Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2006
• Auteurs : Pierre-Jean BarreAlain BouscayrolPhilippe DelarueEric DumetzFrederic GiraudJean-Paul HautierXavier KestelynBetty Lemaire-SemailEric Semail
• Organismes : Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697

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Résumé : Causal Ordering Graph and Energetic Macroscopic Representation are graphical descriptions to model electromechanical systems using integral causality. Inversion rules have been defined in order to deduce control structure step-bystep from these graphical descriptions. These two modeling tools can be used together to develop a two-layer control of system with complex parts. A double-drive paper system is taken as an example. The deduced control yields good performances of tension regulation and velocity tracking.

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Fichiers liés : L2EP_IECON_2006_SEMAIL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Jean-Philippe VerhoyeBertrand de LatourJean-François HeautotMarco VolaThierry LanganayHervé CorbineauAlain LeguerrierXavier BarralJean-Pierre Favre
• Organismes : Laboratoire Traitement du Signal et de l'Image Laboratoire Traitement du Signal et de l'Image Institut de médecine moléculaire de Rangueil
• Publié dans Annals of Vascular Surgery le 26/10/2020

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Résumé : We report the initial experience of two cardiovascular surgery centers in the treatment of descending thoracic aorta lesions with covered stent grafts in high-surgical risk patients. From April 1999 to November 2004, 54 patients, mean age 64 years (range 16-83), were treated by stent graft for a lesion of the descending aorta (degenerative aneurysms n = 22, aortic dissections n = 12, chronic post traumatic aneurysms n = 5, anastomotic false aneurysms n = 2, penetrating ulcers n = 4, intramural hematomas n = 5, traumatic rupture n = 4), with 42.6% treated on an emergency basis. Three devices were used: Talent (n = 49), Excluder (n = 4), and Zenith (n = 1). In three patients, combined surgery of the proximal aorta was performed. Prior bypass of the left supra-aortic arteries was performed in four patients. The follow-up was clinical and radiological (plain chest film and computed tomographic scan) at 1, 3, 6, 12, 18, and 24 months and yearly thereafter. The stent graft was successfully deployed in all cases. Two early deaths related to the stent graft (one migration and aortic rupture and one stroke) and one related to adult respiratory distress syndrome occurred. Morbidity was 16.6% (iliac access damage n = 4, groin reintervention n = 3, transient ischemic attack n = 1, tamponade n = 1). The follow-up was 100% complete (mean 22.8 months, range 3-51). Fifteen primary endoleaks (type I n = 6, type II n = 8, type III n = 1) and one secondary endoleak were reported. They were treated by additional stent graft (n = 7) and elective surgical conversion (n = 1). Six endoleaks resolved spontaneously at 6 months, and two are being monitored. Twelve endoleaks (75%) occurred in patients treated for degenerative aneurysms. Freedom from secondary reintervention was 81.3% at 3 years. Two transient paraparesias were observed at 3 and 18 months. Of the 13 deaths observed during the follow-up, only one was related to the stent graft. Actuarial survival at 12 and 24 months was 90.0% and 75.4%, respectively. Mortality results are encouraging in this specific cohort of high-surgical risk patients. A new kind of morbidity is observed, related to endoleaks, whose necessary management could hinder the durability of the technique.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Marie Potier-CartereauVirginie JoulinSébastien RogerPierre BessonMarie-Lise JourdanJean-Yves LeguennecPhilippe BougnouxChristophe Vandier
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif
• Publié dans Mol Cancer Ther le 01/01/2003

