Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : J.V. BrugniauxLaurent SchmittPaul RobachGérard NicoletJean-Pierre FouillotStéphane MoutereauFrançoise LasneVincent PialouxPhilippe SaasMarie-Claude ChorvotJérémy CornoloNiels V. OlsenJean-Paul Richalet
• Organismes : Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Image et ville Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Service de Biochimie [Mondor] Agence Française de Lutte contre le Dopage Laboratoire de Physiologie-Biologie du Sport Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Department of Pharmacology and Pharmacotherapy [Copenhagen] Réponses Cellulaires et Fonctionnelles à l'Hypoxie
• Publié dans Journal of Applied Physiology le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Aysen TezcanerDavid HicksFouzia BoulmedaisJosé-Alain SahelPierre SchaafJean-Claude VoegelPhilippe Lavalle
• Organismes : Department of Engineering Sciences Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Biomatériaux : Processus biophysiques et biologiques aux interfaces Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Institut de la Vision Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces
• Publié dans Biomacromolecules le 28/10/2020

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Résumé : Reconstruction of extracellular matrix substrates for delivery of functional photoreceptors is crucial in pathologies such as retinal degeneration and age-related macular degeneration. In this study, we assembled polyelectrolyte films using the layer-by-layer deposition method. The buildup of three different films composed of poly(L-lysine)/chondroitin sulfate (PLL/CSA), poly(L-lysine)/poly(styrenesulfonate) (PLL/PSS), or poly(L-lysine)/hyaluronic acid (PLL/HA) was followed by means of quartz crystal microbalance measurements, optical waveguide light mode spectroscopy, confocal microscopy, and atomic force microscopy. The exponential growth regime and the diffusion of PLL chains from the bulk through the PLL/CSA, PLL/PSS, and PLL/HA films was examined. Evaluation of photoreceptor cell viability was optimal on one layer of PLL (PLL(1)), followed by 10 bilayers of PLL/HA [(PLL/HA)(10)] and 10 bilayers of PLL/CSA [(PLL/CSA)(10)]. The number of bilayers and the type of terminating layer also had a significant influence on the number of photoreceptor cells attached. Functionalized polyelectrolyte multilayer films were obtained by adsorbing basic fibroblastic factor (bFGF) or the insoluble fraction of interphotoreceptor matrix (IPM) on or within polyelectrolyte multilayers. bFGF and IPM adsorption on top of the (PLL/CSA)(10)/PLL polyelectrolyte films increased the number of photoreceptor cells attached and maintained the differentiation of rod and cone cells.

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Fichiers liés : Biomacromolecules_revised_.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Philippe ThomasFabrice LallouéPierre-Marie PreuxCyril Hazif-ThomasSylvie ParielRobcis InscaleJoël BelminJean-Pierre Clément
• Organismes : Centre de Mémoire de Ressources et de Recherches [Limoges] Homéostasie Cellulaire et Pathologies Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] CHRU Brest - Psychiatrie Adulte CHU Charles Foix [AP-HP] CHU Charles Foix [AP-HP] Centre de Mémoire de Ressources et de Recherches [Limoges] Neuroépidémiologie Tropicale et Comparée Service de Psychiatrie [CHU Limoges]
• Publié dans International Journal of Geriatric Psychiatry le 25/10/2020

