Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 03/11/2005
• Auteurs : Fabrice CourtinJamonneau VincentEmmanuel OkéBamoro CoulibalyJohan OszwaldSophie DupontGérard CunyJean-Pierre DoumengePhilippe Solano
• Organismes : Littoral, Environnement, Télédétection, Géomatique Université Paul-Valéry - Montpellier 3
• Publié dans International Journal of Health Geographics le 22/10/2020

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Résumé : Background This study aimed at identifying factors influencing the development of Human African Trypanosomosis (HAT, or sleeping sickness) in the focus of Bonon, located in the mesophile forest of Côte d'Ivoire. A previous study mapping the main daytime activity sites of 96 patients revealed an important disparity between the area south of the town- where all the patients lived- and the area north of the town, apparently free of disease. In order to explain this disparity, we carried out a spatial analysis of the key components of the pathogenic system, i.e. the human host, the tsetse vector and the trypanosomes in their environment using a geographic information system (GIS). Results This approach at the scale of a HAT focus enabled us to identify spatial patterns which linked to the transmission and the dissemination of this disease. The history of human settlement (with the rural northern area exploited much earlier than the southern one) appears to be a major factor which determines the land use pattern, which itself may account for differences found in vector densities (tsetse were found six times more abundant in the southern rural area than in the northern). Vector density, according to the human and environmental context in which it is found (here an intense mobility between the town of Bonon and the rural areas), may explain the observed spatial differences in HAT prevalence. Conclusion This work demonstrates the role of GIS analyses of key components of the pathogenic system in providing a better understanding of transmission and dissemination of HAT. Moreover, following the identification of the most active transmission areas, and of an area unfavourable to HAT transmission, this study more precisely delineates the boundaries of the Bonon focus. As a follow-up, targeted tsetse control activities starting north of Bonon (with few chances of reinvasion due to very low densities) going south, and additional medical surveys in the south will be proposed to the Ivoirian HAT control program to enhance the control of the disease in this focus. This work also shows the evolution of HAT regarding time and environment, and the methodology used may be able to predict possible sleeping sickness development/extinction in areas with similar history and space organization.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/11/2005
• Auteurs : Jean-Philippe DelahayeJacques PalicotPierre Leray
• Organismes : Réseau National des Systèmes Complexes Institut d'Électronique et des Technologies du numéRique Institut d'Électronique et des Technologies du numéRique

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Fabienne LaugerettePatricia Passilly-DegraceBruno PatrisIsabelle NiotMaria FebbraioJean-Pierre MontmayeurPhilippe Besnard
• Organismes : Laboratoire de Physiologie de la Nutrition Laboratoire de Physiologie de la Nutrition Laboratoire de Physiologie de la Nutrition Laboratoire de Physiologie de la Nutrition
• Publié dans Journal of Clinical Investigation le 24/10/2020

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Résumé : Rats and mice exhibit a spontaneous attraction for lipids. Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids. The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (LCFAs) and is found in lingual papillae in the rat. To explore this hypothesis further, experiments were conducted in rats and in wild-type and CD36-null mice. In mice, RT-PCR experiments with primers specific for candidate lipid-binding proteins revealed that only CD36 expression was restricted to lingual papillae although absent from the palatal papillae. Immunostaining studies showed a distribution of CD36 along the apical side of circumvallate taste bud cells. CD36 gene inactivation fully abolished the preference for LCFA-enriched solutions and solid diet observed in wild-type mice. Furthermore, in rats and wild-type mice with an esophageal ligation, deposition of unsaturated LCFAs onto the tongue led to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Mirdad KazanjiPhilippe DussartRenan DuprezPatricia TortevoyeJean-François PouliquenJulie VandekerkhovePierre CouppiéJacques MorvanAntoine TalarminPhilippe Mauclère
• Organismes : Laboratoire de Rétrovirologie [Cayenne, Guyane française] Epidémiologie et Physiopathologie des Virus Oncogènes Laboratoire de virologie [Cayenne, Guyane française] Epidémiologie et Physiopathologie des Virus Oncogènes Epidémiologie et Physiopathologie des Virus Oncogènes Laboratoire de Rétrovirologie [Cayenne, Guyane française] Laboratoire de virologie [Cayenne, Guyane française] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Laboratoire de virologie [Cayenne, Guyane française] Laboratoire de virologie [Cayenne, Guyane française] Epidémiologie et Physiopathologie des Virus Oncogènes
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : We evaluated the presence of human herpesvirus 8 (HHV-8) infection among groups of Amerindians in French Guiana. The overall prevalence of antibodies against lytic HHV-8 antigens was 23.0% (180/781), increasing from 18.4% in children <6 years old to approximately 30% in older persons (>45 years). Seroprevalence was higher in Amerindians living in remote localities than it was in those living in the coastal region. Analysis of a 725-base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindians in Brazil and Ecuador.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Estelle Jumas-BilakHélène Jean-PierreJean-Philippe CarlierCorinne TeyssierKathryn BernardBernard GayJosiane CamposFlorent MorioH. Marchandin
• Organismes : Université Montpellier 1 Hôpital Arnaud de Villeneuve [CHU Montpellier] Centre National de Référence des Bactéries Anaérobies et Botulisme - National Reference Center Anaerobic Bacteria and Botulism Université Montpellier 1 Public Health Agency of Canada Hôpital Arnaud de Villeneuve [CHU Montpellier] Hôpital Arnaud de Villeneuve [CHU Montpellier] Hôpital Arnaud de Villeneuve [CHU Montpellier] Hôpital Arnaud de Villeneuve [CHU Montpellier]
• Publié dans International Journal of Systematic and Evolutionary Microbiology le 31/10/2020

