Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/06/2006
• Auteurs : Denis MagnePhilippe LacubeAdela AngoulvantLeila MelianiFrançoise BotterelMarie-Elisabeth BougnouxChristian ChochillonMuriel CornetEric DannaouiAnnick DatryJean DunandGuy GaleazziClaire Bouges-MichelHélène YeraClaudine SarfatiPatricia Roux
• Organismes : Assistance publique - Hôpitaux de Paris (AP-HP) faculté de médecine Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Unité mixte de recherche biologie moléculaire et immunologie parasitaires et fongiques Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) CHU Pitié-Salpêtrière [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Louis Mourier Hôpital Avicenne [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Hopital Saint-Louis [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP)

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/06/2006
• Auteurs : Jérôme RosePerrine ChaurandAnne BenardPhilippe BoningClément SuavetJ. GattaccecaEmmanuel DoelschD BorschneckJean-Paul AmbrosiEdouard BardPierre RochetteJ.Y. Bottero
• Organismes : Collège de France - Chaire Evolution du climat et de l'océan Institut National de l'Environnement Industriel et des Risques Institut National de l'Environnement Industriel et des Risques Collège de France - Chaire Evolution du climat et de l'océan Collège de France - Chaire Evolution du climat et de l'océan Collège de France - Chaire Evolution du climat et de l'océan Recyclage et risque Collège de France - Chaire Evolution du climat et de l'océan centre de Nouméa, Biogéodynamique Supergène et Géomorphologie Tropicale Collège de France - Chaire Evolution du climat et de l'océan Collège de France - Chaire Evolution du climat et de l'océan Collège de France - Chaire Evolution du climat et de l'océan

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Résumé : X-ray spectromicroscopy coupling micro-XRF and X-ray microscopy has been developed on synchrotron source more then ten years ago. At the laboratory scale such techniques were more confidential. Due to recent developments in terms of X-ray source and especially in terms of focalization (capillaries, Zone plates...) laboratory micro-XRF equipment have been commercialized in the last 4 or 5 years (Horiba-Jobin Yvon, EDAX, Shimadzu, COX...). Such laboratory instrument are not only limited to material science but they are known to be very efficient in geosciences and environmental science. In these last domains, the main issue is to assess the transfer of pollutant and/or to localise spatially some element(s) of interest. Elements are often present at low concentration and can not be detected by SEM-EDX. Otherwise,the studied samples are generally disordered, heterogeneous, and/or fragile but X-ray spectromicroscopy is a non destructive method and allows In the present work we will present and discuss the advantages and limitations of micro-XRF/microscope (XGT-5000, Horiba-Jobin-Yvon ) equipped with of a 10 µm spot size on different environmental applications.The X-ray beam is generated with a Rh X-ray tube at an acceleration voltage of 15 to 50 keV with a current adjustable up to 1 mA.The X-ray beam is focused with an X- ray guide tube, whose inner diameter is 10 µm, producing a finely focused and high-intensity X-ray beam. The latter is calibrated by measuring the absorption of a tungsten wire of 5 µm thickness, scanned through the beam. X-ray emission from the irradiated sample is detected with an Energy-Dispersive X-ray (EDX) spectrometer equipped with a liquid-nitrogen-cooled high-purity Si detector. The resolution of the detector is 145 eV at the Mn K(alpha) emission line. Furthermore, a scintillator enables transmission measurements. Many scientific topics benefit from the application of our micro-XRF. For example, the impact of waste reuse can be assessed by determining the transfer mechanism of metal pollutants. Recent results concerning by-products from steel industry indicate that vanadium is released from the initial matrix. Lab-installed m cro XRF helped to identify the mineral bearing phases of V. First results concerning the composition of marine sediments are very promising. For example, the ultra-high resolution analysis of a partly laminated sediment core from the Arabian Sea reveals element variabilities at the seasonal scale (100 µm scale).This helps to determine the extend and exact timing of individual phase transitions with respect to past climatic and oceanic changes. Micro-XRF can also be very helpful to identify and classify extra terrestrial material by analyzing e.g. Fe/Ni and Fe/Si ratio.This technique has been successfully applied to meteorites and m crometeorites. Indeed such materials are rare,fragile and very small (down to a few tens of µm in size for micrometeorites). One needs a non destructive technique. Moreover the surface is generally altered and SEM-EDX failed to discriminate samples. Lab-micro-XRF appears as a very interesting routine tool.

