Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2007
• Auteurs : Xavier GarbetYanick SarazinVirginie GrandgirardGuilhem Dif-PradalierGuillaume DarmetPhilippe GhendrihPaolo AngelinoPierre BertrandNicolas BesseEtienne GravierPierre MorelEric SonnendrückerNicolas CrouseillesJean-Michel DischlerGuillaume LatuEric ViolardMaura BrunettiStephan BrunnerXavier LapillonneM. T. TranLaurent VillardM. Boulet
• Organismes : Association EURATOM-CEA Département de Recherche sur la Fusion Contrôlée Institut de Recherche sur la Fusion par confinement Magnétique University of California [San Diego] Association EURATOM-CEA Institut de Recherche sur la Fusion par confinement Magnétique Association EURATOM-CEA Laboratoire de physique des milieux ionisés et applications Institut Jean Lamour Institut Élie Cartan de Nancy Scientific computation and visualization Laboratoire de physique des milieux ionisés et applications Laboratoire de physique des milieux ionisés et applications Scientific computation and visualization Scientific computation and visualization Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection Centre de Recherches en Physique des Plasmas Centre de Recherches en Physique des Plasmas Centre de Recherches en Physique des Plasmas Centre de Recherches en Physique des Plasmas Centre de Recherches en Physique des Plasmas Laboratoire de Détection et de Géophysique (CEA)
• Publié dans Nuclear Fusion le 24/10/2020

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Résumé : This paper presents the results obtained with a set of gyrokinetic codes based on a semi-Lagrangian scheme. Several physics issues are addressed, namely, the comparison between fluid and kinetic descriptions, the intermittent behaviour of flux driven turbulence and the role of large scale flows in toroidal ITG turbulence. The question of the initialization of full-F simulations is also discussed.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2007
• Auteurs : Pierre SaintignyMarianne KambouchnerMadani LyNoëlia GomesOdile Sainte-CatherineRoger VassySébastien CzernichowPhilippe LetoumelinJean-Luc BreauJean-François BernaudinMichel Kraemer
• Organismes : Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques
• Publié dans Lung Cancer le 27/10/2020

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Résumé : SummaryIntroduction Investigation of the role of vascular endothelial growth factor-C (VEGF-C) and VEGF receptor-3 (VEGFR-3) in non-small-cell lung cancer (NSCLC) has mainly focused on lymph node (LN) metastasis related to lymphangiogenesis. However, the coexpression of VEGF-C/VEGFR-3 by tumour cells can independently play an important role. The present study was therefore designed to evaluate VEGF-C/VEGFR-3 coexpression in tumour cells from the primary tumour and corresponding LN metastases.Methods VEGF-C and VEGFR-3 expression in cancer cells were evaluated by immunohistochemistry in 92 NSCLC samples and 45 metastatic LNs. Ki67 expression and mitotic index (MI) in tumours and clinicopathological data were analysed concurrently.Results VEGFR-3 and VEGF-C expression were observed in 42% and 74% of tumours, respectively. Concurrent expression of VEGF-C and VEGFR-3, observed in 39% of tumours, was significantly associated with a higher proliferation rate and a higher incidence of LN metastases. VEGF-C expression in tumour cells was observed in 100% of metastatic LN and VEGF-C/VEGFR-3 coexpression was observed in 71% of metastatic LN. Finally, concurrent expression of VEGF-C/VEGFR-3 in the primary tumour was associated with poor disease-free survival on univariate analysis.Conclusion In NSCLC cancer cells, VEGF-C/VEGFR-3 coexpression suggests an autocrine/paracrine loop responsible for a high proliferation rate in tumour cells. As VEGF-C/VEGFR-3 coexpression is very frequent in metastatic LN tumour cells, it can be hypothesised that this coexpression participates in the growth of LN metastasis.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2007
• Auteurs : Philippe BoulvaisJean-Pierre BrunD. Sokoutis
• Organismes : Géosciences Rennes Géosciences Rennes Centre for Integrated Solid Earth Sciences
• Publié dans Geofluids le 25/10/2020

