratoire Charles Fabry de l'Institut d'Optique / Optique atomique
• Publié dans Applied Physics B - Laser and Optics le 28/10/2020

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Résumé : We present our the construction of an atom interferometer for inertial sensing in microgravity, as part of the I.C.E. (\textit{Interf\'{e}rom\'{e}trie Coh\'{e}rente pour l'Espace}) collaboration. On-board laser systems have been developed based on fibre-optic components, which are insensitive to mechanical vibrations and acoustic noise, have sub-MHz linewidth, and remain frequency stabilised for weeks at a time. A compact, transportable vacuum system has been built, and used for laser cooling and magneto-optical trapping. We will use a mixture of quantum degenerate gases, bosonic $^{87}$Rb and fermionic $^{40}$K, in order to find the optimal conditions for precision and sensitivity of inertial measurements. Microgravity will be realised in parabolic flights lasting up to 20s in an Airbus. We show that the factors limiting the sensitivity of a long-interrogation-time atomic inertial sensor are the phase noise in reference frequency generation for Raman-pulse atomic beam-splitters and acceleration fluctuations during free fall.

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Fichiers liés : ICE_ps.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/08/2006
• Auteurs : João ZilhãoFrancesco D’erricoJean-Guillaume BordesArnaud LenoblePierre-Jean TexierJean-Philippe Rigaud
• Organismes : Department of Archaeology and Anthropology De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : The Châtelperronian is a Neandertal-associated archeological culture featuring ornaments and decorated bone tools. It is often suggested that such symbolic items do not imply that Neandertals had modern cognition and stand instead for influences received from coeval, nearby early modern humans represented by the Aurignacian culture, whose precocity would be proven by stratigraphy and radiocarbon dates. The Grotte des Fées at Châtelperron (France) is the remaining case of such a potential Châtelperronian–Aurignacian contemporaneity, but reanalysis shows that its stratification is poor and unclear, the bone assemblage is carnivore-accumulated, the putative interstratified Aurignacian lens in level B4 is made up for the most part of Chaˆ telperronian material, the upper part of the sequence is entirely disturbed, and the few Aurignacian items in levels B4-5 represent isolated intrusions into otherwise in situ Châtelperronian deposits. As elsewhere in southwestern Europe, this evidence confirms that the Aurignacian postdates the Châtelperronian and that the latter's cultural innovations are better explained as the Neandertals' independent development of behavioral modernity.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 13/08/2006
• Auteurs : Hélène GilbertJean Pierre BidanelJoseph GruandJean-Claude CaritezYvon BillonPhilippe P. GuillouetJean NobletPierre P. Sellier
• Organismes : Station de Génétique Quantitative et Appliquée Station de Génétique Quantitative et Appliquée Unité de selection porcine Génétique Expérimentale en Productions Animales Génétique Expérimentale en Productions Animales Insémination Caprine et Porcine Systèmes d'Elevage, Nutrition Animale et Humaine Station de Génétique Quantitative et Appliquée

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• Type de publi. : Article dans une revue
• Date de publi. : 12/08/2006
• Auteurs : Pierre MahéLiva RalaivolaVéronique StovenJean-Philippe Vert
• Organismes : Centre de Bioinformatique Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Centre de Bioinformatique Centre de Bioinformatique
• Publié dans Journal of Chemical Information and Modeling le 27/10/2020