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Résumé : Potassium channels have been involved in epithelial tumorigenesis but the role of small-conductance Ca(2+)-activated K(+) channels is unknown. We report here that small-conductance Ca(2+)-activated K(+) channels are expressed in a highly metastasizing mammary cancer cell line, MDA-MB-435s. Patch-clamp recordings showed typical small-conductance Ca(2+)-activated K(+) channel-mediated currents sensitive to apamin, 4-aminopyridine, and tetraethylammonium. Moreover, the cells displayed a high intracellular calcium concentration, which was decreased after 24 hours of apamin treatment. By regulating membrane potential and intracellular calcium concentration, these channels were involved in MDA-MB-435s cell migration, but not in proliferation. Only SK3 protein expression was observed in these cells in contrast to SK2, which was expressed both in cancer and noncancer cell lines. Whereas small interfering RNA directed against SK3 almost totally abolished MDA-MB-435s cell migration, transient expression of SK3 increased migration of the SK3-deficient cell lines, MCF-7 and 184A1. SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues. Thus, SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a potential target for a new class of anticancer agents. [Mol Cancer Ther 2006;5(11):2946-53].

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/11/2006
• Auteurs : Sébastien RogerPierre BessonPhilippe BougnouxJean-Yves Le Guennec
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif

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Résumé : Ionic channels are proteins embedded into the plasma membrane allowing ions to flow into or out of the cells, depending on the electrochemical gradient (see figure 1). Voltage-gated sodium channels (NaV1) are classically found in excitable cells since they are responsible for the depolarisation phase and propagation of action potentials. Tetrodotoxin (TTX), a toxin isolated from tetradontidae puffer fishes, is the reference inhibitor of NaV1 (figure 2). The involvement of ionic channels in oncogenic properties such as proliferation has been known since the 1980s but it took nearly a decade before they were explored functionally (see [1]). In 1997, the expression of functional NaV1 was observed in a human prostatic metastatic cell line [2]. Recently, the presence of the channel protein was correlated with the grade of the disease [3]. In 2003 we described for the first time the presence of a NaV1 in a human breast metastatic cancer cell line, MDA-MB-231 [4]. Later on it was shown that the channel expressed in these cells is the cardiac isoform NaV1.5 [11]. Inhibiting the channel with TTX or conversely increasing its activity with veratridine allowed the demonstration of a high correlation between the activity of the channel and the capacity of the cells to invade a Matrigel® which mimics the extracellular matrix (see figure 3). The membrane potential of breast cancer cells is located within the range -30 to -40mV. At this potential, NaV1.5 are partially open. Thus they let sodium ions enter into the cells continuously. Such a perturbation of the homeostasis of sodium could disturb intracellular pH and calcium homeostasis which in turn could modulate some proteolytic activities. Indeed, we observed that some cysteine proteases, also known as cathepsins, are regulated by functional NaV1.5 (see figure 4). Later on, it was found that NaV1.5 (foetal variant) can be observed in biopsies and this expression is correlated to the grade of the disease [9]. We also worked with the non-small lung cancer cell (NSCLC) lines A549, H23, H460 and Calu-1 and the immortalized non cancerous cell lines NL-20 and BEAS-2B [10]. We did not find any sodium current in these cells (NL-20 and BEAS-2B) nor in the weakly metastatic cell line A549. Conversely, the strongly metastatic cell lines H23, H460 and Calu-1 expressed functional NaV1. The common feature between all the cancer cells expressing functional channels is that the activity of the channels almost doubles the capacity of the cells to invade Matrigel® whatever the isoform of the functional channels.

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Fichiers liés : Roger_et_al_Toxines.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2006
• Auteurs : Pierre-Yves BrichonPhilippe BoitetAntoine DujonJerôme MourouxChristophe PeillonMarc RiquetJean-Francois VellyHans-Beat Ris
• Organismes : Service de Chirurgie thoracique Service de Chirurgie thoracique Service de Chirurgie thoracique Service de Chirurgie thoracique Service de chirurgie cadiovasculaire et thoracique [Rouen] Hôpital Guillaume-et-René-Laennec [CHU Nantes] Service de chirurgie thoracique Service de Chirurgie thoracique
• Publié dans European Journal of Cardio-Thoracic Surgery le 22/10/2020