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Résumé : In the North Aegean Domain, Thassos Island contains a Plio-Pleistocene basin controlled by a large-scale flat-ramp extensional system with a potential décollement located at depth within a marble unit. Numerous mineralizations associated with normal faults of Plio-Pleistocene age are the sign of fluid circulation during extension. Two main generations of fluid flow are recognized, related to Plio-Pleistocene extension. A first circulation under high-temperature conditions (about 100­200°C) resulted in dolomitization of marbles near the base of the Plio-Pleistocene basin. The dolomites are characterized by low d18O values (down to 11 versus Standard Mean Ocean Water). Some cataclastic deformation affected the dolomites. Hydrothermal quartz that crystallized in extension veins above a blind ramp also has low d18O values (about 13). This shows that high-temperature fluids moved up from the décollement level toward the surface. A second downward circulation of continental waters at near-surface temperature is documented by calcite veins in fault zones and at the base of the Plio-Pleistocene basin. These veins have O isotope values relatively constant at about 23­25 and C isotope values intermediate between the high d13C value of the carbonate host rock (about 1­3 versus Peedee Belemnite) and the low d13C value of soil-derived carbon (-10). The calcites associated with the oxidative remobilization of primary sulphide Zn­Pb mineralization of Thassos carbonates have comparable O and C isotope compositions. Hot fluids, within the 100­200°C temperature range, have likely contributed to the weakening of the lower marble unit of Thassos and, thus, to the process of décollement.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2007
• Auteurs : Philippe Martin
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2007
• Auteurs : Philippe Martin
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2007
• Auteurs : Laurent JordaPhilippe LamyG. FauryHorst Uwe KellerStubbe F. HviidMichael KüppersDetlef KoschnyJean LecacheuxPedro J. GutierrezLuisa M. Lara
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Research and Scientific Support Department, ESA-ESTEC Observatoire de Paris Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Planétologie du LESIA Instituto de Astrofísica de Andalucía = Institute of Astrophysics of Andalusia Instituto de Astrofísica de Andalucía = Institute of Astrophysics of Andalusia
• Publié dans Icarus le 30/10/2020

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Résumé : We present an analysis of the observations of the Deep Impact event performed by the OSIRIS narrow angle camera aboard the Rosetta spacecraft over two weeks, in an effort to characterize the cometary dust grains ejected from the nucleus of Comet 9P/Tempel 1. We adopt a Monte Carlo approach to generate calibrated synthetic images, and a linear combination of them is fitted to the calibrated images so as to determine the physical parameters of the dust cloud. Our model considers spherical olivine particles with a density of 3780 kg m^-3. It incorporates constraints on the direction of the cone of emission coming from additional images obtained at Pic du Midi observatory, and constraints on the dust terminal velocities coming from the physics of the impact. We find that the slope of the differential dust size distribution of grains with radii 0.008) is 3.1±0.3, a value typical of cometary dust tails. This shows that there is no evidence in our data for an enhancement in sub-micron particles in the ejecta compared to the typical dust distribution of active comets. We estimate the mass of particles with radii 0.14) to be 1.5±0.2×10 kg. These particles represent more than 80% of the cross-section of the observed dust cloud. The mass carried by larger particles depends whether the gas significantly increases the kinetic energy of the grains in the inner coma; it lies in the range 1 14×10 kg for particles with radii 0.002). We obtain the distribution of terminal velocities reached by the dust after the dust gas interaction which is very well constrained between 10 and 600 m s^-1. It is characterized by Gaussian with a maximum at about 190 m s^-1 and a width at half maximum of 150 m s^-1.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2007
• Auteurs : Philippe Martin
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2007
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. :
• Date de publi. : 01/01/2007
• Auteurs : Jean-Yves DourmadBernard FostierBénédicte LebretPhilippe LecouveyJean NobletYvon SalaünPierre Sellier
• Organismes : Systèmes d'élevage, nutrition animale et humaine Institut du Porc Systèmes d'élevage, nutrition animale et humaine Institut du Porc Systèmes d'élevage, nutrition animale et humaine Institut du Porc Génétique Animale et Biologie Intégrative

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Résumé : absent

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2007
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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