Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 07/03/2006
• Auteurs : Christian HanuiseJean-Claude CerisierFrédéric AuchèreKarine BocchialiniS. BruinsmaNicole Cornilleau-WehrlinN. JakowskiChantal LathuillèreMichel MenvielleJean-Jacques ValetteNicole VilmerJ. WatermannPhilippe Yaya
• Organismes : Laboratoire de physique et chimie de l'environnement Centre d'étude des environnements terrestre et planétaires Institut d'astrophysique spatiale Institut d'astrophysique spatiale Services communs OMP Centre d'étude des environnements terrestre et planétaires DLR Institut für Kommunikation und Navigation Laboratoire de Planétologie de Grenoble Centre d'étude des environnements terrestre et planétaires Collecte Localisation Satellite Laboratoire d'études spatiales et d'instrumentation en astrophysique Danish Meteorological Institute Collecte Localisation Satellite
• Publié dans Annales Geophysicae le 26/10/2020

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Résumé : During the last week of May 2003, the solar active region AR 10365 produced a large number of flares, several of which were accompanied by Coronal Mass Ejections (CME). Specifically on 27 and 28 May three halo CMEs were observed which had a significant impact on geospace. On 29 May, upon their arrival at the L1 point, in front of the Earth's magnetosphere, two interplanetary shocks and two additional solar wind pressure pulses were recorded by the ACE spacecraft. The interplanetary magnetic field data showed the clear signature of a magnetic cloud passing ACE. In the wake of the successive increases in solar wind pressure, the magnetosphere became strongly compressed and the sub-solar magnetopause moved inside five Earth radii. At low altitudes the increased energy input to the magnetosphere was responsible for a substantial enhancement of Region-1 field-aligned currents. The ionospheric Hall currents also intensified and the entire high-latitude current system moved equatorward by about 10°. Several substorms occurred during this period, some of them - but not all - apparently triggered by the solar wind pressure pulses. The storm's most notable consequences on geospace, including space weather effects, were (1) the expansion of the auroral oval, and aurorae seen at mid latitudes, (2) the significant modification of the total electron content in the sunlight high-latitude ionosphere, (3) the perturbation of radio-wave propagation manifested by HF blackouts and increased GPS signal scintillation, and (4) the heating of the thermosphere, causing increased satellite drag. We discuss the reasons why the May 2003 storm is less intense than the October-November 2003 storms, although several indicators reach similar intensities.

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Fichiers liés : angeo-24-129-2006.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 03/03/2006
• Auteurs : Pierre MahéLiva RalaivolaVéronique StovenJean-Philippe Vert
• Organismes : Centre de Bioinformatique Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Centre de Bioinformatique Centre de Bioinformatique

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Résumé : We introduce a family of positive definite kernels specifically optimized for the manipulation of 3D structures of molecules with kernel methods. The kernels are based on the comparison of the three-points pharmacophores present in the 3D structures of molecul es, a set of molecular features known to be particularly relevant for virtual screening applications. We present a computationally demanding exact implementation of these kernels, as well as fast approximations related to the classical fingerprint-based approa ches. Experimental results suggest that this new approach outperforms state-of-the-art algorithms based on the 2D structure of mol ecules for the detection of inhibitors of several drug targets.