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• Type de publi. : Article dans une revue
• Date de publi. : 18/06/2006
• Auteurs : Pierre-Louis TabernaSagar MitraPhilippe PoizotPatrice SimonJean‐marie Tarascon
• Organismes : Centre interuniversitaire de recherche et d'ingénierie des matériaux Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV Centre interuniversitaire de recherche et d'ingénierie des matériaux Laboratoire de Réactivité et de Chimie des Solides - UMR CNRS 7314 UPJV
• Publié dans Nature Materials le 31/10/2020

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Résumé : All battery technologies are known to suffer from kinetic problems linked to the solid-state diffusion of Li in intercalation electrodes, the conductivity of the electrolyte in some cases and the quality of interfaces. For Li-ion technology the latter effect is especially acute when conversion rather than intercalation electrodes are used. Nano-architectured electrodes are usually suggested to enhance kinetics, although their realization is cumbersome. To tackle this issue for the conversion electrode material Fe3O4, we have used a two-step electrode design consisting of the electrochemically assisted template growth of Cu nanorods onto a current collector followed by electrochemical plating of Fe3O4. Using such electrodes, we demonstrate a factor of six improvement in power density over planar electrodes while maintaining the same total discharge time. The capacity at the 8C rate was 80% of the total capacity and was sustained over 100 cycles. The origin of the large hysteresis between charge and discharge, intrinsic to conversion reactions, is discussed and approaches to reduce it are proposed. We hope that such findings will help pave the way for the use of conversion reaction electrodes in future-generation Li-ion batteries.

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Fichiers liés : Taberna_2583.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/06/2006
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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• Type de publi. : Article dans une revue
• Date de publi. : 15/06/2006
• Auteurs : Monica Mameli-EngvallAlexis EvrardStéphanie PonsUwe MaskosTorgny H SvenssonJean-Pierre ChangeuxPhilippe Faure
• Organismes : Récepteurs et Cognition Department of Physiology and Pharmacology Récepteurs et Cognition Récepteurs et Cognition Récepteurs et Cognition Department of Physiology and Pharmacology Récepteurs et Cognition Récepteurs et Cognition
• Publié dans Neuron le 01/11/2020

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Résumé : Nicotine elicits dopamine release by stimulating nicotinic acetylcholine receptors (nAChRs) on dopaminergic neurons. However, a modulation of these neurons by endogenous acetylcholine has not been described. We recorded, in vivo, the spontaneous activity of dopaminergic neurons in the VTA of anaesthetized wt and nAChR knockout mice and their response to nicotine injections. Deleting alpha7 or beta2 subunits modified the spontaneous firing patterns, demonstrating their direct stimulation by endogenous acetylcholine. Quantitative analysis further revealed four principal modes of firing, each depending on the expression of particular nAChR subunits and presenting unique responses to nicotine. The prominent role of the beta2 subunit was further confirmed by its selective lentiviral reexpression in the VTA. These data suggest a hierarchical control of dopaminergic neuron firing patterns by nAChRs: activation of beta2*-nAChR switches cells from a resting to an excited state, whereas activation of alpha7*-nAChRs finely tunes the latter state but only once beta2*-nAChRs have been activated.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/06/2006
• Auteurs : Philippe LeprouxJean-Louis AugusteVincent CoudercChristelle Lesvigne-BuyAude RoyVincent TombelaineJean-Marc BlondyPhilippe RoyChristine RestoinPierre-Olivier Martin
• Organismes : PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE XLIM
• Publié dans Journal de Physique IV Proceedings le 01/01/2003

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• Type de publi. : Article dans une revue
• Date de publi. : 12/06/2006
• Auteurs : Sébastien Le JanNolwenn Le MeurAurélie CazesJosette PhilippeMartine Le CunffJean LégerPierre CorvolStéphane Germain
• Organismes : Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Physiopathologie et pharmacologie cellulaires et moléculaires Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Physiopathologie et pharmacologie cellulaires et moléculaires Physiopathologie et pharmacologie cellulaires et moléculaires Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale Service d'hématologie A [CHU HEGP]
• Publié dans FEBS Letters le 24/10/2020

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Résumé : By triggering an adaptive response to hypoxia which is a common feature of tumor microenvironments, endothelial cells contribute to the onset of angiogenic responses involved in tumor growth. Therefore, identifying hypoxic markers represent a challenge for a better understanding of tumor angiogenesis and for the optimization of anti-angiogenic therapeutic strategy. Using representational difference analysis combined with microarray, we here report the identification of 133 hypoxia-induced transcripts in human microendothelial cells (HMEC-1). By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3), thioredoxin-interacting protein (txnip), neuritin (nrn1). Finally, by performing in situ hybridization on several types of human tumors, we provide evidence for nrn1 and txnip as hypoxic perinecrotic markers and for igfbp3 as a tumor endothelial marker. We propose these hypoxia-induced genes could represent relevant prognostic tools and targets for therapeutic intervention in cancers.

