Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Constant VodouhêErell Le GuenJuan Mendez GarzaGregory FranciusChristophe DéjugnatJoëlle OgierPierre SchaafJean-Claude VoegelPhilippe Lavalle
• Organismes : Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Max Planck Institute of Colloids and Interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces
• Publié dans Biomaterials le 28/10/2020

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Résumé : A surface coating based on polylysine/hyaluronic acid multilayers was designed and acted as a reservoir for an antiproliferative agent, paclitaxel (Taxol). Absolutely no chemical modification of polyelectrolytes or of the drug was needed and the final architecture was obtained in an extremely simple way using the layer-by-layer method. The paclitaxel dose available for human colonic adenocarcinoma cells HT29 seeded on the films could be finely tuned. Moreover, the accessibility of the drugs was controlled by adding on the top of the drug reservoir a capping made of synthetic polyelectrolyte multilayers. This capping was also required to allow adhesion of HT29 cells. Paclitaxel activity was maintained after embedding in the polyelectrolyte multilayers and cellular viability could be reduced by about 80% 96 h after seeding. The strategy described in this paper could be valuable for various other drug/cell systems.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Philippe QuittetPatrice CeballosErnesto LopezZhao-Yang LuPascal LatryCatherine BechtÉric LegouffeNathalie FegueuxCarole ExbrayatDamien PouesselValérie RouilléJean-Pierre DaurèsBernard KleinJean-François Rossi
• Organismes : Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Unité de Thérapie Cellulaire Unité de Thérapie Cellulaire et Génique Immunopathologie des maladies tumorales et autoimmunes Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Unité de Thérapie Cellulaire Unité de Thérapie Cellulaire et Génique Immunopathologie des maladies tumorales et autoimmunes Service d'hématologie et oncologie médicale Immunopathologie des maladies tumorales et autoimmunes
• Publié dans Bone Marrow Transplantation le 01/11/2020

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Résumé : The use of a combination of G-CSF and GM-CSF versus G-CSF alone, after cyclophosphamide (4 g/m2) was compared in two randomized phase III studies, including 120 patients. In study A, 60 patients received 5 x 2 microg/kg/day of G-CSF and GM-CSF compared to 5 mug/kg/day of G-CSF. In study B, 60 patients received 2.5 x 2 microg/kg/day G-CSF and GM-CSF compared to G-CSF alone (5 microg/kg/day). With the aim to collect at least 5 x 10(6)/kg CD34 cells in a maximum of three large volume leukapherises (LK), 123 LK were performed in study A, showing a significantly higher number of patients reaching 10 x 10(6)/kg CD34 cells (21/29 in G+GM-CSF arm vs 11/27 in G-CSF arm, P=0.00006). In study B, 109 LK were performed, with similar results (10/27 vs 15/26, P=0.003). In both the study, the total harvest of CD34 cells/kg was twofold higher in G-CSF plus GM-CSF group (18.3 x 10(6) in study A and 15.85 x 10(6) in study B) than in G-CSF group (9 x 10(6) in study A and 8.1 x 10(6) in study B), a significant difference only seen in multiple myeloma, with no significant difference in terms of mobilized myeloma cells between G-CSF and GM-CSF groups.

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Fichiers liés : G_GM_n120_version_3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : W. D. CollinsV. RamaswamyM. D. SchwarzkopfY.J. SunR. W. PortmannQinjun FuS. E. B. CasanovaJean-Louis DufresneD. W. FillmoreP. M. D. ForsterV. Y. GalinL. K. GoharW. J. IngramD. P. KratzMarie-Pierre LefebvreJ. LiPhilippe MarquetV. OinasY. TsushimaT. UchiyamaW. Y. Zhong
• Organismes : Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539)
• Publié dans Journal of Geophysical Research: Atmospheres le 24/10/2020