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Résumé : BACKGROUND: Incidence of perioperative in-stent thrombosis associated with myocardial infarction in patients undergoing major lung resection within 3 months of coronary stenting. METHODS: Retrospective multi-institutional trial including all patients undergoing major lung resection (lobectomy or pneumonectomy) within 3 months of coronary stenting with non-drug-eluting stents between 1999 and 2004. RESULTS: There were 32 patients (29 men and 3 women), with age ranging from 46 to 82 years. One, two or four coronary stents were deployed in 72%, 22% and 6% of the patients, respectively. The time intervals between stenting and lung surgery were <30 days, 30-60 days and 61-90 days in 22%, 53% and 25% of the patients, respectively. All patients had dual antiplatelet therapy after stenting. Perioperative medication consisted of heparin alone or heparin plus aspirin in 34% and 66% of the patients, respectively. Perioperative in-stent thrombosis with myocardial infarction occurred in three patients (9%) with fatal outcome in one (3%). Twenty patients underwent lung resection after 4 weeks of dual antiplatelet therapy as recommended by the ACC/AHA Guideline Update; however, two out of three perioperative in-stent thrombosis occurred in this group of patients. CONCLUSIONS: Major lung resection performed within 3 months of coronary stenting may be complicated by perioperative in-stent thrombosis despite 4 weeks of dual antiplatelet therapy after stenting as recommended by the ACC/AHA Guideline Update.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2006
• Auteurs : Pierre-François MorlatPhilippe MaryGuillaume VillemaudJean-Marie GorceMarylin Arndt
• Organismes : Architectures of networks of services France Télécom Recherche & Développement Architectures of networks of services Architectures of networks of services France Télécom Recherche & Développement

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Résumé : This paper assesses the efficiency of a multi standard and multi antenna receiver using simulation and test measurements in a real propagation environment. A multi-standard and multi-antenna receiver is firstly designed with the ADS© software. Secondly, the performance of this system is evaluated with several multi-antenna algorithms, under real radio propagation conditions depending on the standard we choose to deal with. At this time the receiver can run with 802.11b and 802.11g standards in a 36 MHz bandwidth. Some first results are presented using multi antenna algorithm in a receiver dealing with two 802.11g or 802.11b transmission on overlapped communication channels.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/10/2006
• Auteurs : Pierre BorgnatNicolas LarrieuPhilippe OwezarskiPatrice AbryJulien AussibalLaurent GallonGuillaume DewaeleKarima BoudaoudLaurent BernailleAntoine ScherrerYu ZhangYann Labit
• Organismes : Laboratoire de Physique de l'ENS Lyon Laboratoire d'analyse et d'architecture des systèmes LAAS-OLC Laboratoire de Physique de l'ENS Lyon IUT des Pays de l'Adour IUT des Pays de l'Adour Laboratoire de Physique de l'ENS Lyon Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis Networks and Performance Analysis Laboratoire de l'Informatique du Parallélisme Compilation and embedded computing systems Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes

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Résumé : Nous nous intéressons à la détection d'attaques sur le réseau Internet. Nos procédures de détection reposent sur l'utilisation de lois non gaussiennes pour modéliser conjointement les distributions marginales du trafic agrégé à différents niveaux. Nous utilisons ensuite plusieurs distances statistiques pour quantifier une rupture dans cette modélisation statistique entre, d'une part, celle estimée dans une fenêtre d'observation et d'autre part celle obtenue sur une référence, constituée par un trafic normal. Les méthodes proposées ont une nature fondamentalement multirésolution : plusieurs niveaux d'agrégation sont analysés conjointement. Nous avons réalisé une série d'expériences d'attaques de Dénis de Service Distribuées (DdSD) et mesuré le trafic sur le lien d'accès de la victime. Contrôlant précisément les caractéristiques de ces DdSD, nous disposons d'une base de données documentée pour valider les performances des procédures de détection proposées. Nous traçons des courbes de performances (probabilité de détection versus probabilité de fausses alarmes) des procédures proposées et montrons qu'elles permettent la détection des attaques, à l'horizon de la minute, même lorsque celles-ci ont une faible intensité en volume.