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Fichiers liés : FEBS.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/06/2006
• Auteurs : Gaël PetitjeanPierre BecquartYassine Al TabaaJean-Pierre VendrellPhilippe Van De Perre
• Organismes : VIH/SIDA et maladies associées VIH/SIDA et maladies associées Laboratoire de Virologie [CHRU Montpellier] Laboratoire de Virologie [CHRU Montpellier] Laboratoire de Virologie [CHRU Montpellier] VIH/SIDA et maladies associées
• Publié dans AIDS. Official journal of the international AIDS Society le 23/08/2019

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Résumé : A proof-of-concept study recently assessed the efficiency of a standard clinical dose of valproic acid in order selectively to induce the expression of HIV-1 latent proviral genome, and potentially to deplete HIV from the blood resting CD4 T-cell reservoir [...].

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/06/2006
• Auteurs : Robert JoumardJuhani LaurikkoTuan Le HanSavas GeivanidisZisis SamarasZoltán OláhPhilippe DevauxJean-Marc AndréErwin CornelisPierre RouveirollesStéphanie O.L. LacourMaria Vittoria PratiRobin VermeulenMichael Zallinger
• Organismes : Laboratoire Transport et Environnement Technical Research Centre of Finland Graz University of Technology [Graz] Laboratory of Applied Thermodynamics Laboratory of Applied Thermodynamics Institute for Transport Science I.C. Engines/Furnaces Laboratoire Transport et Environnement Flemish Institute for Technological Research Renault Centre Technique Lardy Laboratoire Transport et Environnement Istituto Motori [Napoli] TNO Automotive Institute for Internal Combustion Engines and Thermodynamics

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Résumé : Ten European laboratories worked together to study the influence of a lot of parameters of the measurement of light vehicle emission factors on vehicle bench, in order to improve the accuracy, reliability and representativeness of emission factors: driving patterns (driving cycles, gear choice behaviour, driver and cycle following), vehicle related parameters (technical characteristics of the vehicle, emission stability, emission degradation, fuel properties, vehicle cooling and preconditioning), vehicle sampling (method, sample size), and laboratory related parameters (ambient temperature and humidity, dynamometer setting, dilution ratio, heated line sampling temperature, PM filter preconditioning, response time, dilution air). The results are based on literature synthesis, on about 2700 specific tests with 183 vehicles and on the reprocessing of more than 900 tests. These tests concern the regulated atmospheric pollutants and pre-Euro to Euro 4 vehicles. We did not find any influence of 7 parameters, and find only a qualitative influence for 7 other parameters. 6 parameters have a clear and quantifiable influence and 5 among them allow us to design correction factors to normalise emission measurements: gearshift strategy, vehicle mileage, ambient temperature and humidity, dilution ratio. The sixth influencing parameter is the driving cycle, sometimes more significant than the fuel or the emission standard. The results allow us to design recommendations or guidelines for the emission factor measurement method.

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Fichiers liés : com._RJ_accuracy_Reims_06.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/06/2006
• Auteurs : Gérard BaillyCléo BarasPatrick BasSéverine BaudryDenis BeautempsRémi BrunJean-Marc ChasseryFranck DavoineFrédéric EliseiGuillaume GibertLaurent GirinDenis GrisonJean-Pierre LéoniJoël LiénardNicolas MoreauPhilippe Nguyen
• Organismes : Institut de la communication parlée Laboratoire Traitement et Communication de l'Information Laboratoire des images et des signaux Nextamp Institut de la communication parlée Attitude Studio Laboratoire des images et des signaux Heuristique et Diagnostic des Systèmes Complexes [Compiègne] Institut de la communication parlée Institut de la communication parlée Institut de la communication parlée ARTE ARTE Laboratoire des images et des signaux Laboratoire Traitement et Communication de l'Information Nextamp

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Résumé : The ARTUS Project aims at watermarking hand and face gestures of a virtual animated agent in a broadcasted audiovisual sequence. For deaf televiewers that master cued speech, the animated agent can be then incrusted - on demand and at the reception - in the original broadcast as an alternative to subtitling

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Fichiers liés : gb_HANDICAP06.pdf

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