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Résumé : The radiative effects from increased concentrations of well-mixed greenhouse gases (WMGHGs) represent the most significant and best understood anthropogenic forcing of the climate system. The most comprehensive tools for simulating past and future climates influenced by WMGHGs are fully coupled atmosphere-ocean general circulation models (AOGCMs). Because of the importance of WMGHGs as forcing agents it is essential that AOGCMs compute the radiative forcing by these gases as accurately as possible. We present the results of a radiative transfer model intercomparison between the forcings computed by the radiative parameterizations of AOGCMs and by benchmark line-by-line (LBL) codes. The comparison is focused on forcing by CO2, CH4, N2O, CFC-11, CFC-12, and the increased H2O expected in warmer climates. The models included in the intercomparison include several LBL codes and most of the global models submitted to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4). In general, the LBL models are in excellent agreement with each other. However, in many cases, there are substantial discrepancies among the AOGCMs and between the AOGCMs and LBL codes. In some cases this is because the AOGCMs neglect particular absorbers, in particular the near-infrared effects of CH4 and N2O, while in others it is due to the methods for modeling the radiative processes. The biases in the AOGCM forcings are generally largest at the surface level. We quantify these differences and discuss the implications for interpreting variations in forcing and response across the multimodel ensemble of AOGCM simulations assembled for the IPCC AR4.

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Fichiers liés : 2005JD006713.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/08/2006
• Auteurs : Alexandre SkrzypczackPierre SiohanJean-Philippe Javaudin
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 31/07/2006
• Auteurs : Jordi FontJacqueline BoutinNicolas ReulPhilippe WaldteufelCarolina GabarróSonia ZineJoseph TenerelliFrançois PetitcolinJean-Luc Vergely
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/07/2006
• Auteurs : Muriel CarinPierre-Yves ManachOlivier MenesPhilippe RogeonPhilippe PilvinJean-François Sigrist
• Organismes : Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne DCNS Group [Nantes] Laboratoire d'Ingénierie des Matériaux de Bretagne Laboratoire d'Ingénierie des Matériaux de Bretagne DCNS Group [Nantes]

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Résumé : The aim of this study is to estimate residual stresses and distortions during the assembly of dissimilar metallic materials welded by Electron Beam Welding (EBW) technique. This work is motivated by a new welding procedure for the manufacture of large speed reduction gear. The gear consists of a central hub of S275 J2G3 steel and a toothed wheel of 32CrMoV13 steel, chosen for its high fatigue performances. Preliminary experimental welding tests have shown the opening of the joint plane during the circular welding of the gear leading to lack-of-fusion defects. To improve the joining technique, a thermomechanical model has been developed to predict the opening of the joint plane during welding. A two-dimensional finite element model has been applied on a simplified geometry of smaller size. The opening of the joint plane has been modelled by two different ways, the first one uses activation / deactivation elements and the second one uses specific contact elements. Both techniques have shown similar displacements. The assumptions of plane stress or generalized plane strain are discussed. Numerical results obtained with similar metals with or without metallurgical transformations are presented. Calculations carried out with dissimilar metals are compared with experiments in terms of fusion zone size and displacements.

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Fichiers liés : carin2006.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/07/2006
• Auteurs : Gabriel VasileIvan PétillotAndreea JuleaEmmanuel TrouvéPhilippe BolonLionel BombrunMichel GayTania LandesP. GrussenmeyerJean-Marie Nicolas
• Organismes : Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Analyse et Traitement d'Images Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Analyse et Traitement d'Images Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire des images et des signaux Laboratoire des images et des signaux Modèles et simulation pour l'architecture, l'urbanisme et le paysage Modèles et simulation pour l'architecture, l'urbanisme et le paysage Laboratoire Traitement et Communication de l'Information

