Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2005
• Auteurs : Fleur CouvreuxFrancoise GuichardJean-Luc RedelspergerC. KiemleValéry MassonJean-Philippe LaforeCyrille Flamant
• Organismes : Centre national de recherches météorologiques Centre national de recherches météorologiques Centre national de recherches météorologiques DLR Institut für Physik der Atmosphäre = DLR Institute of Atmospheric Physics Centre national de recherches météorologiques Centre national de recherches météorologiques Service d'aéronomie
• Publié dans Quarterly Journal of the Royal Meteorological Society le 27/10/2020

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Résumé : This study presents a comprehensive analysis of the variability of water vapour in a growing convective boundary-layer (CBL) over land, highlighting the complex links between advection, convective activity and moisture heterogeneity in the boundary layer. A Large-eddy Simulation (LES) is designed, based on observations, and validated, using an independent data-set collected during the International H 2 O Project (IHOP 2002) fieldexperiment. Ample information about the moisture distribution in space and time, as well as other important CBL parameters are acquired by mesonet stations, balloon soundings, instruments on-board two aircraft and the DLR airborne water-vapour differential-absorption lidar. Because it can deliver two-dimensional cross-sections at high spatial resolution (140 m horizontal, 200 m vertical), the airborne lidar offers valuable insights of small-scale moisture-variability throughout the CBL. The LES is able to reproduce the development of the CBL in the morning and early afternoon, as assessed by comparisons of simulated mean profiles of key meteorological variables with sounding data. Simulated profiles of the variance of water-vapour mixing-ratio were found to be in good agreement with the lidar-derived counterparts. Finally, probability-density functions of potential temperature, vertical velocity and water-vapour mixing-ratio calculated from the LES show great consistency with those derived from aircraft in situ measurements in the middle of the CBL. Downdraughts entrained from above the CBL are governing the scale of moisture variability. Characteristic length-scales are found to be larger for water-vapour mixing-ratio than for temperature The observed water-vapour variability exhibits contributions from different scales. The influence of the mesoscale (larger than LES domain size, i.e. 10 km) on the smaller-scale variability is assessed using LES and observations. The small-scale variability of water vapour is found to be important and to be driven by the dynamics of the CBL. Both lidar observations and LES evidence that dry downdraughts entrained from above the CBL are governing the scale of moisture variability. Characteristic length-scales are found to be larger for water-vapour mixing-ratio than for temperature and vertical velocity. In particular, intrusions of drier free-troposphere air from above the growing CBL impose a marked negative skewness on the water-vapour distribution within it, both as observed and in the simulation.

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Fichiers liés : Couvreux_etal_2005_qj.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2005
• Auteurs : Pierre-Yves SalaunFrancis CouturaudKarine LacutMichel NonentChristophe Gut-GobertGregoire Le GalPhilippe GuilloJean JouquanDominique MottierChristophe Leroyer
• Organismes : Department of Nuclear Medicine Groupe d'Etude de la Thrombose de Bretagne Occidentale Groupe d'Etude de la Thrombose de Bretagne Occidentale Département de Médecine Interne et Pneumologie [Brest] Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale Département de radiologie [Brest] Département de Médecine Interne et Pneumologie [Brest] Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Department of Nuclear Medicine Département de Médecine Interne et Pneumologie [Brest] Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Groupe d'Etude de la Thrombose de Bretagne Occidentale Département de Médecine Interne et Pneumologie [Brest]
• Publié dans International Journal for Quality in Health Care le 27/10/2020

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Résumé : OBJECTIVE: To achieve a common strategy in the event of a suspected venous thromboembolism. DESIGN: A multifaceted intervention, combining an audit strategy and implementation of local guidelines: phase 1, the first step, consisted of a 6-month audit to identify dysfunction; during phase 2, intervention, local guidelines were formulated by a working group and then implemented; phase 3 consisted of a re-audit over a 6-month period following the intervention. SETTING: A tertiary hospital, France. PARTICIPANTS: 419 patients with suspected venous thromboembolism in phase 1; 287 patients with suspected pulmonary embolism in phase 3. RESULTS: First phase: a dysfunction was observed in three of five criteria under study: (i) the diagnostic procedure lasted more than 48 hours in 114 patients (27.2%); (ii) no anticoagulant therapy at the time of suspicion in 116 patients (27.7%); (iii) an inconclusive lung scan without further testing in the event of a suspected pulmonary embolism in 40 patients (14%); the intervention phase was thus restricted to the management of suspected pulmonary embolism; similar results were found during the phase 3 re-audit. CONCLUSION: No improvement in the diagnostic work-up in the event of a suspected pulmonary embolism was observed following this multifaceted intervention.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2005
• Auteurs : Jean-Louis HouberdonJean-Philippe BabauIsabelle Augé-BlumPierre Combes
• Organismes : Architectures of networks of services CITI Centre of Innovation in Telecommunications and Integration of services Architectures of networks of services France Télécom Recherche & Développement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2005
• Auteurs : Pierre-Alain MullerFranck FleureyDidier VojtisekZoé DreyDamien PolletFrédéric FondementPhilippe StuderJean-Marc Jézéquel
• Organismes : Reliable and efficient component based software engineering Reliable and efficient component based software engineering Reliable and efficient component based software engineering Reliable and efficient component based software engineering Reliable and efficient component based software engineering Laboratoire de Génie Logiciel Modélisation, Intelligence, Processus et Système Reliable and efficient component based software engineering

