Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/07/2006
• Auteurs : Laurent JordaPhilippe LamyG. FauryHorst Uwe KellerMichael KüppersStubbe F. HviidDetlef KoschnyJean LecacheuxPedro J. GutierrezLuisa M. Lara
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Planétologie du LESIA

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/07/2006
• Auteurs : Milan MaksimovicThierry AppourchauxGuillaume AulanierThomas ChustThierry Dudok de WitKarl-Ludwig KleinV. V. KrasnoselskikhPhilippe LouarnA. RouxJean-Claude Vial
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Physique solaire Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Physique solaire Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Physique solaire

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2006
• Auteurs : Richard DelormeChristelle M. DurandCatalina BetancurMichael WagnerStephan RuhrmannHans-Juergen GrabeGudrun NygrenChristopher GillbergMarion LeboyerThomas BourgeronPhilippe CourtetFabrice JollantCatherine BuresiJean-Michel AubryPatrick BaudGuido BondolfiGilles BertschyNader PerroudAlain Malafosse
• Organismes : Génétique Humaine et Fonctions Cognitives Neurobiologie et Psychiatrie Génétique Humaine et Fonctions Cognitives Neurobiologie et Psychiatrie Department of Psychiatry Department of Psychiatry and Psychotherapy Department of Psychiatry Department of Child and Adolescent Psychiatry Department of Child and Adolescent Psychiatry Neurobiologie et Psychiatrie Génétique Humaine et Fonctions Cognitives Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Pathologies du système nerveux : recherche épidémiologique et clinique Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Pathologies du système nerveux : recherche épidémiologique et clinique Department of Mental Health and Psychiatry Department of Mental Health and Psychiatry Department of Mental Health and Psychiatry Department of Mental Health and Psychiatry Department of Mental Health and Psychiatry Department of Mental Health and Psychiatry Pathologies du système nerveux : recherche épidémiologique et clinique Department of Mental Health and Psychiatry
• Publié dans Biological Psychiatry le 01/11/2020

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Résumé : BACKGROUND: It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). METHODS: We explored the occurrence of this variation in patients with affective disorders (n = 646), autism spectrum disorders (n = 224), and obsessive-compulsive disorder (OCD) (n = 201); in healthy volunteers with no psychiatric disorders (n = 246); and in an ethnic panel of control individuals from North Africa, Sub-Saharan Africa, India, China, and Sweden (n = 277). RESULTS: Surprisingly, we did not observe the R441H variant in any of the individuals screened (3188 independent chromosomes). CONCLUSIONS: Our results do not confirm the role of the R441H mutation of the hTPH2 gene in the susceptibility to UP. The absence of the variant from a large cohort of psychiatric patients and control subjects suggests that the findings reported in the original study could be due to a genotyping error or to stratification of the initial population reported. Additional data by other groups should contribute to the clarification of the discrepancy between our results and those previous published.

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Fichiers liés : Delorme_TPH2_Biol_Psychiatry_2006.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 11/07/2006
• Auteurs : Marie LesueurJean-Pierre BoudeCarole Ropars-ColletPhilippe Le GoffeStéphane Gouin
• Organismes : Pôle halieutique Pôle halieutique Pôle halieutique Pôle halieutique Pôle halieutique

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Résumé : In the context where striking a balance between safeguarding the resource, rationalisation of economic activity and maintenance of social objectives is more and more difficult, the asseftion of a multifunctionality of sea fishing and shellfish culture would also have, as for agriculture, to allow the continued existence of a significant uumber of entelprises because of the generated complementary incomes and finaucitrg of non commercial services ensuled within this framework. As in agriculture, specific measul'es would make it possible to genelate new activities in order to make them economically viable in the medium term in particular irnprovement of methods of fishing, diversification of the activities arrd enhancement of sea food products.