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Fichiers liés : techreport_final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2006
• Auteurs : J. MalzacP.O. PetrucciE. JourdainM. Cadolle BelP. SizunG. PooleyC. CabanacSylvain ChatyT. BelloniJoseph RodriguezJean-Pierre RoquesP. DurouchouxA. GoldwurmPhilippe Laurent
• Organismes : Centre d'étude spatiale des rayonnements Laboratoire d'Astrophysique de Grenoble Centre d'étude spatiale des rayonnements AstroParticule et Cosmologie Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée Laboratoire d'Astrophysique de Grenoble Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Centre d'étude spatiale des rayonnements AstroParticule et Cosmologie Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée APC - Astrophysique des Hautes Energies
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : We report the results of an observation of Cygnus X-1 with INTEGRAL, that we combine with simultaneous radio observations with the Ryle telescope. Both spectral and variability properties of the source indicate that Cygnus X-1 was in an Intermediate State. The INTEGRAL spectrum shows a high-energy cut-off or break around 100 keV. The shape of this cut-off differs from pure thermal Comptonisation, suggesting the presence of a non-thermal component at higher energies.The average broad band spectrum is well represented by hybrid thermal/non-thermal Comptonisation models. During the 4 day long observation the source showed an important spectral and flux variability. A principal component analysis demonstrates that most of this variability occurs through 2 independent modes. The first mode consists in changes in the overall luminosity on time scale of hours with almost constant spectra that are strikingly uncorrelated with the variable radio flux. We interpret this variability mode as variations of the dissipation rate in the corona. The second variability mode consists in a pivoting of the spectrum around 10 keV. It acts on a longer time-scale: initially soft, the spectrum hardens in the first part of the observation and then softens again. This pivoting pattern is strongly correlated with the radio (15 GHz) emission: radio fluxes are stronger when the INTEGRAL spectrum is harder. We propose that the pivoting mode represents a 'mini' state transition from a nearly High Soft State to a nearly Low Hard State, and back. This mini-transition would be caused by changes in the soft cooling photons flux in the hot Comptonising plasma associated with an increase of the temperature of the accretion disc. The jet power then appears to be anti-correlated with the disc luminosity and unrelated to the coronal power.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2006
• Auteurs : Philippe ThomasCyril Hazif-ThomasFrançois ViébanPhilippe FaugeronRichard PeixJean-Pierre Clément
• Organismes : Neuroépidémiologie Tropicale et Comparée Service de Psychiatrie [CHU Limoges] Centre de Mémoire de Ressources et de Recherches [Limoges]
• Publié dans Psychologie & neuropsychiatrie du vieillissement le 13/08/2014

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Résumé : GPcog is a screening tool for dementia in the aged. It consists of nine cognitive items and six items assessing the daily living instrumental activities by an informal carer. This study was aimed to assess the reliability of the French version of the GPcog in a psychogeriatric population. Two hundred and eighty inpatients from a short-term psychogeriatric ward, with or without dementia, were examined. Scores on GPcog, MMSE and on a five-word memory test for screening dementia were compared to the final diagnosis of dementia. The mean age of subjects was 77.8+/-7.0 years for males (n=116), and of 80.3+/-6.6 years for females (n=164). One hundred eighty two patients had dementia, mainly of Alzheimer's type, and 98 had psychiatric disorders but were non demented. GPcog sensitivity for the diagnosis of dementia was 96%, specificity 62%, positive predictive value 83% and negative predictive value 90%. GPcog is an accurate and well-accepted instrument for dementia screening in primary care. French results were similar to those obtained with the English version. It can be easily used by non-specialized carers.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2006
• Auteurs : Honglei LiSophie Mac-MaryDavid MarsautJean Marie SainthillierTijani GharbiOlivier de LacharrierePhilippe Humbert
• Organismes : Ingénierie et biologie cellulaire et tissulaire Département de dermatologie Department of Dermatology Ingénierie et biologie cellulaire et tissulaire Département de dermatologie Laboratoire d'optique Pierre Michel Duffieux Ingénierie et biologie cellulaire et tissulaire Laboratoire d'optique Pierre Michel Duffieux Recherche clinique prospective Ingénierie et biologie cellulaire et tissulaire Département de dermatologie Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
• Publié dans Archiv für Dermatologie und Syphilis le 09/12/2014

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Résumé : Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe the age-related changes of the skin topography and skin microcirculation. The microrelief was assessed with special processing software from scanning by interference fringe profilometry of silicone replicas performed on two sites (volar forearm and back of hand) on 50 female volunteers (aged 20-74 years who consisted of ten probands in each decade). The superficial vascular network of both sites was assessed by videocapillaroscopy, and the subpapillary vascular plexus was studied with laser Doppler flowmetry. Skin color, which is affected by blood flow, was observed by colorimeter. The skin roughness and the mean height between peak and valley increased with age. There were statistically significant differences between the evaluated sites. This study also shows that the capillary loops in the dermal papillae decrease but the subpapillary plexus increase with age. The interference fringe profilometry associated with videocapillaroscopy may be useful and accurate to measure the efficacy of medical or cosmetic products to delay skin aging.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2006
• Auteurs : Paul RobachLaurent SchmittJ.V. BrugniauxBelle RoelsGrégoire P MilletPhilippe HellardGérard NicoletAlain DuvalletJean-Pierre FouillotStéphane MoutereauFrançoise LasneVincent PialouxNiels V. OlsenJean-Paul Richalet
• Organismes : Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Image et ville Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire School of Sport and Education Institut des Systèmes Intelligents et de Robotique Institut national du sport, de l'expertise et de la performance Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Service de Biochimie [Mondor] Agence Française de Lutte contre le Dopage Laboratoire de Physiologie-Biologie du Sport Department of Pharmacology and Pharmacotherapy [Copenhagen] Réponses Cellulaires et Fonctionnelles à l'Hypoxie
• Publié dans European Journal of Applied Physiology le 27/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/02/2006
• Auteurs : Antoine ScherrerNicolas LarrieuPierre BorgnatPhilippe OwezarskiPatrice Abry
• Organismes : Laboratoire de l'Informatique du Parallélisme Laboratoire d'analyse et d'architecture des systèmes Laboratoire de Physique de l'ENS Lyon Laboratoire d'analyse et d'architecture des systèmes Laboratoire de Physique de l'ENS Lyon