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Résumé : BACKGROUND: Alzheimer's disease and related syndromes have heavy social and human consequences for the patient and his family. Beyond the neuropsychiatric effects of specific therapies for dementia, one of today's challenges is the quality of life for both patients and their informal caregivers. OBJECTIVES: This survey tends to determine parameters influencing caregivers' quality of life, and its possible link with patients' quality of life. METHODS: A scale measuring caregivers' quality of life, developed from data from previous PIXEL studies was used. It is a questionnaire composed of 20 items. The scale was related to the socio-demographic data of both patients and their main caregivers, to the ADRQL scale (Alzheimer Disease Related Quality Life) of Rabins for the QoL of dementia patients, to the patients medical and therapeutic data, specially a neuropsychological inventory: Folstein's cognition test, Cornell's depression scale, the fast battery of frontal assessment, Katz's dependence index, Cummings' neuropsychiatric inventory for behavioral and psychological symptoms of dementia and to a physician evaluation of caregiver's depression. RESULTS: One hundred patients diagnosed with dementia who live at home with their principal caregivers were recruited for this survey. Patients were 80.2 +/- 6.8 years old and caregivers were 65.7 +/- 12.8 years old. The caregivers' quality of life was correlated to the quality of life of the patients they cared for, the importance of behavioral disorders, and the duration of dementia evolution. Women caregivers had a worse quality of life and were more depressive than men. DISCUSSION: Caregivers' and patients' quality of life are related and both share a community of distress.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : J.V. BrugniauxL. SchmittPaul RobachGérard NicoletJean-Pierre FouillotStéphane MoutereauFrançoise LasneVincent PialouxPhilippe SaasMarie-Claude ChorvotJérémy CornoloNiels V. OlsenJean-Paul Richalet
• Organismes : Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Département Médical Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Service de Biochimie [Mondor] Laboratoire National de Dépistage du Dopage Laboratoire de Physiologie-Biologie du Sport Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Department of Pharmacology and Pharmacotherapy [Copenhagen] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire
• Publié dans Journal of Applied Physiology le 02/11/2020

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Résumé : The efficiency of "living high, training low" (LHTL) remains controversial, despite its wide utilization. This study aimed to verify whether maximal and/or submaximal aerobic performance were modified by LHTL and whether these effects persist for 15 days after returning to normoxia. Last, we tried to elucidate whether the mechanisms involved were only related to changes in oxygen-carrying capacity. Eleven elite middle-distance runners were tested before (Pre), at the end (Post1), and 15 days after the end (Post2) of an 18-day LHTL session. Hypoxic group (LHTL, n = 5) spent 14 h/day in hypoxia (6 nights at 2,500 m and 12 nights at 3,000 m), whereas the control group (CON, n = 6) slept in normoxia (1,200 m). Both LHTL and CON trained at 1,200 m. Maximal oxygen uptake and maximal aerobic power were improved at Post1 and Post2 for LHTL only (+7.1 and +3.4% for maximal oxygen uptake, +8.4 and +4.7% for maximal aerobic power, respectively). Similarly oxygen uptake and ventilation at ventilatory threshold increased in LHTL only (+18.1 and +12.2% at Post1, +15.9 and +15.4% at Post2, respectively). Heart rate during a 10-min run at 19.5 km/h decreased for LHTL at Post2 (-4.4%). Despite the stimulation of erythropoiesis in LHTL shown by the 27.4% increase in serum transferrin receptor and the 10.1% increase in total hemoglobin mass, red cell volume was not significantly increased at Post1 (+9.2%, not significant). Therefore, both maximal and submaximal aerobic performance in elite runners were increased by LHTL mainly linked to an improvement in oxygen transport in early return to normoxia and probably to other process at Post2.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Marie-Bérengère TroadecDenise GlaiseGuillaume LamiraultMartine Le CunffEmilie GuérinNolwenn Le MeurLénaïck DétivaudPierre J. ZindyPatricia LeroyerIsabelle GuisleHélène DuvalPhilippe GriponNathalie ThéretKarim BoudjemaChristiane Guguen-GuillouzoPierre BrissotJean J. LégerOlivier Loréal
• Organismes : Institut de Génétique et Développement de Rennes Régulations des équilibres fonctionnels du foie normal et pathologique Régulations des équilibres fonctionnels du foie normal et pathologique Physiopathologie et pharmacologie cellulaires et moléculaires Physiopathologie et pharmacologie cellulaires et moléculaires Régulations des équilibres fonctionnels du foie normal et pathologique Physiopathologie et pharmacologie cellulaires et moléculaires Signalisation et Réponses aux Agents Infectieux et Chimiques Régulations des équilibres fonctionnels du foie normal et pathologique Foie, métabolismes et cancer Détoxication et réparation tissulaire Régulations des équilibres fonctionnels du foie normal et pathologique Foie, métabolismes et cancer Physiopathologie et pharmacologie cellulaires et moléculaires Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Régulations des équilibres fonctionnels du foie normal et pathologique Signalisation et Réponses aux Agents Infectieux et Chimiques Signalisation et Réponses aux Agents Infectieux et Chimiques Détoxication et réparation tissulaire Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes] Régulations des équilibres fonctionnels du foie normal et pathologique Régulations des équilibres fonctionnels du foie normal et pathologique Régulations des équilibres fonctionnels du foie normal et pathologique Foie, métabolismes et cancer Physiopathologie et pharmacologie cellulaires et moléculaires Régulations des équilibres fonctionnels du foie normal et pathologique Foie, métabolismes et cancer
• Publié dans Genomics le 25/10/2020