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Résumé : SAR interferometric data offers the opportunity to measure temperate glacier surface topography and displacement between the two acquisitions. Recently, reliable estimates of the phase gradient given by interferogram local frequencies become mandatory with the increase of the SAR resolution. In this paper, an original 2-step method for estimating local frequencies is proposed. The 2D phase signal is considered to have two deterministic components corresponding to low-resolution fringes and high-resolution patterns due for instance to the micro-relief. The first step of the proposed algorithm consists in the low-resolution phase flattening. In the second step the local high-resolution frequencies are estimated from the phase auto-correlation functions computed on adaptive neighborhoods using only the pixels which belong to the same HR spatial feature and respect the ”local stationarity” hypothesis. Results with both real ERS 1/2 tandem and simulated TerraSAR-X interferograms are presented to illustrate the potential of the proposed method.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/07/2006
• Auteurs : Gabriel VasileIvan PétillotAndreea JuleaEmmanuel TrouvéPhilippe BolonLionel BombrunMichel GayTania LandesP. GrussenmeyerJean-Marie Nicolas
• Organismes : Laboratoire des images et des signaux Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Analyse et Traitement d'Images Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire des images et des signaux Laboratoire des images et des signaux Modèles et simulation pour l'architecture, l'urbanisme et le paysage Modèles et simulation pour l'architecture, l'urbanisme et le paysage Laboratoire Traitement et Communication de l'Information

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Résumé : SAR interferometric data offers the opportunity to measure temperate glacier surface topography and displacement between the two acquisitions. Recently, reliable estimates of the phase gradient given by interferogram local frequencies become mandatory with the increase of the SAR resolution. In this paper, an original 2-step method for estimating local frequencies is proposed. The 2D phase signal is considered to have two deterministic components corresponding to low-resolution fringes and high-resolution patterns due for instance to the micro-relief. The first step of the proposed algorithm consists in the low-resolution phase flattening. In the second step the local high-resolution frequencies are estimated from the phase auto-correlation functions computed on adaptive neighborhoods using only the pixels which belong to the same HR spatial feature and respect the ”local stationarity” hypothesis. Results with both real ERS 1/2 tandem and simulated TerraSAR-X interferograms are presented to illustrate the potential of the proposed method.

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Fichiers liés : Trouve_ieee_denver2006_PID232702.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 21/07/2006
• Auteurs : Eric C. GaucherPhilippe BlancFrédérique BardotGilles BraibantStéphane BuschaertCatherine CrouzetAnne GautierJean-Pierre GirardEmmanuel JacquotArnault LassinGabrielle NegrelChristophe TournassatA. VinsotScott Altmann
• Organismes : Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Agence Nationale pour la Gestion des Déchets Radioactifs Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières Agence Nationale pour la Gestion des Déchets Radioactifs Geokemex sarl Bureau de Recherches Géologiques et Minières Bureau de Recherches Géologiques et Minières ANDRA Agence Nationale pour la Gestion des Déchets Radioactifs
• Publié dans Comptes Rendus. Géoscience le 29/07/2021

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Résumé : In ANDRA's studies to characterize the Callovian-Oxfordian formation, porewater chemistry is a key topic. Indeed, chemistry determines the durability of the repository materials (bentonite, concrete, metals, nuclear glass) and the speciation (and thus the mobility) of radionuclides. The method developed in the frame of the THERMOAR project enables the acquisition of a complete set of data from core samples to model the porewater chemistry. The method requires a detailed mineralogical study, a model of free-water/bound-water distribution, leaching experiments, adsorbed ion measurements, ion-exchange constant acquisition, and CO2 partial-pressure measurements. These experiments and measurements were done on samples from the site of the Meuse/Haute-Marne laboratory and from ANDRA's regional boreholes. The regional stability of a great number of parameters can be observed, except for a decrease of the Na and Cl concentration following a NE-SW axis passing through the laboratory. The water/rock equilibrium model makes it possible to calculate the chemical composition of interstitial waters of the formation.

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Fichiers liés : Gaucher_10-1016-j-crte-2006-06-002.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/07/2006
• Auteurs : Luc DaméSerge KoutchmyS. KuzinPhilippe LamyJean-Marie MalherbeJ.-C. Noëns
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique solaire Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique solaire

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