Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/05/2006
• Auteurs : Alexandre SkrzypczackJean-Philippe JavaudinPierre Siohan
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Article dans une revue
• Date de publi. : 03/05/2006
• Auteurs : Stéphane RigautCéline OlivierKarine CostuasSylvie ChouaOmrane FadhelJulien MassuePhilippe TurekJean-Yves SaillardPierre H. DixneufDaniel Touchard
• Organismes : Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut Charles Sadron Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut Charles Sadron Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes
• Publié dans Journal of the American Chemical Society le 30/10/2020

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Résumé : Two methodologies of C-C bond formation to achieve organometallic complexes with 7 or 9 conjugated carbon atoms are described. A C7 annelated trans-[Cl(dppe)2Ru=C=C=C-CH=C(CH2)-C[triple bond]C-Ru(dppe)2Cl][X] (X = PF6, OTf) complex is obtained from the diyne trans-[Cl(dppe)2Ru-(C[triple bond]C)2-R] (R = H, SiMe3) in the presence of [FeCp2][PF6] or HOTf, and C7 or C9 complexes trans-[Cl(dppe)2Ru-(C[triple bond]C)n-C(CH3)=C(R1)-C(R2)=C=C=Ru(dppe)2Cl][X] (n = 1, 2; R1 = Me, Ph, R2 = H, Me; X = BF4, OTf) are formed in the presence of a polyyne trans-[Cl(dppe)2Ru-(C[triple bond]C)n-R] (n = 2, 3; R = H, SiMe3) with a ruthenium allenylidene trans-[Cl(dppe)2Ru=C=C=C(CH2R1)R2][X]. These reactions proceed under mild conditions and involve cumulenic intermediates [M+]=(C=)nCHR (n = 3, 5), including a hexapentaenylidene. A combination of chemical, electrochemical, spectroscopic (UV-vis, IR, NIR, EPR), and theoretical (DFT) techniques is used to show the influence of the nature and conformation of the bridge on the properties of the complexes and to give a picture of the electron delocalization in the reduced and oxidized states. These studies demonstrate that the C7 bridging ligand spanning the metal centers by almost 12 angstroms is implicated in both redox processes and serves as a molecular wire to convey the unpaired electron with no tendency for spin localization on one of the halves of the molecules. The reactivity of the C7 complexes toward protonation and deprotonation led to original bis(acetylides), vinylidene-allenylidene, or carbyne-vinylidene species such as trans-[Cl(dppe)2Ru[triple bond]C-CH=C(CH3)-CH=C(CH3)-HC=C=Ru(dppe)2Cl][BF4]3.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2006
• Auteurs : Agnès GoubleJulianne SmithSylvia BruneauChristophe PerezValérie GuyotJean‐pierre CabaniolsSophie LeducLaurence FiettePatrick AvéBéatrice MicheauPhilippe DuchateauFrédéric Pâques
• Organismes : Cellectis Cellectis Cellectis Cellectis Cellectis Cellectis Cellectis Histotechnologie et Pathologie Histotechnologie et Pathologie Cellectis Cellectis Cellectis
• Publié dans The Journal of Gene Medicine le 25/10/2020