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Fichiers liés : lesueur et al_pole_hal_2006.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 11/07/2006
• Auteurs : David EhrenreichAlain Lecavelier Des EtangsJean-Philippe BeaulieuOlivier Grasset
• Organismes : Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112]

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Résumé : Extrasolar planets as light as a few Earths are now being detected. Such planets are likely not gas or ice giants. Here, we present a study on the possible properties of the small and cold extrasolar planets, applied to the case of the recently discovered planet OGLE-2005-BLG-390Lb (Beaulieu et al. 2006). This planet (5.5[+5.5/-2.7] Earth masses) orbits 2.6[+1.5/-0.6]-astronomical units away from an old M-type star of the Galactic Bulge. The planet should be entirely frozen given the low surface temperature (35 to 47 K). However, depending on the rock-to-ice mass ratio in the planet, the radiogenic heating could be sufficient to make the existence of liquid water within an icy crust possible. This possibility is estimated as a function of the planetary mass and the illumination received from the parent star, both being strongly related by the observational constraints. The results are presented for water-poor and water-rich planets. We find that no oceans can be present in any cases at 9-10 Gyr, a typical age for a star of the Bulge. However, we find that, in the past when the planet was < 5-billion-years old, liquid water was likely present below an icy surface. Nevertheless, the planet is now likely to be entirely frozen.

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Fichiers liés : ms.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/07/2006
• Auteurs : François d'HautevilleMarianela FornerinoJean-Philippe Perrouty
• Organismes : Marchés, Organisations, Institutions et Stratégies d'Acteurs Institut national d’études supérieures agronomiques de Montpellier Centre d'études et de recherches appliquées à la gestion Marchés, Organisations, Institutions et Stratégies d'Acteurs Wine Intelligence

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Résumé : Disconfirmation of expectations is the mismatch between the expected and blind evaluation of a product (Anderson, 1973). From the consumer’s point of view, the hedonic evaluation of a product under full information (intrinsic and extrinsic) is considered as a measure of perceived quality. Generally, the perceived quality of a product differs according to tasting conditions (blind, or full information). Based on previous literature on food marketing we assume that the change of preference between blind and full conditions reflects the influence of extrinsic information (here, the region of origin). Two types of results can be expected from disconfirmation : “Assimilation” occurs when the final evaluation of the product changes in the direction of the expectation provided by the extrinsic cue, whereas “contrast” occurs when this change is contrary to the expectation. We experiment on five wines selected among regions with different reputation levels, and two groups of consumers, characterized by their level of expertise (trained/untrained students). Our experiments suggest that disconfirmation may be used to measure and interpret brand equity on a behavioural basis rather than just attitudinal.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/07/2006
• Auteurs : Albert HagègeJean-Pierre MarolleauJean-Thomas VilquinArmelle AlhéritièreSéverine PeyrardDenis DubocEric AbergelEmmanuel MessasElie MousseauxKetty SchwartzMichel DesnosPhilippe Menasché
• Organismes : Université Paris Descartes - Paris 5 Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Hopital Saint-Louis [AP-HP] Physiopathologie et thérapie du muscle strié Université Paris Descartes - Paris 5 Institut de Myologie Hôpital Cochin [AP-HP] Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5 Physiopathologie et thérapie du muscle strié Hopital Saint-Louis [AP-HP] Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5
• Publié dans Circulation le 29/10/2020

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Résumé : Background— Skeletal myoblast (SM) transplantation (Tx) in a post-myocardial infarction (MI) scar experimentally improves left ventricular (LV) ejection fraction (EF). Short-term follow-up (FU) studies have suggested that a similar benefit could clinically occur despite an increased risk of LV arrhythmias. Methods and Results— We report the long-term FU of the first worldwide cohort of grafted patients (n =9, 61.8±11.6 years, previous MI, EF ≤35%) operated on (autologous SM Tx and bypass surgery) in 2000 to 2001 and evaluated before Tx, at 1 month (M1) and at a median FU of 52 (18 to 58) months after Tx (37 patient-years). NYHA class improved from 2.5±0.5 to 1.8±0.4 at M1 ( P =0.004 versus baseline) and 1.7±0.5 at FU ( P =not significant versus M1; P =0.0007 versus baseline). EF increased from 24.3±4% to 31±4.1% at M1 (+28%, P =0.001 versus baseline) and remained stable thereafter (28.7±8.1%, +18% versus baseline). There were 5 hospitalizations for heart failure in 3 patients at 28.6±9.9 months, allowing implant in 2 patients with a resynchronization pacemaker. An automatic cardiac defibrillator (ACD) was implanted in 5 patients for nonsustained (n =1) or sustained (n =4) ventricular tachycardia at 12.2±18.6 (1 to 45) months. Despite a beta-blocker/amiodarone combination therapy, there were 14 appropriate shocks for 3 arrhythmic storms in 3 patients at 6, 7, and 18 months after ACD implantation. Conclusions— In this cohort of severe heart failure patients both clinical status and EF stably improve over time with a strikingly low incidence of hospitalizations for heart failure (0.13/patient-years) and the arrhythmic risk can be controlled by medical therapy and/or on-request ACD implantation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Philippe Berthet RambaudPascal PerrotinFabien DelhommeMichel MommessinJean Pierre MouginJean TonelloJacky Mazars
• Organismes : Laboratoire régional des ponts et chaussées de Lyon Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Bureau d'études Tonello I.C Laboratoire Sols, Solides, Structures
• Publié dans BLPC - Bulletin des Laboratoires des Ponts et Chaussées le 08/06/2017