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Résumé : Domain specific languages for model transformation have recently generated significant interest in the model-driven engineering community. The adopted QVT specification has normalized some scheme of model transformation language; however several different model transformation language paradigms are likely to co-exist in the near future, ranging from imperative to declarative (including hybrid). It remains nevertheless questionable how model transformation specific languages compare to more general purpose languages, in terms of applicability, scalability and robustness. In this paper we report on our specific experience in applying an executable meta-language to the model transformation field.

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Fichiers liés : Muller05c.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2005
• Auteurs : Christine GrangerPhilippe BareyJean-Pierre da CostaJ. ToutainMaud Cansell
• Organismes : Laboratoire des Milieux Dispersés Alimentaires Business Line Texturant Systems France SAS Business Line Texturant Systems France SAS Laboratoire de l'intégration, du matériau au système Transferts, écoulements, fluides, énergétique Laboratoire des Milieux Dispersés Alimentaires

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2005
• Auteurs : Noushine ShahidzadehPhilippe ViéXavier ChateauJean-Noël RouxDaniel Bonn
• Organismes : Universiteit van Amsterdam = University of Amsterdam Laboratoire des matériaux et structures du génie civil Rhéophysique Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique Statistique de l'ENS
• Publié dans Physical Review Letters le 02/11/2020

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Fichiers liés : 2005-Phys-Rev-Lett.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2005
• Auteurs : Natacha BernardLionel DeveveyCéline JacquemontPascale ChrétienPhilippe HelisseyJean-Jacques GuillossonMichel ArockJoëlle Nafziger
• Organismes : Université Pierre et Marie Curie - Paris 6 Unité sous contrat biologie environnementale Epidémiologie, santé publique et développement Service de médecine interne Laboratoire de génie électrique de Paris Laboratoire de Biologie et de Pharmacologie Appliquée
• Publié dans Experimental Hematology le 23/10/2020

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Résumé : OBJECTIVE: Although B acute lymphoblastic leukemia (B-ALL) is the most common leukemia among children, no chemically inducible model of this leukemia has yet been described in vivo. METHODS: Leukemia was chemically induced in male WKAH/Hkm rats by a nitrosourea derivative, N-butylnitrosourea (BNU), an alkylating agent, administered orally 5 days a week for 24 weeks. Development of leukemia was monitored by clinical observation, follow-up of blood parameters, and appearance of blast cells in peripheral blood samples. The phenotype of the leukemia was determined by cytological examination, cytochemical reactions, and by immunophenotyping of bone marrow cells using various markers. The feasibility of leukemia transplantation was investigated. Clonality and karyotype analyses were also performed. RESULTS: We observed the appearance of acute leukemia in 60% of the rats treated with BNU. Of these, 65% developed pre-B-ALL, which was serially transplantable to healthy WKAH/Hkm male rats. Karyotype analysis did not reveal clonal abnormalities. Clonality determined by immunoglobulin gene rearrangement sequencing disclosed that the pre-B-ALL were mostly oligoclonal. CONCLUSION: This new in vivo model of inducible pre-B-ALL might be useful for investigating the effects of co-initiating or promoting agents suspected to be involved in leukemia development, and for disclosing new molecular events leading to leukemogenic processes.

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• Type de publi. :
• Date de publi. : 01/10/2005
• Auteurs : Philippe Rygiel
• Organismes : Action publique et mondes urbains
• Publié dans Menestrel le 07/03/2019

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Résumé : La refonte du site ménestrel, portail pionnier de la science médiévistique était l'occasion de réfléchir à la notion de portail, et aux fonctions assumés par ceux-ci dans le contexte du web de première génération, en insistant sur l'architecture des liens de ces objets, qui en faisaient des nodes, des points de rencontre, plus que des clotures délimitant un espace disciplinaire.

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Fichiers liés : PortailsLamop.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/09/2005
• Auteurs : Michel LagardePierre AstorgPhilippe P. GuesnetJean-Louis Sébédio
• Organismes : Institut National de la Santé et de la Recherche Médicale Laboratoire de nutrition et sécurité alimentaire Laboratoire de nutrition et sécurité alimentaire Unité de Nutrition Humaine

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• Type de publi. :
• Date de publi. : 26/09/2005
• Auteurs : Joël LemaireFabrice BoyrieLuke MacaleesePierre BoisselFrançois GlotinJean-Michel OrtegaPhilippe Maıtre
• Organismes : Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay Laboratoire de Chimie Physique D'Orsay Laboratoire pour l'utilisation du rayonnement électromagnétique Laboratoire pour l'utilisation du rayonnement électromagnétique Laboratoire de Chimie Physique D'Orsay

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Fichiers liés : poster-sfsmv03corrigé.pdf

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