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Résumé : Background Sequence‐specific endonucleases with large recognition sites can cleave DNA in living cells, and, as a consequence, stimulate homologous recombination (HR) up to 10 000‐fold. The recent development of artificial meganucleases with chosen specificities has provided the potential to target any chromosomal locus. Thus, they may represent a universal genome engineering tool and seem to be very promising for acute gene therapy. However, in toto applications depend on the ability to target somatic tissues as well as the proficiency of somatic cells to perform double‐strand break (DSB)‐induced HR. Methods In order to investigate DSB‐induced HR in toto , we have designed transgenic mouse lines carrying a LagoZ gene interrupted by one I‐ Sce I cleavage site surrounded by two direct repeats. The LagoZ gene can be rescued upon cleavage by I‐ Sce I and HR between the two repeats in a process called single‐strand annealing. β‐Galactosidase activity is monitored in liver after tail vein injection of adenovirus expressing the meganuclease I‐SceI. Results In toto staining revealed a strong dotted pattern in all animals injected with adenovirus expressing I‐SceI. In contrast, no staining could be detected in the control. β‐Galactosidase activity in liver extract, tissue section staining, and PCR analysis confirmed the presence of the recombined LagoZ gene. Conclusions We demonstrate for the first time that meganucleases can be successfully delivered in animal and induce targeted genomic recombination in mice liver in toto . These results are an essential step towards the use of designed meganucleases and show the high potential of this technology in the field of gene therapy. Copyright © 2006 John Wiley & Sons, Ltd.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2006
• Auteurs : Emmanuel MessasAlain BelMiguel Cortes MorichettiClaire CarrionMarc HandschumacherSéverine PeyrardJean-Thomas VilquinMichel DesnosPatrice BrunevalAlain CarpentierPhilippe MenaschéRobert LevineAlbert Hagège
• Organismes : Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Physiopathologie et thérapie du muscle strié Institut de Myologie CHU Pitié-Salpêtrière [AP-HP] Harvard Medical School [Boston] CIC - HEGP Physiopathologie et thérapie du muscle strié Institut de Myologie CHU Pitié-Salpêtrière [AP-HP] Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Immunopathologie humaine Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Harvard Medical School [Boston] Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP]
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Objectives: This study was designed to assess whether post-myocardial infarction (MI) in-scar transplantation of skeletal myoblasts (SM) could reduce chronic ischemic mitral regurgitation (MR) by decreasing left ventricular (LV) remodeling. Background: Extensive work has confirmed the relationship between ischemic MR and post-myocardial infarction (MI) remodeling of the LV. Methods: An infero-posterior MI was created in 13 sheep, thereby resulting in increasing MR. Two months post-MI, the animals were randomized and in-scar injected with expanded autologous SM (n = 6, mean: 251 x 10(6) cells) or culture medium only (n = 7). Three-dimensional echocardiography was performed at baseline, before transplantation, and for two months thereafter (sacrifice), with measurements of LV end-diastolic and end-systolic volumes (ESV), ejection fraction (EF), MR stroke volume, and leaflet tethering distance; wall motion score index (WMSi) was assessed by two-dimensional echo. Results: Measurements were similar between groups at baseline and before transplantation. At sacrifice, transplantation was found to have reduced MR progression (regurgitant volume change: -1.83 +/- 0.32 ml vs. 5.9 +/- 0.7 ml in control group, p < 0.0001) and tethering distance (-0.41 +/- 0.09 cm vs. 0.44 +/- 0.12 cm in control group, p < 0.001), with significant improvement of EF (2.01 +/- 0.94% vs. -4.86 +/- 2.23%, p = 0.02), WMSi (-0.25 +/- 0.11 vs. 0.13 +/- 0.03 in controls, p < 0.01) and a trend to a lesser increase in ESV (23.3 +/- 3.5 ml vs. 35.4 +/- 4.2 ml in control group, p = 0.055). Conclusions: Autologous skeletal myoblast transplantation attenuates mild-to-moderate chronic ischemic MR, which otherwise is progressive, by decreasing tethering distance and improving EF and wall motion score, thereby enhancing valve coaptation. These data shed additional light on the mechanism by which skeletal myoblast transplantation may be cardioprotective.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2006
• Auteurs : Samuel BernardKoffi FiatyDavid CornuPhilippe MielePierre Laurent
• Organismes : Institut Européen des membranes Institut Européen des membranes Institut Européen des membranes Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Macromoléculaires
• Publié dans Journal of Physical Chemistry B le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2006
• Auteurs : Louis HennetIrina PozdnyakovaAleksei BytchkovViviana CristiglioPierre PalleauHenry FischerGabriel J. CuelloMark JohnsonPhilippe MelinDidier ZanghiSéverine BrassaminJean-François BrunDavid L. PriceMarie-Louise Saboungi
• Organismes : Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Institut Laue-Langevin Institut Laue-Langevin Institut Laue-Langevin Institut Laue-Langevin Institut Laue-Langevin Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de recherches sur les matériaux à haute température Centre de Recherche sur la Matière Divisée
• Publié dans Review of Scientific Instruments le 02/11/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/05/2006
• Auteurs : C. Camy-PeyretSébastien PayenPascal PrunetEmmanuel DufourRoger BruggeAlan O'NeillJean GirouxPhilippe Lagueux
• Organismes : Laboratoire de Physique Moleculaire pour l'Atmosphere et l'Astrophysique Laboratoire de Physique Moleculaire pour l'Atmosphere et l'Astrophysique NOVELTIS [Sté] NOVELTIS [Sté] University of Reading University of Reading