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Résumé : We introduce a family of positive definite kernels specifically optimized for the manipulation of 3D structures of molecules with kernel methods. The kernels are based on the comparison of the three-point pharmacophores present in the 3D structures of molecules, a set of molecular features known to be particularly relevant for virtual screening applications. We present a computationally demanding exact implementation of these kernels, as well as fast approximations related to the classical fingerprint-based approaches. Experimental results suggest that this new approach is competitive with state-of-the-art algorithms based on the 2D structure of molecules for the detection of inhibitors of several drug targets.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Evelyne DerelleConchita FerrazStephane RombautsPierre RouzéAlexandra Z WordenSteven RobbensFrédéric PartenskySven DegroeveSophie EcheyniéRichard CookeYvan SaeysJan WuytsKamel JabbariChris BowlerOlivier PanaudBenoît PiéguSteven G BallJean-Philippe RalFrancois-Yves BougetG. PiganeauBernard de BaetsAndré PicardMichel DelsenyJacques DemailleYves van de PeerHervé Moreau
• Organismes : Modèles en biologie cellulaire et évolutive Institut de génétique humaine VIB-UGent Center for Plant Systems Biology VIB-UGent Center for Plant Systems Biology Adaptation et diversité en milieu marin VIB-UGent Center for Plant Systems Biology Institut de génétique humaine Laboratoire Génome et développement des plantes VIB-UGent Center for Plant Systems Biology VIB-UGent Center for Plant Systems Biology Laboratoire Génome et développement des plantes Laboratoire Génome et développement des plantes Modèles en biologie cellulaire et évolutive Modèles en biologie cellulaire et évolutive Modèles en biologie cellulaire et évolutive Laboratoire Génome et développement des plantes Institut de génétique humaine VIB-UGent Center for Plant Systems Biology Modèles en biologie cellulaire et évolutive
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : The green lineage is reportedly 1,500 million years old, evolving shortly after the endosymbiosis event that gave rise to early photosynthetic eukaryotes. In this study, we unveil the complete genome sequence of an ancient member of this lineage, the unicellular green alga Ostreococcus tauri (Prasinophyceae). This cosmopolitan marine primary producer is the world's smallest free-living eukaryote known to date. Features likely reflecting optimization of environmentally relevant pathways, including resource acquisition, unusual photosynthesis apparatus, and genes potentially involved in C(4) photosynthesis, were observed, as was downsizing of many gene families. Overall, the 12.56-Mb nuclear genome has an extremely high gene density, in part because of extensive reduction of intergenic regions and other forms of compaction such as gene fusion. However, the genome is structurally complex. It exhibits previously unobserved levels of heterogeneity for a eukaryote. Two chromosomes differ structurally from the other eighteen. Both have a significantly biased G+C content, and, remarkably, they contain the majority of transposable elements. Many chromosome 2 genes also have unique codon usage and splicing, but phylogenetic analysis and composition do not support alien gene origin. In contrast, most chromosome 19 genes show no similarity to green lineage genes and a large number of them are specialized in cell surface processes. Taken together, the complete genome sequence, unusual features, and downsized gene families, make O. tauri an ideal model system for research on eukaryotic genome evolution, including chromosome specialization and green lineage ancestry.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Brigitte GranelChristophe ChevillardYannick AllanoreViolaine ArnaudSandrine CabantousSandrine MarquetPierre-Jean WeillerJean-Marc DurandJean-Robert HarléClaire GrangeYves FrancesPhilippe BerbisJean GaudartPhilippe de MiccoAndré KahanAlain Dessein
• Organismes : Hôpital Nord [CHU - APHM] Génétique et immunologie des maladies parasitaires Service de rhumatologie [CHU Cochin] UNIROUEN - UFR Santé Institut de biologie et chimie des protéines [Lyon] Génétique et immunologie des maladies parasitaires Service de Médecine Interne Hôpital Edouard Herriot, Pavillon T Service de Chirurgie Centre de Recherche Roland Mousnier Histoire et Civilisation Service de Médecine interne [CHU Saint-Etienne] Hôpital Nord [CHU - APHM] Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Anthropologie bio-culturelle, Droit, Ethique et Santé Service de rhumatologie [CHU Cochin] Génétique et immunologie des maladies parasitaires
• Publié dans Immunogenetics le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Jamal BamoulidCécile CourivaudMarina DeschampsPatricia MercierChristophe FerrandAlfred PenfornisPierre TiberghienJean-Marc ChalopinPhilippe SaasDidier Ducloux
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Service de Diabétologie - Endocrinologie [CHRU Besançon] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon
• Publié dans Journal of the American Society of Nephrology le 26/10/2020

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Résumé : New-onset diabetes after transplantation (NODAT) is a serious complication of transplantation. This study tested whether IL-6 production capacity may influence the development of NODAT in two different groups of patients. The occurrence of NODAT was analyzed with respect to IL-6 gene promoter polymorphism at position -174 (G-->C) and other relevant risk factors retrospectively in 217 renal transplant recipients and prospectively in 132. A linear increase in both circulating IL-6 (P = 0.09) and C-reactive protein (an indicator of basal IL-6 secretion; P = 0.03) concentrations from the CC genotype to the GG genotype was observed. In the multivariate model, the CC genotype was associated with a decreased risk for NODAT compared with the GG genotype in the two cohorts. Homeostasis Model Assessment for Insulin Resistance also revealed lesser insulin sensitivity in the GG carriers than in the CC carriers (2.15 +/- 2 versus 1.32 +/- 1.03; P = 0.03). Subgroup analysis showed that the influence of IL-6 gene promoter polymorphism on the development of NODAT was restricted mostly to overweight patients. These results highly suggest that IL-6 production capacity influences the development of NODAT and that diabetes-inducing drug administration should be limited in overweight patients who carry the GG genotype.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Jean-Claude DesportPhilippe CouratierPierre-Marie Preux
• Organismes : Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale et Comparée Université de Limoges Neuroépidémiologie Tropicale et Comparée Université de Limoges Neuroépidémiologie Tropicale et Comparée Université de Limoges
• Publié dans Clinical Nutrition le 30/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Constant VodouhêErell Le GuenJuan Mendez GarzaGregory FranciusChristophe DéjugnatJoëlle OgierPierre SchaafJean-Claude VoegelPhilippe Lavalle
• Organismes : Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Max Planck Institute of Colloids and Interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces
• Publié dans Biomaterials le 28/10/2020

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Résumé : A surface coating based on polylysine/hyaluronic acid multilayers was designed and acted as a reservoir for an antiproliferative agent, paclitaxel (Taxol). Absolutely no chemical modification of polyelectrolytes or of the drug was needed and the final architecture was obtained in an extremely simple way using the layer-by-layer method. The paclitaxel dose available for human colonic adenocarcinoma cells HT29 seeded on the films could be finely tuned. Moreover, the accessibility of the drugs was controlled by adding on the top of the drug reservoir a capping made of synthetic polyelectrolyte multilayers. This capping was also required to allow adhesion of HT29 cells. Paclitaxel activity was maintained after embedding in the polyelectrolyte multilayers and cellular viability could be reduced by about 80% 96 h after seeding. The strategy described in this paper could be valuable for various other drug/cell systems.

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