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Résumé : Due to the variety of services and applications available on today's Internet, many properties of the traffic stray from the classical characteristics (Gaussianity and short memory) of standard models. The goal of the present contribution is to propose a statistical model able to account both for the non Gaussian and long memory properties of aggre- gated count processes. First, we introduce the model and a procedure to estimate the corresponding parameters. Second, using a large set of data taken from public reference repositories (Bellcore, LBL, Auckland, UNC, CAIDA) and collected by ourselves, we show that this stochastic process is relevant for Internet traffic modeling for a wide range of aggregation levels. In conclusion we indicate how this modeling could be used in IDS design.

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Fichiers liés : 5.3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/02/2006
• Auteurs : Maud LemoineVéronique BarbuPierre Marie GirardMin Ji KimJean-Philippe BastardDominique WendumFrançois PayeChantal HoussetJacqueline CapeauLawrence Serfaty
• Organismes : Pathologie de l'Adipocyte et des Cellules Hepatiques
• Publié dans AIDS. Official journal of the international AIDS Society le 23/08/2019

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/02/2006
• Auteurs : Jean-Pierre BarthélemyAngélique LegrainPhilippe LencaBenoît Vaillant
• Organismes : Département Logique des Usages, Sciences sociales et Sciences de l'Information Département Logique des Usages, Sciences sociales et Sciences de l'Information Département Logique des Usages, Sciences sociales et Sciences de l'Information Département Logique des Usages, Sciences sociales et Sciences de l'Information

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Résumé : L'un des principaux problèmes posés par l'extraction de règ les d'as- sociation est l'évaluation de la qualité des règles produit es par les algorithmes de type A PRIORI . De nombreuses mesures ont été définies afin de pouvoir classe r les règles dites intéressantes . Très hétérogènes, elles produisent des classements forts variés. C'est pourquoi, plutôt que de privilégier une mesure il paraît inté- ressant de tenir compte des différentes informations appor tées par les mesures. Ainsi, nous avons adopté une nouvelle approche : l'agrégati on à l'aide de re- lations valuées permettant de mesurer le degré d'intensité de préférence d'une règle sur une autre. Elles permettent d'une part de retransc rire la nature numé- rique des mesures, et d'autre part de réduire les problèmes d 'incomparabilité entre les mesures. Nous avons étudié différents opérateurs d'agrégation. Dan s cet article, nous illustrons les résultats obtenus à l'aide d'un exemple joue t en utilisant le plus simple opérateur d'agrégation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/02/2006
• Auteurs : Marie-Pierre Létourneau MontminyCatherine C. JondrevillePhilippe LescoatFrancois F. MeschyCandido PomarJean-Yves DourmadAurélie WilfartJaap J. van MilgenDaniel Sauvant
• Organismes : Physiologie de la Nutrition et Alimentation Systèmes d'Elevage, Nutrition Animale et Humaine Unité de Recherches Avicoles Physiologie de la Nutrition et Alimentation Centre de Recherche et de Développement sur le bovin laitier et le porc de Lennoxville Systèmes d'Elevage, Nutrition Animale et Humaine Systèmes d'Elevage, Nutrition Animale et Humaine Systèmes d'Elevage, Nutrition Animale et Humaine Physiologie de la Nutrition et Alimentation

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