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Résumé : Because of their high spectral resolution (0.035 cm-1 unapodised), MIPAS spectra contain potential information on the Doppler shifts due to wind along the line-of-sight (LOS) in a given limb scan sequence. The intrinsic absolute stability of the MIPAS wavenumber scale is not granted to the required precision, however. The present ESA operational spectral calibration algorithm is relying on the position of the atmospheric emission lines themselves (assuming no wind effect and in a small range of tangent altitudes where lines are neither too broadened by pressure effects, nor too weak). An algorithm has been proposed that just relies on the relative stability of the wavenumber scale within a given limb scan sequence (usually 17 spectra recorded from about 65 to 10 km in approximately 75 s) to derive a vertical LOS relative wind profile. This LOS wind information is derived by an appropriate algorithm called ANA (for analytical method because an explicit formula is used) producing a wavenumber scaling factor between consecutive spectra in a given limb scan. This scaling factor is derived from a number of optimised wind spectra windows spanning the 5 bands covered by MIPAS. Because of the relative nature of the process, the absolute interband/interwindow calibration is not needed and an optimum weighted average value of the scaling factors can be derived with weights (and an associated occupation matrix) representing the impact of radiometric noise in each window w and for each pair of tangent heights. The average scaling factor is then converted to a relative LOS wind difference and, assuming the LOS wind is known at one level, an absolute LOS wind profile can be provided. The algorithm has been developed (through an ESA contract study), coded and tested on simulated spectra (to check the performances of the method and to establish the noise amplification error factors). We are in the process of testing the algorithm on a set of selected MIPAS spectra recorded in correlation with standard meteorological radio- soundings (providing T, u and v as a function of P). Preliminary results of this study will be presented including comparisons with ECMWF and sonde results, showing that a precision reaching the target of 5 m/s could be expected in the altitude range 20 to 35 km.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/04/2006
• Auteurs : Cécile CourivaudChristophe FerrandMarina DeschampsPierre TiberghienJean-Marc ChalopinAnne DuperrierPhilippe SaasDidier Ducloux
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon
• Publié dans Transplantation le 25/10/2020

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Résumé : Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated levels of C-reactive protein and by a correlation between posttransplant AE and Toll-like receptor-4 Asp299Gly polymorphism. Here, we analyze the influence NOD2/CARD15 gene polymorphism since NOD2 can modulate macrophage pro-inflammatory activity and macrophage is present in early atherosclerotic lesions. The incidence of single nucleotide polymorphism (SNP) in the three major polymorphic region of NOD2 gene (SNP8, SNP12 and SNP13) was assessed in 182 RTR and the correlation between such polymorphism and the development of AE was analyzed. No correlation was observed between NOD2 gene polymorphism and the occurrence of AE after renal transplantation. NOD2 gene polymorphism thus does not appear to influence cardiovascular complications in RTR.

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Fichiers liés : Courivaud_C_Transplantation_2006.pdf inserm-00473148_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 21/04/2006
• Auteurs : Emilie CollartAbhay ShuklaJean-Pascal RueffPhilippe LeiningerHirofumi IshiiIgnace JarrigeYong CaiSang-Wook CheongGuy Dhalenne
• Organismes : Institut de minéralogie et de physique des milieux condensés Institut de minéralogie et de physique des milieux condensés Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement National Synchrotron Radiation Research Center National Synchrotron Radiation Research Center National Synchrotron Radiation Research Center Rutgers, The State University of New Jersey [New Brunswick] Laboratoire de Physico-Chimie de l'État Solide
• Publié dans Physical Review Letters le 02/11/2020

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Résumé : The dynamics of doped charge in an antiferromagnetic lattice is central to the description of the insulator-metal transition that occurs on doping the parent high Tc compounds. In this work we use high resolution resonant inelastic x-ray scattering to investigate the dynamics of the charge-transfer exciton by measuring its energy dispersion in two prototype compounds, La2CuO4 and La2NiO4. We show that this behavior is radically different in the cuprate with respect to a system known to exhibit strong polaronic behavior, namely, the nickelate: the exciton is mobile in the cuprate while it is well localized in the nickelate. Using a simple Wannier-Mott model we can estimate the total hole plus electron effective mass in the cuprate to be 3.5±0.3me which would exclude strong localization in the undoped cuprate.

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Fichiers liés : PhysRevLett.96.157004.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2006
• Auteurs : L BollingerPierre HenryJean‐philippe Avouac
• Organismes : Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement
• Publié dans Earth and Planetary Science Letters le 01/11/2020

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Résumé : We model crustal deformation and the resulting thermal structure across the Nepal Himalaya, assuming that, since 20 Ma, shortening across the range has been primarily taken up by slip along a single thrust fault, the Main Himalayan Thrust (MHT) Fault, and that the growth of the Himalayan wedge has resulted mainly from underplating and to the development of a duplex at midcrustal depth. We show that this process can account for the inverse thermal metamorphic gradient documented throughout the Lesser Himalaya (LH), the discontinuity of peak metamorphic temperatures across the MCT, as well as the distribution of age of exhumation across the range. This study suggests that the metamorphic evolution of the range over about the last 20 million years is compatible with the kinematics of recent crustal deformation deduced from morphotectonic and geodetic studies.

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