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Résumé : Seventeen anaerobic, Gram-negative, tiny coccobacilli were collected in France from various human clinical samples. Biochemical analyses as well as molecular studies, including 16S rRNA and dnaK gene sequencing, affiliated all the isolates to the genus Dialister . However, 16S rRNA and dnaK gene sequence similarities were below 95·2 and 79·7 %, respectively, when comparisons were performed with the currently described species Dialister pneumosintes and Dialister invisus . Two clusters consisting of 13 and four isolates could be differentiated. 16S rRNA- and dnaK -based phylogeny confirmed that these two clusters represent two novel and distinct lineages within the genus Dialister . Finally, phenotypic, genotypic and phylogenetic data supported the proposal of the two novel species Dialister micraerophilus sp. nov. (type strain ADV 04.01 T =AIP 25.04 T =CIP 108278 T =CCUG 48837 T ) and Dialister propionicifaciens sp. nov. (type strain ADV 1053.03 T =AIP 26.04 T =CIP 108336 T =CCUG 49291 T ). The G+C content of the DNA of the D. micraerophilus type strain is 36·3 mol%. On the basis of 16S rRNA gene sequence analysis, 11 isolates originating from Canada could also be affiliated to D. micraerophilus sp. nov., and were included in the species description.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2005
• Auteurs : Emmanuel TrouvéMichel GayPhilippe BolonGabriel VasileJean-Marie NicolasJocelyn ChanussotP. GrussenmeyerTania Landes
• Organismes : Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Modèles et simulation pour l'architecture, l'urbanisme et le paysage Modèles et simulation pour l'architecture, l'urbanisme et le paysage

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Jean-François RossiNathalie FegueuxZhao Yang LuÉric LegouffeCarole ExbrayatMarie-Cécile BozonnatRobert NavarroErnesto LopezPhilippe QuittetJean-Pierre DaurèsValérie RouilléTarik KanouniJohn WidjenesBernard Klein
• Organismes : Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Unité de Thérapie Cellulaire et Génique Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Diaclone Research Unité de Thérapie Cellulaire et Génique
• Publié dans Bone Marrow Transplantation le 01/11/2020

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Résumé : Interleukin-6 (IL-6) is a major survival factor for multiple myeloma (MM) cells preventing apoptosis induced by dexamethasone (DEX) or chemotherapy. In all, 24 consecutive patients with MM in first-line therapy received DEX for 4 days, followed by melphalan (HDM: 140 mg/m2) and autologous stem cell transplantation (ASCT). The anti-IL-6 monoclonal antibody (mAb) (B-E8) was given till haematological recovery, starting 1 day before DEX. Results were historically compared to MM patients treated with HDM 140 and 200 mg/m2. Our results show (1) that B-E8 was able to fully neutralize IL-6 activity in vivo before and after HDM as shown by inhibition of C reactive protein (CRP) production; (2) no haematological toxicity; (3) a significant reduction of mucositis and fever; (4) a median event-free survival of 35 months and an overall survival of 68.2% at 5 years with a median follow-up of 72 months; and (5) the overall daily IL-6 production progressively increased on and after 7 days post-HDM, with the increased serum CRP levels. In the 5/24 patients with uncontrolled CRP production, a large IL-6 production was detected (320 microg/day) that could not possibly be neutralized by B-E8. These data show the feasibility to neutralize IL-6 in vivo with anti-IL-6 mAb in the context of HDM.

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Fichiers liés : anti-IL-6_MMfinal_versionBMTcorrected_0505.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/11/2005
• Auteurs : Roland CahenXavier RodetJean-Philippe Lambert
• Organismes : Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris]

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Résumé : Sound Navigation consists in browsing through different sound objects and sound generators situated within a virtual world including virtual spatialized sound and visual scenes, to perform a musical trajectory and composition. In the PHASE Project installation, the 3D virtual world resembles the surface of a vinyl disk, magnified so that one can see the groove and move a “needle” (the “reading head”) in it and out of it to read the disk. Another such “needle” (the “writing head”) can “write” music in the groove. A part of the game is a pursuit between the writing head and the reading head handled by the player. Different musical devices have been implemented. Most of them have a haptic behavior. The scenario is fully related to the musical metaphor and aims to give equivalent pleasure to contemplative as well as to competitive players.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Virginie ArchaimbaultPhilippe Usseglio-PolateraJean-Pierre Vanden Bossche
• Organismes : Laboratoire Interdisciplinaire des Environnements Continentaux
• Publié dans Hydrobiologia le 30/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2005
• Auteurs : Jean-Pierre Vanden BosschePhilippe Usseglio-Polatera
• Organismes : Laboratoire Interdisciplinaire des Environnements Continentaux
• Publié dans Hydrobiologia le 30/10/2020

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