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Résumé : High liver iron content is a risk factor for developing hepatocellular carcinoma (HCC). However, HCC cells are always iron-poor. Therefore, an association between hepatocyte iron storage capacity and differentiation is suggested. To characterize biological processes involved in iron loading capacity, we used a cDNA microarray to study the differentiation of the human HepaRG cell line, from undifferentiated proliferative cells to hepatocyte differentiated cells. We were able to identify genes modulated along HepaRG differentiation, leading us to propose new genes not previously associated with HCC. Moreover, using Gene Ontology annotations, we demonstrated that HepaRG hepatocyte iron loading capacity occurred both with the repression of genes involved in cell motility, signal transduction, and biosynthesis and with the appearance of genes linked to lipid metabolism and immune response. These results provide new insights in the understanding of the relationship between iron and hepatocyte differentiation during iron-related hepatic diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : François M. KleinclaussSylvain PerrucheEmeline MassonMarcelo de Carvalho-BittencourtSabeha BiichleJean-Paul Remy-MartinChristophe FerrandMael MartinHugues BittardJean-Marc ChalopinEstelle SeillesPierre TiberghienPhilippe Saas
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
• Publié dans Cell Death and Differentiation le 29/10/2020

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Résumé : Apoptotic leukocytes are endowed with immunomodulatory properties that can be used to enhance hematopoietic engraftment and prevent graft-versus-host disease (GvHD). This apoptotic cell-induced tolerogenic effect is mediated by host macrophages and not recipient dendritic cells or donor phagocytes present in the bone marrow graft as evidenced by selective cell depletion and trafficking experiments. Furthermore, apoptotic cell infusion is associated with TGF-beta-dependent donor CD4+CD25+ T-cell expansion. Such cells have a regulatory phenotype (CD62L(high) and intracellular CTLA-4+), express high levels of forkhead-box transcription factor p3 (Foxp3) mRNA and exert ex vivo suppressive activity through a cell-to-cell contact mechanism. In vivo CD25 depletion after apoptotic cell infusion prevents the apoptotic cell-induced beneficial effects on engraftment and GvHD occurrence. This highlights the role of regulatory T cells in the tolerogenic effect of apoptotic cell infusion. This novel association between apoptosis and regulatory T-cell expansion may also contribute to preventing deleterious autoimmune responses during normal turnover.

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Fichiers liés : F_Kleinclauss_Cell_Death_Differ_200-2.pdf inserm-00473141_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Frédéric MarchalDominique EliasPhilippe RauchRasa ZarnegarAgnès LerouxJoseph StinèsJean-Luc VerhaegheFrançois GuilleminJean-Pierre CarteauxJean-Pierre Villemot
• Organismes : Centre Alexis Vautrin Institut Gustave Roussy Centre Alexis Vautrin Institut Gustave Roussy Centre Alexis Vautrin Centre Alexis Vautrin Centre Alexis Vautrin Centre Alexis Vautrin Centre de Recherche en Automatique de Nancy Centre Alexis Vautrin Chirurgie Expérimentale
• Publié dans Annals of Surgery le 26/10/2020