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Résumé : Des expérimentations ont été récemment réalisées en France sur un nouveau type de protection contre les chutes de blocs, caractérisé par une dalle sans couche amortissante simplement posée sur sa structure porteuse par l'intermédiaire de fusibles métalliques. L'étude directe des mesures, effectuées sur maquette à l'échelle 1/3, permet de comprendre les principaux phénomènes mécaniques en jeu pendant les phases de l'impact. Le poinçonnement et la percussion sont analysés pour quantifier la force d'impact. Une modélisation tri-dimensionnelle de la structure et de ses appuis est également proposée. Cette analyse numérique introduit la sollicitation comme en situation réelle et est fondée sur une approche par éléments finis couplée à une loi de comportement, qui permet une représentation réaliste du comportement et de l'endommagement du béton sous chargements dynamiques. Ces travaux devraient conduire à la mise au point de règles de conception et de dimensionnement performantes utilisables par les bureaux d'étude.

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Fichiers liés : aer000001756.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Barbara SeliskoHélène DutartreJean-Claude GuillemotClaire DebarnotDelphine BenarrochAlexander KhromykhPhilippe DesprèsMarie-Pierre EgloffBruno Canard
• Organismes : Architecture et fonction des macromolécules biologiques Oncogenèse rétrovirale – Retroviral Oncogenesis [CIRI] Laboratoire de biochimie des protéines Centre de recherche en neurobiologie - neurophysiologie de Marseille Laboratoire de Biologie Moléculaire de la Cellule Département de radio-oncologie and Centre de recherche du CHU de Québec Architecture et fonction des macromolécules biologiques
• Publié dans Virology le 24/10/2020

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Résumé : Flavivirus protein NS5 harbors the RNA-dependent RNA polymerase (RdRp) activity. In contrast to the RdRps of hepaci- and pestiviruses, which belong to the same family of Flaviviridae, NS5 carries two activities, a methyltransferase (MTase) and a RdRp. RdRp domains of Dengue virus (DV) and West Nile virus (WNV) NS5 were purified in high yield relative to full-length NS5 and showed full RdRp activity. Steady-state enzymatic parameters were determined on homopolymeric template poly(rC). The presence of the MTase domain does not affect the RdRp activity. Flavivirus RdRp domains might bear more than one GTP binding site displaying positive cooperativity. The kinetics of RNA synthesis by four Flaviviridae RdRps were compared. In comparison to Hepatitis C RdRp, DV and WNV as well as Bovine Viral Diarrhea virus RdRps show less rate limitation by early steps of short-product formation. This suggests that they display a higher conformational flexibility upon the transition from initiation to elongation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Jean-François PongeStéphanie TopoliantzSylvain BallofJean-Pierre RossiPatrick LavelleJean-Marie BetschPhilippe Gaucher
• Organismes : Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers Direction territoriale Guyane Biodiversité, Gènes et Ecosystèmes Biodiversité et fonctionnement des sols Réseaux trophiques du sol Mission d'Etude pour la Création du Parc de la Guyane
• Publié dans Soil Biology and Biochemistry le 22/10/2020

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Résumé : It is now attested that a large part of the Amazonian rain forest has been cultivated during Pre-Colombian times, using charcoal as an amendment. The incorporation of charcoal to the soil is a starting point for the formation of fertile Amazonian Dark Earths, still selected by Indian people for shifting cultivation. We showed that finely separated charcoal was commonly incorporated in the topsoil by Pontoscolex corethrurus, a tropical earthworm which thrives after burning and clearing of the rain forest, and that this natural process could be used to improve tropical soil fertility. Our paper is a contribution to the present debate about (i) the origin of black carbon in fertile Dark Earths, (ii) the detrimental vs favourable role of Pontoscolex corethrurus in tropical agriculture, (iii) natural processes which might be used to increase tropical soil fertility.

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Fichiers liés : Article_SBB.pdf

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