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Fichiers liés : CFIP-ID-37.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2006
• Auteurs : Catherine DodéLuis TeixeiraJacqueline LevilliersCorinne FouveautPhilippe BouchardMarie-Laure KottlerJames LespinasseAnne Lienhardt-RoussieMichèle MathieuAlexandre MoermanGraeme MorganArnaud MuratJean-Edmont ToublancSlawomir WolczynskiMarc DelpechChristine PetitJacques YoungJean-Pierre Hardelin
• Organismes : Institut Cochin Institut Cochin Génétique des Déficits Sensoriels Hôpital Cochin [AP-HP] CHU Saint-Antoine [AP-HP] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Métropole Savoie [Chambéry] Centre Hospitalier Universitaire Dupuytren 1 et 2 CHU Amiens-Picardie Hôpital Jeanne de Flandres Sydney IVF [Sydney, Australia] Hôpital Hôtel-Dieu [CHU Nantes] Hôpital Saint-Vincent de Paul Institut Cochin Génétique des Déficits Sensoriels Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Génétique des Déficits Sensoriels
• Publié dans PLoS Genetics le 27/10/2020

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Résumé : Kallmann syndrome combines anosmia, related to defective olfactory bulb morphogenesis, and hypogonadism due to gonadotropin-releasing hormone deficiency. Loss-of-function mutations in KAL1 and FGFR1 underlie the X chromosome-linked form and an autosomal dominant form of the disease, respectively. Mutations in these genes, however, only account for approximately 20% of all Kallmann syndrome cases. In a cohort of 192 patients we took a candidate gene strategy and identified ten and four different point mutations in the genes encoding the G protein-coupled prokineticin receptor-2 (PROKR2) and one of its ligands, prokineticin-2 (PROK2), respectively. The mutations in PROK2 were detected in the heterozygous state, whereas PROKR2 mutations were found in the heterozygous, homozygous, or compound heterozygous state. In addition, one of the patients heterozygous for a PROKR2 mutation was also carrying a missense mutation in KAL1, thus indicating a possible digenic inheritance of the disease in this individual. These findings reveal that insufficient prokineticin-signaling through PROKR2 leads to abnormal development of the olfactory system and reproductive axis in man. They also shed new light on the complex genetic transmission of Kallmann syndrome.

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Fichiers liés : pgen_0020175.pdf

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• Type de publi. :
• Date de publi. : 20/10/2006
• Auteurs : Vincent CoudercPhilippe LeprouxVincent TombelainePierre-Alain ChampertAlain BarthélémyJean-Louis AugusteJean-Marc Blondy
• Organismes : PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE PHOTONIQUE

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• Type de publi. : Article dans une revue
• Date de publi. : 19/10/2006
• Auteurs : Vladimir KorobovLaurent HilicoJean-Philippe Karr
• Organismes : Bogoliubov Laboratory of Theoretical Physics [Dubna] Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry)
• Publié dans Physical Review A : Atomic, molecular, and optical physics [1990-2015] le 02/11/2020

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Résumé : The hyperfine splitting of energy levels in the H2+ molecular ion is calculated within the framework of the spin-dependent part of the Breit-Pauli Hamiltonian. This is the first ab initio calculation based on the precise variational solution of the three-body Schrodinger equation. It is shown that inclusion of the nuclear spin-spin tensor interaction, neglected in previous theoretical considerations, brings the agreement with the most precise hyperfine transition measurements obtained by Jefferts to about 1 kHz for the lower frequency intervals in the 5-100 MHz range. Finally, we investigate the hyperfine structure of some transitions, candidates for high-precision two-photon spectroscopy.

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