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Résumé : OBJECTIVE: To prevent bile duct injury by using a cold 5% glucose isotonic solution cooling in the bile ducts when radiofrequency (RF) is performed in a porcine model. SUMMARY BACKGROUND DATA: Complications that may arise during liver RF ablation include biliary stenosis and abscesses. METHODS: The RITA 1500 generator was used for the experiments. Two lesions were performed in the left liver. The pigs were killed 1 or 3 weeks after the procedure. An ex vivo cholangiogram was obtained by direct injection into the main bile duct. Samples of RF lesions, of liver parenchyma near and at a distance from the RF lesions, underwent pathologic studies. Two groups of 20 pigs each were treated: one without perfusion of the bile ducts and the other with perfusion of cold 5% glucose isotonic solution into the bile ducts. The Pringle maneuver was used in 50% of the RF procedures. Radiologic lesions were classified as biliary stenosis, complete interruption of the bile duct, or extravasation of the radiologic contrast liquid. RESULTS: Histologic lesions of the bile ducts were observed near the ablated RF lesion site and at a distance from the RF lesions when a Pringle maneuver was performed. Radiologic and histologic lesions of the bile ducts were significantly reduced (P < 0.0001) when the bile ducts were cooled. CONCLUSIONS: Cooling of the bile ducts with a cold 5% glucose isotonic solution significantly protects the intrahepatic bile ducts from damages caused by the heat generated by RF when performed close to the bile ducts.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Gilles MartelAmmar HideurBülend OrtaçJean-Bernard LecourtC. ChédotMarc BrunelB. ChéronJens LimpertT. TunnermannPhilippe GreluMaud GuezoC. LabbeSlimane LoualichePhilippe RoussignolFrançois SanchezH. LeblondA. Komarov
• Organismes : Complexe de recherche interprofessionnel en aérothermochimie Complexe de recherche interprofessionnel en aérothermochimie Complexe de recherche interprofessionnel en aérothermochimie Institut für Angewandte Physik Complexe de recherche interprofessionnel en aérothermochimie Complexe de recherche interprofessionnel en aérothermochimie Complexe de recherche interprofessionnel en aérothermochimie Complexe de recherche interprofessionnel en aérothermochimie Institut für Angewandte Physik Fraunhofer Institute for Applied Optics and Precision Engineering [Jena] Fraunhofer Institute for Applied Optics and Precision Engineering [Jena] Laboratoire de Physique de l'Université de Bourgogne Fonctions Optiques pour les Technologies de l'informatiON Fonctions Optiques pour les Technologies de l'informatiON Fonctions Optiques pour les Technologies de l'informatiON Laboratoire Pierre Aigrain Propriétés Optiques des Matériaux et Applications Propriétés Optiques des Matériaux et Applications Propriétés Optiques des Matériaux et Applications Institute of Automation and Electrometry
• Publié dans Journal de Physique IV Proceedings le 01/01/2003

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Gentiane VenturePierre-Jean RipertWisama KhalilMaxime GautierPhilippe Bodson
• Organismes : Institut de Recherche en Communications et en Cybernétique de Nantes Institut de Recherche en Communications et en Cybernétique de Nantes Institut de Recherche en Communications et en Cybernétique de Nantes Institut de Recherche en Communications et en Cybernétique de Nantes PSA Peugeot-Citroen
• Publié dans IEEE Transactions on Intelligent Transportation Systems le 26/10/2020

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Résumé : This paper deals with the problem of dynamicmodeling and identification of passenger cars. It presents a new method that is based on robotics techniques for modeling and description of tree-structured multibody systems. This method enables us to systematically obtain the dynamic identification model, which is linear with respect to the dynamic parameters. The estimation of the parameters is carried out using a weighted least squares method. The identification is tested using vehicle dynamics simulation software used by the car manufacturer PSA Peugeot-Citroën in order to define a set of trajectories with good excitation properties and to determine the number of degrees of freedom of the model. The method has then been used to estimate the dynamic parameters of an experimental Peugeot 406, which is equipped with different position, velocity, and force sensors.

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Fichiers liés : IEEE_ITS5-final-mars-06.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Aurélien DantanJean CviklinskiMichel PinardPhilippe Grangier
• Organismes : Laboratoire Charles Fabry de l'Institut d'Optique / Optique quantique Laboratoire Kastler Brossel Laboratoire Kastler Brossel Laboratoire Charles Fabry de l'Institut d'Optique / Optique quantique
• Publié dans Physical Review A : Atomic, molecular, and optical physics [1990-2015] le 02/11/2020

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Résumé : We study the transfer dynamics of non-classical fluctuations of light to the ground-state collective spin components of an atomic ensemble during a pulsed quantum memory sequence, and evaluate the relevant physical quantities to be measured in order to characterize such a quantum memory. We show in particular that the fluctuations stored into the atoms are emitted in temporal modes which are always different than those of the readout pulse, but which can nevertheless be retrieved efficiently using a suitable temporal mode-matching technique. We give a simple toy model - a cavity with variable transmission - which accounts for the behavior of the atomic quantum memory.

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Fichiers liés : memoire7.pdf

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